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1. 发明申请

US20170226201A1 Methods of diagnosing and treating hyperproliferative disorders 审中-公开
公开(公告)号：US20170226201A1
公开(公告)日：2017-08-10
申请号：US14146387
申请日：2014-01-02
申请人： Hartmut M. Hanauske-Abel , Myung-Hee Park , Edith C. Wolff , Debra Sheldon-Heller , Bernadette M. Cracchiolo , Anthony Popowicz , Paul M. Clement
发明人： Hartmut M. Hanauske-Abel , Myung-Hee Park , Edith C. Wolff , Debra Sheldon-Heller , Bernadette M. Cracchiolo , Anthony Popowicz , Paul M. Clement
IPC分类号： C07K16/28 , G01N33/68 , G01N33/574 , C07K16/30
CPC分类号： C07K16/28 , C07K16/18 , G01N33/57407 , G01N33/57496 , G01N33/6812 , G01N33/6872
摘要： The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.

2. 发明授权

US07141589B2 Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation 有权
标题翻译：抑制血管通道形成的方法和抑制增殖的方法
公开(公告)号：US07141589B2
公开(公告)日：2006-11-28
申请号：US10486671
申请日：2002-08-23
申请人： Myung Hee Park , Paul M Clement , Hartmut M Hanauske-Abel , Edith C. Wolff , Hynda K Kleinman , Bernadette M Cracchiolo
发明人： Myung Hee Park , Paul M Clement , Hartmut M Hanauske-Abel , Edith C. Wolff , Hynda K Kleinman , Bernadette M Cracchiolo
IPC分类号： A61K31/44 , A61K38/00
CPC分类号： A61K31/16 , A61K31/44 , A61K31/4412
摘要： A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.
摘要翻译：抑制组织中血管通道形成的方法和抑制非血管化上皮内瘤变细胞增殖的方法，所述方法包括向组织或细胞施用化合物。

3. 发明授权

US5789426A Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation 失效
标题翻译：通过应用蛋白质羟化作用抑制剂治疗纤维增生性疾病的方法
公开(公告)号：US5789426A
公开(公告)日：1998-08-04
申请号：US377137
申请日：1995-01-20
申请人： Hartmut M. Hanauske-Abel , Timothy A. McCaffrey , Robert Walter Grady
发明人： Hartmut M. Hanauske-Abel , Timothy A. McCaffrey , Robert Walter Grady
IPC分类号： C07D213/69 , A61K31/00 , A61K31/4412 , A61K31/4422 , A61K38/00 , A61P1/16 , A61P11/00 , A61P13/12 , A61P17/02 , A61P43/00 , C07K5/02 , A01N43/40
CPC分类号： A61K31/00 , A61K31/4412 , A61K31/4422 , C07K5/02 , C07K5/0215
摘要： The present invention relates to a method of treating a patient with a fibrotic or fibroproliferative disorder and a method of suppressing formation of collagen and collagen-like substances or biosynthesis of procollagen in living systems by administering to a patient or living system, respectively, an effective amount of a compound of Formulae (I) or (II) and derivatives thereof: ##STR1## R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each individually represent a hydrogen, an alkyl, alkenyl, or alkoxy group containing 1 to about 8 carbon atoms, an aryl, aralkyl, or cycloalkyl group containing about 5 to 12 carbon atoms, or a carboalkoxy or carbamyl group containing up to 8 carbon atoms, or a peptide or peptidomimetic moiety containing 10 to about 30 carbon atoms.
摘要翻译：本发明涉及一种治疗患有纤维化或纤维增生性病症的患者的方法，以及通过对患者或生活系统分别施用有效的方式抑制胶原蛋白和胶原样物质的形成或生物体内生物合成的方法，式（I）或（II）的化合物及其衍生物的量：R1，R2，R3和R4各自独立地表示氢，烷基，烯基或烷氧基，其含有1〜约8个碳原子，含有约5至12个碳原子的芳基，芳烷基或环烷基，或含有至多8个碳原子的烷氧基或氨基甲酰基，或含有10至约30个碳原子的肽或肽模拟部分。

4. 发明申请

US20140206637A1 Inhibition of Nonsense Mediated mRNA Decay by Drugs that Prevent Hypusination of Eukaryotic Initiation Factor 5A 有权
标题翻译：通过预防真核启动因子5A阻滞的药物抑制无义介导的mRNA衰变
公开(公告)号：US20140206637A1
公开(公告)日：2014-07-24
申请号：US14126342
申请日：2012-06-13
申请人： Tsafi Pe'ery , Michael B. Mathews , Mainul Hoque , Hartmut M. Hanauske-Abel
发明人： Tsafi Pe'ery , Michael B. Mathews , Mainul Hoque , Hartmut M. Hanauske-Abel
IPC分类号： A61K31/7105 , A61K31/704 , A61K31/498 , A61K31/4985 , A61K31/4412 , A61K31/7064
CPC分类号： A61K31/7105 , A61K31/4375 , A61K31/4412 , A61K31/4418 , A61K31/502 , A61K31/5025 , A61K31/7036 , A61K31/7048 , A61K31/7064 , A61K45/06 , A61K2300/00
摘要： Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
摘要翻译：提供了用于治疗NAD的方法，包括对患有NMD的NMD抑制剂和无义抑制剂的患者施用，由此NMD敏感性mRNA的降解降低，并且在错放的无义密码子处的翻译终止被阻断。

5. 发明申请

US20120225093A1 Abrogating HIV-1 Infection via Drug-Induced Reactivation of Apoptosis 审中-公开
标题翻译：通过药物诱导的细胞凋亡反应来消除HIV-1感染
公开(公告)号：US20120225093A1
公开(公告)日：2012-09-06
申请号：US13271190
申请日：2011-10-11
申请人： Michael B. Mathews , Hartmut M. Hanauske-Abel , Tsafi Pe'ery , Mainul Hoque , Paul Palumbo , Deepti Saxena , Darlene D'Alliessi-Gandolfi , Myung-Hee Park
发明人： Michael B. Mathews , Hartmut M. Hanauske-Abel , Tsafi Pe'ery , Mainul Hoque , Paul Palumbo , Deepti Saxena , Darlene D'Alliessi-Gandolfi , Myung-Hee Park
IPC分类号： A61K31/4412 , A61K31/4418 , A61P37/04 , C40B30/04 , A61P31/18 , C12Q1/70 , A61K39/21
CPC分类号： C12Q1/18 , A61K31/4412 , A61K31/4418 , A61K39/12 , A61K39/21 , A61K2039/515 , C12N2740/16034 , G01N2333/5428 , G01N2333/57 , A61K2300/00
摘要： The present invention relates to compositions and methods of treating, inhibiting, or controlling HIV infection.
摘要翻译：本发明涉及治疗，抑制或控制HIV感染的组合物和方法。

6. 发明授权

US6080766A Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation 失效
标题翻译：通过应用蛋白质羟化作用抑制剂治疗纤维增生性疾病的方法
公开(公告)号：US6080766A
公开(公告)日：2000-06-27
申请号：US991124
申请日：1997-12-16
申请人： Hartmut M. Hanauske-Abel , Timothy A. McCaffrey , Robert Walter Grady
发明人： Hartmut M. Hanauske-Abel , Timothy A. McCaffrey , Robert Walter Grady
IPC分类号： C07D213/69 , A61K31/00 , A61K31/4412 , A61K31/4422 , A61K38/00 , A61P1/16 , A61P11/00 , A61P13/12 , A61P17/02 , A61P43/00 , C07K5/02 , A61K31/44
CPC分类号： A61K31/00 , A61K31/4412 , A61K31/4422 , C07K5/02 , C07K5/0215
摘要： The present invention relates to a method of treating a patient with a fibrotic or fibroproliferative disorder and a method of suppressing formation of collagen and collagen-like substances or biosynthesis of procollagen in living systems by administering to a patient or living system, respectively, an effective amount of a compound of Formulae (I) or (II) and derivatives thereof: ##STR1## R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each individually represent a hydrogen, an alkyl, alkenyl, or alkoxy group containing 1 to about 8 carbon atoms, an aryl, aralkyl, or cycloalkyl group containing about 5 to 12 carbon atoms, or a carboalkoxy or carbamyl group containing up to 8 carbon atoms, or a peptide or peptidomimetic moiety containing 10 to about 30 carbon atoms.
摘要翻译：本发明涉及一种治疗患有纤维化或纤维增生性病症的患者的方法，以及通过对患者或生活系统分别施用有效的方式抑制胶原蛋白和胶原样物质的形成或生物体内生物合成的方法式（I）或（II）化合物及其衍生物的量：R1，R2，R3和R4各自独立地表示含有1至约8个碳原子的氢，烷基，烯基或烷氧基，芳基，含有约5至12个碳原子的芳烷基或环烷基，或含有至多8个碳原子的烷氧基或氨基甲酰基，或含有10至约30个碳原子的肽或肽模拟部分。

7. 发明授权

US5849587A Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells 失效
标题翻译：抑制真核细胞中病毒复制和诱导病毒感染细胞凋亡的方法
公开(公告)号：US5849587A
公开(公告)日：1998-12-15
申请号：US488811
申请日：1995-06-09
申请人： Hartmut M. Hanauske-Abel , Robert Walter Grady , Axel Hanauske , Linda Andrus , Paul Szabo
发明人： Hartmut M. Hanauske-Abel , Robert Walter Grady , Axel Hanauske , Linda Andrus , Paul Szabo
IPC分类号： A61K45/00 , A61K31/00 , A61K31/44 , A61K31/4412 , A61K38/04 , A61K38/06 , A61P31/00 , A61P31/12 , C12N5/08
CPC分类号： A61K38/06 , A61K31/00 , A61K31/4412 , A61K38/04
摘要： The present invention is directed to methods which employ inhibition of the post-translational hypusine formation in the intracelluar protein eIF-5A, for the purpose of suppressing infections by viruses that parasitize eIF-5A so as to promote their own replication. Intentional inhibition of the post-translational formation of hypusine in infected host cells with compounds generically termed `hypusine inhibitors` not only selectively suppresses the production of viral proteins and of infectious viral particles, but also causes, particularly after hypusine inhibitor withdrawal, apoptosis in such virally-infected cells. Each of these methods, respectively, involves administering, to eukaryotic cells, tissues, or individuals, an agent which blocks the post-translational intracellular formation of hypusine, in an amount sufficient to: suppress biosynthesis of bioactive eIF-5A, suppress translational interaction of eIF-5A with viral elements of nucleic acid and/or protein structure, inhibit biosynthesis of viral proteins of Rev-dependent lentiviruses or of viruses dependent on interaction of eIF-5A with viral elements of nucleic acid and/or protein structure, inhibit replication of Rev-dependent lentiviruses or of viruses dependent on interaction of eIF-5A with viral elements of nucleic acid and/or protein structure, and induce apoptosis of virally-infected cells. This agent can be a compound of Formulae I or II and derivatives thereof as follows: ##STR1## R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each individually represent a hydrogen, an alkyl, alkenyl, or alkoxy group containing 1 to about 8 carbon atoms, an aryl, aralkyl, or cycloalkyl group containing about 5 to 12 carbon atoms, or a carboalkoxy or carbamyl group containing up to 8 carbon atoms, or a peptide or peptidomimetic moiety containing 10 to about 30 carbon atoms.
摘要翻译：本发明涉及在胞内蛋白eIF-5A中采用抑制翻译后丘脑形成抑制作用的方法，目的是抑制寄生eIF-5A的病毒感染以促进其自身的复制。通常称为“hypusine抑制剂”的化合物在感染宿主细胞中翻译后形成hypusine的有意抑制不仅选择性地抑制病毒蛋白质和感染性病毒颗粒的产生，而且还导致，特别是在hypusine抑制剂撤除后，细胞凋亡病毒感染细胞。这些方法中的每一种分别涉及向真核细胞，组织或个体施用足以抑制生物活性eIF-5A的生物合成的量的阻断翻译后细胞内形成hypusine的药剂，抑制翻译后的相互作用具有核酸和/或蛋白质结构的病毒元件的eIF-5A抑制Rev依赖性慢病毒的病毒蛋白的生物合成或依赖于eIF-5A与核酸和/或蛋白质结构的病毒元件相互作用的病毒，抑制复制依赖于依赖于依赖于依赖于eIF-5A与核酸和/或蛋白质结构的病毒元件的相互作用的依赖于慢病毒的病毒或依赖于病毒感染细胞凋亡的病毒。该试剂可以是式I或II的化合物及其衍生物如下：R1，R2，R3和R4各自独立地表示氢，烷基，烯基或烷氧基，其含有1〜约8个碳原子，含有约5至12个碳原子的芳基，芳烷基或环烷基，或含有至多8个碳原子的烷氧基或氨基甲酰基，或含有10至约30个碳原子的肽或肽模拟部分。

8. 发明申请

US20180237517A9 Methods of diagnosing and treating hyperproliferative disorders 审中-公开
公开(公告)号：US20180237517A9
公开(公告)日：2018-08-23
申请号：US14146387
申请日：2014-01-02
申请人： Hartmut M. Hanauske-Abel , Myung-Hee Park , Edith C. Wolff , Debra Sheldon-Heller , Bernadette M. Cracchiolo , Anthony Popowicz , Paul M. Clement
发明人： Hartmut M. Hanauske-Abel , Myung-Hee Park , Edith C. Wolff , Debra Sheldon-Heller , Bernadette M. Cracchiolo , Anthony Popowicz , Paul M. Clement
IPC分类号： C07K16/28 , C07K16/30 , G01N33/68 , G01N33/574
CPC分类号： C07K16/28 , C07K16/18 , G01N33/57407 , G01N33/57496 , G01N33/6812 , G01N33/6872
摘要： The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.

9. 发明授权

US5965586A Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation 失效
公开(公告)号：US5965586A
公开(公告)日：1999-10-12
申请号：US991758
申请日：1997-12-16
申请人： Hartmut M. Hanauske-Abel , Timothy A. McCaffrey , Robert Walter Grady
发明人： Hartmut M. Hanauske-Abel , Timothy A. McCaffrey , Robert Walter Grady
IPC分类号： C07D213/69 , A61K31/00 , A61K31/4412 , A61K31/4422 , A61K38/00 , A61P1/16 , A61P11/00 , A61P13/12 , A61P17/02 , A61P43/00 , C07K5/02 , A01N43/40 , A61K31/44
CPC分类号： A61K31/00 , A61K31/4412 , A61K31/4422 , C07K5/02 , C07K5/0215
摘要： The present invention relates to a method of treating a patient with a fibrotic or fibroproliferative disorder and a method of suppressing formation of collagen and collagen-like substances or biosynthesis of procollagen in living systems by administering to a patient or living system, respectively, an effective amount of a compound of Formulae (I) or (II) and derivatives thereof: ##STR1## R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each individually represent a hydrogen, an alkyl, alkenyl, or alkoxy group containing 1 to about 8 carbon atoms, an aryl, aralkyl, or cycloalkyl group containing about 5 to 12 carbon atoms, or a carboalkoxy or carbamyl group containing up to 8 carbon atoms, or a peptide or peptidomimetic moiety containing 10 to about 30 carbon atoms.

10. 发明授权

US09849146B2 Inhibition of nonsense mediated mRNA decay by drugs that prevent hypusination of eukaryotic initiation factor 5A 有权
公开(公告)号：US09849146B2
公开(公告)日：2017-12-26
申请号：US14126342
申请日：2012-06-13
申请人： Tsafi Pe'ery , Michael B. Mathews , Mainul Hoque , Hartmut M. Hanauske-Abel
发明人： Tsafi Pe'ery , Michael B. Mathews , Mainul Hoque , Hartmut M. Hanauske-Abel
IPC分类号： A61K31/4412 , A61K31/7105 , A61K31/7064 , A61K31/4375 , A61K45/06 , A61K31/4418 , A61K31/502 , A61K31/5025 , A61K31/7036 , A61K31/7048
CPC分类号： A61K31/7105 , A61K31/4375 , A61K31/4412 , A61K31/4418 , A61K31/502 , A61K31/5025 , A61K31/7036 , A61K31/7048 , A61K31/7064 , A61K45/06 , A61K2300/00
摘要： Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

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