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1. 发明申请

US20080234294A1 Cxcr4 Binding Molecules 审中-公开
标题翻译： Cxcr4结合分子
公开(公告)号：US20080234294A1
公开(公告)日：2008-09-25
申请号：US12064068
申请日：2006-08-17
申请人： Jiri Kovarik , Gebhard Thoma , Beat Weidmann , Timothy Wright , Hans-Gunter Zerwes
发明人： Jiri Kovarik , Gebhard Thoma , Beat Weidmann , Timothy Wright , Hans-Gunter Zerwes
IPC分类号： A61K31/519 , A61K31/155 , A61P37/00
CPC分类号： A61K31/429 , A61K31/519
摘要： This invention relates to the use of a CXCR binding molecules as described in the specification, in WHIM syndrome.
摘要翻译：本发明涉及在WHIM综合征中描述的CXCR结合分子的用途。

2. 发明申请

US20090018127A1 Ergoline Derivatives 失效
标题翻译：二元醇衍生物
公开(公告)号：US20090018127A1
公开(公告)日：2009-01-15
申请号：US11914570
申请日：2006-05-29
申请人： Rolf Baenteli , Fraser Glickman , Jiri Kovarik , Ian Lewis , Markus Streiff , Gebhard Thoma , Hans-Gunter Zerwes
发明人： Rolf Baenteli , Fraser Glickman , Jiri Kovarik , Ian Lewis , Markus Streiff , Gebhard Thoma , Hans-Gunter Zerwes
IPC分类号： A61K31/48 , C07D457/04 , A61K31/496 , A61K31/5377
CPC分类号： C07D457/06 , C07D457/08
摘要： Disclosed are ergoline derivatives, Formula (I), wherein either each of R1 and R2, independently, is H; optionally R10 and/or R11-substituted-phenyl or -phenyl-C1-4alkyl; optionally R10 and/or R11-substituted-heteroaryl or -heteroaryl-C1-4alkyl; optionally R10 and/or R11-substituted heteroaryl N-oxide; optionally R10-substituted C1-C8 alkyl; optionally R10-substituted C2-C8 alkenyl, optionally R10-substituted C2-C8 alkynyl; optionally R10-substituted C3-C8 cycloalkyl, or optionally R10-substituted C4-C8 cycloalkenyl; or R1 and R2 form together with the nitrogen atom to which they are attached an optionally R10-substituted 3-8 membered ring containing in addition to the nitrogen atom up to 2 heteroatoms selected independently from N, O and S; R3 is H; OR1; CH2R1R2; (CH2)1-2NR1R2; CH2—CH2—OR1; CH2—CO—NR1R2; or CO—CH2R1R2; R4 is F; Cl; Br; I; OR1; NR1R2 or has one of the significances given for R1; and R5 has one of the significances given for R1, in free form or in salt form for preventing or treating disorders or diseases mediated by interactions between chemokine receptors and their ligands.
摘要翻译：公开了麦角灵衍生物，式（I），其中R 1和R 2各自独立地为H; 任选的R 10和/或R 11取代的苯基或 - 苯基-C 1-4烷基; 任选的R 10和/或R 11取代的杂芳基或 - 杂芳基-C 1-4烷基; 任选的R 10和/或R 11取代的杂芳基N-氧化物; 任选的R 10取代的C 1 -C 8烷基; 任选的R 10取代的C 2 -C 8烯基，任选的R 10取代的C 2 -C 8炔基; 任选的R 10取代的C 3 -C 8环烷基，或任选的R 10取代的C 4 -C 8环烯基; 或R 1和R 2与它们所连接的氮原子一起形成任选的R 10取代的3-8元环，除了氮原子以外，还含有独立地选自N，O和S的2个杂原子; R3为H; OR1; CH2R1R2; （CH2）1-2NR1R2; CH2-CH2-OR1; CH2-CO-NR1R2; 或CO-CH 2 R 1 R 2; R4是F; Cl; Br; 一世; OR1; NR1R2或具有R1的意义之一; R5具有以游离形式或盐形式用于预防或治疗由趋化因子受体及其配体之间相互作用介导的疾病或疾病的R1的意义。

3. 发明申请

US20140187574A1 USE OF RAPAMYCIN DERIVATIVES IN VASCULOPATHIES AND XENOTRANSPLANTATION 审中-公开
标题翻译： RAPAMYCIN衍生物在血管造影和XENOTRANSPLANTATION中的应用
公开(公告)号：US20140187574A1
公开(公告)日：2014-07-03
申请号：US14197368
申请日：2014-03-05
申请人： Walter Schuler , Hendrik J. Schuurman , Gisbert Weckbecker , Hans-Gunter Zerwes
发明人： Walter Schuler , Hendrik J. Schuurman , Gisbert Weckbecker , Hans-Gunter Zerwes
IPC分类号： A61K31/436
CPC分类号： A61K31/436
摘要： Use of a rapamycin derivative of formula I as defined in the claims for preventing or treating vasculopathies and manifestations of xenotransplantation.
摘要翻译：在权利要求中定义的式I的雷帕霉素衍生物用于预防或治疗血管病变和异种移植的表现的用途。

4. 发明申请

US20080249111A1 Piperdine Derivatives as CCR5 Inhibitors 审中-公开
标题翻译：哌啶衍生物作为CCR5抑制剂
公开(公告)号：US20080249111A1
公开(公告)日：2008-10-09
申请号：US12114297
申请日：2008-05-02
申请人： Rainer ALBERT , Nigel Graham Cooke , Gebhard Thoma , Christian Bruns , Francois Nuninger , Markus Streiff , Hans-Gunter Zerwes
发明人： Rainer ALBERT , Nigel Graham Cooke , Gebhard Thoma , Christian Bruns , Francois Nuninger , Markus Streiff , Hans-Gunter Zerwes
IPC分类号： A61K31/4545 , C07D401/14 , C07D401/04 , C07D417/14 , A61P29/00 , A61P37/00 , A61K31/506 , A61K31/4709
CPC分类号： C07D401/14 , C07D211/58 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.
摘要翻译：公开了式I化合物：其中R 1，R 2，R 3和X如本文所定义，为游离或盐形式，其可用作CCR5抑制剂，例如在预防或治疗由趋化因子受体及其配体之间相互作用介导的疾病。

5. 发明申请

US20060004047A1 Piperidine derivatives as ccr5 inhibitors 失效
标题翻译：哌啶衍生物作为ccr5抑制剂
公开(公告)号：US20060004047A1
公开(公告)日：2006-01-05
申请号：US10529776
申请日：2003-10-06
申请人： Rainer Albert , Nigel Cooke , Gebhard Thoma , Christian Bruns , Francois Nuninger , Markus Streiff , Hans-Gunter Zerwes
发明人： Rainer Albert , Nigel Cooke , Gebhard Thoma , Christian Bruns , Francois Nuninger , Markus Streiff , Hans-Gunter Zerwes
IPC分类号： A61K31/4545 , C07D41/14
CPC分类号： C07D401/14 , C07D211/58 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.
摘要翻译：公开了式I化合物：其中R 1，R 2，R 3和X如本文所定义，为游离或盐形式，其可用作CCR5抑制剂，例如在预防或治疗由趋化因子受体及其配体之间相互作用介导的疾病。

6. 发明申请

US20070161618A1 Isothiourea derivatives 失效
标题翻译：异硫脲衍生物
公开(公告)号：US20070161618A1
公开(公告)日：2007-07-12
申请号：US10590399
申请日：2005-02-25
申请人： Fraser Glickman , Markus Streiff , Gebhard Thoma , Hans-Gunter Zerwes
发明人： Fraser Glickman , Markus Streiff , Gebhard Thoma , Hans-Gunter Zerwes
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/43 , C07D498/04
CPC分类号： C07D277/42 , C07D513/04
摘要： The present invention relates to isothiourea derivatives, processes for their production, their uses, in particular in transplantation, autoimmune or infectious diseases, and pharmaceutical compositions containing them.
摘要翻译：本发明涉及异硫脲衍生物，其制备方法，其用途，特别是移植，自身免疫或感染性疾病，以及含有它们的药物组合物。

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