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1. 发明授权

US07156996B2 Multichamber microdialysis device 有权
标题翻译：多室微透析装置
公开(公告)号：US07156996B2
公开(公告)日：2007-01-02
申请号：US10652938
申请日：2003-09-02
申请人： Manfred Watzele , Bernd Buchberger , Hans Schels , Horst Menzler , Ulrike Fischer
发明人： Manfred Watzele , Bernd Buchberger , Hans Schels , Horst Menzler , Ulrike Fischer
IPC分类号： B01D63/00 , C12M1/12 , B01L11/00
CPC分类号： B01D61/28 , B01L3/50255 , B01L3/50855 , B01L2300/0829 , G01N1/405
摘要： The invention is a multichamber microdialysis device with a multitude of sample chambers in close side by side arrangement (similar to a microtiter plate) for receiving liquid samples, and at least one dialysate chamber for receiving a dialysate liquid. The sample chambers are surrounded by circumferential sidewalls and are in liquid exchange contact to a neighboring dialysis chamber via an exchange opening covered by a semipermeable membrane. The semipermeable membrane is fixed liquid-tight to the walls of the sample chamber, so that a diffusion exchange between the sample chamber and the correspondingly neighboring dialysate chamber is only possible via the membrane. Consequently, only molecules with a molecular weight below the molecular cut-off of the semipermeable membrane can diffuse from the sample chamber to the dialysate chamber or from the dialysate chamber to the sample chamber.
摘要翻译：本发明是一种多室微透析装置，其具有用于接收液体样品的紧密并排布置（类似于微量滴定板）的多个样品室和用于接收透析液体的至少一个透析室。样品室被圆周侧壁包围，并通过由半透膜覆盖的交换开口与邻近的透析室液体交换接触。半透膜不透液体地固定在样品室的壁上，使样品室和相应的相邻透析液室之间的扩散交换只能通过膜。因此，只有分子量低于半透膜的分子截止分子的分子可以从样品室扩散到透析液室或从透析液室扩散到样品室。

2. 发明申请

US20060008899A1 Method and device for carrying out biochemical reactions with a high throughput 失效
标题翻译：用于以高产量进行生化反应的方法和装置
公开(公告)号：US20060008899A1
公开(公告)日：2006-01-12
申请号：US11224719
申请日：2005-09-13
申请人： Thomas Metzler , Hans Schels , Rolf Reichhuber , Jochen Kluge
发明人： Thomas Metzler , Hans Schels , Rolf Reichhuber , Jochen Kluge
IPC分类号： C12M1/12
CPC分类号： C12M23/34 , B01J19/0046 , B01J19/2475 , B01J2219/00051 , B01J2219/00286 , B01J2219/00315 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00511 , B01J2219/00585 , B01J2219/00599 , B01J2219/0072 , B01J2219/00725 , B01L3/50255 , B01L3/50855 , C12M23/12 , C12M23/38 , C12M27/02 , C12M27/16 , C12M29/04 , C12P21/02 , C40B60/14
摘要： Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.
摘要翻译：用于进行生物化学反应的装置，方法和试剂盒，特别是用于封闭具有合并孔的内部壳体的外部壳体的无细胞多肽生物合成，其中内部壳体的孔各自包含生产系统生化反应，供应室在生化反应期间含有供应液体，并且内壳体和供应室的孔由半透膜隔开，其特征在于，内壳体具有至少两个井，其下端封闭通过半透膜，其上端从包含在供给室中的供给液体突出，并且连接到用于移动和孵育生产系统和供应液体的装置。

3. 发明授权

US06670173B1 Bioreaction module for biochemical reactions 失效
标题翻译：用于生化反应的生物反应模块
公开(公告)号：US06670173B1
公开(公告)日：2003-12-30
申请号：US09890090
申请日：2001-07-26
申请人： Hans Schels , Horst Menzler , Ulrike Fischer
发明人： Hans Schels , Horst Menzler , Ulrike Fischer
IPC分类号： C12M112
CPC分类号： C12M23/34 , C12M21/18 , C12M23/38 , C12M29/04 , C12M29/20
摘要： A bioreaction module for biochemical reactions, in particular for cell-free polypeptide biosynthesis, having a housing (1) including a system chamber (12) and a supply chamber (10), wherein the system chamber (12) contains a producing system during the biochemical reaction and the supply chamber (10) contains a supply liquid during the biochemical reaction, and the system chamber (12) and the supply chamber (10) are separated by a semi-permeable membrane (7). The housing (1) comprises a system chamber element (5) and at least one supply chamber element (3) between which the semi-permeable membrane (7) is mounted in such a manner that the system chamber (12) is defined by the system chamber element (5) and the semi-permeable membrane (7) and the supply chamber (10) is defined by the supply chamber element (3) and the semi-permeable membrane (7).
摘要翻译：一种用于生物化学反应，特别是无细胞多肽生物合成的生物反应模块，具有包括系统室（12）和供应室（10）的壳体（1），其中所述系统室（12）包含在生化反应和供给室（10）在生化反应期间含有供液，系统室（12）和供料室（10）由半透膜（7）分开。壳体（1）包括系统室元件（5）和至少一个供应室元件（3），半透膜（7）以这样的方式安装，使得系统室（12）由系统室元件（5）限定，半透膜（7）和供给室（10）由供给室元件（3）和半透膜（7）构成。

4. 外观设计

USD437408S1 Dialyzer 失效
标题翻译：透析器
公开(公告)号：USD437408S1
公开(公告)日：2001-02-06
申请号：US29112844
申请日：1999-10-25
申请人： Horst Menzler , Hans Schels
设计人： Horst Menzler , Hans Schels

5. 发明授权

US5819508A Device for removing or twisting off caps from vessels 失效
标题翻译：用于从船只移除或扭转帽子的装置
公开(公告)号：US5819508A
公开(公告)日：1998-10-13
申请号：US627620
申请日：1996-04-04
申请人： Peter Kraft , Horst Menzler , Hans Schels , Peter Wenzig
发明人： Peter Kraft , Horst Menzler , Hans Schels , Peter Wenzig
IPC分类号： B67B7/02 , B67B7/18 , B67B7/14
CPC分类号： B67B7/182 , B67B7/02
摘要： Device for pulling out or twisting off caps from vessels, wherein the vessel is held, and the cap is removed by means of a cap-holding device; the cap-holding device executes both a linear movement in direction of the vessel axis as well as a rotating movement around the vessel axis. The cap-holding device advantageously has several clamping jaws that are pressed against the circumference of the cap.
摘要翻译：用于从容器中拉出或扭转帽的装置，其中容器被保持，并且帽通过盖保持装置移除; 盖保持装置在容器轴线的方向上执行线性运动以及围绕容器轴线的旋转运动。盖保持装置有利地具有几个压靠在盖的圆周上的夹爪。

6. 发明授权

US5780306A Method and system for mixing liquids 失效
标题翻译：混合液体的方法和系统
公开(公告)号：US5780306A
公开(公告)日：1998-07-14
申请号：US744506
申请日：1996-11-07
申请人： Hans Schels , Karl-Heinz Mann , Horst Menzler , Leonhard Geissler , Georg Kuffer
发明人： Hans Schels , Karl-Heinz Mann , Horst Menzler , Leonhard Geissler , Georg Kuffer
IPC分类号： B01F13/02 , B01F15/00 , G01N1/10
CPC分类号： B01F13/0272 , B01F15/00155 , B01F15/00253 , B01F2215/0037 , Y10T436/119163 , Y10T436/25 , Y10T436/25625
摘要： The invention relates to a system for mixing a liquid with another liquid or a solid material by blowing a gas onto the surface of the liquid. The invention further relates to a system for implementing said method. Gas is blown onto the surface of the liquid from a distance which can be adjusted by determining the level of the liquid. A system of the invention, hence, comprises a device for blowing a gas onto the surface of a liquid and a device for detecting the level of a liquid.
摘要翻译：本发明涉及一种通过将气体吹送到液体表面上而将液体与另一种液体或固体材料混合的系统。本发明还涉及一种用于实现所述方法的系统。气体从一定距离吹到液体表面，该距离可以通过确定液体的液位来调节。因此，本发明的系统包括用于将气体吹送到液体表面上的装置和用于检测液体液位的装置。

7. 发明授权

US07863015B2 Method and device for carrying out biochemical reactions with a high throughput 有权
标题翻译：用于以高产量进行生化反应的方法和装置
公开(公告)号：US07863015B2
公开(公告)日：2011-01-04
申请号：US11224719
申请日：2005-09-12
申请人： Thomas Metzler , Hans Schels , Rolf Reichhuber , Jochen Kluge
发明人： Thomas Metzler , Hans Schels , Rolf Reichhuber , Jochen Kluge
IPC分类号： C12M1/12 , C12M1/40 , C12P21/00
CPC分类号： C12M23/34 , B01J19/0046 , B01J19/2475 , B01J2219/00051 , B01J2219/00286 , B01J2219/00315 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00511 , B01J2219/00585 , B01J2219/00599 , B01J2219/0072 , B01J2219/00725 , B01L3/50255 , B01L3/50855 , C12M23/12 , C12M23/38 , C12M27/02 , C12M27/16 , C12M29/04 , C12P21/02 , C40B60/14
摘要： Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.
摘要翻译：用于进行生物化学反应的装置，方法和试剂盒，特别是用于封闭具有合并孔的内部壳体的外部壳体的无细胞多肽生物合成，其中内部壳体的孔各自包含生产系统生化反应，供应室在生化反应期间含有供应液体，并且内壳体和供应室的孔由半透膜隔开，其特征在于，内壳体具有至少两个井，其下端封闭通过半透膜，其上端从包含在供给室中的供给液体突出，并且连接到用于移动和孵育生产系统和供应液体的装置。

8. 发明授权

US6107055A Method and device for carrying out biochemical reactions 失效
标题翻译：进行生化反应的方法和装置
公开(公告)号：US6107055A
公开(公告)日：2000-08-22
申请号：US124985
申请日：1998-07-30
申请人： Hermann Bauer , Horst Menzler , Gerd Kleinhammer , Hans Schels , Peter Bendzko , Ute Fink , Bernd Maciej
发明人： Hermann Bauer , Horst Menzler , Gerd Kleinhammer , Hans Schels , Peter Bendzko , Ute Fink , Bernd Maciej
IPC分类号： C12M1/00 , C12M1/12 , C12M1/40 , C12P21/00 , C12P21/06 , C12P1/00
CPC分类号： C12M23/34 , C12M29/04 , C12M29/18
摘要： Method and apparatus for carrying out biochemical reactions in particular for cell-free polypeptide biosynthesis. A bioreactor has, within a housing, a reaction chamber containing a producing system as well as a supply chamber separated from the reaction chamber by means of a semi-permeable membrane and containing a liquid serving as supply medium for the producing system. The supply chamber is subdivided within the bioreactor into a first partial chamber and a second partial chamber which are each connected to the reaction chamber via a semi-permeable supply membrane and which are connected to each other by means of a connection conduit. During the biochemical reaction, liquid is circulated from the first partial chamber of the supply chamber through the reaction chamber and into the second partial chamber of the supply chamber in such a fashion that, during each passage of liquid out of the first partial chamber into the reaction chamber, liquid simultaneously passes from the reaction chamber into the second partial chamber and liquid flows out of the second partial chamber via the connection conduit back into the first partial chamber.
摘要翻译：用于进行生化反应的方法和装置，特别是用于无细胞的多肽生物合成。生物反应器在壳体内具有包含生产系统的反应室以及通过半透膜与反应室分离并且含有用作生产系统的供应介质的液体的供应室。供应室在生物反应器内被分为第一部分室和第二部分室，第一部分室和第二部分室通过半渗透供应膜连接到反应室，并通过连接导管相互连接。在生化反应期间，液体从供给室的第一部分室通过反应室循环，并进入供给室的第二部分室，使得在液体从第一部分室流出之前进入反应室，液体同时从反应室通入第二部分室，并且液体经由连接导管从第二部分室流出回到第一部分室中。

9. 发明授权

US5362147A Method and apparatus for the contactless automatic mixing of a reaction mixture in an analysis unit 失效
标题翻译：用于在分析单元中的非接触式自动混合反应混合物的方法和装置
公开(公告)号：US5362147A
公开(公告)日：1994-11-08
申请号：US123994
申请日：1993-09-21
申请人： Hans Schels , Horst Menzler
发明人： Hans Schels , Horst Menzler
IPC分类号： B01F13/02 , G01N1/36 , G01N35/02
CPC分类号： B01F13/0272
摘要： Method for the contactless automatic mixing of a liquid reaction mixture in an analysis unit, in which the reaction mixture is located in a vessel accessible from above through an opening, by means of a gas jet escaping from an outlet opening of a mixing element, a rapid, effective and reliable non-invasive thorough mixing of the liquid is achieved by the mixing element being lowered at the start of the mixing operation in the direction of the liquid surface and the lowering movement being stopped in a bottom end position in which the mixing element projects into the vessel, but does not touch the liquid surface, the gas jet is switched on during the lowering of the mixing element, the gas jet is so aligned that it brings about an asymmetrical lowering of a part of the liquid surface in the vicinity of the vessel wall, and the gas jet has a rotational component of motion so that the lowered part of the liquid surface is set in rotation about the axis of the vessel.
摘要翻译：在分析单元中非离子自动混合液体反应混合物的方法，其中反应混合物通过从混合元件的出口排出的气体喷射器通过开口位于从上方可接近的容器中，通过混合元件在混合操作开始时在液面的方向上降低液体的快速，有效和可靠的非侵入性彻底混合，并且下降运动停止在下端位置元件投射到容器中，但不接触液体表面，在混合元件降低期间气体射流被接通，气体射流如此对齐，使得气体射流引起液体表面的一部分的不对称降低容器壁附近，气体射流具有运动的旋转分量，使得液面的下降部分围绕容器的轴线旋转。

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