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1. 发明申请

WO2009155565A1 TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS 审中-公开
标题翻译：三唑吡啶JAK抑制剂化合物和方法
公开(公告)号：WO2009155565A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/048041
申请日：2009-06-19
申请人： GENENTECH, INC. , ZHU, Bing-yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao , LIU, Wendy
发明人： ZHU, Bing-yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao , LIU, Wendy
IPC分类号： A01N43/64 , A61K31/41
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.
摘要翻译：其中R 1，R 2，R 3，R 4和R 5在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作JAK激酶抑制剂。公开了包含式I化合物和药学上可接受的载体，佐剂或载体的药物组合物，以及治疗或减轻对患者中JAK激酶活性的抑制作用的疾病或病症的严重程度的方法。

2. 发明申请

WO2009155551A1 TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS 审中-公开
标题翻译：三唑吡啶JAK抑制剂化合物和方法
公开(公告)号：WO2009155551A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/048017
申请日：2009-06-19
申请人： GENENTECH, INC. , ZHU, Bing-Yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao
发明人： ZHU, Bing-Yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao
IPC分类号： A01N43/64 , A61K31/41
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07D487/04
摘要： A compound of Formula (I), enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed. Formula (I).
摘要翻译：式（I）的化合物，其对映体，非对映体，互变异构体或其药学上可接受的盐，其中R1，R2，R3，R4和R5如本文所定义，可用作JAK激酶抑制剂。公开了包含式（I）化合物和药学上可接受的载体，佐剂或媒介物的药物组合物，以及治疗或减轻对患者中JAK激酶活性抑制作出反应的疾病或病症的严重性的方法。式（I）。

3. 发明申请

US20140092333A1 Thin-Film Transistor (TFT) Array Structure and Liquid Crystal Display (LCD) Panel Thereof 有权
标题翻译：薄膜晶体管（TFT）阵列结构和液晶显示器（LCD）面板
公开(公告)号：US20140092333A1
公开(公告)日：2014-04-03
申请号：US13203753
申请日：2011-06-20
申请人： Shiqi Li , Jiali Jiang , Haiying He
发明人： Shiqi Li , Jiali Jiang , Haiying He
IPC分类号： G02F1/1362 , G02F1/1368
CPC分类号： G02F1/136213 , G02F1/133 , G02F1/1362 , G02F1/13624 , G02F1/1368 , G09G3/3648 , G09G2300/0852 , G09G2320/0252 , H01L27/12 , H01L29/786
摘要： A thin-film transistor (TFT) array structure and a liquid crystal display (LCD) panel thereof are described. The TFT array structure includes a plurality of scan lines, a plurality of first data lines, a plurality of second data lines, a plurality of pixel units and a plurality of control module. Each of the control modules is coupled among the scan line, one second data line and one pixel unit. The second data line charges the later control module when the scan line is selected to be activated for charging the pixel unit by the first data line. The charged later control module charges another pixel unit when the scan line is inactivated and another scan line is selected to be activated for charging another pixel unit by the first data line. The TFT array structure can reduce the charging duration of the pixels.
摘要翻译：描述薄膜晶体管（TFT）阵列结构及其液晶显示器（LCD）面板。 TFT阵列结构包括多个扫描线，多个第一数据线，多条第二数据线，多个像素单元和多个控制模块。每个控制模块耦合在扫描线，一秒数据线和一个像素单元之间。当选择激活扫描线以通过第一数据线对像素单元进行充电时，第二数据线对后面的控制模块充电。当扫描线不被激活并且另一个扫描线被选择被激活用于通过第一数据线对另一个像素单元充电时，带电的稍后的控制模块对另一个像素单元进行充电。 TFT阵列结构可以减少像素的充电持续时间。

4. 发明授权

US08797249B2 Thin-film transistor (TFT) array structure and liquid crystal display (LCD) panel thereof 有权
标题翻译：薄膜晶体管（TFT）阵列结构及其液晶显示（LCD）面板
公开(公告)号：US08797249B2
公开(公告)日：2014-08-05
申请号：US13203753
申请日：2011-06-20
申请人： Shiqi Li , Jiali Jiang , Haiying He
发明人： Shiqi Li , Jiali Jiang , Haiying He
IPC分类号： G09G3/36 , G02F1/1362 , H01L27/12 , G02F1/1368 , G02F1/133 , H01L29/786
CPC分类号： G02F1/136213 , G02F1/133 , G02F1/1362 , G02F1/13624 , G02F1/1368 , G09G3/3648 , G09G2300/0852 , G09G2320/0252 , H01L27/12 , H01L29/786
摘要： A thin-film transistor (TFT) array structure and a liquid crystal display (LCD) panel thereof are described. The TFT array structure includes a plurality of scan lines, a plurality of first data lines, a plurality of second data lines, a plurality of pixel units and a plurality of control module. Each of the control modules is coupled among the scan line, one second data line and one pixel unit. The second data line charges the later control module when the scan line is selected to be activated for charging the pixel unit by the first data line. The charged later control module charges another pixel unit when the scan line is inactivated and another scan line is selected to be activated for charging another pixel unit by the first data line. The TFT array structure can reduce the charging duration of the pixels.
摘要翻译：描述薄膜晶体管（TFT）阵列结构及其液晶显示器（LCD）面板。 TFT阵列结构包括多个扫描线，多个第一数据线，多条第二数据线，多个像素单元和多个控制模块。每个控制模块耦合在扫描线，一秒数据线和一个像素单元之间。当选择激活扫描线以通过第一数据线对像素单元进行充电时，第二数据线对后面的控制模块充电。当扫描线不被激活并且另一个扫描线被选择被激活用于通过第一数据线对另一个像素单元充电时，带电的稍后的控制模块对另一个像素单元进行充电。 TFT阵列结构可以减少像素的充电持续时间。

5. 发明申请

US20130100005A1 LCD Panel and Method of Manufacturing the Same 审中-公开
标题翻译：液晶面板及其制造方法
公开(公告)号：US20130100005A1
公开(公告)日：2013-04-25
申请号：US13376589
申请日：2011-10-21
申请人： Ming Hung Shih , Haiying He
发明人： Ming Hung Shih , Haiying He
IPC分类号： G09G3/36 , H01L33/08
CPC分类号： G02F1/136286 , G02F1/136209 , G02F2001/136295 , G09G2300/0465
摘要： A liquid crystal display panel and its manufacturing method are proposed. The liquid crystal display includes pixels, scan lines, and data lines. The scan lines are formed by a first metallic layer. Each pixel includes multiple subpixels. Each subpixel includes a pixel electrode, a thin-film transistor, and a common electrode line. The common electrode line includes a main branch, a first shielding metallic area, and a second shielding metallic area. The first and second shielding metallic areas are parallel to the scan lines and are connected to the main branch. The data lines and the common electrode lines are formed by the second metallic layer. The scan line and the common electrode line are formed after the first and second metallic layers undergo different etching processes, causing the distance between the scan line and the common electrode line to be shortened and the width of the common electrode line serving as a shielding metallic area partially to be properly decreased. Accordingly, the pixel aperture ratio is increased.
摘要翻译：提出了一种液晶显示面板及其制造方法。液晶显示器包括像素，扫描线和数据线。扫描线由第一金属层形成。每个像素包括多个子像素。每个子像素包括像素电极，薄膜晶体管和公共电极线。公共电极线包括主分支，第一屏蔽金属区域和第二屏蔽金属区域。第一和第二屏蔽金属区域平行于扫描线并连接到主支路。数据线和公共电极线由第二金属层形成。在第一和第二金属层进行不同的蚀刻工艺之后形成扫描线和公共电极线，使得扫描线和公共电极线之间的距离缩短，并且用作屏蔽金属的公共电极线的宽度面积部分要适当减少。因此，像素开口率增加。

6. 发明申请

US20110111059A1 Compositions Comprising Quinazoline Derivatives, Preparation Methods and Uses Thereof 有权
标题翻译：包含喹唑啉衍生物的组合物，其制备方法和用途
公开(公告)号：US20110111059A1
公开(公告)日：2011-05-12
申请号：US12993629
申请日：2009-05-21
申请人： Jianhui Guo , Haiying He
发明人： Jianhui Guo , Haiying He
IPC分类号： A61K31/517 , A61K33/24 , A61P35/00 , A61P27/02 , A61P9/10 , A61P29/00 , A61P17/06 , A61P11/00
CPC分类号： A61K31/517 , A61K9/0095 , A61K9/2018 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K9/4866 , C07D239/94
摘要： The present invention provides a pharmaceutical composition, useful for the treatment of diseases characterized by abnormal PTKs activity of erbB family in a mammal, comprising pharmaceutically acceptable salts of N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]quinazolin-6-yl}-acrylamide, optionally a pharmaceutically applicable carrier or diluent, and a stabilizer having a dispersing and/or protective effect on the active ingredient. The present invention further provides a pharmaceutical formulation comprising said composition, methods for preparation of said composition and said formulation, as well as use of said composition and said formulation for treating diseases characterized by abnormal PTKs activity of erbB family in a mammal.
摘要翻译：本发明提供了一种药物组合物，其可用于治疗哺乳动物中erbB家族异常PTKs活性特征的疾病，其包含N- {4- [3-氯-4-（3-氟 - 苄氧基）苯基氨基]喹唑啉-6-基} - 丙烯酰胺，任选的药学上可用的载体或稀释剂，以及对活性成分具有分散和/或保护作用的稳定剂。本发明还提供了包含所述组合物的药物制剂，所述组合物和所述制剂的制备方法，以及所述组合物和所述制剂用于治疗哺乳动物中erbB家族的异常PTK活性特征的疾病的用途。

7. 发明申请

US20170217897A1 QUINOLONE DERIVATIVES AS ANTIBACTERIALS 审中-公开
公开(公告)号：US20170217897A1
公开(公告)日：2017-08-03
申请号：US15500870
申请日：2015-08-03
申请人： Zhigan JIANG , Jianhua XIA , Haiying HE , NOVARTIS AG
发明人： Javier de Vicente FIDALGO , Haiying HE , Cheng HU , Zhigan JIANG , Xiaolin LI , Peichao LU , Wosenu MERGO , Daniel MUTNICK , Folkert RECK , Alexey RIVKIN , Colin Keith SKEPPER , Xiaojing Michael WANG , Jianhua XIA , Yongjin XU
IPC分类号： C07D215/38 , A61K31/4709 , A61K31/496 , C07D401/14 , C07D413/14 , C07D419/14 , C07D405/14 , C07D471/04 , C07D498/10 , A61K31/5377 , A61K31/5386 , C07D487/10 , C07D471/10 , A61K45/06 , C07D401/04
CPC分类号： C07D215/38 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5386 , A61K45/06 , C07D215/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D419/14 , C07D471/04 , C07D471/10 , C07D487/10 , C07D498/10 , Y02A50/406 , Y02A50/47 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

8. 发明申请

US20140167160A1 TFT array substrate 审中-公开
标题翻译： TFT阵列基板
公开(公告)号：US20140167160A1
公开(公告)日：2014-06-19
申请号：US13264577
申请日：2011-09-01
申请人： Shyh-Feng Chen , Ming Hung Shih , Haiying He
发明人： Shyh-Feng Chen , Ming Hung Shih , Haiying He
IPC分类号： G02F1/1335
CPC分类号： G02F1/133512 , G02F1/136209 , G02F1/136286 , H01L27/124
摘要： The present invention discloses a thin film transistor (TFT) array substrate, which includes a plurality of scan lines, data lines, and common electrode lines disposed on a substrate. The scan lines and the data lines cross with each other to define a plurality of pixel regions that have a plurality of TFTs disposed in the crossing regions therebetween. A plurality of pixel electrodes are disposed in the pixel regions. The TFT array substrate further includes a patterned shielding layer which is insulatively disposed below the data lines. The patterned shielding layer of the present invention can shield the back light directly, and the area of the black matrix on the color filter substrate can be reduced so as to increase the aperture ratio.
摘要翻译：本发明公开了一种薄膜晶体管（TFT）阵列基板，其包括设置在基板上的多条扫描线，数据线和公共电极线。扫描线和数据线彼此交叉以限定多个像素区域，其具有设置在它们之间的交叉区域中的多个TFT。多个像素电极设置在像素区域中。 TFT阵列基板还包括图案化屏蔽层，其被绝配地设置在数据线下方。本发明的图案化屏蔽层可以直接屏蔽背光，并且可以减小滤色器基板上的黑矩阵的面积以增加开口率。

9. 发明授权

US08710504B2 Flat display panel and method for forming the same 有权
标题翻译：平板显示面板及其形成方法
公开(公告)号：US08710504B2
公开(公告)日：2014-04-29
申请号：US13380881
申请日：2011-12-20
申请人： Shyh-Feng Chen , Ming Hung Shih , Haiying He
发明人： Shyh-Feng Chen , Ming Hung Shih , Haiying He
IPC分类号： H01L29/04 , H01L29/10 , H01L31/00
CPC分类号： H01L27/124 , G02F1/136209 , G02F1/136286 , G02F2001/136295
摘要： The present invention proposes to a flat display panel and a method for forming the same. The flat display panel includes a plurality of rows of scan lines, a plurality of columns of data lines and a plurality of blocking lines which are parallel and overlapped to the data lines. The plurality of blocking lines are placed at one side of pixel electrodes one on one and made of the same metallic layer with the plurality of scan lines. Each blocking line made of the same metallic layer with the scan line is wider than a corresponding data line, so that light not blocked by the data line is blocked by the wider blocking line.
摘要翻译：本发明提出一种平板显示面板及其形成方法。平面显示面板包括多行扫描线，多列数据线和多条与数据线并行并重叠的阻挡线。多个阻挡线一个一个地放置在像素电极的一侧，并由与多个扫描线相同的金属层制成。由与扫描线相同的金属层制成的每个阻挡线比对应的数据线宽，使得未被数据线阻挡的光被较宽的阻挡线阻挡。

10. 发明授权

US08507010B2 Compositions comprising quinazoline derivatives 有权
标题翻译：包含喹唑啉衍生物的组合物
公开(公告)号：US08507010B2
公开(公告)日：2013-08-13
申请号：US12993629
申请日：2009-05-21
申请人： Jianhui Guo , Haiying He
发明人： Jianhui Guo , Haiying He
IPC分类号： A61K31/517 , A61K33/24 , A61P35/00 , A61P27/02 , A61P9/10 , A61P29/00 , A61P17/06 , A61P11/00
CPC分类号： A61K31/517 , A61K9/0095 , A61K9/2018 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K9/4866 , C07D239/94
摘要： The present invention provides a pharmaceutical composition, useful for the treatment of diseases characterized by abnormal PTKs activity of erbB family in a mammal, comprising pharmaceutically acceptable salts of N-{4-[3-chloro-4-(3-fluoro-benzyloxy) phenylamino]quinazolin-6-yl}-acrylamide, optionally a pharmaceutically applicable carrier or diluent, and a stabilizer having a dispersing and/or protective effect on the active ingredient. The present invention further provides a pharmaceutical formulation comprising said composition, methods for preparation of said composition and said formulation, as well as use of said composition and said formulation for treating diseases characterized by abnormal PTKs activity of erbB family in a mammal.
摘要翻译：本发明提供了一种药物组合物，其可用于治疗哺乳动物中erbB家族异常PTKs活性特征的疾病，其包含N- {4- [3-氯-4-（3-氟 - 苄氧基）苯基氨基]喹唑啉-6-基} - 丙烯酰胺，任选的药学上可用的载体或稀释剂，以及对活性成分具有分散和/或保护作用的稳定剂。本发明还提供了包含所述组合物的药物制剂，所述组合物和所述制剂的制备方法，以及所述组合物和所述制剂用于治疗哺乳动物中erbB家族的异常PTK活性特征的疾病的用途。

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