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1. 发明申请

WO2009155565A1 TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS 审中-公开
标题翻译：三唑吡啶JAK抑制剂化合物和方法
公开(公告)号：WO2009155565A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/048041
申请日：2009-06-19
申请人： GENENTECH, INC. , ZHU, Bing-yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao , LIU, Wendy
发明人： ZHU, Bing-yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao , LIU, Wendy
IPC分类号： A01N43/64 , A61K31/41
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.
摘要翻译：其中R 1，R 2，R 3，R 4和R 5在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作JAK激酶抑制剂。公开了包含式I化合物和药学上可接受的载体，佐剂或载体的药物组合物，以及治疗或减轻对患者中JAK激酶活性的抑制作用的疾病或病症的严重程度的方法。

2. 发明申请

WO2009155551A1 TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS 审中-公开
标题翻译：三唑吡啶JAK抑制剂化合物和方法
公开(公告)号：WO2009155551A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/048017
申请日：2009-06-19
申请人： GENENTECH, INC. , ZHU, Bing-Yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao
发明人： ZHU, Bing-Yan , SIU, Michael , MAGNUSON, Steven, R. , PASTOR, Richard , HAIYING, He , YISONG, Xiao , JIFU, Zheng , XING, Xu , JUNPING, Zhao
IPC分类号： A01N43/64 , A61K31/41
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07D487/04
摘要： A compound of Formula (I), enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed. Formula (I).
摘要翻译：式（I）的化合物，其对映体，非对映体，互变异构体或其药学上可接受的盐，其中R1，R2，R3，R4和R5如本文所定义，可用作JAK激酶抑制剂。公开了包含式（I）化合物和药学上可接受的载体，佐剂或媒介物的药物组合物，以及治疗或减轻对患者中JAK激酶活性抑制作出反应的疾病或病症的严重性的方法。式（I）。

3. 发明授权

US09504747B2 Lipids and lipid compositions for the delivery of active agents 有权
标题翻译：用于递送活性剂的脂质和脂质组合物
公开(公告)号：US09504747B2
公开(公告)日：2016-11-29
申请号：US14200359
申请日：2014-03-07
申请人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C07C229/12 , A61K47/22 , A61K9/127 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C235/46 , C07C237/08 , C07D213/79 , C07D317/24 , C07D317/28 , C07D205/04 , C07D295/096 , C07D213/69 , C12N15/113
CPC分类号： A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

4. 发明授权

US08874524B1 Handling copy on first write data for snapshot purposes 有权
标题翻译：处理第一次写入数据的副本用于快照
公开(公告)号：US08874524B1
公开(公告)日：2014-10-28
申请号：US13530503
申请日：2012-06-22
申请人： Junping Zhao , Ivan Bassov , Kevin Xu , Gang Xie , Jialin Yang , Wei Qi
发明人： Junping Zhao , Ivan Bassov , Kevin Xu , Gang Xie , Jialin Yang , Wei Qi
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30088 , G06F11/2071 , G06F2201/84
摘要： A technique performs a write operation. The technique involves receiving, after a snapshot of a file system is taken, a write instruction to write new data to a particular portion of the file system. The technique further involves includes reading, in response to the write instruction, metadata to determine whether the new data is a first update of the particular portion since the snapshot was taken. The metadata identifies portions of the file system which have changed since the snapshot was taken. The technique further involves, when the new data is a first update of the particular portion since the snapshot was taken, copying the original data from cache memory (i.e., from the file system buffer cache) to snapshot storage (i.e., to a dedicated save area) and, after the original data is copied, updating the original data in the cache memory with the new data.
摘要翻译：一种技术执行写操作。该技术涉及在文件系统的快照之后接收写入指令以将新数据写入文件系统的特定部分。该技术还包括响应于写入指令读取元数据以确定新数据是否是拍摄快照以来特定部分的第一更新。元数据标识自拍摄快照以来已经更改的文件系统的部分。该技术还涉及当新数据是拍摄快照后特定部分的第一次更新时，将原始数据从高速缓冲存储器（即，从文件系统缓冲区高速缓存）复制到快照存储（即，到专用保存区域），并且在原始数据被复制之后，用新数据更新高速缓冲存储器中的原始数据。

5. 发明申请

US20140303232A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS 有权
标题翻译：用于递送活性剂的脂肪和脂质组合物
公开(公告)号：US20140303232A1
公开(公告)日：2014-10-09
申请号：US14200359
申请日：2014-03-07
申请人： Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura Ellen West , Thomas ZABAWA , Junping ZHAO
发明人： Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura Ellen West , Thomas ZABAWA , Junping ZHAO
IPC分类号： A61K47/18 , A61K47/12 , A61K47/14 , C12N15/113 , A61K47/22
CPC分类号： A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R 1 -R 4，L和X如本文所定义。式（I）化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。

6. 发明申请

US20110200582A1 LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM 审中-公开
标题翻译：脂肪酸，脂肪组合物和使用它们的方法
公开(公告)号：US20110200582A1
公开(公告)日：2011-08-18
申请号：US12974906
申请日：2010-12-21
申请人： Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
发明人： Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
IPC分类号： A61K39/395 , A61K47/06 , C07J43/00 , A61P35/00 , A61K47/28 , C07D303/24 , C07C43/178 , C07C271/16 , A61K31/575 , A61K38/02 , A61K31/7088 , A61K38/43
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/7088 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/30 , A61K2300/00 , C07J9/00 , C07J31/006 , C07J41/0055 , C07J43/003
摘要： Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.
摘要翻译：公开了用于将治疗有效量的生物活性剂递送到肝，肿瘤和/或其它细胞或组织的制剂和优化方案。还提供了式（I）的阳离子脂质化合物的组合物和用途。本发明还涉及式（XI）的隐形脂质的组合物和用途。还提供了制备这种化合物，组合物和制剂以及这些化合物，组合物和制剂的方法和用途以将生物活性剂递送至细胞和/或组织的方法。

7. 发明授权

US09301923B2 Lipids, lipid compositions, and methods of using them 有权
标题翻译：脂质，脂质组成和使用它们的方法
公开(公告)号：US09301923B2
公开(公告)日：2016-04-05
申请号：US14197124
申请日：2014-03-04
申请人： Jeremy Baryza , Keith Bowman , Andrew Geall , Tanzina Labonte , Cameron Lee , Chandra Vargeese , Laura West , Junping Zhao
发明人： Jeremy Baryza , Keith Bowman , Andrew Geall , Tanzina Labonte , Cameron Lee , Chandra Vargeese , Laura West , Junping Zhao
IPC分类号： A61K31/575 , A61K47/06 , A61K9/127 , A61K31/7088 , A61K47/18 , A61K47/28 , A61K47/30 , C07J9/00 , C07J41/00 , C07J43/00 , A61K47/14 , C07J31/00
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/7088 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/30 , A61K2300/00 , C07J9/00 , C07J31/006 , C07J41/0055 , C07J43/003
摘要： Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.
摘要翻译：公开了用于将治疗有效量的生物活性剂递送到肝，肿瘤和/或其它细胞或组织的制剂和优化方案。还提供了式（I）的阳离子脂质化合物的组合物和用途。本发明还涉及式（XI）的隐形脂质的组合物和用途。还提供了制备这种化合物，组合物和制剂以及这些化合物，组合物和制剂的方法和用途以将生物活性剂递送至细胞和/或组织的方法。

8. 发明申请

US20140309277A1 LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM 审中-公开
标题翻译：脂肪酸，脂肪组合物和使用它们的方法
公开(公告)号：US20140309277A1
公开(公告)日：2014-10-16
申请号：US14197124
申请日：2014-03-04
申请人： Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
发明人： Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
IPC分类号： A61K9/127 , A61K47/14 , A61K31/7088 , A61K47/28
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/7088 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/30 , A61K2300/00 , C07J9/00 , C07J31/006 , C07J41/0055 , C07J43/003
摘要： Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.
摘要翻译：公开了用于将治疗有效量的生物活性剂递送到肝，肿瘤和/或其它细胞或组织的制剂和优化方案。还提供了式（I）的阳离子脂质化合物的组合物和用途。本发明还涉及式（XI）的隐形脂质的组合物和用途。还提供了制备这种化合物，组合物和制剂以及这些化合物，组合物和制剂的方法和用途以将生物活性剂递送至细胞和/或组织的方法。

9. 发明申请

US20170196979A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS 审中-公开
公开(公告)号：US20170196979A1
公开(公告)日：2017-07-13
申请号：US15277402
申请日：2016-09-27
申请人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C12N15/113 , A61K47/22
CPC分类号： A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

10. 发明申请

US20160106842A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：用于递送活性剂的脂肪和脂质组合物
公开(公告)号：US20160106842A1
公开(公告)日：2016-04-21
申请号：US14779939
申请日：2014-03-06
申请人： Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-Munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura WEST , Thomas ZABAWA , Junping ZHAO
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C12N15/113 , A61K38/22 , C07D295/096 , C07D205/04 , C07C235/42 , A61K47/22 , C07C229/14 , C07C229/12 , C07D213/79 , C07D213/69 , C07C217/58 , C07D317/28
CPC分类号： A61K47/18 , A61K9/0019 , A61K9/1272 , A61K9/5123 , A61K31/713 , A61K38/2264 , A61K47/22 , A61K48/00 , C07C217/58 , C07C219/06 , C07C229/12 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/28 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R 1 -R 4，L和X如本文所定义。式（I）化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。

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