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1. 发明专利

JP2009282442A Finger hygiene enforcement system 有权
标题翻译：手指卫生执法系统
公开(公告)号：JP2009282442A
公开(公告)日：2009-12-03
申请号：JP2008136704
申请日：2008-05-26
申请人： Advanced Telecommunication Research Institute International , Hyogo College Of Medicine , 学校法人兵庫医科大学 , 株式会社国際電気通信基礎技術研究所
发明人： TSUCHIDA TOSHIE , NAYA FUTOSHI , MIYAMAE MASAKAZU , NOMA HARUO , TORIYAMA TOMOJI , KOGURE KIYOSHI
IPC分类号： G09B19/00 , A61B5/11 , A61H35/00 , G06Q50/22
摘要： PROBLEM TO BE SOLVED: To provide a finger hygiene enforcement system for enhancing the compliance with finger hygiene actions. SOLUTION: The finger hygiene enforcement system 100 includes a PC 10 and acceleration sensors 12a-12d. The acceleration sensors 12a-12d are worn by an examinee and repeatedly detect the movement of the examinee's body. The PC 10 recognizes the examinee's actions on the basis of the detected motion to create action information, evaluates the execution state of the finger hygiene actions by the examinee on the basis of the action information, and gives advice to the examinee in relation to the evaluation result. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于增强手指卫生行为的符合性的手指卫生执行系统。手指卫生执行系统100包括PC 10和加速度传感器12a-12d。加速度传感器12a-12d由受检者佩戴，并重复地检测被检体的运动。 PC 10根据检测到的动作识别被检者的行为以创建动作信息，根据动作信息评估受检者的手指卫生动作的执行状态，并且向受检者提供与评估有关的建议结果。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2009273539A Method for extracting state variation from imaging data, system for visualizing state variation, and computer program 有权
标题翻译：从成像数据提取状态变化的方法，用于可视化状态变化的系统和计算机程序
公开(公告)号：JP2009273539A
公开(公告)日：2009-11-26
申请号：JP2008125453
申请日：2008-05-13
申请人： Chiba Univ , Hyogo College Of Medicine , Keio Gijuku , Research Organization Of Information & Systems , 国立大学法人千葉大学 , 大学共同利用機関法人情報・システム研究機構 , 学校法人兵庫医科大学 , 学校法人慶應義塾
发明人： SANBUICHI FUMIKAZU , KOSHIHISA KIMINORI , OKADA YASUMASA , ISHIGURO MAKIO , TAMURA YOSHIHO , KAWAI SEIJI
IPC分类号： A61B5/00
摘要： PROBLEM TO BE SOLVED: To provide an imaging data processing method for intuitively understanding how state variation points change on imaging data of an object to be measured which has been measured, a computer program, and its operating method.
SOLUTION: When data obtained by measuring time-variable imaging data in still images of signals emitted by the object to be measured in a stationary state at a plurality of times is acquired, the object to be measured is partitioned into a plurality of regions on the imaging data for data of each measurement, and a model function of a stationary state is generated for each section. Then, time-series residual data for each section is calculated by using the generated model function of the stationary state, and a statistical test of is performed for the residual data. The imaging data processing method for mapping the calculated examination values with respect to the prescribed section at prescribed time when calculating the examination value equal to or higher than a prescribed level of significance, the computer program, and its operating method are provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种成像数据处理方法，用于直观地了解已经测量的被测量对象的成像数据的状态变化点如何变化，计算机程序及其操作方法。解决方案：当获取通过在静止状态下多次测量待测物体的信号的静止图像中的时间变化成像数据获得的数据时，被测量对象被划分为多个针对每个测量的数据的成像数据上的区域，以及针对每个部分生成静止状态的模型函数。然后，通过使用所产生的静止状态的模型函数来计算每个部分的时间序列残差数据，并且对剩余数据执行统计检验。提供了当计算检验值等于或高于规定的有效程度时，在规定时间将计算出的检查值映射到计算机程序及其操作方法的成像数据处理方法。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009114153A Tranilast gel-like suspension preparation 审中-公开
标题翻译： TRANILAST凝胶状悬浮液制备
公开(公告)号：JP2009114153A
公开(公告)日：2009-05-28
申请号：JP2007292011
申请日：2007-11-09
申请人： Hyogo College Of Medicine , Kissei Pharmaceut Co Ltd , Univ Kinki , キッセイ薬品工業株式会社 , 学校法人兵庫医科大学 , 学校法人近畿大学
发明人： OKAMOTO NORIO , ITO YOSHIMASA , ONO SHINICHIRO , KAWAKAMI YOSHIMI , NAGAI KISHO , KURIMOTO TAKUJI
IPC分类号： A61K31/196 , A61K9/06 , A61K9/10 , A61K47/36 , A61P1/02 , A61P17/02 , A61P27/02 , A61P41/00
摘要： PROBLEM TO BE SOLVED: To provide a tranilast-containing preparation as a gel-like suspension preparation or micronized suspension useful as a scarring inhibitor or vitreous body visualizer after operation and having effects equivalent to or higher than the case with conventional continuous oral administration. SOLUTION: The gel-like suspension preparation contains tranilast or a pharmacologically acceptable salt thereof 1-4 μm in the center of particle size distribution and 5 μm or smaller in 90% median diameter and at least one of sodium hyaluronate and sodium chondroitin sulfate. This gel-like suspension preparation as an embrocation is useful as a scarring inhibitor after operation. The micronized suspension is obtained by mixing tranilast or a pharmacologically acceptable salt thereof and at least one of sodium hyaluronate and sodium chondroitin sulfate into a physiological saline solution followed by micronization, wherein the tranilast is 1-4 μm in the center of particle size distribution and 5 μm or smaller in 90% median diameter. This micronized suspension is useful as a vitreous body visualizer. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种含有曲马列斯的制剂作为凝胶状悬浮液制剂或微粉化悬浮液，其用作操作后的瘢痕形成抑制剂或玻璃体观察剂，并具有与常规连续口服的情况相当或更高的效果行政。凝胶状悬浮液制剂含有曲米他特或其药理学上可接受的盐，其粒度分布中心为1-4μm，中位粒径为90μm或更小，透明质酸钠和软骨素钠中的至少一种硫酸盐。这种凝胶状悬浮液制剂作为刺绣在手术后可用作瘢痕形成抑制剂。通过将曲尼司特或其药理学上可接受的盐和透明质酸钠和硫酸软骨素钠中的至少一种混合到生理盐水溶液中随后进行微粉化获得微粉化悬浮液，其中曲尼司特在粒度分布中心为1-4μm，在90％中值直径中为5μm或更小。该微粉化悬浮液可用作玻璃体观察剂。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2014171425A Screening method of compound for therapy and/or prevention of tdp-43 agglomerate-accumulating disease 有权
标题翻译：用于治疗和/或预防TDP-43 AGGLOMERATE-ACCUMULATING DISEASE的化合物的筛选方法
公开(公告)号：JP2014171425A
公开(公告)日：2014-09-22
申请号：JP2013046451
申请日：2013-03-08
申请人： Shiga Univ Of Medical Science , 国立大学法人滋賀医科大学 , Ritsumeikan , 学校法人立命館 , Hyogo College Of Medicine , 学校法人兵庫医科大学
发明人： URUSHIYA MAKOTO , KITAHARA AKIRA , FUJIWARA NORIKO , ITO HIDEFUMI
IPC分类号： C12N15/09 , A01K67/027 , A01K67/033 , A61K31/7088 , A61K39/00 , A61K39/395 , A61P25/28 , A61P37/04 , A61P43/00 , C07K14/47 , C07K16/18 , G01N33/15 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a TDP-43 variant having agglomerate forming ability and cytotoxicity in the whole length sequence; and a screening method of a compound for therapy and/or prevention of TDP-43 agglomerate-accumulating diseases by utilizing the TDP-43 variant.SOLUTION: A TDP-43 variant comprises an amino acid sequence with a cysteine at the 173 and/or 175 positions being substituted in TDP-43 amino acid sequence. A screening method of a compound for therapy and/or prevention of TDP-43 agglomerate-accumulating diseases comprises the following steps of: (1) bringing the TDP-43 variant into contact with a compound as a candidate; (2) detecting agglomerate formation inhibitory activity of the compound; and (3) selecting a compound inhibiting agglomerate formation.
摘要翻译：要解决的问题：提供在整个长度序列中具有附聚形成能力和细胞毒性的TDP-43变体; 和用于通过使用TDP-43变体治疗和/或预防TDP-43聚集积聚疾病的化合物的筛选方法。解决方案：TDP-43变体包含在173位具有半胱氨酸的氨基酸序列和/或 175个位置被替换为TDP-43氨基酸序列。用于治疗和/或预防TDP-43聚集积聚疾病的化合物的筛选方法包括以下步骤：（1）使TDP-43变体与作为候选物的化合物接触; （2）检测化合物的附聚物形成抑制活性; 和（3）选择抑制附聚物形成的化合物。

5. 发明专利

JP2011105715A Substance inhibiting toxin production of toxin-producing bacteria including vibrio cholera 有权
标题翻译：毒素生产毒素的物质抑制毒素，包括抗生素胆固醇
公开(公告)号：JP2011105715A
公开(公告)日：2011-06-02
申请号：JP2010236938
申请日：2010-10-22
申请人： Fuso Pharmaceutical Industries Ltd , Hyogo College Of Medicine , Osaka Prefecture Univ , 公立大学法人大阪府立大学 , 学校法人兵庫医科大学 , 扶桑薬品工業株式会社
发明人： YAMAZAKI SHINJI , ASAKURA MASAHIRO , AOKI SHUNJI
IPC分类号： A61K36/18 , A61K31/085 , A61K31/165 , A61K31/4525 , A61K36/23 , A61K36/81 , A61P31/04
CPC分类号： Y02A50/471 , Y02A50/473
摘要： PROBLEM TO BE SOLVED: To provide a vibrio cholera toxin production inhibitor including a spice extract as an active ingredient, to provide a method for inhibiting the production of vibrio cholera toxin; besides, to provide a medicament for treating and/or preventing cholera, containing such a spice extract as active ingredient, and to provide methods (each) for treating and/or preventing cholera. SOLUTION: Studies have been conducted based on believing that spice used willingly in tropical nations contain a substance having curative and preventive effects on vibrio cholera also as an endemic in such tropical nations originally. As a result, it has been found that alcohol extracts of some kinds of such spice have the effects of inhibiting the toxin production by toxin-producing bacteria including vibrio cholera. Further, it has been found that medicinal ingredients including capsaicin, piperine, trans-anethole and 4-allyl anethole, derived from such kinds of spice, have the effects of inhibiting the toxin production by toxin-producing bacteria including vibrio cholera as well. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种包括香料提取物作为活性成分的霍乱弧菌毒素生产抑制剂，以提供抑制霍乱弧菌毒素生产的方法; 此外，提供用于治疗和/或预防霍乱的药物，其含有作为活性成分的香料提取物，并且提供用于治疗和/或预防霍乱的方法（各自）。
解决方案：研究是基于相信热带国家自愿使用的香料含有对霍乱弧菌具有治疗和预防作用的物质，也是这些热带国家的地方病。结果发现，某些类型的香料的酒精提取物具有抑制由霍乱弧菌引起的毒素产生细菌产生毒素的作用。此外，已经发现衍生自这种香料的药物成分包括辣椒素，胡椒碱，反式异戊烯和4-烯丙基茴香醚，具有抑制由产生霍乱弧菌的毒素产生细菌产生毒素的作用。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2013070653A Model animal with allergic rhinitis, method for screening allergic rhinitis-curing agent, and use thereof 有权
标题翻译：具有过敏性病毒的模型动物，筛选过敏性固化剂的方法及其用途
公开(公告)号：JP2013070653A
公开(公告)日：2013-04-22
申请号：JP2011211159
申请日：2011-09-27
申请人： Hyogo College Of Medicine , 学校法人兵庫医科大学
发明人： YOSHIMOTO TOMOHIRO
IPC分类号： A01K67/027 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a model animal exhibiting a pathology closely resembling human allergic rhinitis, to provide a method for screening an allergic rhinitis-curing agent using the model animal, and to provide use of the agent.SOLUTION: The model animal with allergic rhinitis is obtained by sensitizing a non-human model animal having endogenous interleukin 33 with ragweed pollen, and then administering ragweed pollen into the nasal cavity of the model animal.
摘要翻译：待解决的问题：提供一种表现出类似于人类过敏性鼻炎的病理学的模型动物，以提供使用该模型动物筛选过敏性鼻炎固化剂的方法，并提供该试剂的使用。解决方案：具有过敏性鼻炎的模型动物是通过用豚草花粉敏感具有内源性白细胞介素33的非人模型动物，然后将豚草花粉施用到模型动物的鼻腔中获得的。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2011250711A NEW HUMAN LYMPHOCYTE, PRODUCTION METHOD THEREOF AND METHOD FOR PROLIFERATING γδT CELL 有权
标题翻译：新人淋巴细胞，其生产方法及增加γδT细胞的方法
公开(公告)号：JP2011250711A
公开(公告)日：2011-12-15
申请号：JP2010125140
申请日：2010-05-31
申请人： Hyogo College Of Medicine , Hiromichi Yamanishi , 学校法人兵庫医科大学 , 博道山西
发明人： OKAMURA HARUKI , RI FUMI , YAMANISHI HIROMICHI
IPC分类号： C12N5/0786 , C12N5/0783
摘要： PROBLEM TO BE SOLVED: To provide a human lymphocyte which has a strong cytokine-producing ability and cytotoxic activity and can promote the proliferation of γδT cells, to provide a production method thereof, and to provide a method for proliferating the γδT cells with the human lymphocyte.SOLUTION: In the human lymphocyte stimulated with at least interleukin 2 and interleukin 18, expression intensity of CD56 is ≥10, and the expression intensity of CD11c is 10to 10, wherein the expression intensity is measured by flow cytometry.
摘要翻译：待解决的问题：提供具有强的细胞因子产生能力和细胞毒性活性的人淋巴细胞，并且可以促进γδT细胞的增殖，以提供其制备方法，并提供增殖γδT细胞的方法与人淋巴细胞。解决方案：在用至少白细胞介素2和白细胞介素18刺激的人淋巴细胞中，CD56的表达强度≥10 2 ，CD11c的表达强度为10 1 至10 2 ，其中通过流式细胞术测量表达强度。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2011017548A Hardness measuring penetrator and method for manufacturing the same 审中-公开
标题翻译：硬度测量穿透器及其制造方法
公开(公告)号：JP2011017548A
公开(公告)日：2011-01-27
申请号：JP2009160669
申请日：2009-07-07
申请人： Hyogo College Of Medicine , Sanei Me:Kk , 学校法人兵庫医科大学 , 有限会社三栄エムイー
发明人： SHIMIZU AKIHIKO , UEHARA TADAO
IPC分类号： G01N3/42 , A61C19/04
摘要： PROBLEM TO BE SOLVED: To provide a hardness measuring penetrator capable of accurately measuring the hardness, over a large number of times of measurements.SOLUTION: The hardness measuring penetrator 10 is used for measuring the hardness of an object 90 to be measured, having an electrically conductive surface and the penetrator 10 includes its body 11 including a conductive material and the insulating chip 12 attached to the leading end of the body 11 to be pressed to the object 90 to be measured. The boundary line 14 of the body 11 and the insulating chip 12 on the outer peripheral surface 15 of the penetrator 10 is positioned within the plane B vertical to the long axis 13 of the penetrator 10. Since the penetrator 10 does not contain the film for covering the surface of the penetrator 10, peeling of the film by a large number of times of measurements and lowering of measurement accuracy accompanying the peeling of the film do not arise. The penetrator 10 can measure accurate hardness over a large number of times of measurements.
摘要翻译：要解决的问题：提供能够在大量测量中精确测量硬度的硬度测量穿透器。解决方案：硬度测量穿透器10用于测量待测物体90的硬度，具有导电表面和穿透器10包括其主体11，其包括导电材料和绝缘芯片12，该绝缘芯片12附接到主体11的前端以被压到要测量的对象90。主体11的边界线14和穿透器10的外周面15上的绝缘芯片12位于与穿透器10的长轴13垂直的平面B内。由于穿透器10不包含用于覆盖穿透器10的表面，不会出现伴随剥离膜的大量测量和降低测量精度的膜的剥离。穿透器10可以在大量测量时测量精确的硬度。

9. 发明专利

JP2010017134A Vgamma9Vdelta2 T CELL PROLIFERATION AGENT, METHOD FOR PRODUCING ACTIVATED Vgamma9Vdelta2 T CELL, AND USE THEREOF 有权
标题翻译： Vgamma9Vdelta2 T细胞增殖剂，用于生产活化的Vgamma9Vdelta2 T细胞的方法及其用途
公开(公告)号：JP2010017134A
公开(公告)日：2010-01-28
申请号：JP2008180749
申请日：2008-07-10
申请人： Hyogo College Of Medicine , 学校法人兵庫医科大学
发明人： OKAMURA HARUKI , KUBO SHUJI , RI FUMI
IPC分类号： C12N5/07 , A61K35/12 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00
CPC分类号： A61K31/663 , A61K38/20 , A61K38/2013 , C12N5/0638 , C12N2501/2302 , C12N2501/2318 , C12N2501/999 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a Vgamma9Vdelta2 T cell proliferation agent proliferating Vgamma9Vdelta2 T cells having anti-tumor activity and cytokine-producing ability with significantly high proliferation efficiency, method for producing activated Vgamma9Vdelta2 T cells and uses thereof. SOLUTION: Disclosed are a Vgamma9Vdelta2 T cell proliferation agent and proliferation kit containing at least bisphosphonate such as zoledronate, interleukin 2 and interleukin 18 and also medicines containing the T cells. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供具有抗肿瘤活性和具有显着高增殖效率的细胞因子产生能力的Vgamma9Vdelta2T细胞增殖的Vgamma9Vdelta2T细胞增殖剂，用于产生活化的VgammaVV2 T细胞的方法及其用途。解决方案：公开了含有至少二膦酸盐如唑来膦酸盐，白细胞介素2和白细胞介素18的Vgamma9Vdelta2T细胞增殖剂和增殖试剂盒，以及含有T细胞的药物。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2013140030A Blood marker for kidney cancer 有权
标题翻译：血液标记为KIDNEY癌症
公开(公告)号：JP2013140030A
公开(公告)日：2013-07-18
申请号：JP2011289649
申请日：2011-12-28
申请人： Shimadzu Corp , 株式会社島津製作所 , Mukogawa Gakuin , 学校法人武庫川学院 , Hyogo College Of Medicine , 学校法人兵庫医科大学
发明人： MATSUO EIICHI , KANEKO NAOKI , WATANABE MAKOTO , NISHIMURA TADASHI , OKAMURA NOBORU , GOTO AKINOBU
IPC分类号： G01N33/68 , C12N9/88 , C12Q1/527
CPC分类号： G01N33/57438 , C12N9/96 , G01N33/6893 , G01N2333/4724 , G01N2333/988
摘要： PROBLEM TO BE SOLVED: To provide a blood marker for kidney cancer, in particular, a blood marker practicable for a clinical diagnosis of kidney cancer; and a blood marker practicable for a progress observation after treatment (surgery) of kidney cancer and during treatment (medical treatment such as administration of drug).SOLUTION: A blood marker is selected from the group consisting of galectin-1, galectin-3, and α-enolase. Galectin-1 and/or galectin-3 are used as a blood marker for kidney cancer for inspection before image diagnosis. α-enolase is used as a blood marker for kidney cancer for monitoring during and/or after treatment of kidney cancer.
摘要翻译：要解决的问题：提供肾癌的血液标志物，特别是可用于临床诊断肾癌的血液标志物; 以及用于肾癌治疗（手术）后和治疗期间（药物给药等药物治疗）进行观察的血液标记物。溶液：血液标志物选自半乳凝素-1，半乳凝素-3，和α-烯醇化酶。 Galectin-1和/或半乳凝素-3用作肾癌的血液标志物用于在图像诊断之前进行检查。 α-烯醇化酶用作肾癌的血液标志物，用于在肾癌治疗期间和/或之后进行监测。

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