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1. 发明专利

JP2009114153A Tranilast gel-like suspension preparation 审中-公开
标题翻译： TRANILAST凝胶状悬浮液制备
公开(公告)号：JP2009114153A
公开(公告)日：2009-05-28
申请号：JP2007292011
申请日：2007-11-09
申请人： Hyogo College Of Medicine , Kissei Pharmaceut Co Ltd , Univ Kinki , キッセイ薬品工業株式会社 , 学校法人兵庫医科大学 , 学校法人近畿大学
发明人： OKAMOTO NORIO , ITO YOSHIMASA , ONO SHINICHIRO , KAWAKAMI YOSHIMI , NAGAI KISHO , KURIMOTO TAKUJI
IPC分类号： A61K31/196 , A61K9/06 , A61K9/10 , A61K47/36 , A61P1/02 , A61P17/02 , A61P27/02 , A61P41/00
摘要： PROBLEM TO BE SOLVED: To provide a tranilast-containing preparation as a gel-like suspension preparation or micronized suspension useful as a scarring inhibitor or vitreous body visualizer after operation and having effects equivalent to or higher than the case with conventional continuous oral administration. SOLUTION: The gel-like suspension preparation contains tranilast or a pharmacologically acceptable salt thereof 1-4 μm in the center of particle size distribution and 5 μm or smaller in 90% median diameter and at least one of sodium hyaluronate and sodium chondroitin sulfate. This gel-like suspension preparation as an embrocation is useful as a scarring inhibitor after operation. The micronized suspension is obtained by mixing tranilast or a pharmacologically acceptable salt thereof and at least one of sodium hyaluronate and sodium chondroitin sulfate into a physiological saline solution followed by micronization, wherein the tranilast is 1-4 μm in the center of particle size distribution and 5 μm or smaller in 90% median diameter. This micronized suspension is useful as a vitreous body visualizer. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种含有曲马列斯的制剂作为凝胶状悬浮液制剂或微粉化悬浮液，其用作操作后的瘢痕形成抑制剂或玻璃体观察剂，并具有与常规连续口服的情况相当或更高的效果行政。凝胶状悬浮液制剂含有曲米他特或其药理学上可接受的盐，其粒度分布中心为1-4μm，中位粒径为90μm或更小，透明质酸钠和软骨素钠中的至少一种硫酸盐。这种凝胶状悬浮液制剂作为刺绣在手术后可用作瘢痕形成抑制剂。通过将曲尼司特或其药理学上可接受的盐和透明质酸钠和硫酸软骨素钠中的至少一种混合到生理盐水溶液中随后进行微粉化获得微粉化悬浮液，其中曲尼司特在粒度分布中心为1-4μm，在90％中值直径中为5μm或更小。该微粉化悬浮液可用作玻璃体观察剂。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2009227650A Therapeutic agent for glaucoma comprising cyclodextrin-clathrate compound of cilostazole as active ingredient 有权
标题翻译：含有作为活性成分的西洛他唑环糊精 - 柠檬酸复合物的GLAUCOMA治疗剂
公开(公告)号：JP2009227650A
公开(公告)日：2009-10-08
申请号：JP2008199301
申请日：2008-08-01
申请人： Hyogo College Of Medicine , Otsuka Pharmaceut Co Ltd , Univ Kinki , 大塚製薬株式会社 , 学校法人兵庫医科大学 , 学校法人近畿大学
发明人： OKAMOTO NORIO , ITO YOSHIMASA , KAWAKAMI YOSHIMI , KURIMOTO TAKUJI , NAGAI KISHO , YAMASHITA TATSUYA
IPC分类号： A61K31/4709 , A61K9/08 , A61K47/40 , A61P27/06
CPC分类号： A61K31/4709 , A61K9/0048 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16 , C08L1/26
摘要： PROBLEM TO BE SOLVED: To provide a new type therapeutic agent for glaucoma administered as eye drops.
SOLUTION: The therapeutic agent for glaucoma administered as eye drops contains a carbostyryl derivative expressed by general formula (1) or a salt thereof, and a cyclodextrin. A clathrate compound prepared through clathration of the carbostyryl derivative or the salt thereof with the cyclodextrin is improved in solubility and is effective for treating glaucoma. In the formula, A represents a lower alkylene group; R represents a cycloalkyl group; and the bond between position 3 and position 4 of the carbostyryl skeleton represents a single bond or a double bond.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供作为滴眼剂给予的青光眼的新型治疗剂。作为滴眼剂给药的青光眼治疗剂含有通式（1）表示的喹喔啉衍生物或其盐和环糊精。通过将环糊精包合喹喔啉衍生物或其盐制备的包合物化合物的溶解度提高，对于治疗青光眼是有效的。在该式中，A表示低级亚烷基; R表示环烷基; 并且喹喔啉骨架的位置3和位置4之间的键表示单键或双键。版权所有（C）2010，JPO＆INPIT

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