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1. 发明申请

WO2004087162A1 USES OF TRYPROSTATIN FOR THE REVERSAL OF CANCER DRUG RESISTANCE 审中-公开
标题翻译：用于抗癌药物耐药性的TRYPROSTATIN的使用
公开(公告)号：WO2004087162A1
公开(公告)日：2004-10-14
申请号：PCT/EP2004/003129
申请日：2004-03-24
申请人： HUMBOLDT-UNIVERSITÄT ZU BERLIN , UNIVERSITÄTSKLINIKUM CHARITÉ DER HUMBOLDT-UNIVERSITÄT ZU BERLIN , HERRMANN, Andreas , LAGE, Hermann , WOEHLECKE, Holger
发明人： HERRMANN, Andreas , LAGE, Hermann , WOEHLECKE, Holger
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985 , G01N33/5011
摘要： The phenomenon of multidrug resistance (MDR) in human cancers is one of the major causes of failure of chemotherapy. The fungal secondary metabolite tryprostatin A (TPS-A), a diketopiperazine, has been shown to overcome multi-drug resistance, and to inhibit lipid transport, whilst no cytotoxicity of the compound itself could be observed.
摘要翻译：人类癌症中多药耐药（MDR）的现象是化疗失败的主要原因之一。已经显示真菌次级代谢物抗孕激素A（TPS-A）是一种二酮哌嗪，可以克服多药耐药，并抑制脂质转运，同时无法观察到化合物本身的细胞毒性。

2. 发明授权

US11719765B2 Sensor for measuring a magnetic field 有权
公开(公告)号：US11719765B2
公开(公告)日：2023-08-08
申请号：US17739066
申请日：2022-05-06
申请人： Humboldt-Universität zu Berlin , Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Tim Schröder , Felipe Perona Martinez , Julian Bopp , Moritz Kleinert , Hauke Conradi
IPC分类号： G01R33/32 , G01R33/032 , G01R33/02
CPC分类号： G01R33/032 , G01R33/0206
摘要： An embodiment of the invention relates to a sensor comprising a sensor element (10) for measuring a magnetic field, the sensor element (10) comprising a set of at least two first input ports (I1), a set of at least two exit ports (E) each of which is connected to one of the first input ports (I1) via a corresponding first beam path (B1), a set of at least two second input ports (I2) each of which is connected to a second beam path (B2), wherein the first beam paths (B1) extend through a common plane (CP) located inside the sensor element (10), said plane (CP) comprising a plurality of magneto-optically responsive defect centers, wherein the second beam paths (B2) also extend through said common plane (CP), but are angled with respect to the first beam paths (B1) such that a plurality of intersections between the first and second beam paths (B2) is defined, and wherein each intersection forms a sensor pixel (P) located at at least one of said magneto-optically responsive defect centers.

3. 发明授权

US11268899B2 Photoacoustic method with a measuring light having a predetermined wavelength range for the determination of properties of an inhomogeneous sample 有权
公开(公告)号：US11268899B2
公开(公告)日：2022-03-08
申请号：US16756348
申请日：2018-10-26
申请人： HUMBOLDT-UNIVERSITÄT ZU BERLIN
发明人： Raphael Schlesinger , Jan-Ferenc Kischkat , Hermann Von Lilienfeld-Toal
IPC分类号： G01N21/17 , A61B5/145 , A61B5/00
摘要： A method comprises a) radiating at least one measurement light pulse having a pulse duration and intensity onto a measurement area of the inhomogeneous sample; b) detecting at least one pressure transient at the measurement area; and c) calculating a value for the energy density absorbed by the sample during the pulse duration from a curve of the at least one pressure transient at the start and at the end of the at least one measurement light pulse. The method further includes: repeating steps a) to c) for different angles of incidence of the measurement light; modelling the inhomogeneous sample as a stack of layers, each layer being assigned at least a layer thickness and an absorption coefficient, at least one absorption coefficient of a layer being a fitting parameter; and performing a fitting procedure for the fitting parameters; outputting the fitted fitting parameters.

4. 发明申请

US20150216932A1 PROBIOTIC BACTERIA AS CARRIER FOR A HELMINTH-DERIVED IMMUNOMODULATOR FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的有益于免疫细胞免疫调节因子的携带者的生物细菌
公开(公告)号：US20150216932A1
公开(公告)日：2015-08-06
申请号：US14426612
申请日：2013-09-06
申请人： HUMBOLDT-UNIVERSITÄT ZU BERLIN , FREIE UNIVERSITÄT BERLIN
发明人： Susanne Hartmann , Lothar Wieler , Rose Whelan , Sebastian Rausch
IPC分类号： A61K38/17 , C07K14/435 , A61K35/741
CPC分类号： A61K38/1767 , A61K35/74 , A61K35/741 , A61K38/57 , A61K2035/11 , C07K14/4354 , Y02A50/473
摘要： The present invention is directed to a transgenic probiotic microorganism genetically engineered to express and secrete cystatin, wherein said cystatin is preferably comprises or consists of: an amino acid sequence with SEQ ID NO. 1 to 3; and an amino acid sequence that is at least 70% identical, preferably at least 80% identical, more preferably at least 90% identical and most preferably at least 99% identical to an amino acid sequence with SEQ ID NO. 1 to 3, and to its use for treatment of gastrointestinal inflammatory diseases.
摘要翻译：本发明涉及基因工程改造以表达和分泌半胱氨酸蛋白酶抑制剂的转基因益生菌微生物，其中所述半胱氨酸蛋白酶抑制剂优选包含或由以下组成：具有SEQ ID NO： 1〜3; 和与SEQ ID NO：1的氨基酸序列具有至少70％相同，优选至少80％同一，更优选至少90％相同，最优选至少99％的氨基酸序列。 1至3，并用于治疗胃肠道炎症性疾病。

5. 发明申请

US20200333296A1 PHOTO-ACOUSTIC SENSOR HEAD AND PHOTO-ACOUSTIC MEASURING APPARATUS WITH IMPROVED INTERFERENCE SIGNAL SUPPRESSION 审中-公开
公开(公告)号：US20200333296A1
公开(公告)日：2020-10-22
申请号：US16756164
申请日：2018-10-26
申请人： HUMBOLDT-UNIVERSITÄT ZU BERLIN
发明人： Hermann VON LILIENFELD-TOAL , Jan-Ferenc KISCHKAT , Oliver SUPPLIE
IPC分类号： G01N29/24 , G01N29/22
摘要： The disclosure relates to a photoacoustic sensor head for detecting acoustic signals which are excited in a sample by absorption of pulsed measuring light, comprising a contact prism which is transparent for the measuring light and has a sample contact surface, a detection surface arranged opposite the sample contact surface and a light entrance surface arranged adjacent to the detection surface, as well as means for radiating the measuring light through the light entrance surface in the direction of the sample contact surface, wherein a detection device comprising at least one sound transducer is arranged in a manner covering the detection surface, characterized in that those portions of the measuring light which are reflected at the sample contact surface are directed to the detection surface or to the light entrance surface, wherein a material layer containing a material which absorbs the measuring light is arranged between the detection surface and the detection device.

6. 发明申请

US20160187579A1 WAVEGUIDE ARRANGEMENT 审中-公开
标题翻译：波形安排
公开(公告)号：US20160187579A1
公开(公告)日：2016-06-30
申请号：US14650711
申请日：2013-11-26
申请人： HUMBOLDT-UNIVERSITÄT ZU BERLIN , FORSCHUNGSVERBUND BERLIN E.V.
发明人： Rico HENZE , Andreas THIES , Oliver BENSON
IPC分类号： G02B6/122 , G02B6/136
摘要： The invention relates to a waveguide arrangement (10) comprising a substrate (20) and at least one strip-shaped waveguide made of a wave-guiding layer material (30). The strip waveguide extends strip-like in a longitudinal direction and can guide waves in its longitudinal direction so that the wave propagation direction corresponds to the longitudinal direction of the strip waveguide. The refractive index of the substrate (20) is greater than the refractive index of the layer material (30). In order to guide waves vertically, the strip waveguide forms a waveguide bridge (60) which is located above a recess (100) in the substrate (20) and which is at least partially spatially separated from the substrate (20) there.
摘要翻译：本发明涉及一种波导装置（10），其包括基板（20）和由波导层材料（30）制成的至少一个条形波导。带状波导沿纵向方向延伸成条状，并且可以在其纵向方向上引导波，使得波传播方向对应于条形波导的纵向方向。基板（20）的折射率大于层材料（30）的折射率。为了垂直地引导波浪，带状波导形成位于基底（20）中的凹部（100）上方并且至少部分空间上与基底（20）分离的波导桥（60）。

7. 发明公开

US20240352500A1 INCREASE OF PROTEIN EXPRESSION AND SECRETION BY ARTIFICIAL CO-EXPRESSION OF HDLBP/VIGILIN 审中-公开
公开(公告)号：US20240352500A1
公开(公告)日：2024-10-24
申请号：US18684500
申请日：2022-08-18
申请人： Max-Delbrück-Centrum für Molekulare Medizin , Humboldt-Universität zu Berlin
发明人： Markus Landthaler , Ulrike Zinnall , Igor Minia
IPC分类号： C12P21/02 , C07K14/505 , C07K14/565 , C07K14/59 , C07K14/62 , C12N9/22 , C12N15/11 , C12N15/90
CPC分类号： C12P21/02 , C07K14/505 , C07K14/565 , C07K14/59 , C07K14/62 , C12N9/22 , C12N15/11 , C12N15/907 , C07K2319/30 , C12N2310/20
摘要： The invention is related to a method for producing a secreted recombinant protein of interest in a cell, wherein the method comprises artificially co-expressing a protein different from the secreted recombinant protein of interest.

8. 发明申请

US20220390529A1 SENSOR FOR MEASURING A MAGNETIC FIELD 有权
公开(公告)号：US20220390529A1
公开(公告)日：2022-12-08
申请号：US17739066
申请日：2022-05-06
申请人： Humboldt-Universität zu Berlin , Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Tim SCHRÖDER , Felipe PERONA MARTINEZ , Julian BOPP , Moritz KLEINERT , Hauke CONRADI
IPC分类号： G01R33/032 , G01R33/02
摘要： An embodiment of the invention relates to a sensor comprising a sensor element (10) for measuring a magnetic field, the sensor element (10) comprising a set of at least two first input ports (I1), a set of at least two exit ports (E) each of which is connected to one of the first input ports (I1) via a corresponding first beam path (B1), a set of at least two second input ports (I2) each of which is connected to a second beam path (B2), wherein the first beam paths (B1) extend through a common plane (CP) located inside the sensor element (10), said plane (CP) comprising a plurality of magneto-optically responsive defect centers, wherein the second beam paths (B2) also extend through said common plane (CP), but are angled with respect to the first beam paths (B1) such that a plurality of intersections between the first and second beam paths (B2) is defined, and wherein each intersection forms a sensor pixel (P) located at at least one of said magneto-optically responsive defect centers.

9. 发明申请

US20170252418A1 GENETICALLY MODIFIED COCCIDIAN PARASITES USEFUL AS VACCINES 审中-公开
公开(公告)号：US20170252418A1
公开(公告)日：2017-09-07
申请号：US15510933
申请日：2015-09-16
申请人： HUMBOLDT-UNIVERSITÄT ZU BERLIN , UNIVERSITEIT UTRECHT HOLDING B.V.
发明人： Nishith GUPTA , Ruben ARROYO-OLARTE , Richard LUCIUS , Jos BROUWERS , J. Bernd HELMS , Ildiko DUNAY
IPC分类号： A61K39/012 , C12N1/36 , C12N1/10 , C07F9/10 , C12N9/12
CPC分类号： A61K39/012 , A61K2039/522 , A61K2039/552 , C07F9/106 , C12N1/10 , C12N1/36 , C12N9/1288
摘要： A genetically modified coccidian parasites wherein expression of phosphatidylthreonine synthase (PTS) is disrupted, a polynucleotide including a nucleotide sequence encoding a phosphatidylthreonine synthase (PTS) enzyme, which catalyzes the production of a lipid, phosphatidylthreonine (PtdThr). PtdThr is an exclusive, major and physiologically important lipid in selected coccidian parasites, which is required for a normal growth and virulence of coccidian parasites. Coccidian parasites, having the expression of PTS disrupted as described herein, are useful as vaccines. The phosphatidylthreonine synthase enzyme and the nucleotide encoding sequences thereof as well as the phosphatidylthreonine phospholipid can find use in diagnostic methods and diagnostic kits or in vaccine and drug development applications.

10. 发明申请

US20200326274A1 PHOTOACOUSTIC METHOD WITH A MEASURING LIGHT HAVING A PREDETERMINED WAVELENGTH RANGE FOR THE DETERMINATION OF PROPERTIES OF AN INHOMOGENEOUS SAMPLE 审中-公开
公开(公告)号：US20200326274A1
公开(公告)日：2020-10-15
申请号：US16756348
申请日：2018-10-26
申请人： HUMBOLDT-UNIVERSITÄT ZU BERLIN
发明人： Raphael SCHLESINGER , Jan-Ferenc KISCHKAT , Hermann VON LILIENFELD-TOAL
IPC分类号： G01N21/17 , A61B5/145
摘要： The invention relates to a photoacoustic method comprising a measurement light having a predefined wavelength range for determining properties of an inhomogeneous sample, the sample having a mean absorption length μ from the range of 1 to 100 micrometers for the predefined wavelength range, the method comprising the following steps: a) radiating at least one measurement light pulse having a predefined pulse duration and a predefined intensity onto a measurement area of the area F with √F>>μ in the surface of the inhomogeneous sample; b) detecting at least one pressure transient at the measurement area, the pressure transient resulting from the absorption of the at least one measurement light pulse in the inhomogeneous sample with production of a pressure wave propagating to the measurement area; c) calculating a value for the energy density absorbed by the sample during the pulse duration from the curve of the at least one pressure transient at the start and at the end of the at least one measurement light pulse; characterized by d) repetition of steps a) to c) for different angles of incidence of the measurement light with respect to the normal of the measurement area, the energy density values determined in c) each being indicated with the angle of incidence; e) modeling the inhomogeneous sample as a stack of layers, each layer being assigned at least a layer thickness and an absorption coefficient, at least one absorption coefficient of a layer being a fitting parameter; f) performing a fitting procedure for the fitting parameters of the stack of layers, the division of the energy density values indicated with the angle of incidence into contributions of the individual layers being varied by variation of the fitting parameters until a predefined consistency criterion is met; g) reading out the fitted fitting parameters as values at least for the depth-resolved absorption coefficient of the inhomogeneous sample.

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