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1. 发明专利

IL138663A STEROIDAL SAPOGENINS AND THEIR DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE 未知
公开(公告)号：IL138663A
公开(公告)日：2006-08-01
申请号：IL13866300
申请日：2000-09-24
申请人： PHYTOPHARM PLC , XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WIEJUN , GUNNING PHIL
发明人： XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WIEJUN , GUNNING PHIL
IPC分类号： C12N15/09 , A61K20060101 , A61K31/343 , A61K31/352 , A61K31/58 , A61K31/70 , A61K31/704 , A61K35/00 , A61K36/18 , A61K36/896 , A61P9/00 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D493/10 , C07J71/00 , C12Q1/68 , G01N33/94
摘要： The invention discloses the use of a number of saponins and sapogenins, notably those of steroidal structure, in the treatment of cognitive disfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

2. 发明申请

WO03082893A8 THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES 审中-公开
标题翻译：治疗方法和青蒿素及其衍生物的使用
公开(公告)号：WO03082893A8
公开(公告)日：2003-12-31
申请号：PCT/GB0301380
申请日：2003-03-27
申请人： PHYTOPHARM PLC , REES DARYL , GUNNING PHIL , ORSI ANTONIA , XIA ZONGQIN , HU YAER
发明人： REES DARYL , GUNNING PHIL , ORSI ANTONIA , XIA ZONGQIN , HU YAER
IPC分类号： A61K31/58 , A61K31/585 , A61K31/655 , A61P9/02 , A61P9/04 , A61P11/06 , A61P21/00 , A61P21/04 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/00 , C07J20060101 , C07J71/00 , C07J
CPC分类号： A61K31/58 , A61K31/655 , C07J71/00 , C07J71/0005
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
摘要翻译：本发明公开了某些甾体皂苷元，相关化合物及其衍生物在治疗非认知神经退行性疾病，非认知性神经肌肉变性，运动感觉神经变性或受体功能障碍或不存在认知神经和神经损伤的情况下的治疗方法和用途。神经肌肉损伤

3. 发明申请

WO2002079221A2 SAPOGENIN DERIVATIVES, THEIR SYNTHESIS AND USE, AND METHODS BASED UPON THEIR USE 审中-公开
标题翻译： SAPOGENIN衍生物，其合成与使用及其使用方法
公开(公告)号：WO2002079221A2
公开(公告)日：2002-10-10
申请号：PCT/GB2002/001578
申请日：2002-03-28
申请人： PHYTOTECH LIMITED , BARRACLOUGH, Paul , HANSON, Jim , GUNNING, Phil , REES, Daryl , XIA, Zongqin , HU, Yaer
发明人： BARRACLOUGH, Paul , HANSON, Jim , GUNNING, Phil , REES, Daryl , XIA, Zongqin , HU, Yaer
IPC分类号： C07J71/00
CPC分类号： C07J71/00 , A61K31/585
摘要： The invention discloses certain steroidal sapogenins and derivatives thereof, and their use in the treatment of cognitive dysfunction, non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, and receptor loss in the absence of cognitive, neural and neuromuscular impairment. Methods of synthesis, treatment and pharmaceutical compositions are also disclosed.
摘要翻译：本发明公开了某些甾族皂甙元及其衍生物，以及它们在不存在认知，神经和神经肌肉损伤的情况下用于治疗认知功能障碍，非认知神经变性，非认知性神经肌肉变性和受体损失。还公开了合成，治疗和药物组合物的方法。

4. 发明申请

WO02079221A3 SAPOGENIN DERIVATIVES, THEIR SYNTHESIS AND USE 审中-公开
标题翻译： SAPOGENIN衍生物，合成和使用
公开(公告)号：WO02079221A3
公开(公告)日：2003-04-17
申请号：PCT/GB0201578
申请日：2002-03-28
申请人： PHYTOTECH LTD , BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER
发明人： BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER
IPC分类号： A23L1/30 , A61K20060101 , A61K31/58 , A61K31/585 , A61K36/18 , A61P3/02 , A61P9/02 , A61P9/04 , A61P11/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/00 , A61P27/02 , C07J41/00 , C07J71/00 , C07J75/00
CPC分类号： C07J71/00 , A61K31/585
摘要： The invention discloses certain steroidal sapogenins and derivatives thereof, and their use in the treatment of cognitive dysfunction, non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, and receptor loss in the absence of cognitive, neural and neuromuscular impairment. Methods of synthesis, treatment and pharmaceutical compositions are also disclosed.
摘要翻译：本发明公开了某些甾族皂甙元及其衍生物，以及它们在不存在认知，神经和神经肌肉损伤的情况下用于治疗认知功能障碍，非认知神经变性，非认知性神经肌肉变性和受体损失。还公开了合成，治疗和药物组合物的方法。

5. 发明申请

WO0149703A3 SUBSTITUTED SAPOGENINS AND THEIR USE 审中-公开
标题翻译：取代的生产者及其使用
公开(公告)号：WO0149703A3
公开(公告)日：2002-02-21
申请号：PCT/GB0100048
申请日：2001-01-08
申请人： PHYTOPHARM PLC , BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER
发明人： BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER
IPC分类号： A23L2/38 , A23L1/30 , A23L2/52 , A61K31/575 , A61K31/58 , A61P21/04 , A61P25/16 , A61P25/28 , A61P43/00 , C07J9/00 , C07J71/00
CPC分类号： C07J71/0005
摘要： The invention discloses substituted sapogenins and their use in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed.
摘要翻译：本发明公开了取代的皂苷元及其在治疗认知障碍和类似病症中的用途。还公开了治疗方法和药物组合物。

6. 发明申请

WO2010084356A1 TREATMENT OF NEUROTROPHIC FACTOR MEDIATED DISORDERS 审中-公开
标题翻译：治疗神经介导因子介导性疾病
公开(公告)号：WO2010084356A1
公开(公告)日：2010-07-29
申请号：PCT/GB2010/050098
申请日：2010-01-22
申请人： PHYTOPHARM PLC , REES, Daryl , ORSI, Antonia , HOWSON, Patrick , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , ORSI, Antonia , HOWSON, Patrick , XIA, Zongqin , HU, Yaer
IPC分类号： A61K31/58 , A61P17/02 , A61P17/16 , A61P17/18 , A61P25/00 , A61P37/00
CPC分类号： A61K31/58 , A61K31/7048
摘要： An agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone and glycosylated forms thereof is used to induce self- regulated homeostasis of neurotrophic factors(NFs), for example BDNF and/or GDNF, NFs with limited and manageable side effects in a subject, by modulating NFs in a non- toxic manner under homeostatic control. An effective amount of at least one such agent is administered to the subject, particularly in the treatment or prevention of a range of NF- mediated disorders, particularly neurological, psychiatric, inflammatory,allergic,immune and neoplastic disorders, and in the restoration or normalisation of neuronal and other function in or in relation to any damaged or abnormal tissue, including when assisting tissue (for example, skin, bone, eye and muscle) healing and general skin, bone, eye and muscle health.
摘要翻译：使用选自A / B-顺式呋喃斯坦，呋喃葡萄烯，螺甾烷和螺甾烷基甾体皂苷元及其酯，醚，酮及其糖基化形式的药剂诱导神经营养因子（NF）的自我调节的体内平衡，例如BDNF和/或GDNF 通过在稳态控制下以非毒性方式调节NFs，在受试者中具有有限和易于治疗的副作用的NF。向受试者施用有效量的至少一种这样的药剂，特别是在治疗或预防一系列NF介导的病症，特别是神经，精神，炎症，过敏，免疫和肿瘤性疾病中，以及在恢复或正常化中包括当辅助组织（例如皮肤，骨骼，眼睛和肌肉）愈合和一般皮肤，骨骼，眼睛和肌肉健康时，神经元和其他功能在任何损伤或异常组织中或与之相关。

7. 发明申请

WO9948482A3 SMILAGENIN AND ANZUROGENIN-D FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的辛伐他宁和安祖祖G
公开(公告)号：WO9948482A3
公开(公告)日：2000-11-23
申请号：PCT/GB9900960
申请日：1999-03-26
申请人： PHYTOPHARM PLC , XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WEIJUN , GUNNING PHIL
发明人： XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WEIJUN , GUNNING PHIL
IPC分类号： C12N15/09 , A61K20060101 , A61K31/343 , A61K31/352 , A61K31/58 , A61K31/70 , A61K31/704 , A61K35/00 , A61K36/18 , A61K36/896 , A61P9/00 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D493/10 , C07J71/00 , C12Q1/68 , G01N33/94
CPC分类号： A61K31/704 , A61K31/58 , A61K31/7048 , A61K36/88 , A61K36/896 , A61K36/8964 , A61K36/8965 , A61K36/90 , G01N33/944
摘要： The invention discloses the use of a smilagenin and anzurogenin-D in the treatment of cognitive disfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.
摘要翻译：本发明公开了用于治疗认知功能障碍和类似病症的杀螟昔宁和嘌呤嘌呤D的用途。还公开了治疗方法和药物组合物。

8. 发明申请

WO2003082893A3 THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES 审中-公开
公开(公告)号：WO2003082893A3
公开(公告)日：2003-10-09
申请号：PCT/GB2003/001380
申请日：2003-03-27
申请人： PHYTOPHARM PLC , REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
IPC分类号： A61K31/585
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.

9. 发明申请

WO2003082893A2 THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES 审中-公开
标题翻译： SAPOGENINS及其衍生物的治疗方法和用途
公开(公告)号：WO2003082893A2
公开(公告)日：2003-10-09
申请号：PCT/GB2003/001380
申请日：2003-03-27
申请人： PHYTOPHARM PLC , REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
IPC分类号： C07J
CPC分类号： A61K31/58 , A61K31/655 , C07J71/00 , C07J71/0005 , Y02A50/465
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
摘要翻译：本发明公开了某些甾体皂草苷配基，相关化合物及其衍生物治疗非认知性神经变性，非认知性神经肌肉变性，运动感觉神经变性或受体功能障碍或丧失的治疗方法和用途在没有认知，神经和神经肌肉损伤的情况下。

10. 发明申请

WO9948507A3 STEROIDAL SAPONINS FOR TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的STEROIDAL SAPONINS
公开(公告)号：WO9948507A3
公开(公告)日：1999-11-25
申请号：PCT/GB9900951
申请日：1999-03-26
申请人： PHYTOPHARM PLC , XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WEIJUN , GUNNING PHIL
发明人： XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WEIJUN , GUNNING PHIL
IPC分类号： C12N15/09 , A61K20060101 , A61K31/343 , A61K31/352 , A61K31/58 , A61K31/70 , A61K31/704 , A61K35/00 , A61K36/18 , A61K36/896 , A61P9/00 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D493/10 , C07J71/00 , C12Q1/68 , G01N33/94
CPC分类号： A61K31/704 , A61K31/58 , A61K31/7048 , A61K36/88 , A61K36/896 , A61K36/8964 , A61K36/8965 , A61K36/90 , G01N33/944
摘要： The invention discloses the use of a number of saponins and sapogenins, notably those of steroidal structure, in the treatment of cognitive disfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.
摘要翻译：本发明公开了许多皂角蛋白和皂角蛋白，特别是类固醇结构的皂苷元在治疗认知障碍和类似病症中的用途。还公开了治疗方法和药物组合物。

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