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1. 发明申请

WO2002079221A2 SAPOGENIN DERIVATIVES, THEIR SYNTHESIS AND USE, AND METHODS BASED UPON THEIR USE 审中-公开
标题翻译： SAPOGENIN衍生物，其合成与使用及其使用方法
公开(公告)号：WO2002079221A2
公开(公告)日：2002-10-10
申请号：PCT/GB2002/001578
申请日：2002-03-28
申请人： PHYTOTECH LIMITED , BARRACLOUGH, Paul , HANSON, Jim , GUNNING, Phil , REES, Daryl , XIA, Zongqin , HU, Yaer
发明人： BARRACLOUGH, Paul , HANSON, Jim , GUNNING, Phil , REES, Daryl , XIA, Zongqin , HU, Yaer
IPC分类号： C07J71/00
CPC分类号： C07J71/00 , A61K31/585
摘要： The invention discloses certain steroidal sapogenins and derivatives thereof, and their use in the treatment of cognitive dysfunction, non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, and receptor loss in the absence of cognitive, neural and neuromuscular impairment. Methods of synthesis, treatment and pharmaceutical compositions are also disclosed.
摘要翻译：本发明公开了某些甾族皂甙元及其衍生物，以及它们在不存在认知，神经和神经肌肉损伤的情况下用于治疗认知功能障碍，非认知神经变性，非认知性神经肌肉变性和受体损失。还公开了合成，治疗和药物组合物的方法。

2. 发明申请

WO2003082893A3 THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES 审中-公开
公开(公告)号：WO2003082893A3
公开(公告)日：2003-10-09
申请号：PCT/GB2003/001380
申请日：2003-03-27
申请人： PHYTOPHARM PLC , REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
IPC分类号： A61K31/585
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.

3. 发明申请

WO2003082893A2 THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES 审中-公开
标题翻译： SAPOGENINS及其衍生物的治疗方法和用途
公开(公告)号：WO2003082893A2
公开(公告)日：2003-10-09
申请号：PCT/GB2003/001380
申请日：2003-03-27
申请人： PHYTOPHARM PLC , REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , GUNNING, Phil , ORSI, Antonia , XIA, Zongqin , HU, Yaer
IPC分类号： C07J
CPC分类号： A61K31/58 , A61K31/655 , C07J71/00 , C07J71/0005 , Y02A50/465
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
摘要翻译：本发明公开了某些甾体皂草苷配基，相关化合物及其衍生物治疗非认知性神经变性，非认知性神经肌肉变性，运动感觉神经变性或受体功能障碍或丧失的治疗方法和用途在没有认知，神经和神经肌肉损伤的情况下。

4. 发明申请

WO2010084356A1 TREATMENT OF NEUROTROPHIC FACTOR MEDIATED DISORDERS 审中-公开
标题翻译：治疗神经介导因子介导性疾病
公开(公告)号：WO2010084356A1
公开(公告)日：2010-07-29
申请号：PCT/GB2010/050098
申请日：2010-01-22
申请人： PHYTOPHARM PLC , REES, Daryl , ORSI, Antonia , HOWSON, Patrick , XIA, Zongqin , HU, Yaer
发明人： REES, Daryl , ORSI, Antonia , HOWSON, Patrick , XIA, Zongqin , HU, Yaer
IPC分类号： A61K31/58 , A61P17/02 , A61P17/16 , A61P17/18 , A61P25/00 , A61P37/00
CPC分类号： A61K31/58 , A61K31/7048
摘要： An agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone and glycosylated forms thereof is used to induce self- regulated homeostasis of neurotrophic factors(NFs), for example BDNF and/or GDNF, NFs with limited and manageable side effects in a subject, by modulating NFs in a non- toxic manner under homeostatic control. An effective amount of at least one such agent is administered to the subject, particularly in the treatment or prevention of a range of NF- mediated disorders, particularly neurological, psychiatric, inflammatory,allergic,immune and neoplastic disorders, and in the restoration or normalisation of neuronal and other function in or in relation to any damaged or abnormal tissue, including when assisting tissue (for example, skin, bone, eye and muscle) healing and general skin, bone, eye and muscle health.
摘要翻译：使用选自A / B-顺式呋喃斯坦，呋喃葡萄烯，螺甾烷和螺甾烷基甾体皂苷元及其酯，醚，酮及其糖基化形式的药剂诱导神经营养因子（NF）的自我调节的体内平衡，例如BDNF和/或GDNF 通过在稳态控制下以非毒性方式调节NFs，在受试者中具有有限和易于治疗的副作用的NF。向受试者施用有效量的至少一种这样的药剂，特别是在治疗或预防一系列NF介导的病症，特别是神经，精神，炎症，过敏，免疫和肿瘤性疾病中，以及在恢复或正常化中包括当辅助组织（例如皮肤，骨骼，眼睛和肌肉）愈合和一般皮肤，骨骼，眼睛和肌肉健康时，神经元和其他功能在任何损伤或异常组织中或与之相关。

5. 发明公开

EP1383787A2 SAPOGENIN DERIVATIVES, THEIR SYNTHESIS AND USE 有权
标题翻译：皂甙元衍生物，它们的合成和应用
公开(公告)号：EP1383787A2
公开(公告)日：2004-01-28
申请号：EP02708534.9
申请日：2002-03-28
申请人： PHYTOTECH LIMITED
发明人： BARRACLOUGH, Paul , HANSON, Jim , GUNNING, Phil , REES, Daryl , XIA, Zongqin , HU, Yaer
IPC分类号： C07J71/00
CPC分类号： C07J71/00 , A61K31/585
摘要： The invention discloses certain steroidal sapogenins and derivatives thereof, and their use in the treatment of cognitive dysfunction, non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, and receptor loss in the absence of cognitive, neural and neuromuscular impairment. Methods of synthesis, treatment and pharmaceutical compositions are also disclosed.

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