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1. 发明申请

WO2011071783A1 HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF 审中-公开
标题翻译：人类抗原结合蛋白，其结合BETA-KLOTHO，FGF受体及其复合物
公开(公告)号：WO2011071783A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/058984
申请日：2010-12-03
申请人： AMGEN INC. , HU, Shaw-Fen, Sylvia , FOLTZ, Ian , KING, Chadwick Terence , LI, Yang , ARORA, Taruna
发明人： HU, Shaw-Fen, Sylvia , FOLTZ, Ian , KING, Chadwick Terence , LI, Yang , ARORA, Taruna
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395 , A61P3/04 , C07K19/00 , C07K14/71
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides compositions and methods relating to or derived from antigen binding proteins activate FGF21 -mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β -Klotho; (ii) FGFRIc, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β -Klotho and one of FGFRIc, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, the antigen binding proteins are fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β -Klotho; (ii) FGFRIc, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β -Klotho and one of FGFRIc, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
摘要翻译：本公开提供了与抗原结合蛋白相关或衍生自组合物和方法激活FGF21介导的信号传导。在实施方案中，抗原结合蛋白特异性结合（i）β-Klotho; （ii）FGFRIc，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFRIc，FGFR2c，FGFR3c和FGFR4之一的复合物。在一些实施方案中，抗原结合蛋白诱导FGF21样信号传导。在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，所述抗体的结合片段和衍生物，以及特异性结合（i）β-Klotho的多肽; （ii）FGFRIc，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFRIc，FGFR2c，FGFR3c和FGFR4之一的复合物。其它实施方案提供了编码这种抗原结合蛋白的核酸及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物以及多肽，以及使用这些抗原结合蛋白的方法，其片段及其衍生物和多肽，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症的受试者的方法。

2. 发明申请

WO2010108154A3 SELECTIVE AND POTENT PEPTIDE INHIBITORS OF KV1.3 审中-公开
标题翻译： KV1.3的选择和磷酸肽抑制剂
公开(公告)号：WO2010108154A3
公开(公告)日：2011-03-03
申请号：PCT/US2010028061
申请日：2010-03-19
申请人： AMGEN INC , SULLIVAN JOHN K , MIRANDA LESLIE P , GEGG COLIN V , HU SHAW-FEN SYLVIA , BELOUSKI EDWARD J , MURRAY JUSTIN K , NGUYEN HUNG , WALKER KENNETH W , ARORA TARUNA , JACOBSEN FREDERICK W , LI YUE-SHENG , BOONE THOMAS C
发明人： SULLIVAN JOHN K , MIRANDA LESLIE P , GEGG COLIN V , HU SHAW-FEN SYLVIA , BELOUSKI EDWARD J , MURRAY JUSTIN K , NGUYEN HUNG , WALKER KENNETH W , ARORA TARUNA , JACOBSEN FREDERICK W , LI YUE-SHENG , BOONE THOMAS C
IPC分类号： A61K38/00
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed are compositions of matter having an amino acid sequence of SEQ ID NO:4, or a pharmaceutically acceptable salt thereof, including embodiments comprising a toxin peptide analog related to ShK, HmK, and AETX-K and pharmaceutical compositions or medicaments containing them along with a pharmaceutically acceptable carrier. Some embodiments include a half-life extending moiety. Also disclosed are a method of preventing or mitigating a relapse of a symptom of multiple sclerosis and a method of treating an autoimmune disorder using the compositions.
摘要翻译：公开了具有SEQ ID NO：4的氨基酸序列或其药学上可接受的盐的物质组合物，包括包含与ShK，HmK和AETX-K相关的毒素肽类似物的实施方案，以及含有它们的药物组合物或药物以及药学上可接受的载体。一些实施方案包括半衰期延长部分。还公开了预防或减轻多发性硬化症状的复发的方法以及使用该组合物治疗自身免疫病症的方法。

3. 发明申请

WO2008088422A2 TOXIN PEPTIDE THERAPEUTIC AGENTS 审中-公开
标题翻译：毒素代谢治疗药物
公开(公告)号：WO2008088422A2
公开(公告)日：2008-07-24
申请号：PCT/US2007/022831
申请日：2007-10-25
申请人： AMGEN INC. , SULLIVAN, John, K. , MCGIVERN, Joseph, G. , MIRANDA, Leslie, P. , NGUYEN, Hung, Q. , WALKER, Kenneth, W. , HU, Shaw-Fen, Sylvia , GEGG, Colin, V., Jr. , ARORA KHARE, Taruna , ADLER, Beverly, S. , MARTIN, Francis, H.
发明人： SULLIVAN, John, K. , MCGIVERN, Joseph, G. , MIRANDA, Leslie, P. , NGUYEN, Hung, Q. , WALKER, Kenneth, W. , HU, Shaw-Fen, Sylvia , GEGG, Colin, V., Jr. , ARORA KHARE, Taruna , ADLER, Beverly, S. , MARTIN, Francis, H.
IPC分类号： A61K38/00
CPC分类号： C07K14/43522 , A61K38/00 , A61K47/60 , C07K2319/30 , C07K2319/31
摘要： Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
摘要翻译：公开了包含OSK1肽类似物的物质组合物，并且在一些实施方案中为其药学上可接受的盐。药物组合物包含该组合物和药学上可接受的载体。还公开了编码本发明组合物的DNA，包含DNA的表达载体和包含表达载体的宿主细胞。还公开了治疗自身免疫性疾病和预防或减轻多发性硬化症状的复发的方法。

4. 发明申请

WO2012170438A3 HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING β-KLOTHO AND AN FGF RECEPTOR 审中-公开
公开(公告)号：WO2012170438A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/040941
申请日：2012-06-05
申请人： AMGEN INC. , LI, Yang , STEVENS, Jennitte , KING, Chadwick, Terence , FOLTZ, Ian , KANNAN, Gunasekaran , YIE, Junming , HU, Shaw-Fen, Sylvia
发明人： LI, Yang , STEVENS, Jennitte , KING, Chadwick, Terence , FOLTZ, Ian , KANNAN, Gunasekaran , YIE, Junming , HU, Shaw-Fen, Sylvia
IPC分类号： C07K16/28 , A61P3/00 , A61P3/04 , A61P3/10 , C07K14/71
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

5. 发明申请

WO2009005726A1 ANTIGEN BINDING PROTEINS THAT BIND PAR-2 审中-公开
标题翻译：抗体结合蛋白质，包括PAR-2
公开(公告)号：WO2009005726A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/008037
申请日：2008-06-26
申请人： AMGEN INC. , VIRCA, George Duke , HU, Shaw-fen Sylvia
发明人： VIRCA, George Duke , HU, Shaw-fen Sylvia
IPC分类号： C07K16/28 , A61K39/395 , A61P19/02 , A61P29/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/30
摘要： The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
摘要翻译：本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。在具体实施方案中，本发明提供了结合PAR-2，PAR-2结合片段和此类抗体的衍生物的人抗体，以及包含此类片段的PAR-2结合多肽。其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断患有PAR-2相关疾病或病症的受试者。

6. 发明申请

WO2011130417A3 HUMAN FGF RECEPTOR AND ß-KLOTHO BINDING PROTEINS 审中-公开
标题翻译：人FGF受体和ß-KLOTHO结合蛋白
公开(公告)号：WO2011130417A3
公开(公告)日：2012-03-08
申请号：PCT/US2011032333
申请日：2011-04-13
申请人： AMGEN INC , FACHINI ROGER , FOLTZ IAN , HAN SEOG JOON , HARRIS SUSIE MIKI , HU SHAW-FEN SYLVIA , KING CHADWICK TERENCE , LI YANG , LU JI , MICHAELS MARK LEO , SUN JEONGHOON
发明人： FACHINI ROGER , FOLTZ IAN , HAN SEOG JOON , HARRIS SUSIE MIKI , HU SHAW-FEN SYLVIA , KING CHADWICK TERENCE , LI YANG , LU JI , MICHAELS MARK LEO , SUN JEONGHOON
IPC分类号： C07K16/28 , A61K39/395 , A61P3/10
CPC分类号： A61K39/3955 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/32 , C07K2317/75 , C07K2317/92 , C07K2319/75
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins and antigen binding protein-FGF21 fusions that specifically bind to ß-Klotho, or ß-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins and antigen binding protein-FGF21 fusions induce FGF21-like signaling. In some embodiments, an antigen binding protein or antigen binding protein-FGF21 fusion antigen binding component is a fully human, humanized, or chimeric antibody, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to ß-Klotho, or ß-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins and antigen binding protein-FGF21 fusions, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
摘要翻译：本发明提供与抗原结合蛋白和特异性结合ß-Klotho或ß-Klotho以及FGFR1c，FGFR2c，FGFR3c和FGFR4中的一种或多种的抗原结合蛋白和抗原结合蛋白-FGF21融合物相关或衍生的组合物和方法。在一些实施方案中，抗原结合蛋白和抗原结合蛋白FGF21融合物诱导FGF21样信号传导。在一些实施方案中，抗原结合蛋白或抗原结合蛋白-FGF21融合抗原结合组分是完全人，人源化或嵌合抗体，这种抗体的结合片段和衍生物，以及特异性结合ß-Klotho或ß- Klotho和FGFR1c，FGFR2c，FGFR3c和FGFR4中的一种或多种。其他实施方案提供编码这种抗原结合蛋白和抗原结合蛋白-FGF21融合体的核酸，及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备这种抗原结合蛋白的方法和抗原结合蛋白-FGF21融合物，其衍生物和多肽，以及使用这种抗原结合蛋白和抗原结合蛋白-FGF21融合体，其片段和衍生物和多肽的方法，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症。

7. 发明申请

WO2011130417A2 HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS 审中-公开
标题翻译：人FGF受体和ß-KLOTHO结合蛋白
公开(公告)号：WO2011130417A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/032333
申请日：2011-04-13
申请人： AMGEN INC. , FACHINI, Roger , FOLTZ, Ian , HAN, Seog Joon , HARRIS, Susie Miki , HU, Shaw-Fen Sylvia , KING, Chadwick Terence , LI, Yang , LU, Ji , MICHAELS, Mark Leo , SUN, Jeonghoon
发明人： FACHINI, Roger , FOLTZ, Ian , HAN, Seog Joon , HARRIS, Susie Miki , HU, Shaw-Fen Sylvia , KING, Chadwick Terence , LI, Yang , LU, Ji , MICHAELS, Mark Leo , SUN, Jeonghoon
IPC分类号： C07K16/28
CPC分类号： A61K39/3955 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/32 , C07K2317/75 , C07K2317/92 , C07K2319/75
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins and antigen binding protein-FGF21 fusions that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins and antigen binding protein-FGF21 fusions induce FGF21-like signaling. In some embodiments, an antigen binding protein or antigen binding protein-FGF21 fusion antigen binding component is a fully human, humanized, or chimeric antibody, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to β-Klotho, or β-Klotho and one or more of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins and antigen binding protein-FGF21 fusions, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins and antigen binding protein-FGF21 fusions, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
摘要翻译：本发明提供与抗原结合蛋白和特异性结合ß-Klotho或ß-Klotho以及FGFR1c，FGFR2c，FGFR3c和FGFR4中的一种或多种的抗原结合蛋白和抗原结合蛋白-FGF21融合物相关或衍生的组合物和方法。在一些实施方案中，抗原结合蛋白和抗原结合蛋白FGF21融合物诱导FGF21样信号传导。在一些实施方案中，抗原结合蛋白或抗原结合蛋白-FGF21融合抗原结合组分是完全人，人源化或嵌合抗体，这种抗体的结合片段和衍生物，以及特异性结合ß-Klotho或ß- Klotho和FGFR1c，FGFR2c，FGFR3c和FGFR4中的一种或多种。其他实施方案提供编码这种抗原结合蛋白和抗原结合蛋白-FGF21融合体的核酸，及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备这种抗原结合蛋白的方法和抗原结合蛋白-FGF21融合物，其衍生物和多肽，以及使用这种抗原结合蛋白和抗原结合蛋白-FGF21融合体，其片段和衍生物和多肽的方法，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症。

8. 发明申请

WO2007092640A3 ANTIBODIES THAT BIND PAR-2 审中-公开
公开(公告)号：WO2007092640A3
公开(公告)日：2007-08-16
申请号：PCT/US2007/003796
申请日：2007-02-09
申请人： AMGEN INC. , VIRCA, George, Duke , HU, Shaw-Fen, Sylvia
发明人： VIRCA, George, Duke , HU, Shaw-Fen, Sylvia
IPC分类号： C07K16/28 , A61K39/395 , A61P29/00
摘要： The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides antibodies that bind human PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.

9. 发明申请

WO2007092640A2 ANTIBODIES THAT BIND PAR-2 审中-公开
标题翻译： BIND PAR-2的抗体
公开(公告)号：WO2007092640A2
公开(公告)日：2007-08-16
申请号：PCT/US2007003796
申请日：2007-02-09
申请人： AMGEN INC , VIRCA GEORGE DUKE , HU SHAW-FEN SYLVIA
发明人： VIRCA GEORGE DUKE , HU SHAW-FEN SYLVIA
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides antibodies that bind human PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
摘要翻译：本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。在具体实施方案中，本发明提供了结合人PAR-2，PAR-2-结合片段和此类抗体衍生物的抗体，以及包含此类片段的PAR-2结合多肽。其它实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断患有PAR-2相关疾病或病症的受试者。

10. 发明申请

WO2012170438A2 HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING ß-KLOTHO AND AN FGF RECEPTOR 审中-公开
标题翻译：包含ß-KLOTHO和FGF受体的复合物的人抗原结合蛋白
公开(公告)号：WO2012170438A2
公开(公告)日：2012-12-13
申请号：PCT/US2012040941
申请日：2012-06-05
申请人： AMGEN INC , LI YANG , STEVENS JENNITTE , KING CHADWICK TERENCE , FOLTZ IAN , KANNAN GUNASEKARAN , YIE JUNMING , HU SHAW-FEN SYLVIA
发明人： LI YANG , STEVENS JENNITTE , KING CHADWICK TERENCE , FOLTZ IAN , KANNAN GUNASEKARAN , YIE JUNMING , HU SHAW-FEN SYLVIA
IPC分类号： A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/71 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2319/00 , C07K2319/30 , C12Y302/01031
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising ß-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising ß-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
摘要翻译：本发明提供与能够诱导B-Klotho和/或FGF21样介导的信号传导的抗原结合蛋白相关或衍生的组合物和方法。在实施方案中，抗原结合蛋白特异性结合包含β-Klotho和（i）FGFR1c，（ii）FGFR2c和（iii）FGFR3c中的至少一种的复合物。在一些实施方案中，抗原结合蛋白诱导FGF21样信号传导。在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，所述抗体的结合片段和衍生物，以及特异性结合包含β-Klotho和（i）FGFR1c，（ ii）FGFR2c和（iii）FGFR3c。其它实施方案提供了编码这种抗原结合蛋白的核酸及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物以及多肽，以及使用这种抗原结合蛋白的方法，其片段及其衍生物和多肽，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症的受试者的方法。

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