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1. 发明申请

WO2009071701A1 PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES 审中-公开
标题翻译：吡唑衍生物及其作为CYCLIN依赖性激酶的抑制剂的用途
公开(公告)号：WO2009071701A1
公开(公告)日：2009-06-11
申请号：PCT/EP2008/067037
申请日：2008-12-08
申请人： NOVARTIS AG , ASTEX THERAPEUTICS LTD. , BRAIN, Christopher Thomas , CHO, Young Shin , HOU, Ying , SUNG, Moo
发明人： BRAIN, Christopher Thomas , CHO, Young Shin , HOU, Ying , SUNG, Moo
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D407/14 , A61K31/4439 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D453/02
摘要： The present application describes organic compounds of formula (I) that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrazole compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.
摘要翻译：本申请描述了可用于治疗，预防和/或改善疾病，特别是吡唑化合物的式（I）的有机化合物和描述其抑制蛋白激酶的衍生物。有机化合物可用于治疗增殖性疾病。

2. 发明申请

WO2005067564A3 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES 审中-公开
标题翻译： 6-11双金属红霉素衍生物
公开(公告)号：WO2005067564A3
公开(公告)日：2005-11-10
申请号：PCT/US2005000153
申请日：2005-01-05
申请人： ENANTA PHARM INC , WANG GUOQIANG , VO NHA HUU , XU GUOYOU , HOU YING , SUN YING , PHAN LY TAM , WANG ZHE , OR YAT SUN
发明人： WANG GUOQIANG , VO NHA HUU , XU GUOYOU , HOU YING , SUN YING , PHAN LY TAM , WANG ZHE , OR YAT SUN
IPC分类号： A61K31/70 , A61K31/7048 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a 5 racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：具有抗菌性质。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

3. 发明申请

WO2010020675A1 PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS 审中-公开
标题翻译：吡咯啉化合物作为CDK抑制剂
公开(公告)号：WO2010020675A1
公开(公告)日：2010-02-25
申请号：PCT/EP2009/060793
申请日：2009-08-20
申请人： NOVARTIS AG , ASTEX THERAPEUTICS LTD. , BESONG, Gilbert , BRAIN, Christopher Thomas , BROOKS, Clinton A. , CONGREVE, Miles Stuart , DAGOSTIN, Claudio , HE, Guo , HOU, Ying , HOWARD, Steven , LI, Yue , LU, Yipin , MORTENSON, Paul , SMITH, Troy , SUNG, Moo , WOODHEAD, Steven , WRONA, Wojciech
发明人： BESONG, Gilbert , BRAIN, Christopher Thomas , BROOKS, Clinton A. , CONGREVE, Miles Stuart , DAGOSTIN, Claudio , HE, Guo , HOU, Ying , HOWARD, Steven , LI, Yue , LU, Yipin , MORTENSON, Paul , SMITH, Troy , SUNG, Moo , WOODHEAD, Steven , WRONA, Wojciech
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , C07D487/08
摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.
摘要翻译：所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

4. 发明申请

WO2005067564A2 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES 审中-公开
标题翻译： 6-11双环红霉素衍生物
公开(公告)号：WO2005067564A2
公开(公告)日：2005-07-28
申请号：PCT/US2005/000153
申请日：2005-01-05
申请人： ENANTA PHARMACEUTICALS, INC. , WANG, Guoqiang , VO, Nha, Huu , XU, Guoyou , HOU, Ying , SUN, Ying , PHAN, Ly, Tam , WANG, Zhe , OR, Yat, Sun
发明人： WANG, Guoqiang , VO, Nha, Huu , XU, Guoyou , HOU, Ying , SUN, Ying , PHAN, Ly, Tam , WANG, Zhe , OR, Yat, Sun
IPC分类号： A61K31/70 , A61K31/7048 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a 5 racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌特性。本发明还涉及包含前述化合物的药物组合物，用于向需要抗生素治疗的受试者施用。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

5. 发明申请

US20110043268A1 LEVEL SHIFTER WITH NATIVE DEVICE 审中-公开
标题翻译：具有原始装置的水平变换器
公开(公告)号：US20110043268A1
公开(公告)日：2011-02-24
申请号：US12546276
申请日：2009-08-24
申请人： HOU-YING HUANG
发明人： HOU-YING HUANG
IPC分类号： H03L5/00
CPC分类号： H03K19/018521
摘要： A level shifter includes an inverter, a first native device, a second native device, a first transistor, and a second transistor. First ends of the first and the second transistors are coupled to a first voltage. A second end and a control end of the first transistor are respectively coupled to the first ends of the first and the second native devices. A second end and a control end of the second transistor are respectively coupled to the first ends of the second and the first native devices. A second end and a control end of the first native device are respectively coupled to an output end and an input end of the inverter. A second end and a control end of the second native device are respectively coupled to the input end and the output end of the inverter.
摘要翻译：电平移位器包括反相器，第一天体器件，第二天体器件，第一晶体管和第二晶体管。第一和第二晶体管的第一端耦合到第一电压。第一晶体管的第二端和控制端分别耦合到第一和第二天体器件的第一端。第二晶体管的第二端和控制端分别耦合到第二和第一天然器件的第一端。第一本机装置的第二端和控制端分别耦合到反相器的输出端和输入端。第二本机装置的第二端和控制端分别耦合到反相器的输入端和输出端。

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