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1. 发明公开

EP1743241A2 COMPUTATION OF RADIATING PARTICLE AND WAVE DISTRIBUTIONS USING A GENERALIZED DISCRETE FIELD CONSTRUCTED FROM REPRESENTATIVE RAY SETS 审中-公开
标题翻译：计算方法的STRAHLUNGSPARTIKEL-和波场分布使用广义离散，从表示波束组的DESIGNED场
公开(公告)号：EP1743241A2
公开(公告)日：2007-01-17
申请号：EP05714004.8
申请日：2005-02-24
申请人： Holland, Richard Andrew
发明人： Holland, Richard Andrew
IPC分类号： G06F7/60
CPC分类号： G05B13/04 , A61N5/1031 , A61N5/1045 , A61N2005/1091 , G06F17/5018 , G06F2217/10 , G06F2217/16
摘要： The present System and method for simulating particles and waves is useful for calculations involving nuclear and full spectrum radiation transport, quantum particle transport, plasma transport and charged particle transport. The invention provides a mechanism for creating accurate invariants for embedding in general three-dimensional problems and describes means by which a series of simple single collision interaction finite elements can be extended to formulate a complex multi-collision finite element.

2. 发明申请

WO2021188389A2 CATIONIC LIPIDS FOR LIPID NANOPARTICLE DELIVERY OF THERAPEUTICS TO HEPATIC STELLATE CELLS 审中-公开
公开(公告)号：WO2021188389A2
公开(公告)日：2021-09-23
申请号：PCT/US2021/022201
申请日：2021-03-12
申请人： GENEVANT SCIENCES GMBH , HEYES, James , LAM, Kieu Mong , HOLLAND, Richard J.
发明人： HEYES, James , LAM, Kieu Mong , HOLLAND, Richard J.
IPC分类号： A61K31/047 , A61K31/352 , A61K36/185
摘要： Certain embodiments of the invention provide lipids useful for preparing lipid nanoparticles for delivering therapeutic agents to, e.g., hepatic stellate cells.

3. 发明申请

WO2021081420A2 CONJUGATES AND METHODS FOR TREATING ACROMEGALY 审中-公开
公开(公告)号：WO2021081420A2
公开(公告)日：2021-04-29
申请号：PCT/US2020/057185
申请日：2020-10-23
申请人： GENEVANT SCIENCES GMBH , KONDRATOWICZ, Drew , HEYES, James , HOLLAND, Richard J. , ESAU, Christine , MCCLINTOCK, Kevin , PASETKA, Chris Justin , WOOD, Mark , MARTIN, Alan D. , SCHWARZ, Margrit , CROWE, David , TYLER, Steven
发明人： KONDRATOWICZ, Drew , HEYES, James , HOLLAND, Richard J. , ESAU, Christine , MCCLINTOCK, Kevin , PASETKA, Chris Justin , WOOD, Mark , MARTIN, Alan D. , SCHWARZ, Margrit , CROWE, David , TYLER, Steven
IPC分类号： C12N15/87 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/713 , A61P5/00 , C07K9/001
摘要： Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. He conjugates are useful to treat certain diseases, such as acromegaly.

4. 发明申请

WO2018011634A1 COMPOSITION FOR PRODUCING HYDROGEN RICH WATER AND OTHER PRODUCTS 审中-公开
标题翻译：用于生产富氢水和其他产品的组合物
公开(公告)号：WO2018011634A1
公开(公告)日：2018-01-18
申请号：PCT/IB2017/001067
申请日：2017-07-17
申请人： TARNAVA, Alexander , HOLLAND, Richard, James
发明人： TARNAVA, Alexander , HOLLAND, Richard, James
IPC分类号： A61K33/00 , A23L33/16 , A61K47/02 , A61K47/12 , A61K47/26 , A61K9/00 , C01B3/08 , C01F5/00
摘要： The invention provides compositions for producing hydrogen rich water, nutraceuticals, cosmetics, pharmaceuticals, and other products. In one embodiment, the invention provides a composition, e.g., a tablet, including magnesium metal, at least one water-soluble acid, and a binding agent. The magnesium metal and at least one water-soluble acid may be present in amounts sufficient to maintain a pH of less than 7, e.g., at a specific time period after reaction, and a concentration of at least 0.5 mM H 2 after reaction in 50 mL water in a container e.g., a sealed or an open container, e.g., at least 0.5 mM H 2 after reaction in 100 mL water or at least 0.5 mM H 2 after reaction in 500 mL water. The composition may also include a lubricant.
摘要翻译：本发明提供了用于生产富氢水，营养品，化妆品，药物和其他产品的组合物。在一个实施方案中，本发明提供了包含镁金属，至少一种水溶性酸和粘合剂的组合物，例如片剂。金属镁和至少一种水溶性酸可以以足以维持小于7的pH的量存在，例如在反应后的特定时间段，并且浓度至少为0.5mM H 2 / 在容器中，例如密封或开放的容器中，在50mL水中反应后，在100mL水或至少0.5mM H 2 O中反应后，例如至少0.5mM H 2 O 在500mL水中反应后进行。该组合物还可以包含润滑剂。

5. 发明申请

WO2017177326A1 TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS 审中-公开
标题翻译：靶向的核酸共轭物组合物
公开(公告)号：WO2017177326A1
公开(公告)日：2017-10-19
申请号：PCT/CA2017/050447
申请日：2017-04-11
申请人： PROTIVA BIOTHERAPEUTICS, INC. , HEYES, James , HOLLAND, Richard J. , MARTIN, Alan D. , WOOD, Mark
发明人： HEYES, James , HOLLAND, Richard J. , MARTIN, Alan D. , WOOD, Mark
IPC分类号： C12N15/113 , A61K47/54 , C07C217/52 , C07C235/06 , C07C237/08 , C07C237/20 , C07D207/08 , C07D207/12 , C07D209/12 , C07D209/52 , C07F9/40 , C07H15/26 , C07H21/00 , C07H21/02 , C07J63/00 , C07J9/00 , C12N15/87
摘要： The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
摘要翻译：本发明提供包含靶向部分，核酸和任选的连接基团的缀合物以及可用于制备缀合物的合成中间体和合成方法。该缀合物可用于将治疗性核酸靶向肝脏并治疗肝病（包括肝炎（例如乙型肝炎和丁型肝炎））。

6. 发明申请

WO2012116440A1 BENZIMIDAZOLE INHIBITORS OF THE SODIUM CHANNEL 审中-公开
标题翻译：钠通道的苯并咪唑抑制剂
公开(公告)号：WO2012116440A1
公开(公告)日：2012-09-07
申请号：PCT/CA2012/000193
申请日：2012-03-02
申请人： ZALICUS PHARMACEUTICALS LTD. , PAJOUHESH, Hassan , HOLLAND, Richard , ZHANG, Lingyun , PAJOUHESH, Hossein , LAMONTAGNE, Jason , WHELAN, Brendan
发明人： PAJOUHESH, Hassan , HOLLAND, Richard , ZHANG, Lingyun , PAJOUHESH, Hossein , LAMONTAGNE, Jason , WHELAN, Brendan
IPC分类号： C07D235/14 , A61K31/165 , A61K31/166 , A61K31/401 , A61K31/4184 , A61K31/4458 , A61K31/454 , A61K31/5377 , A61P25/00 , A61P29/00 , C07C237/06 , C07C237/30 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D403/06 , C07D413/04
CPC分类号： C07C237/06 , C07C237/04 , C07C237/22 , C07C237/24 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D207/16 , C07D211/60 , C07D231/14 , C07D235/14 , C07D241/08 , C07D265/30 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/04 , C07D413/06
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions. Formula (I)
摘要翻译：本发明涉及可用于治疗与电压门控离子通道功能相关的病症的化合物，特别是与钠通道活性相关的病症。更具体地，本发明涉及可用于治疗各种疾病和病症的化合物（例如，表1的式（I） - （XIII）或化合物（1） - （236）中任一项的化合物）。式（I）

7. 发明申请

WO2009132453A1 CYCLYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译：环丙基胺衍生物作为钙通道阻断剂
公开(公告)号：WO2009132453A1
公开(公告)日：2009-11-05
申请号：PCT/CA2009/000579
申请日：2009-04-28
申请人： NEUROMED PHARMACEUTICALS LTD. , GALEMMO JR , Robert , HOLLAND, Richard , HUM, Gabriel , PAJOUHESH, Hossein , CHAHAL, Navjot , SEID-BAGHERZADEH, Mehran , GIRARD, Amy
发明人： GALEMMO JR , Robert , HOLLAND, Richard , HUM, Gabriel , PAJOUHESH, Hossein , CHAHAL, Navjot , SEID-BAGHERZADEH, Mehran , GIRARD, Amy
IPC分类号： C07C233/00 , A61K31/165 , A61K31/277 , A61K31/395 , A61P29/00 , C07C255/00 , C07C317/32 , C07D207/00 , C07D213/00 , C07D231/00 , C07D241/00 , C07D261/00 , C07D277/00 , C07D295/192 , C07D309/00 , C07D401/12 , C07D405/12 , C07D413/12 , C07D413/14
CPC分类号： C07D277/28 , C07C233/81 , C07C237/24 , C07C255/41 , C07C311/08 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/40 , C07D213/75 , C07D213/81 , C07D231/12 , C07D241/12 , C07D261/08 , C07D295/067 , C07D295/185 , C07D309/08 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of substituted or unsubstituted cyclylamine derivatives as shown in formulas (1).
摘要翻译：公开了有效改善特征在于不需要的钙通道活性，特别是不需要的N型和/或T型钙通道活性的病症的方法和化合物。具体而言，是式（1）所示的一系列取代或未取代的环基胺衍生物的化合物。

8. 发明申请

WO2008141446A8 AMINO ACID DERIVATIVES AS CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译：氨基酸衍生物作为钙通道阻断剂
公开(公告)号：WO2008141446A8
公开(公告)日：2009-02-26
申请号：PCT/CA2008000962
申请日：2008-05-16
申请人： NEUROMED PHARMACEUTICALS LTD , GALEMMO ROBERT JR , HOLLAND RICHARD , DING YANBING , ZHANG LINGYUN , HUM GABRIEL , CHAHAL NAVJOT , DUFFY JOSEPH , STEVENSON CHRISTIAN , ULLMAN ANDREW
发明人： GALEMMO ROBERT JR , HOLLAND RICHARD , DING YANBING , ZHANG LINGYUN , HUM GABRIEL , CHAHAL NAVJOT , DUFFY JOSEPH , STEVENSON CHRISTIAN , ULLMAN ANDREW
IPC分类号： A61K31/166 , A61K31/277 , A61K31/44
CPC分类号： A61K31/166 , A61K31/277 , A61K31/4453 , A61K31/5375
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both an amino acid functionality and multiple aromatic rings are disclosed of the general formula (1) where X is benzhydryl, or an aromatic or heteroaromatic ring.
摘要翻译：公开了有效改善特征在于不需要的钙通道活性，特别是不需要的N型和/或T型钙通道活性的病症的方法和化合物。具体地，公开了一系列含有氨基酸官能团和多个芳环的化合物，其通式（1）其中X是二苯甲基或芳族或杂芳族环。

9. 发明申请

WO2008153515A1 COMPOSITE BALLISTIC PANELS AND METHOD OF USE 审中-公开
标题翻译：复合弹丸板及其使用方法
公开(公告)号：WO2008153515A1
公开(公告)日：2008-12-18
申请号：PCT/US2007/012541
申请日：2007-05-25
申请人： POLYSTRAND, INC. , PILPEL, Edward, D. , HOLLAND, Richard, H. , JOHNSON, Steven, RS
发明人： PILPEL, Edward, D. , HOLLAND, Richard, H. , JOHNSON, Steven, RS
IPC分类号： F41H5/04
CPC分类号： F41H5/0485
摘要： A panel had a first face and a second face, including a strike face portion (22) having a first plurality of plies each containing fibers in a matrix material (26). There is a support portion (28) adjacent to the strike face portion (22), the support portion (28) containing a second plurality of plies each having fibers in a matrix material (36). Each ply is bound to an adjacent ply and the first fibers are lower- performing relative to the second fibers. Protection from a ballistic threat may be provided by providing such a panel with the strike face (23) disposed toward the threat. In another aspect, a composite ballistic panel may contain fibers in a thermoplastic matrix material, to the substantial exclusion of thermosetting matrix materials.
摘要翻译：面板具有第一面和第二面，包括具有第一多个层的冲击面部分（22），每个层包含基质材料（26）中的纤维。存在与冲击面部分（22）相邻的支撑部分（28），支撑部分（28）包含第二多个层，每个层具有基体材料（36）中的纤维。每个帘布层与相邻的帘布层结合，并且第一纤维相对于第二纤维的性能较低。通过为这样的面板提供朝向威胁设置的打击面（23），可以提供防止弹道威胁的保护。另一方面，复合弹道板可以包含热塑性基体材料中的纤维，从而基本排除热固性基质材料。

10. 发明申请

WO2007118323A8 ISOXAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译： ISOXAZOLE衍生物作为钙通道阻断剂
公开(公告)号：WO2007118323A8
公开(公告)日：2008-09-25
申请号：PCT/CA2007000632
申请日：2007-04-17
申请人： NEUROMED PHARMACEUTICALS LTD , PAJOUHESH HASSAN , HOLLAND RICHARD , PAJOUHESH HOSSEIN
发明人： PAJOUHESH HASSAN , HOLLAND RICHARD , PAJOUHESH HOSSEIN
IPC分类号： C07D413/06 , A61K31/42 , A61K31/496 , C07D261/08 , C07D261/18
CPC分类号： C07D261/08 , A61K31/42 , A61K31/496 , C07D261/18 , C07D295/03 , C07D413/06
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of isoxazole containing compounds are disclosed of the general formula (1) where Z is N or CHNR 3 and (Ar 1 ) 2 CR 4 is optionally substituted benzhydryl.
摘要翻译：公开了有效改善由不需要的钙通道活性，特别是不需要的N型或T型钙通道活性表征的病症的方法和化合物。具体地说，通式（1）中公开了一系列含异唑的化合物，其中Z是N或CHNR 3，和（Ar 1）2 CR 4是任选取代的二苯甲基。

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