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1. 发明申请

WO2004087209A9 PREPARATION FOR SUSTAINING THERAPEUTICALLY EFFECTIVE BLOOD CONCENTRATION OF ANALGESIC ACTIVITY POTENTIATOR 审中-公开
标题翻译：维持治疗有效活性血液浓度的准备
公开(公告)号：WO2004087209A9
公开(公告)日：2005-01-20
申请号：PCT/JP0303805
申请日：2003-03-27
申请人： HISAMITSU PHARMACEUTICAL CO , SUZUKI MANZO , UEMURA KENGO , GOTO TAKESHI , TERAHARA TAKAAKI , MORI KENJI , HIGO NARUHITO , SATO SHUJI
发明人： SUZUKI MANZO , UEMURA KENGO , GOTO TAKESHI , TERAHARA TAKAAKI , MORI KENJI , HIGO NARUHITO , SATO SHUJI
IPC分类号： A61K9/70 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/222 , A61K31/439 , A61K31/44 , A61K31/485 , A61K45/06 , A61P25/04 , A61K45/00 , A61K9/20
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/222 , A61K31/439 , A61K31/44 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： A preparation for enhancing the analgesic effect of an analgesic while avoiding side effects characterized by containing an analgesic activity potentiator and being capable of sustaining the blood concentration of the analgesic potentiator in the steady state at 10 to 150 ng/ml.
摘要翻译：一种用于增强止痛剂镇痛作用的制剂，同时避免以含有止痛活性增强剂为特征的副作用，并能够以10〜150ng / ml的速度维持稳定的镇痛增效剂的血药浓度。

2. 发明申请

WO1997006847A1 PLASTER STRUCTURE FOR IONTOPHORESIS 审中-公开
标题翻译：塑料结构用于IOPOPHORESIS
公开(公告)号：WO1997006847A1
公开(公告)日：1997-02-27
申请号：PCT/JP1995001614
申请日：1995-08-14
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIGO, Naruhito , MORI, Kenji , NAKAMURA, Katsuhiro
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/30
CPC分类号： A61N1/0448 , A61N1/0428 , A61N1/303
摘要： A plaster structure for iontophoresis which can stably store a bioactive substance without reducing a preset amount thereof until applied to a patient. When applied, it performs stable whole-body administration of the preset amount of the bioactive substance, and prevents interaction between an adhesive and the bioactive substance, an additive or the like, and maintains an adhesive strength of the adhesive to stay firmly on the patient during administration. The plaster structure comprises: an electrically conductive medicine storing layer (1) containing a bioactive substance; a backing layer (2) covering the medicine storing layer (1) and holding an electrode (3) thereunder; a protective layer (4) supporting the medicine storing layer (1) and being non-permeable to the bioactive substance; an adhesive layer (5) laminated on the other surface of the protective layer (4) and made of a pressure sensitive adhesive or the like that has a good skin and/or mucous membrane sticking property; a liner layer (6) laminated on the other surface of the adhesive layer (5); and a cut portion (7) formed in the protective layer (4).
摘要翻译：一种用于离子电渗疗法的石膏结构，其可以稳定地存储生物活性物质，而不会减少其预定量，直到施用于患者。当施用时，其对预设量的生物活性物质进行稳定的全身施用，并且防止粘合剂与生物活性物质，添加剂等之间的相互作用，并且保持粘合剂的粘合强度以牢固地保持在患者身上在管理期间。膏药结构包括：含有生物活性物质的导电药物储存层（1）; 覆盖药物储存层（1）并保持其下面的电极（3）的背衬层（2）; 保护层（4），其支撑药物储存层（1）并且对生物活性物质不可渗透; 层压在保护层（4）的另一个表面上并由压敏粘合剂等制成的粘合剂层（5），其具有良好的皮肤和/或粘膜粘附性; 层压在所述粘合剂层（5）的另一个表面上的衬垫层（6）; 和形成在保护层（4）中的切口部分（7）。

3. 发明申请

WO1995035132A1 ELECTRODE FOR IONTOPHORESIS AND DEVICE USING THE SAME 审中-公开
标题翻译：用于静电放电的电极及使用该电极的装置
公开(公告)号：WO1995035132A1
公开(公告)日：1995-12-28
申请号：PCT/JP1995001193
申请日：1995-06-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIGO, Naruhito , MORI, Kenji , KATAGAI, Kazuya , NAKAMURA, Katsuhiro
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/30
CPC分类号： A61N1/0436 , A61N1/05 , A61N1/30
摘要： This invention relates to an electrode for iontophoresis, capable of being applied to, especially, a mucosa or a tunica mucosa oris, capable of being directly pasted on, especially, a tunica mucosa oris in a human organism, having a high medication efficiency, capable of being operated very simply and having a small weight. The electrode Ka for iontophoresis according to the present invention has a structure provided with a support layer (1), a current scattering conductive layer (2) laminated on the support layer (1) and comprising silver or silver chloride, and a spacer layer (3) laminated on the current scattering conductive layer (2), having adhesive property with respect to a tunica mucosa oris and comprising a film type or a sheet type or a cloth type water-soluble, swelling, dry polymeric layer.
摘要翻译：本发明涉及一种用于离子电渗疗法的电极，其能够特别适用于能够直接粘贴在人体生物体上的特别是粘膜上的粘膜或粘膜上皮，具有高的药效，能够操作非常简单，重量轻。根据本发明的用于离子电渗疗法的电极Ka具有设置有支撑层（1），层叠在支撑层（1）上并且包含银或氯化银的电流散射导电层（2）和间隔层（ 3）层压在电流散射导电层（2）上，具有相对于粘膜粘膜的粘合性，并且包括膜型或片状或布型水溶性，溶胀，干燥的聚合物层。

4. 发明申请

WO1997042952A1 PERCUTANEOUS TAPE PREPARATION CONTAINING FENTANYL 审中-公开
标题翻译：包含FENTANYL的PERCUTANEOUS TAPE制剂
公开(公告)号：WO1997042952A1
公开(公告)日：1997-11-20
申请号：PCT/JP1997001595
申请日：1997-05-13
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , CHONO, Hideharu , TERAHARA, Takaaki , SUZUKI, Tatsuaki , HIGO, Naruhito
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K31/445
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/4453 , A61K31/4468 , A61K47/12
摘要： A percutaneous tape preparation containing fentanyl or its salt, a pressure-sensitive adhesive and sodium acetate. It is preferable that the salt of fentanyl is fentanyl citrate. This preparation is little irritative to the skin and excellent in the percutaneous permeation of fentanyl and has a high stability even after the passage of time.
摘要翻译：含有芬太尼或其盐的经皮胶带制剂，压敏粘合剂和乙酸钠。芬太尼的盐优选为柠檬酸芬太尼。该制剂对皮肤刺激性很小，芬太尼的经皮渗透性优异，即使经过时也具有高稳定性。

5. 发明申请

WO1997034657A1 ELECTRODE DEVICE FOR IONTOPHORESIS 审中-公开
标题翻译：电极装置
公开(公告)号：WO1997034657A1
公开(公告)日：1997-09-25
申请号：PCT/JP1997000113
申请日：1997-01-20
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIGO, Naruhito , MENO, Tatsuya
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0444
摘要： A reusable electrode device for iontophoresis, which prevents metal ions originated from an electrode from entering a human body, minimizes the generation of a gas which causes polarization, greatly increases a transmission current, and prevents damage to the skin which is ascribed to the variation of pH occurring when the device is used for a long period of time. This electrode device for iontophoresis comprises a packing member (1) having an edge portion (1a) of an opening and a chamber (4) to be packed on the inner side of the opening; an electrode terminal (2) provided in the chamber (4); non-adhesive gel (5) containing an electrolytic solvent, a depolarizer, a pH regulator and chemicals and packed in the chamber (4); an inactive electrode (3) covering a base portion of the electrode terminal (2); and a liner (7) bonded to an adhesive layer (6) laminated on the edge portion (1a) to cover the opening.
摘要翻译：用于离子电渗疗法的可重复使用的电极装置，其防止源自电极的金属离子进入人体，使产生极化的气体的产生最小化，大大增加透射电流，并且防止由于变化引起的对皮肤的损伤当器件长时间使用时发生pH。该离子电渗电极装置包括具有开口部的边缘部分（1a）和填充在开口内侧的室（4）的包装部件（1）设置在所述室（4）中的电极端子（2）; 包含电解溶剂的非粘性凝胶（5），去极化剂，pH调节剂和化学品并包装在室（4）中; 覆盖电极端子（2）的基部的无源电极（3）; 以及粘合到层压在边缘部分（1a）上以覆盖开口的粘合剂层（6）的衬垫（7）。

6. 发明申请

WO1997007853A1 IONTOPHORESIS DEVICE AND METHOD OF CURRENT CONTROL THEREFOR 审中-公开
标题翻译：电流控制装置及其电流控制方法
公开(公告)号：WO1997007853A1
公开(公告)日：1997-03-06
申请号：PCT/JP1996002286
申请日：1996-08-12
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , MORI, Kenji , NAKAMURA, Katsuhiro , HIGO, Naruhito , KUZUMAKI, Noriyuki
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0448 , A61N1/325
摘要： An iontophoresis device which is capable of reducing variations in drug delivery caused by the individual difference in the impedances of the skin or mucous membrane and inhibiting a decrease in drug delivery at a different electrode and is excellent in pharmacological effects, safety, reliability, and mass-producibility. The device comprises a different electrode, an indifferent electrode, a current detection section for determining an active current value as a difference between the value of an applied current flowing between the different and indifferent electrodes when pulse voltage/current are applied and the value of a discharge current flowing when the electric charge accumulated in the living organism is discharged as a result of short-circuiting in the different and indifferent electrodes occurring when the application of pulse voltage/current is suspended, and a feedback control section for controlling the active current value by making pulse voltage/current amplitudes variable. The method of current control for the device comprises the step of determining the active current value and the feedback control step for controlling the active current value.
摘要翻译：一种离子电渗装置，其能够减少由皮肤或粘膜的阻抗的个体差异引起的药物递送的变化，并且抑制不同电极的药物递送的降低，并且药理作用，安全性，可靠性和质量优异 -producibility。该装置包括不同的电极，无关电极，电流检测部分，用于将脉冲电压/电流施加时，将有效电流值确定为在不同电极和不同电极之间流动的施加电流的值之间的差值，由于在暂时施加脉冲电压/电流时发生的不同电位和不相关电极的短路，积蓄在生物体中的电荷的放电电流流过的放电电流，以及用于控制有功电流值的反馈控制部通过使脉冲电压/电流幅度变化。该装置的电流控制方法包括确定有功电流值和用于控制有功电流值的反馈控制步骤的步骤。

7. 发明申请

WO1996016642A1 MATRIX TYPE PATCH PREPARATION 审中-公开
标题翻译：矩阵类型拼接准备
公开(公告)号：WO1996016642A1
公开(公告)日：1996-06-06
申请号：PCT/JP1995001073
申请日：1995-06-01
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIGO, Naruhito , KOMORI, Ken-ichi , TERAHARA, Takaaki
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/7053 , A61K9/7076
摘要： A matrix type patch preparation having a pressure-sensitive adhesive layer comprising a physiologically active substance, organic acid, hydrophobic polymer, tackifier resin, plasticizer and sorbefacient preferably in the proportion of 0.1-20 wt.%, 0.01-15 wt.%, 15-60 wt.%, 10-70 wt.%, 10-60 wt.% and 0.01-20 wt.%, respectively. Preferable examples of the organic acid are aliphatic carboxylic acids, aromatic carboxylic acids, alkylsulfonic acids, alkylsulfonic acid derivatives, cholic acid derivatives, and water-soluble inorganic salts thereof. This preparation serves to enhance percutaneous absorbability of the physiologically active substance and is extremely reduced in skin irritation.
摘要翻译：一种基质型贴片制剂，其具有包含生理活性物质，有机酸，疏水性聚合物，增粘剂树脂，增塑剂和吸收剂的压敏粘合剂层，优选0.1-20重量％，0.01-15重量％，15重量％ -60重量％，10-70重量％，10-60重量％和0.01-20重量％。有机酸的优选实例是脂族羧酸，芳族羧酸，烷基磺酸，烷基磺酸衍生物，胆酸衍生物及其水溶性无机盐。该制剂用于增强生理活性物质的经皮吸收能力，并且皮肤刺激性极度降低。

8. 发明申请

WO1995028914A1 PERCUTANEOUSLY ADMINISTRABLE BASE COMPOSITION AND PERCUTANEOUSLY ADMINISTRABLE DRUG COMPOSITION PREPARED THEREFROM 审中-公开
标题翻译：非常适宜的基质组合物及其制备的非常适用的药物组合物
公开(公告)号：WO1995028914A1
公开(公告)日：1995-11-02
申请号：PCT/JP1995000774
申请日：1995-04-19
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIGO, Naruhito , KOMORI, Ken-ichi
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K09/00
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/12 , A61K47/26
摘要： A percutaneously administrable base composition comprising a sorbefacient, humectant, water, torpent, lower alcohol and organic acid; and a percutaneously administrable drug composition comprising a drug and the base composition.
摘要翻译：一种经皮给药的基础组合物，其包含吸收剂，保湿剂，水，酮，低级醇和有机酸; 以及包含药物和所述基础组合物的经皮给药的药物组合物。

9. 发明申请

WO1994002119A1 PERCUTANEOUSLY ADMINISTRABLE BASE COMPOSITION AND DRUG COMPOSITION PREPARED THEREFROM 审中-公开
标题翻译： PERCUTANEOUSLY ADMINISTRLY BASASE COMPOSITION AND DRUG COMPOSITION PREPARED THEREFROM
公开(公告)号：WO1994002119A1
公开(公告)日：1994-02-03
申请号：PCT/JP1993001034
申请日：1993-07-23
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIGO, Naruhito; , KOJIMA, Yukio; , KOMORI, Ken-ichi;
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K09/00
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/38
摘要： A percutaneously administrable base composition which facilitates the percutaneous absorption of drugs and is remarkably reduced in the irritancy against the skin. The composition comprises 10-60 wt. % of lower alcohol, 10-50 wt. % of humectant, 10-70 wt. % of water, 0.1-15 wt. % of abirritant and 0.1-15 wt. % of absorption promoter. A drug composition is prepared by adding to the above composition various active ingredients such as antitussive, expectorant, skeletal muscle relaxant, antivertiginous drug, narcotic, drug for the circulatory system, and so forth.
摘要翻译：促进药物经皮吸收的经皮给药的基础组合物，并且对皮肤的刺激性显着降低。组合物包含10-60wt。％的低级醇，10-50wt。％的湿润剂，10-70wt。％的水，0.1-15wt。百分比的刺激剂和0.1-15重量％％的吸收促进剂。通过向上述组合物中加入各种活性成分如镇咳药，祛痰剂，骨骼肌松弛药，止痒药，麻醉剂，循环系统药物等来制备药物组合物。

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