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1. 发明专利

GB726786A New salicyclic acid derivatives 未知
公开(公告)号：GB726786A
公开(公告)日：1955-03-23
申请号：GB964052
申请日：1952-04-17
申请人： HERTS PHARMACEUTICALS LTD , FLORENCE JUNE MACRAE , DONALD EDWIN SEYMOUR
IPC分类号： C07C233/00
摘要： The invention comprises straight-chain alkyl ethers of salicylamide having from 3 to 6 carbon atoms in the alkyl radical, and the preparation thereof by the reaction of salicyamide with the required alkyl halide, e.g. an alkyl bromide, in the presence of a basic condensing agent, e.g. sodium ethylate. In the examples, 2-n-propoxy-, 2-n-butoxy-, 2-n-amyloxy- and 2-n-hexyloxy-benzamide are prepared.

2. 发明专利

DE1685333U 未知
公开(公告)号：DE1685333U
公开(公告)日：1954-10-21
申请号：DEH0011366
申请日：1953-05-28
申请人： HERTS PHARMACEUTICALS LTD

3. 发明专利

GB713178A Improvements in and relating to salicylic acid compounds 未知
公开(公告)号：GB713178A
公开(公告)日：1954-08-04
申请号：GB1240651
申请日：1951-05-28
申请人： HERTS PHARMACEUTICALS LTD , DONALD EDWIN SEYMOUR , PROMODE RANJAN BANERJEA , KARL HOWARD OVERTON
摘要： The invention comprises an aryl ester of 2-hydroxy-4-aminobenzoic acid in which the aryl group comprises a benzene ring carrying a fused-on ring or having at least one nuclear substituent which is alkyl, nitro or amino. Such esters are obtained by reducing the corresponding aryl ester of 2-hydroxy-4-nitrobenzoic acid, the amino-aryl ester being produced from a nitro-substituted aryl ester. The starting compounds may be obtained by condensing 2 - hydroxy - 4 - nitrobenzene with an alkyl-substituted phenol, a naphthol or a nitro-phenol. Nitro-aryl esters may also be obtained by condensing a 2-acyloxy-4-nitro-benzoic acid halide with a nitro-phenol and then hydrolysing off the acyl group. Reduction is preferably effected by catalytic hydrogenation. Zinc dust may also be used. In examples: (1) b - naphthyl - 2 - hydroxy - 4 - nitrobenzoate is prepared by reacting 2-hydroxy-4-nitrobenzoic acid and b -naphthol in the presence of phosphorous oxychloride. The o-, m-, and p-cresyl esters are prepared similarly. The b -naphthyl ester is hydrogenated with Adams platinum oxide catalyst to b -naphthyl-2-hydroxy-4-aminobenzoate; (2) the same product is also obtained by reducing b -naphthyl-2 - hydroxy - 4 - nitrobenzoate with zinc dust and ammonium chloride solution. By either method of reduction the cresyl esters prepared in (1) are reduced to the o-, m- and p-cresyl esters of 2-hydroxy-4-aminobenzoic acid; (3) 31 - nitrophenyl - 2 - hydroxy - 4 - nitrobenzoate (prepared by condensing 2-hydroxy-4-nitrobenzoic acid and 3-nitrophenol) is reduced with zinc dust and ammonium hydrochloride to 31-aminophenyl - 2 - hydroxy - 4 - aminobenzoate; (4) 41 - nitrophenyl - 2 - hydroxy - 4 - nitrobenzoate (obtained by condensing 2-hydroxy-4-nitrobenzoic acid and 4-nitrophenol as in (1)) is hydrogenated catalytically to 41-aminophenyl - 2 - hydroxy - 4 - aminobenzoate; (5) 2 - acetoxy - 4 - nitrobenzoyl chloride (from 2-acetoxy - 4 - nitrobenzoic acid and thionyl chloride) is reacted with 2-nitrophenol and a pyridine catalyst to give 21-nitrophenyl-2-acetoxy-4-nitrobenzoate which is hydrolysed to 21-nitrophenyl - 2 - hydroxy - 4 - nitrobenzoate. This compound on reduction gives 21-aminophenyl - 2 - hydroxy - 4 - aminobenzoate. The Provisional Specification includes also the preparation of phenyl 2-hydroxy-4-nitro-benzoate and a process for its reduction to phenyl-2-hydroxy-4-amino-benzoate.

4. 发明专利

FI26267A Sätt att tillverka p-amino-salicylsyra 未知
公开(公告)号：FI26267A
公开(公告)日：1953-04-10
申请号：FI26267D
申请日：1950-08-02
申请人： HERTS PHARMACEUTICALS LTD
发明人： JOHN DRAIN DAVID , EDWIN SEYMOUR DONALD , DONALD SUDDABY
IPC分类号： C07C101/74

5. 发明专利

GB654029A Improvements in and relating to adhesive tape 未知
公开(公告)号：GB654029A
公开(公告)日：1951-05-30
申请号：GB2764148
申请日：1948-10-25
申请人： HERTS PHARMACEUTICALS LTD , GEIGY CO LTD , DONALD EDWIN SEYMOUR
IPC分类号： C09J7/02
摘要： 654,029. Adhesive tape. HERTS PHARMACEUTICALS, Ltd., GEIGY CO., Ltd., and SEYMOUR, D. E. Oct. 25, 1948, No. 27641. [Class 140] A pressure-sensitive adhesive tape for use in sealing food containers comprises sheet material, e.g. a woven textile fabric, paper, plastic material such as regenerated cellulose, a cellulose ester or ether or a polymeric substance such as polyvinyl chloride, with an adhesive coating which may include rubber with or without other ingredients or synthetic plastic materials of a sticky or adhesive nature, the sheet material or the adhesive or both, including an insecticidal composition of the general formula (where R means a phenyl radical containing as a substituent in the para position a chlorine, bromine or fluorine atom or a methoxy group or an alkyl group, especially methyl, ethyl, or propyl, and is otherwise unsubstituted), e.g. 4: 4 1 .dichlorodiphenyltrichloroethane. The composition may be incorporated in the coating in admixture with a solid inert diluent. Specifications 547,871, 547,874, [both in Group IV], 577,124 and 590,826 are referred to.

6. 发明专利

GB636347A Improvements in and relating to the manufacture of aromatic amino carboxylic acids 未知
公开(公告)号：GB636347A
公开(公告)日：1950-04-26
申请号：GB1520547
申请日：1947-06-10
申请人： HERTS PHARMACEUTICALS LTD , DAVID DUNCANSON MARTIN , DONALD EDWIN SEYMOUR , FRANK STUART SPRING
摘要： Alkali metal salts of 2-hydroxy-4-amino-benzoic acid are prepared by heating m-aminophenol with carbon dioxide and alkali metal hydroxide, carbonate or bicarbonate at 105-135 DEG C. in a polyhydric alcohol. The free acid may be isolated by adding hydrochloric acid to the reaction product until just acid to litmus or by adding the reaction product to an excess of hydrochloric acid to precipitate the hydrochloride of the amino acid which is separated, dried and decomposed by the addition of an alkali metal bicarbonate and just sufficient water to dissolve the alkali metal chloride formed. In an example, m-amino-phenol is heated with potassium bicarbonate in glycerol at 130 DEG C. while a stream of carbon dioxide is passed in, the product is converted to the hydrochloride from which the free acid is liberated by the addition of the equivalent quantity of sodium bicarbonate.

7. 发明专利

GB594185A A process and apparatus for the manufacture of sterile surgical dressings 未知
公开(公告)号：GB594185A
公开(公告)日：1947-11-05
申请号：GB1643245
申请日：1945-06-27
申请人： HERTS PHARMACEUTICALS LTD , SIDNEY CHARLES MITCHELL , CLAUS WOLFGANG PICARD , GEOFFREY LAMBERT SAWER , THOMAS SHAW , ROCHE PRODUCTS LTD , FRANZ BERGEL , ALEXANDER LANG MORRISON , ALBERT RONALD MOSS
IPC分类号： A61F13/15
摘要： 594,185. Medicated dressings. HERTS PH ARMACEUTICALS, Ltd., ' MITCHELL, S. C., PICARD, C. W., SAWER, G. L., SHAW, T.., ROCHE PRODUCTS, Ltd., BERGEL, F., MORRISON, A. L., and MOSS, A. R. June 27, 1945, No. 16432. [Classes 81 (i) and 81 (ii)] A continuous process for the manufacture of sterile surgical dressings comprises passing sterile surgical gauze or like absorbent - fabric through a solution of penicillin, for example in the form of its calcium salt, or other therapeutic substances, drying the impregnated fabric under sterile conditions to a moisture con- .tent well below that at which the fabric is normally in equilibrium with air of 50 per cent. relative humidity at 70‹F., and enclosing it, preferably after cutting it into portions, in a hermetically sealed sterile envelope. In Fig. I, surgical gauze from a spool or spools 2 is passed through tensionings rolls 4 to an impregnating tank 5 containing a solution of the therapeutic substance in water or an organic solvent, such as acetone or alcohol, or -mixture thereof with water. Thence the gauze passes through rollers 6, which may be eccentrically adjusted, to express fluid therefrom and leave for example 1c.c. fluid per 1gm. of gauze, to a drying tunnel 8 supplied with sterile hot air from chamber 9. If more than one ply of gauze is used, they may be separated by means of transverse glass rods for passage through the tunnel and reunited at the further end thereof. More hot air is supplied to the tunnel than fan 12 will exhaust therefrom. The gauze next passes through rollers 13 to guillotine 14 whence the individual pieces are transported by a shutter to between two layers of plastic film 60, for example of " Pliofilm " (Registered Trade Mark) polyvinyl chloride or other non-permeable film, from spools 16. The film is sterilised by exposure to ultra-violet light lamps 17 and is supplied at a faster rate than the gauze portions. The films containing the gauze pass between rollers 15, under guide roller 18, to sealing jig 18a, and thence to rollers 19 and guillotine 20. Transparent hoods 1 are provided when necessary as a protection against airborne infection. The moving parts are powered from a shaft 26, rollers 6, 13, 15 and 19 through bevel gears and guillotines 14 and 20 and jig 18a through intermittent bevel gears driving a shaft on which is mounted a cam acting on a rocker arm connected with the operating member. The rocker arm which drives guillotine 14 also operates the shutter by means of gear and a bell crank. The top blades of guillotine 14 and 20 are pivoted and have spring loaded adjustments. The air heating of the gauze may be supplemented by electronic heating. Specification 581,234 is referred to.

8. 发明专利

GB581234A A process for the manufacture of stable surgical dressings containing penicillin 未知
公开(公告)号：GB581234A
公开(公告)日：1946-10-04
申请号：GB1761844
申请日：1944-09-14
申请人： HERTS PHARMACEUTICALS LTD , SIDNEY CHARLES MITCHELL , CLAUS WOLFGANG PICARD , ROCHE PRODUCTS LTD , FRANZ BERGEL , ALEXANDER LANG MORRISON , ALBERT RONALD MOSS , RICHARD KLEIN , HEINRICH RINDERKNECHT , LESLIE DOUGLAS GALLOWAY
IPC分类号： A61L15/46
摘要： For impregnating dressings consisting of absorbent fibrous material there is employed a sterile solution of a salt of penicillin adjusted to a pH value of 5.5-7.5 and preferably 5.5-6.5, which may be prepared from filtered crude penicillin-containing metabolic solutions, or from purified penicillin solutions, or from pure penicillin salts. The penicillin content is recoverable from the impregnated dressings by soaking them in water. Several examples are given, relating to the use of calcium, ammonium, magnesium and a mixture of sodium and potassium salts of penicillin having a bacteriostatic activity ranging between 11 and 900 Oxford units per c.c.ALSO:A dressing consisting of absorbent fibrous material, e.g., cotton gauze, cotton wool, fabrics of glass fibres, nylon, cellulose acetate, spun viscose &c. is impregnated with a sterile solution of a salt of penicillin adjusted to a pH value of 5.5-7.5 and preferably 5.5-6.5, dried to a constant weight and placed in a moisture-proof container. Drying may be effected in a current of air or inert gas such as nitrogen at a temperature not exceeding 120 DEG C., e.g., at 60-85 DEG C. for 5-10 minutes, or by infra-red radiation in a current of air or inert gas, or in vacuo at low temperatures suitably in the presence of a drying agent such as caustic potash or phosphorous pentoxide. The solution employed may be prepared from filtered crude penicillin-containing metabolic solutions, or from purified penicillin solutions, or from pure penicillin salts. The dressings so produced are stable and the penicillin content is recoverable by soaking them in water. Several examples are given, relating to the use of calcium, ammonium, magnesium, and a mixture of sodium and potassium salts of penicillin having a bacteriostatic activity ranging between 11 and 900 Oxford units per c.c.

9. 发明专利

GB691182A New or improved method and process for applying a coating to a web or strip of material 未知
公开(公告)号：GB691182A
公开(公告)日：1953-05-06
申请号：GB293350
申请日：1950-02-04
申请人： HERTS PHARMACEUTICALS LTD
发明人： SIMMONITE DONALD
IPC分类号： A61F13/02
摘要： 691,182. Coating webs. HERTS. PHARMACEUTICALS, Ltd. May 4, 1951. [Feb. 4, 1950] No. 2933/50. Class 140. A web or strip of material is coated while leaving a selected area or areas uncoated by placing a blank or blanks of magnetic material on the selected area or areas, holding the blank or blanks on the material by magnetic force while applying the coating composition to the material and to the blank or blanks, and then removing the blank or blanks by magnetic force. As shown, a web 1 from a roll 2 is led around a roller 3 and over a flat magnetic chuck 4 which serves to hold firmly in position on the web a series of magnetic blanks 6 delivered one at a time from a device 5. Coating composition from a hopper 8 is spread over the web and the blanks by a roller 7 and the blanks are removed by an intermittently magnetised electromagnet 9. The coating, which may be a pressure, sensitive adhesive applied to a semi-permeable film backing, may be dried while the strip passes on an endless belt 12 through a drying tunnel 13 through which warm air is blown. A backing material 17 from roll 19 may be pressed on between driven rollers 16 and the strip severed by a punch 20 into individual dressings each with a central window free of adhesive. The magnetic material may be thin steel plates or sheets of paper or plastic composition impregnated with iron powder.

10. 发明专利

FR1023803A 未知
公开(公告)号：FR1023803A
公开(公告)日：1953-03-24
申请号：FR1023803D
申请日：1948-02-20
申请人： HERTS PHARMACEUTICALS LTD

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