专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

WO2014007831A1 BORON-CONTAINING SMALL MOLECULES 审中-公开
标题翻译：含硼的小分子
公开(公告)号：WO2014007831A1
公开(公告)日：2014-01-09
申请号：PCT/US2012/045842
申请日：2012-07-06
申请人： ANACOR PHARMACEUTICALS, INC. , PLATTNER, Jacob, J. , LI, Xianfeng , HERNANDEZ, Vincent, S.
发明人： PLATTNER, Jacob, J. , LI, Xianfeng , HERNANDEZ, Vincent, S.
IPC分类号： C07F5/02 , A61K41/00
CPC分类号： C07F5/025
摘要： This invention provides benzoxaborole-containing phenylalanine analogues useful in boron neutron capture therapy.
摘要翻译：本发明提供了可用于硼中子捕获治疗的含苯并恶唑的苯丙氨酸类似物。

3. 发明申请

WO2009140309A2 BORON-CONTAINING SMALL MOLECULES 审中-公开
标题翻译：含硼的小分子
公开(公告)号：WO2009140309A2
公开(公告)日：2009-11-19
申请号：PCT/US2009043672
申请日：2009-05-12
申请人： ANACOR PHARMACEUTICALS INC , GLAXOSMITHKLINE , XIA YI , ALLEY MICHAEL RICHARD KEVIN , ZHOU YASHEEN , HERNANDEZ VINCENT S , PLATTNER JACOB J , DING CHARLES Z , CAO KATHY , ZHANG YONG-KANG , AKAMA TSUTOMU , SLIGAR JESSICA , BENOWITZ ANDREW , JIA GUOFENG , OU LIGONG , SARASWAT NEERJA , RAMACHANDRAN SREEKANTH , DIAPER CHRIS , ZHANG YANCHEN , BANDA GOVERDHAN REDDY , NIEMAN JAMES , KERAMANE MEDHI , MOHAMMAD RAHIM , SUBEDI RAJENDRA , LIANG HONG , SINGH RAJESHWAR
发明人： XIA YI , ALLEY MICHAEL RICHARD KEVIN , ZHOU YASHEEN , HERNANDEZ VINCENT S , PLATTNER JACOB J , DING CHARLES Z , CAO KATHY , ZHANG YONG-KANG , AKAMA TSUTOMU , SLIGAR JESSICA , BENOWITZ ANDREW , JIA GUOFENG , OU LIGONG , SARASWAT NEERJA , RAMACHANDRAN SREEKANTH , DIAPER CHRIS , ZHANG YANCHEN , BANDA GOVERDHAN REDDY , NIEMAN JAMES , KERAMANE MEDHI , MOHAMMAD RAHIM , SUBEDI RAJENDRA , LIANG HONG , SINGH RAJESHWAR
IPC分类号： A62D3/36 , A62D101/22
CPC分类号： A61K31/33 , A61K31/43 , A61K45/06 , C07F5/025 , A61K2300/00
摘要： This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译：本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。

4. 发明申请

WO2007095638A3 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS 审中-公开
公开(公告)号：WO2007095638A3
公开(公告)日：2007-08-23
申请号：PCT/US2007/062350
申请日：2007-02-16
申请人： ANACOR PHARMACEUTICALS, INC. , BAKER, Stephen, J. , SANDERS, Virginia , AKAMA, Tsutomu , BELLINGER-KAWAHARA, Carolyn , FREUND, Yvonne , MAPLES, Kirk, R. , PLATTNER, Jacob, J. , ZHANG, Yong-Kang , ZHOU, Huchen , HERNANDEZ, Vincent, S.
发明人： BAKER, Stephen, J. , SANDERS, Virginia , AKAMA, Tsutomu , BELLINGER-KAWAHARA, Carolyn , FREUND, Yvonne , MAPLES, Kirk, R. , PLATTNER, Jacob, J. , ZHANG, Yong-Kang , ZHOU, Huchen , HERNANDEZ, Vincent, S.
IPC分类号： A01N55/08 , A61K31/69
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.

5. 发明申请

WO2006089067A2 BORON-CONTAINING SMALL MOLECULES 审中-公开
标题翻译：含硼的小分子
公开(公告)号：WO2006089067A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005542
申请日：2006-02-16
申请人： ANACOR PHARMACEUTICALS, INC. , BAKER, Stephen, J. , AKAMA, Tsutomu , BELLINGER-KAWAHARA, Carolyn , HERNANDEZ, Vincent, S. , HOLD, Karin, M. , LEYDEN, James, J. , MAPLES, Kirk, R. , PLATTNER, Jacob, J. , SANDERS, Virginia , ZHANG, Yong-Kang
发明人： BAKER, Stephen, J. , AKAMA, Tsutomu , BELLINGER-KAWAHARA, Carolyn , HERNANDEZ, Vincent, S. , HOLD, Karin, M. , LEYDEN, James, J. , MAPLES, Kirk, R. , PLATTNER, Jacob, J. , SANDERS, Virginia , ZHANG, Yong-Kang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译：本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。本发明涉及对真菌具有活性的化合物，并且具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，头发，爪或蹄特定部位的性质。特别地，本发明化合物具有促进钉板穿透的物理化学性质。

6. 发明申请

WO02095356A3 METHODS AND COMPOSITIONS FOR ANALYZING PROTEINS 审中-公开
标题翻译：分析蛋白质的方法和组合物
公开(公告)号：WO02095356A3
公开(公告)日：2004-12-23
申请号：PCT/US0216098
申请日：2002-05-21
申请人： ACLARA BIOSCIENCES INC , SINGH SHARAT , SALIMI-MOOSAVI HOSSEIN , TAHIR SYED HASAN , WALLWEBER GERALD J , KIRAKOSSIAN HRAIR , MATRAY TRACY J , HERNANDEZ VINCENT S
发明人： SINGH SHARAT , SALIMI-MOOSAVI HOSSEIN , TAHIR SYED HASAN , WALLWEBER GERALD J , KIRAKOSSIAN HRAIR , MATRAY TRACY J , HERNANDEZ VINCENT S
IPC分类号： G01N33/483 , G01N21/78 , G01N27/447 , G01N33/53 , G01N33/536 , G01N33/68
CPC分类号： G01N33/6842 , C07K16/00 , C07K2317/40 , G01N33/582 , G01N33/6803
摘要： Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and a first binding agent for a binding site on a target polypeptide is subjected to conditions under which binding of respective binding moieties occurs. The binding site is the result of post-translational modification activity involving the target polypeptide. The method may be employed to determine the target polypeptide itself. In another embodiment the presence and/or amount of the target polypeptide is related to the presence and/or amount and/or activity of an agent such as an enzyme involved in the post-translational modification of the target polypeptide. The interaction between the first binding agent and the binding site brings the cleavage-inducing moiety into close proximity to a cleavable moiety, which is associated with the polypeptide and is susceptible to cleavage only when in proximity to the cleavage-inducing moiety. In this way, an electrophoretic tag for each of the polypeptides may be released. Released electrophoretic tags are separated and the presence and/or amount of the target polypeptides are determined based on the corresponding electrophoretic tags.
摘要翻译：公开了用于确定样品中一种或多种靶多肽已经经历了翻译后修饰的方法，组合物和试剂盒。包含样品和包含切割诱导部分和用于靶多肽上的结合位点的第一结合剂的第一试剂的混合物经受各自结合部分的结合发生的条件。结合位点是涉及靶多肽的翻译后修饰活性的结果。该方法可用于确定靶多肽本身。在另一个实施方案中，靶多肽的存在和/或量与试剂例如涉及靶多肽的翻译后修饰的酶的存在和/或量和/或活性有关。第一结合剂和结合位点之间的相互作用使切割诱导部分紧密接近与多肽相关的可切割部分，并且仅在接近切割诱导部分时易于切割。以这种方式，可以释放每个多肽的电泳标签。分离出释放的电泳标签，并且基于相应的电泳标签确定靶多肽的存在和/或量。

7. 发明申请

WO2011060199A1 BORON-CONTAINING SMALL MOLECULES 审中-公开
标题翻译：含硼的小分子
公开(公告)号：WO2011060199A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056423
申请日：2010-11-11
申请人： ANACOR PHARMACEUTICALS, INC. , HERNANDEZ, Vincent, S. , LI, Xianfeng , ZHANG, Suoming , AKAMA, Tsutomu , ZHANG, Yanchen , LIU, Yang , PLATTNER, Jacob, J. , ALLEY, Michael Kevin, Richard , ZHOU, Yasheen , NEIMAN, James, A.
发明人： HERNANDEZ, Vincent, S. , LI, Xianfeng , ZHANG, Suoming , AKAMA, Tsutomu , ZHANG, Yanchen , LIU, Yang , PLATTNER, Jacob, J. , ALLEY, Michael Kevin, Richard , ZHOU, Yasheen , NEIMAN, James, A.
IPC分类号： C07F5/02 , A61K31/69 , A61P31/04
CPC分类号： C07F5/025
摘要： This invention relates to 6-substituted benzoxaborole compounds of the following formulae and their use for treating bacterial infections.
摘要翻译：本发明涉及下式的6-取代苯并恶唑化合物及其用于治疗细菌感染的用途。

9. 发明申请

WO2006089067A3 BORON-CONTAINING SMALL MOLECULES 审中-公开
标题翻译：含硼的小分子
公开(公告)号：WO2006089067A3
公开(公告)日：2007-07-19
申请号：PCT/US2006005542
申请日：2006-02-16
申请人： ANACOR PHARMACEUTICALS INC , BAKER STEPHEN J , AKAMA TSUTOMU , BELLINGER-KAWAHARA CAROLYN , HERNANDEZ VINCENT S , HOLD KARIN M , LEYDEN JAMES J , MAPLES KIRK R , PLATTNER JACOB J , SANDERS VIRGINIA , ZHANG YONG-KANG
发明人： BAKER STEPHEN J , AKAMA TSUTOMU , BELLINGER-KAWAHARA CAROLYN , HERNANDEZ VINCENT S , HOLD KARIN M , LEYDEN JAMES J , MAPLES KIRK R , PLATTNER JACOB J , SANDERS VIRGINIA , ZHANG YONG-KANG
IPC分类号： A61K31/343 , C07D307/77
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译：本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。本发明涉及对真菌具有活性的化合物，并且具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。特别地，本发明化合物具有促进钉板穿透的物理化学性质。

10. 发明申请

WO2011037731A1 BORON CONTAINING SMALL MOLECULES 审中-公开
标题翻译：含有BORON的小分子
公开(公告)号：WO2011037731A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/047355
申请日：2010-08-31
申请人： ANACOR PHARMACEUTICALS, INC. , HERNANDEZ, Vincent, S. , DING, Charles , PLATTNER, Jacob , ALLEY, Michael, Richard Kevin , ZHANG, Yong-Kang , ZHANG, Yanchen
发明人： HERNANDEZ, Vincent, S. , DING, Charles , PLATTNER, Jacob , ALLEY, Michael, Richard Kevin , ZHANG, Yong-Kang , ZHANG, Yanchen
IPC分类号： C07F5/02 , A61K31/69
CPC分类号： C07F5/025
摘要： This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译：本发明尤其提供了可用于治疗细菌感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式