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    • 4. 发明申请
    • SYNERGISTIC COMBINATIONS OF DIETARY FIBER AND N-SAIDS FOR THE TREATMENT OF CANCER
    • 用于治疗癌症的膳食纤维和N-糖苷的协同组合
    • WO2004028527A1
    • 2004-04-08
    • PCT/EP2003/010544
    • 2003-09-23
    • TIENSE SUIKERRAFFINADERIJ N.V.VAN LOO, JanFRIPPIAT, AnneHERMANS, Johny
    • VAN LOO, JanFRIPPIAT, AnneHERMANS, Johny
    • A61K31/19
    • A61K31/19A61K31/715
    • Pharmaceutical compositions are disclosed that present synergistic anti-cancer effects in humans and vertebrate animals, comprising a combination of a fermentable dietary fiber (FDF) which is a fructan and a non-steroidal anti-inflammatory drug (NSAID) with cyclo-oxygenase2 (COX2) inhibiting activity, the FDF being present in the FDF/NSAID combination in a weight ratio FDF: NSAID of minimum 1:1. Typical compositions comprise a FDF/NSAID combination wherein the FDF component is chicory inulin, oligofructose or a mixture thereof, and the NSAID component is sulindac, piroxicam or aspirin. The synergistic ant-cancer effects of the compositions are demonstrated in aberrant crypt foci studies in rats. The pharmaceutical compositions are useful in the prevention and inhibition of carcinogenesis or recurrence of cancer and for the treatment of cancer in humans and vertebrate animals. The invention also relates to a method for prevention or inhibition of carcinogenesis and recurrence of cancer and for the treatment of cancer in humans and vertebrate animals involving administration of a therapeutically effective dose of said pharmaceutical compositions to a human or vertebrate animal.
    • 公开了药物组合物,其在人和脊椎动物中表现出协同的抗癌作用,其包括作为果聚糖的可发酵膳食纤维(FDF)和非甾体抗炎药(NSAID)与环氧合酶2(COX2)的组合 )抑制活性,FDF存在于FDF / NSAID组合中,重量比FDF:NSAID最小为1:1。 典型的组合物包含FDF / NSAID组合,其中FDF组分是菊苣菊糖,低聚果糖或其混合物,NSAID组分是舒林酸,吡罗昔康或阿司匹林。 在大鼠的异常隐窝灶研究中证明了组合物的协同抗癌作用。 药物组合物可用于预防和抑制癌症的癌发生或复发以及用于治疗人类和脊椎动物的癌症。 本发明还涉及用于预防或抑制癌症的癌发生和复发以及用于治疗人类和脊椎动物中的癌症的方法,其涉及向人或脊椎动物施用治疗有效剂量的所述药物组合物。