专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005117985A3 LIPOPOLYPLEX CONSTRUCT WITH AN INTEGRIN BINDING PEPTIDE FOR DELIVERY OF NUCLEIC ACIDS, PEPTIDES OR DRUGS 审中-公开
标题翻译：用于交付核酸，肽或药物的整合蛋白结合肽的脂多糖构建
公开(公告)号：WO2005117985A3
公开(公告)日：2006-11-09
申请号：PCT/GB2005002178
申请日：2005-06-02
申请人： UCL BIOMEDICA PLC , HAILES HELEN , TABOR ALETHEA BERNICE , WONG JOHN BOSCO , PILKINGTON-MIKSA MICHAEL , HART STEPHEN LEWIS , HURLEY CHRISTOPHER ANTHONY
发明人： HAILES HELEN , TABOR ALETHEA BERNICE , WONG JOHN BOSCO , PILKINGTON-MIKSA MICHAEL , HART STEPHEN LEWIS , HURLEY CHRISTOPHER ANTHONY
IPC分类号： A61K47/48
CPC分类号： C12N15/88 , A61K47/543 , A61K47/62 , A61K47/6921
摘要： The invention provides a complex suitable for delivery of a biologically-active material to a cell, which complex comprises: (a) a lipid of formula: (III); wherein R I , R 2 , R 3 , B, Q and m are as defined herein; (b) a biologically-active material; and (c) an integrin-binding peptide. The invention also provides a complex suitable for delivery of a biologically-active material to a cell, which complex comprises: (a) a lipid of formula: (I); wherein R 1 , R 2 , X 1 , X 2 and R 5 ,are as defined herein; (b) a biologically-active material; and (c) an integrin-binding peptide of formula: [DNA-Binding]-[Spacer] k -[Ligand] wherein DNA-Binding, Spacer, k and Ligand are as defined herein.
摘要翻译：本发明提供了适合于向细胞递送生物活性物质的复合物，该复合物包括：（a）式（III）的脂质：其中R 1，R 2，R 3，B，Q和m如本文所定义; （b）生物活性物质; 和（c）整联蛋白结合肽。本发明还提供了适合于向细胞递送生物活性物质的复合物，该复合物包括：（a）式（I）的脂质：其中R 1，R 2，X 1，X 2和R 5，，如本文所定义; （b）生物活性物质; 和（c）下式的整联蛋白结合肽：[DNA结合] - [间隔] - [配体]其中DNA-结合，间隔子，配位体和配体如本文所定义。

2. 发明申请

WO2002072616A2 TRANSFECTION COMPLEXES 审中-公开
标题翻译：转移复合物
公开(公告)号：WO2002072616A2
公开(公告)日：2002-09-19
申请号：PCT/GB2002/001215
申请日：2002-03-14
申请人： ICH PRODUCTIONS LIMITED , HART, Stephen, Lewis , WRITER, Michele
发明人： HART, Stephen, Lewis , WRITER, Michele
IPC分类号： C07K2/00
CPC分类号： C40B30/04 , A61K38/00 , A61K39/00 , A61K47/62 , A61K47/65 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07K5/0815 , C07K5/101 , C07K7/06 , C07K14/001 , C12N15/88 , G01N33/566 , G01N33/6845 , G01N2500/10
摘要： The invention provides a peptide having at least 3 amino acids comprising an amino acid sequence selected from a) X 1 SM [SEQ.ID.NO.:1] b) LX 2 HK [SEQ.ID.NO.:2] c) PSGX 3 ARA [SEQ.ID.NO.:9] d) SX 4 RSMNF [SEQ.ID.NO.:16] e) LX 5 HKSMP [SEQ.ID.NO.:18] in which X is a basic amino acid residue, X 1 is Q or P, X 2 is A or T, X 3 is an acidic amino acid residue and X 4 is P or Q. the invention further provides non-viral cell-targeting vector complexes and methods associated therewith.
摘要翻译：本发明提供了具有至少3个氨基酸的肽，其包含选自以下氨基酸序列：a）X 1 SM [SEQ ID NO：1] b）LX 2 HK [SEQ ID NO： 2] c）PSGX 3 ARA [SEQ.ID.NO.:9] d）SX 4 RSMNF [SEQ.ID.NO.:16] e）LX5 HKSMP [SEQ.ID.NO. ：18]其中X为碱性氨基酸残基，X 1为Q或P，X 2为A或T，X 3为酸性氨基酸残基，X 4为P或Q 本发明进一步提供非病毒细胞靶向载体复合物和与其相关的方法。

3. 发明申请

WO1996015811A1 INTERNALISATION OF DNA, USING CONJUGATES OF POLY-L-LYSINE AND AN INTEGRIN RECEPTOR LIGAND 审中-公开
标题翻译：使用聚-L-赖氨酸和整合素受体配体的结合使用DNA的内部分析
公开(公告)号：WO1996015811A1
公开(公告)日：1996-05-30
申请号：PCT/GB1995002706
申请日：1995-11-17
申请人： IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE , HART, Stephen, Lewis , HARBOTTLE, Richard, Paul
发明人： IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE
IPC分类号： A61K47/48
CPC分类号： C12N15/87 , A61K47/645 , A61K48/00
摘要： Compositions comprising DNA associated with a polycation moiety wherein the polycation moiety is itself coupled to an integrin receptor binding moiety are disclosed. Preferably, the integrin receptor binding moiety is a peptide, and the compositions can be used to deliver DNA to a cell where it will be expressed, for example, to treat a condition by gene therapy. In a preferred embodiment, the integrin receptor binding moiety comprises a peptide, in particular a cyclic peptide, comprising the sequence RGD. In a particularly preferred embodiment, the peptide comprises the sequence GGCRGDMFGC. Cyclic configuration in this sequence is imposed by virtue of the presence of two cysteine residues which can form a disulphide bond.
摘要翻译：公开了包含与聚阳离子部分相关的DNA的组合物，其中聚阳离子部分本身与整联蛋白受体结合部分偶联。优选地，整联蛋白受体结合部分是肽，并且所述组合物可用于将DNA递送至将被表达的细胞，例如通过基因治疗来治疗病症。在优选的实施方案中，整联蛋白受体结合部分包含包含序列RGD的肽，特别是环肽。在特别优选的实施方案中，肽包含序列GGCRGDMFGC。由于存在可形成二硫键的两个半胱氨酸残基，因此该顺序中的环状结构被施加。

4. 发明申请

WO2007138324A3 MATERIALS AND COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS 审中-公开
标题翻译：将生物活性材料递送到细胞的材料和复合物
公开(公告)号：WO2007138324A3
公开(公告)日：2008-03-13
申请号：PCT/GB2007002012
申请日：2007-05-30
申请人： UNIV LONDON , HART STEPHEN LEWIS , GROSSE STEPHANIE , TABOR ALETHEA BERNICE , WONG JOHN BOSCO , ELBS MARTIN , HAILES HELEN CLAIRE , MOHD MUSTAPA MOHD FIROUZ
发明人： HART STEPHEN LEWIS , GROSSE STEPHANIE , TABOR ALETHEA BERNICE , WONG JOHN BOSCO , ELBS MARTIN , HAILES HELEN CLAIRE , MOHD MUSTAPA MOHD FIROUZ
IPC分类号： C12N15/88 , A61K47/48 , A61P35/00 , C07C229/30 , C07K14/00
CPC分类号： A61K9/1271 , A61K9/0019 , A61K38/00 , A61K47/543 , A61K47/64 , A61K47/6455 , A61K47/65 , A61K47/6911 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C07C217/28
摘要： The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG) q - Linker - Spacer - Cationic headgroup - carbon skeleton - (hydrophobic chain) o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q = 1, 2 or 3; o denotes the number of hydrophobic chains and o = 1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.
摘要翻译：本发明提供式A-B-C的肽衍生物，其中A是聚阳离子核酸结合组分; B是对细胞内切割敏感的间隔元件肽; C是细胞表面受体结合成分。本发明还提供通式（I）的脂质衍生物：（PEG） - 连接剂 - 间隔物 - 阳离子头基 - 碳骨架 - （疏水链）其中：接头是一个容易在细胞内裂解的组; Spacer是将Linker与阳离子头组联系起来的组; q表示PEG链的数量，q = 1,2或3; o表示疏水链的数目，o = 1,2或3; 碳骨架是将疏水链与阳离子头基连接的基团。肽和脂质衍生物用于非病毒基因递送系统。

5. 发明申请

WO2004108938A3 PEPTIDE LIGANDS OF DENDRITIC CELLS FOR NUCLEIC ACID VECTOR TARGETING 审中-公开
标题翻译：树突状细胞用于核酸载体靶向的肽配体
公开(公告)号：WO2004108938A3
公开(公告)日：2005-05-12
申请号：PCT/GB2004002421
申请日：2004-06-07
申请人： ICH PRODUCTIONS LTD , HART STEPHEN LEWIS , WRITER MICHELE
发明人： HART STEPHEN LEWIS , WRITER MICHELE
IPC分类号： A61K48/00 , C07K5/083 , C07K5/117 , C07K7/06 , C12N15/861
CPC分类号： C07K5/1024 , C07K5/081 , C07K7/06
摘要： A peptide consisting of or comprising an amino acid sequence selected from a ) Px X X T [SEQ.ID.NO.:1]; b) PSX S [SEQ.ID.NO. :2]; C) QX X X Q [SEQ.ID.NO.:3]; d) SX S [SEQ-ID.NO.:4], in which X , X and X , which may be the same or different, each represents an amino acid residue; X is preferably N or L; X represents an amino acid residue, preferably N or L; X and X , which may be the same or different, each represents an amino acid residue, X represents an amino acid residue having an amide side chain; and X represent an amino acid having an aliphatic side chain, which peptide binds to dendritic cells and also to other types of cells. The peptide may be used a target non-viral and viral vectors to such cells.
摘要翻译：由选自a）Px 1 X 2 X 3 T [SEQ.ID.NO.:1]的氨基酸序列组成或由其组成的肽; b）PSX 4 S [SEQ.ID.NO. ：2]; C）QX 5 X 6 X 7 Q [SEQ.ID.NO.:3]; d）SX 8 S [SEQ- ID.NO.:4]，其中X 1，X 2和X 3可以相同或不同，各自代表氨基酸残基; X 2优选为N或L; X 4代表氨基酸残基，优选N或L; X 5和X 7可以相同或不同，各自代表氨基酸残基，X 6代表具有酰胺侧链的氨基酸残基; 和X 8代表具有脂肪族侧链的氨基酸，该肽与树突细胞以及其他类型的细胞结合。该肽可以用于靶向非病毒载体和病毒载体。

6. 发明申请

WO02072616A3 TRANSFECTION COMPLEXES 审中-公开
标题翻译：转移复合物
公开(公告)号：WO02072616A3
公开(公告)日：2003-07-03
申请号：PCT/GB0201215
申请日：2002-03-14
申请人： ICH PRODUCTIONS LTD , HART STEPHEN LEWIS , WRITER MICHELE
发明人： HART STEPHEN LEWIS , WRITER MICHELE
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K47/18 , A61K47/24 , A61K47/34 , A61K47/42 , A61K47/48 , A61K48/00 , A61P9/12 , A61P11/00 , A61P11/06 , A61P35/00 , C07K5/08 , C07K5/09 , C07K5/093 , C07K5/103 , C07K7/06 , C07K14/00 , C12N15/88 , C12Q1/70 , C40B30/04 , G01N33/566 , G01N33/68 , A61K38/02 , A61K38/06 , A61K38/07 , A61K38/08
CPC分类号： C40B30/04 , A61K38/00 , A61K39/00 , A61K47/62 , A61K47/65 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07K5/0815 , C07K5/101 , C07K7/06 , C07K14/001 , C12N15/88 , G01N33/566 , G01N33/6845 , G01N2500/10
摘要： The invention provides a peptide having at least 3 amino acids comprising an amino acid sequence selected from a) X SM [SEQ.ID.NO.:1] b) LX HK [SEQ.ID.NO.:2] c) PSGX ARA [SEQ.ID.NO.:9] d) SX RSMNF [SEQ.ID.NO.:16] e) LX HKSMP [SEQ.ID.NO.:18] in which X is a basic amino acid residue, X is Q or P, X is A or T, X is an acidic amino acid residue and X is P or Q. the invention further provides non-viral cell-targeting vector complexes and methods associated therewith.
摘要翻译：本发明提供了具有至少3个氨基酸的肽，其包含选自以下氨基酸序列：a）X 1 SM [SEQ ID NO：1] b）LX 2 HK [SEQ ID NO： 2] c）PSGX 3 ARA [SEQ.ID.NO.:9] d）SX 4 RSMNF [SEQ.ID.NO.:16] e）LX5 HKSMP [SEQ.ID.NO. ：18]其中X为碱性氨基酸残基，X 1为Q或P，X 2为A或T，X 3为酸性氨基酸残基，X 4为P或Q 本发明进一步提供非病毒细胞靶向载体复合物和与其相关的方法。

7. 发明申请

WO0192543A3 IMPROVED METHODS OF TRANSFECTION 审中-公开
标题翻译：改进的转移方法
公开(公告)号：WO0192543A3
公开(公告)日：2002-09-12
申请号：PCT/GB0102396
申请日：2001-05-30
申请人： ICH PRODUCTIONS LTD , HART STEPHEN LEWIS
发明人： HART STEPHEN LEWIS
IPC分类号： C12N15/09 , A61K31/7088 , A61K48/00 , A61P35/00 , C12N5/10 , C12N15/87 , C12P21/02 , C12N15/88 , C07K7/06 , C07K7/08 , C07K16/28 , C12P21/00
CPC分类号： C12N15/87 , A61K2039/53
摘要： Transfection of confluent cells or other slowly dividing or non-dividing cells that are in contact with each other with a nucleic acid using a non-viral receptor targeted vector may be improved by the concurrent use of an agent that disrupts cell-cell junctions, especially EGTA. The vector is especially an integrin-targeting transfection vector complex comprising (i) a nucleic acid, especially a nucleic acid encoding a sequence of interest, (ii) an integrin-binding component, especially an integrin-targeting peptide, (iii) a polycationic nucleic acid-binding component, especially an oligolysine, and (iv) a lipid component, especially, DOPE, DOTMA, DOSPA or combinations thereof. Various applications of the improved method of transfection are described.
摘要翻译：特别是通过使用非病毒受体靶向载体与核酸相互接触的汇合细胞或其他缓慢分裂或非分裂细胞的转染，可以通过同时使用破坏细胞 - 细胞连接的试剂 EGTA。载体特别是整合素靶向转染载体复合物，其包含（i）核酸，特别是编码感兴趣序列的核酸，（ii）整联蛋白结合组分，特别是整联蛋白靶向肽，（iii）聚阳离子核酸结合组分，特别是寡聚赖氨酸，和（iv）脂质成分，特别是DOPE，DOTMA，DOSPA或其组合。描述了改进的转染方法的各种应用。

8. 发明申请

WO2007138324A2 MATERIALS AND COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS 审中-公开
标题翻译：将生物活性材料递送到细胞的材料和复合物
公开(公告)号：WO2007138324A2
公开(公告)日：2007-12-06
申请号：PCT/GB2007/002012
申请日：2007-05-30
申请人： UNIVERSITY COLLEGE LONDON , HART, Stephen, Lewis , GROSSE, Stephanie , TABOR, Alethea, Bernice , WONG, John, Bosco , ELBS, Martin , HAILES, Helen, Claire , MOHD MUSTAPA, Mohd, Firouz
发明人： HART, Stephen, Lewis , GROSSE, Stephanie , TABOR, Alethea, Bernice , WONG, John, Bosco , ELBS, Martin , HAILES, Helen, Claire , MOHD MUSTAPA, Mohd, Firouz
IPC分类号： C12N15/88 , A61K47/48 , C07K14/00 , C07C229/30
CPC分类号： A61K9/1271 , A61K9/0019 , A61K38/00 , A61K47/543 , A61K47/64 , A61K47/6455 , A61K47/65 , A61K47/6911 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C07C217/28
摘要： The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG) q - Linker - Spacer - Cationic headgroup - carbon skeleton - (hydrophobic chain) o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q = 1, 2 or 3; o denotes the number of hydrophobic chains and o = 1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.
摘要翻译：本发明提供式A-B-C的肽衍生物，其中A是聚阳离子核酸结合组分; B是对细胞内切割敏感的间隔元件肽; C是细胞表面受体结合成分。本发明还提供通式（I）的脂质衍生物：（PEG） - 连接剂 - 间隔物 - 阳离子头基 - 碳骨架 - （疏水链）其中：接头是一个容易在细胞内裂解的组; Spacer是将Linker与阳离子头组联系起来的组; q表示PEG链的数量，q = 1,2或3; o表示疏水链的数目，o = 1,2或3; 碳骨架是将疏水链与阳离子头基连接的基团。肽和脂质衍生物用于非病毒基因递送系统。

9. 发明申请

WO2004108938B1 PEPTIDE LIGANDS OF DENDRITIC CELLS FOR NUCLEIC ACID VECTOR TARGETING 审中-公开
标题翻译：用于核酸载体靶向的细胞的肽配体
公开(公告)号：WO2004108938B1
公开(公告)日：2005-07-07
申请号：PCT/GB2004002421
申请日：2004-06-07
申请人： ICH PRODUCTIONS LTD , HART STEPHEN LEWIS , WRITER MICHELE
发明人： HART STEPHEN LEWIS , WRITER MICHELE
IPC分类号： A61K48/00 , C07K5/083 , C07K5/117 , C07K7/06 , C12N15/861
CPC分类号： C07K5/1024 , C07K5/081 , C07K7/06
摘要： A peptide consisting of or comprising an amino acid sequence selected from a ) Px X X T [SEQ.ID.NO.:1]; b) PSX S [SEQ.ID.NO. :2]; C) QX X X Q [SEQ.ID.NO.:3]; d) SX S [SEQ-ID.NO.:4], in which X , X and X , which may be the same or different, each represents an amino acid residue; X is preferably N or L; X represents an amino acid residue, preferably N or L; X and X , which may be the same or different, each represents an amino acid residue, X represents an amino acid residue having an amide side chain; and X represent an amino acid having an aliphatic side chain, which peptide binds to dendritic cells and also to other types of cells. The peptide may be used a target non-viral and viral vectors to such cells.
摘要翻译：由选自a）Px X X T [SEQ ID NO：1]的氨基酸序列组成或包含的肽。 b）PSX4S [SEQ.ID.NO. ：2]; C）Q X 5 X 6 Q [SEQ.ID.NO.:3]; d）SX 8 S [SEQ ID NO：4]，其中X 1，X 2和X 3各自可以相同或不同，表示氨基酸残基; X 2优选为N或L; X 4表示氨基酸残基，优选为N或L; X 5和X 7可以相同或不同，各自表示氨基酸残基，X 6表示具有酰胺侧链的氨基酸残基; X 8表示具有脂肪族侧链的氨基酸，该肽与树突细胞结合，也与其它类型的细胞结合。肽可以用于这种细胞的靶非病毒和病毒载体。

10. 发明申请

WO2004108938A2 PEPTIDE LIGANDS 审中-公开
标题翻译：肽配体
公开(公告)号：WO2004108938A2
公开(公告)日：2004-12-16
申请号：PCT/GB2004/002421
申请日：2004-06-07
申请人： ICH PRODUCTIONS LIMITED , HART, Stephen, Lewis , WRITER, Michele
发明人： HART, Stephen, Lewis , WRITER, Michele
IPC分类号： C12N15/861
CPC分类号： C07K5/1024 , C07K5/081 , C07K7/06
摘要： A peptide consisting of or comprising an amino acid sequence selected from a ) Px1X2X3 T [SEQ.ID.NO.:11]; b) PSX4S [SEQ.ID.NO. :2]; C) QX5X6X7Q [SEQ.ID.NO.:3]; d) SX8S [SEQ-ID.NO.:4], in which X1, X2 and X3, which may be the same or different, each represents an amino acid residue; X4 represents an amino acid residue; and x 5 and X7, which may be the same or different, each represents an amino acid residue, X6 represents an amino acid residue having an amide side chain; and X8 represent an amino acid having an aliphatic side chain, which peptide binds to dendritic cells and also to other types of cells. The peptide may be used a target non-viral and viral vectors to such cells.
摘要翻译：由选自以下的氨基酸序列组成或包含的肽：a）Px1X2X3T [SEQ.ID.NO.:11]; b）PSX4S [SEQ.ID.NO. ：2]; C）QX5X6X7Q [SEQ.ID.NO.:3]; d）SX8S [SEQ ID NO：4]，其中X1，X2和X3可以相同或不同，各代表氨基酸残基; X4表示氨基酸残基; 和X 5和X 7可以相同或不同，各代表氨基酸残基，X6表示具有酰胺侧链的氨基酸残基; X8表示具有脂肪族侧链的氨基酸，该肽与树突状细胞结合，也与其他类型的细胞结合。肽可以用于这种细胞的靶非病毒和病毒载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式