专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003094974A1 COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS 审中-公开
标题翻译：用于将生物活性材料递送至细胞的复合物
公开(公告)号：WO2003094974A1
公开(公告)日：2003-11-20
申请号：PCT/GB2003/001985
申请日：2003-05-08
申请人： UNIVERSITY COLLEGE LONDON , HURLEY, Christopher, Antony , HAILES, Helen, Claire , TABOR, Alethea, Bernice , HART, Stephen, Lewis
发明人： HURLEY, Christopher, Antony , HAILES, Helen, Claire , TABOR, Alethea, Bernice , HART, Stephen, Lewis
IPC分类号： A61K47/48
CPC分类号： A61K47/543
摘要： A complex suitable for delivery of a biologically-active material to a cell, which complex comprises: (i) a lipid of general formula (I) or (II): wherein: -X 1 and X 2 are the same or different and are selected from -O-CH 2 -, and -O-C(O)-; -R 1 and R 2 are the same or different and are straight or branched, saturated or unsaturated C 7 to C 24 hydrocarbyl groups which are unsubstituted or substituted by one or more substituents selected from hydroxy, halogen and OR', wherein R' is a C 1 to C 6 hydrocarbyl group; -Each R 3 and each R 4 is the same or different and is a straight or branched, saturated or unsaturated C 1 to C 10 hydrocarbyl group which is unsubstituted or substituted by one or more substituents selected from hydroxy, halogen, -OR', -C(O)OH, -CN, -NR'R", and -C(O)R" wherein R' and R" are the same or different and are C 1 to C 6 hydrocarbyl; (Formula II) Wherein: X 1 and X 2 are the same or different and are as defined above; R 1 and R 2 are the same or different and are as defined above; R 5 is -N ⊕ (R 3 ) 2 -R 6 wherein each R 3 is the same or different and is as defined above and R 6 is either: (a) (Formula A) wherein each Y is the same or different and is -N ⊕ (R 4 ) 2 -, wherein R 4 is as defined above, each A is the same or different and is a C 1 to C 20 alkylene group which is unsubstituted or substituted by one or more substituents selected from hydroxy, halogen, -OR', -C(O)OH, -CN, -NR'R", and -C(O)R" wherein R' and R" are the same or different and are C 1 to C 6 hydrocarbyl, n is from 1 to 10, and R 4 is as defined above; or (b)-(Formula (B) wherein each B is the same or different and is a C 1 to C 10 alkylene group which is unsubstituted or substituted by one or more substituents selected from hydroxy, halogen, -OR', -C(O)OH, -CN, -NR'R" and -C(O)R" wherein R' and R" are the same or different and are C 1 to C 6 hydrocarbyl, m is from 1 to 10, and Q is selected from N ⊕ (R 3 ) 3 , OH, OR', OC(O)R' and halogen, wherein R 3 and R' are as defined above; and (ii) A biologically-active material. Such complexes may be used to deliver biologically active material to a cell, for example in gene therapy and vaccination.
摘要翻译：一种适于将生物活性物质递送至细胞的复合物，该复合物包括：（i）通式（I）或（II）的脂质：其中：-X 1和X 2相同或不同的并且选自-O-CH 2 - 和-OC（O） - ; -R 1和R 2相同或不同，是未取代或被一个或多个选自羟基，卤素和OR'的取代基取代的直链或支链，饱和或不饱和的C 7至C 24烃基，其中R '是C1至C6烃基; - 每个R 3和每个R 4相同或不同，并且是未取代的或被一个或多个选自羟基，卤素-OR的取代基取代的直链或支链，饱和或不饱和的C1至C10烃基 '，-C（O）OH，-CN，-NR'R“和-C（O）R”，其中R'和R“相同或不同，为C 1至C 6烃基;（式II）其中： X 1和X 2相同或不同，如上所定义; R 1和R 2相同或不同，如上所定义; R 5为-N <⊕> （R 3）2 -R 6其中每个R 3相同或不同，如上所定义，R 6是：（a）（式A）其中每个Y相同或不同，为-N≡（R 4）2-，其中R 4如上所定义，各A相同或不同，为未取代的或被一个或多个取代基取代的C 1〜C 20亚烷基选自羟基，卤素，-OR'， - C（O）OH，-CN，-NR'R“和-C（O）R”中的更多取代基，其中R'和R“相同或不同，为C1 至C6氢化芳基，n为1至10，R 4如上定义; 或（b） - （式（B））其中每个B相同或不同，并且是未取代的或被一个或多个选自羟基，卤素，-OR'，-C（O））OH，-CN，-NR'R“和-C（O）R”，其中R'和R“相同或不同，为C1至C6烃基，m为1至10，Q选自N （ⅲ）3，OH，OR'，OC（O）R'和卤素，其中R 3和R'如上所定义;和（ⅱ）生物活性物质，可用于将生物活性物质递送至细胞，例如在基因治疗和疫苗接种中。

2. 发明申请

WO2007138324A3 MATERIALS AND COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS 审中-公开
标题翻译：将生物活性材料递送到细胞的材料和复合物
公开(公告)号：WO2007138324A3
公开(公告)日：2008-03-13
申请号：PCT/GB2007002012
申请日：2007-05-30
申请人： UNIV LONDON , HART STEPHEN LEWIS , GROSSE STEPHANIE , TABOR ALETHEA BERNICE , WONG JOHN BOSCO , ELBS MARTIN , HAILES HELEN CLAIRE , MOHD MUSTAPA MOHD FIROUZ
发明人： HART STEPHEN LEWIS , GROSSE STEPHANIE , TABOR ALETHEA BERNICE , WONG JOHN BOSCO , ELBS MARTIN , HAILES HELEN CLAIRE , MOHD MUSTAPA MOHD FIROUZ
IPC分类号： C12N15/88 , A61K47/48 , A61P35/00 , C07C229/30 , C07K14/00
CPC分类号： A61K9/1271 , A61K9/0019 , A61K38/00 , A61K47/543 , A61K47/64 , A61K47/6455 , A61K47/65 , A61K47/6911 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C07C217/28
摘要： The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG) q - Linker - Spacer - Cationic headgroup - carbon skeleton - (hydrophobic chain) o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q = 1, 2 or 3; o denotes the number of hydrophobic chains and o = 1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.
摘要翻译：本发明提供式A-B-C的肽衍生物，其中A是聚阳离子核酸结合组分; B是对细胞内切割敏感的间隔元件肽; C是细胞表面受体结合成分。本发明还提供通式（I）的脂质衍生物：（PEG） - 连接剂 - 间隔物 - 阳离子头基 - 碳骨架 - （疏水链）其中：接头是一个容易在细胞内裂解的组; Spacer是将Linker与阳离子头组联系起来的组; q表示PEG链的数量，q = 1,2或3; o表示疏水链的数目，o = 1,2或3; 碳骨架是将疏水链与阳离子头基连接的基团。肽和脂质衍生物用于非病毒基因递送系统。

3. 发明申请

WO2005023744A2 CALIXARENES AS INHIBITORS OF PROTEIN KINASE B 审中-公开
标题翻译：作为蛋白激酶B的抑制剂的化合物
公开(公告)号：WO2005023744A2
公开(公告)日：2005-03-17
申请号：PCT/GB2004003858
申请日：2004-09-09
申请人： IMP COLLEGE INNOVATIONS LTD , WOSCHOLSKI RUDIGER , HAILES HELEN CLAIRE , NUMBERE MACBA GOLDA
发明人： WOSCHOLSKI RUDIGER , HAILES HELEN CLAIRE , NUMBERE MACBA GOLDA
IPC分类号： C07C43/225 , C07C217/60 , C07C43/00
CPC分类号： C07C43/225 , C07C217/60
摘要： The present invention provides compounds useful in inhibiting protein kinase B (PKB/Akt). Compositions comprising such compounds and their use are also provided.
摘要翻译：本发明提供了可用于抑制蛋白激酶B（PKB / Akt）的化合物。还提供了包含这些化合物的组合物及其用途。

4. 发明申请

WO2005023744A3 CALIXARENES AS INHIBITORS OF PROTEIN KINASE B 审中-公开
公开(公告)号：WO2005023744A3
公开(公告)日：2005-03-17
申请号：PCT/GB2004/003858
申请日：2004-09-09
申请人： IMPERIAL COLLEGE INNOVATIONS LTD , WOSCHOLSKI, Rudiger , HAILES, Helen, Claire , NUMBERE, Macba, Golda
发明人： WOSCHOLSKI, Rudiger , HAILES, Helen, Claire , NUMBERE, Macba, Golda
IPC分类号： C07C217/60
摘要： The present invention provides compounds useful in inhibiting protein kinase B (PKB/Akt). Compositions comprising such compounds and their use are also provided.

5. 发明申请

WO2007072000A1 SUPRAMOLECULAR POLYMERS 审中-公开
公开(公告)号：WO2007072000A1
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004823
申请日：2006-12-20
申请人： THE SECRETARY OF STATE FOR DEFENCE , BALA, Kason , HAILES, Helen, Claire , LAFITTE, Valerie, Gisele, Helene , ALIEV, Abil , GOLDING, Peter
发明人： BALA, Kason , HAILES, Helen, Claire , LAFITTE, Valerie, Gisele, Helene , ALIEV, Abil , GOLDING, Peter
IPC分类号： C08G81/02
CPC分类号： C08G81/025
摘要： The invention concerns novel cytosine based modules and in particular their application in linear multiple hydrogen bonded arrays to form supramolecular polymers of the formula (II): and the use of these in supramolecular materials.
摘要翻译：本发明涉及新的基于胞嘧啶的模块，特别是其在线性多重氢键阵列中的应用，以形成式（II）的超分子聚合物：以及它们在超分子材料中的应用。

6. 发明申请

WO2007138324A2 MATERIALS AND COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS 审中-公开
标题翻译：将生物活性材料递送到细胞的材料和复合物
公开(公告)号：WO2007138324A2
公开(公告)日：2007-12-06
申请号：PCT/GB2007/002012
申请日：2007-05-30
申请人： UNIVERSITY COLLEGE LONDON , HART, Stephen, Lewis , GROSSE, Stephanie , TABOR, Alethea, Bernice , WONG, John, Bosco , ELBS, Martin , HAILES, Helen, Claire , MOHD MUSTAPA, Mohd, Firouz
发明人： HART, Stephen, Lewis , GROSSE, Stephanie , TABOR, Alethea, Bernice , WONG, John, Bosco , ELBS, Martin , HAILES, Helen, Claire , MOHD MUSTAPA, Mohd, Firouz
IPC分类号： C12N15/88 , A61K47/48 , C07K14/00 , C07C229/30
CPC分类号： A61K9/1271 , A61K9/0019 , A61K38/00 , A61K47/543 , A61K47/64 , A61K47/6455 , A61K47/65 , A61K47/6911 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C07C217/28
摘要： The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG) q - Linker - Spacer - Cationic headgroup - carbon skeleton - (hydrophobic chain) o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q = 1, 2 or 3; o denotes the number of hydrophobic chains and o = 1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.
摘要翻译：本发明提供式A-B-C的肽衍生物，其中A是聚阳离子核酸结合组分; B是对细胞内切割敏感的间隔元件肽; C是细胞表面受体结合成分。本发明还提供通式（I）的脂质衍生物：（PEG） - 连接剂 - 间隔物 - 阳离子头基 - 碳骨架 - （疏水链）其中：接头是一个容易在细胞内裂解的组; Spacer是将Linker与阳离子头组联系起来的组; q表示PEG链的数量，q = 1,2或3; o表示疏水链的数目，o = 1,2或3; 碳骨架是将疏水链与阳离子头基连接的基团。肽和脂质衍生物用于非病毒基因递送系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式