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1. 发明申请

WO2004000811A1 ARYLSULFONYLHYDROXAMIC ACID AND AMIDE DERIVATIVES AND THEIR USE AS PROTEASE INHIBITORS 审中-公开
标题翻译： ARYLSULFONYLHYDROXAMICIC酸和酰胺衍生物及其作为蛋白酶抑制剂的用途
公开(公告)号：WO2004000811A1
公开(公告)日：2003-12-31
申请号：PCT/US2003/020028
申请日：2003-06-25
申请人： PHARMACIA CORPORATION , CHEN, Yiyuan , FRESKOS, John, N. , GASIECKI, Alan, F. , GRAPPERHAUS, Margaret, L. , HANSEN, Donald, W., Jr. , HEINTZ, Robert, M. , KHANNA, Ish, K. , KOLODZIEJ, Steve, A. , MANTEGANI, Sergio , MASSA, Mark, A. , MCDONALD, Joseph, J. , MISCHKE, Deborah, A. , NAGY, Mark, A. , PERRONE, Ettore , SCHMIDT, Michelle, A. , SPANGLER, Dale, P. , TALLEY, John, J. , TRIVEDI, Mahima , WYNN, Thomas, A. , BECKER, Daniel, P. , RICO, Joseph, G.
发明人： CHEN, Yiyuan , FRESKOS, John, N. , GASIECKI, Alan, F. , GRAPPERHAUS, Margaret, L. , HANSEN, Donald, W., Jr. , HEINTZ, Robert, M. , KHANNA, Ish, K. , KOLODZIEJ, Steve, A. , MANTEGANI, Sergio , MASSA, Mark, A. , MCDONALD, Joseph, J. , MISCHKE, Deborah, A. , NAGY, Mark, A. , PERRONE, Ettore , SCHMIDT, Michelle, A. , SPANGLER, Dale, P. , TALLEY, John, J. , TRIVEDI, Mahima , WYNN, Thomas, A. , BECKER, Daniel, P. , RICO, Joseph, G.
IPC分类号： C07D213/34
CPC分类号： C07D241/12 , C07C317/46 , C07D211/66 , C07D213/34 , C07D309/08 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： This invention is directed generally to hydroxamic acid and amide compounds (including salts of such compounds), and, more particularly, to aryl- and heteroaryl-arylsulfonylmethyl hydroxamic acids and amides that, inter alia , inhibit protease activity, particularly matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. These compounds generally correspond in structure to formula (I): wherein A l , A 2 , A 3 , E l , E 2 , E 3 , and E 4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly pathological conditions.
摘要翻译：本发明一般涉及异羟肟酸和酰胺化合物（包括这些化合物的盐），更具体地说，涉及芳基 - 和杂芳基 - 芳基磺酰基甲基异羟肟酸和酰胺，其特别是抑制蛋白酶活性，特别是基质金属蛋白酶作为“基质金属蛋白酶”或“MMP”）活性和/或蛋白聚糖蛋白聚糖酶活性。这些化合物通常在结构上对应于式（I）：其中A 1，A 2，A 3，E 11，E 2，E 3和E 4如在该专利中定义。本发明还涉及这些化合物的组合物，用于合成这些化合物的中间体，制备这些化合物的方法，以及用于治疗与MMP活性和/或蛋白聚糖蛋白聚糖酶活性特别是病理状况相关的病症的方法。

2. 发明申请

WO1996035677A1 NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES 审中-公开
标题翻译：从循环载体衍生的氮氧化物合成酶抑制剂
公开(公告)号：WO1996035677A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006831
申请日：1996-05-09
申请人： G.D. SEARLE & CO. , HANSEN, Donald, W., Jr. , HAGEN, Timothy, J. , KRAMER, Steven, W. , METZ, Suzanne , PETERSON, Karen, B. , SPANGLER, Dale, P. , TOTH, Mihaly, V. , FOK, Kam, F. , WEBBER, R., Keith , TJOENG, Foe, S. , PITZELE, Barnett, S. , HALLINAN, E., Ann
发明人： G.D. SEARLE & CO.
IPC分类号： C07D223/12
CPC分类号： C07D403/06 , C07D207/22 , C07D207/24 , C07D211/72 , C07D211/74 , C07D223/12 , C07D243/08 , C07D267/10 , C07D413/06 , C07D413/12 , C07D471/10
摘要： Compounds having formula (I) wherein R , R , R and R are hydrogen or certain specified substituents; R and R are independently hydrogen, hydroxy or alkoxy; and X, A and B are independently NR , O, S, SO, SO2, CH=CH or (CH2)p, p being 0-6; are useful as nitric oxide synthase inhibitors.
摘要翻译：具有式（I）的化合物，其中R 1，R 5，R 6和R 7是氢或某些特定的取代基; R 8和R 9独立地是氢，羟基或烷氧基; 并且X，A和B独立地为NR 2，O，S，SO，SO 2，CH = CH或（CH 2）p，p为0-6; 可用作一氧化氮合酶抑制剂。

3. 发明申请

WO9946240A3 HALOGENATED AMIDINO AMINO ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：用作氮氧化物合成酶抑制剂的氢化氨基酸氨基酸衍生物
公开(公告)号：WO9946240A3
公开(公告)日：1999-11-11
申请号：PCT/US9903728
申请日：1999-03-04
申请人： SEARLE & CO , HALLINAN E ANN , PITZEL BARNETT S , SPANGLER DALE P , BERGMANIS ARIJA A , HAGEN TIMOTHY J , TSYMBALOV SOFYA , TOTH MIHALY V , WEBBER R KEITH , HANSEN DONALD W JR , AWASTHI ALIK K
发明人： HALLINAN E ANN , PITZEL BARNETT S , SPANGLER DALE P , BERGMANIS ARIJA A , HAGEN TIMOTHY J , TSYMBALOV SOFYA , TOTH MIHALY V , WEBBER R KEITH , HANSEN DONALD W JR , AWASTHI ALIK K
IPC分类号： C07D333/38 , A61K20060101 , A61K31/00 , A61K31/155 , A61K31/198 , A61K31/38 , A61K31/381 , A61K31/55 , A61P9/00 , A61P43/00 , C07C20060101 , C07C233/58 , C07C257/14 , C07C323/00 , C07C323/58 , C07D20060101 , C07D333/24
CPC分类号： C07D333/24 , C07C257/14 , C07C323/58 , C07C2601/02
摘要： Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors of Formula (I) or a pharmaceutically acceptable salt thereof, wherein all substituents are described in the specification.
摘要翻译：可用作式（I）的一氧化氮合酶抑制剂的卤代脒基氨基酸衍生物或其药学上可接受的盐，其中所有取代基在说明书中描述。

4. 发明申请

WO1997032844A1 HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：用作氧化氮合酶抑制剂的羟基氨基衍生物
公开(公告)号：WO1997032844A1
公开(公告)日：1997-09-12
申请号：PCT/US1997003282
申请日：1997-03-05
申请人： G.D. SEARLE & CO. , GAPUD, Rolando, E. , HAGEN, Timothy, J. , HALLINAN, E., Ann , HANSEN, Donald, W., Jr. , MANNING, Robert, E. , METZ, Suzanne, S. , PITZELE, Barnett, S. , TJOENG, Foe, S. , TOTH, Mihaly, V. , WEBBER, Keith, R.
发明人： G.D. SEARLE & CO.
IPC分类号： C07C259/14
CPC分类号： C07D261/08 , C07C257/14 , C07C259/14 , C07C275/16 , C07C313/28 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07F7/081
摘要： The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
摘要翻译：本发明公开了可用作一氧化氮合酶抑制剂的羟基脒基衍生物。

5. 发明申请

WO2004048368A3 HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS 审中-公开
标题翻译：羟丙基甲基羟乙酸和氨基酸及其作为蛋白酶抑制剂的用途
公开(公告)号：WO2004048368A3
公开(公告)日：2004-08-12
申请号：PCT/US0337942
申请日：2003-11-24
申请人： PHARMACIA CORP , BECKER DANIEL P , CARROLL JEFFERY N , FOBIAN YVETTE M , GRAPPERHAUS MARGARET L , HANSEN DONALD W JR , HEINTZ ROBERT M , KASSAB DARREN J , MASSA MARK A , MCDONALD JOSEPH J , NAGY MARK A , PITZELE BARNETT S , RICO JOSEPH G , SCHMIDT MICHELLE A , SPANGLER DALE P
发明人： BECKER DANIEL P , CARROLL JEFFERY N , FOBIAN YVETTE M , GRAPPERHAUS MARGARET L , HANSEN DONALD W JR , HEINTZ ROBERT M , KASSAB DARREN J , MASSA MARK A , MCDONALD JOSEPH J , NAGY MARK A , PITZELE BARNETT S , RICO JOSEPH G , SCHMIDT MICHELLE A , SPANGLER DALE P
IPC分类号： A61P9/10 , A61P19/00 , A61P35/00 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04 , A61K31/41 , A61K31/425 , A61K31/435
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： This invention is directed generally to heteroarylsulfonylmethyl hydroxamic acids and amides that, inter alia, tend to inhibit protease activity, particularly matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to compositions of such compounds; intermediates for the syntheses of such compounds; methods for making such compounds; and methods for treating conditions associated with MMP, tumor necrosis factors (or "TNFs"), and/or aggrecanase activity, particularly pathological conditions.
摘要翻译：本发明通常涉及杂芳基磺酰基甲基异羟肟酸和酰胺，其特别是倾向于抑制蛋白酶活性，特别是基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP”）活性和/或软骨聚集蛋白聚糖酶活性。本发明还涉及这些化合物的组合物; 用于合成这些化合物的中间体; 制备这些化合物的方法; 以及用于治疗与MMP相关的病症，肿瘤坏死因子（或“TNFs”）和/或软骨聚集蛋白聚糖酶活性，特别是病理状况的方法。

6. 发明申请

WO2004048368A2 HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS 审中-公开
标题翻译：杂芳基磺酰基甲基羟肟酸和酰胺及其作为蛋白酶抑制剂的用途
公开(公告)号：WO2004048368A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/037942
申请日：2003-11-24
申请人： PHARMACIA CORPORATION , BECKER, Daniel, P. , CARROLL, Jeffery, N. , FOBIAN, Yvette, M. , GRAPPERHAUS, Margaret, L. , HANSEN, Donald, W., Jr. , HEINTZ, Robert, M. , KASSAB, Darren, J. , MASSA, Mark, A. , MCDONALD, Joseph, J. , NAGY, Mark, A. , PITZELE, Barnett, S. , RICO, Joseph, G. , SCHMIDT, Michelle, A. , SPANGLER, Dale, P.
发明人： BECKER, Daniel, P. , CARROLL, Jeffery, N. , FOBIAN, Yvette, M. , GRAPPERHAUS, Margaret, L. , HANSEN, Donald, W., Jr. , HEINTZ, Robert, M. , KASSAB, Darren, J. , MASSA, Mark, A. , MCDONALD, Joseph, J. , NAGY, Mark, A. , PITZELE, Barnett, S. , RICO, Joseph, G. , SCHMIDT, Michelle, A. , SPANGLER, Dale, P.
IPC分类号： C07D409/00
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： This invention is directed generally to heteroarylsulfonylmethyl hydroxamic acids and amides that, inter alia, tend to inhibit protease activity, particularly matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to compositions of such compounds; intermediates for the syntheses of such compounds; methods for making such compounds; and methods for treating conditions associated with MMP, tumor necrosis factors (or "TNFs"), and/or aggrecanase activity, particularly pathological conditions.
摘要翻译：本发明通常涉及杂芳基磺酰基甲基异羟肟酸和酰胺，其特别倾向于抑制蛋白酶活性，特别是基质金属蛋白酶（也称为“基质金属蛋白酶”或 “MMP”）活性和/或聚集蛋白聚糖酶活性。本发明还涉及这些化合物的组合物; 用于合成这些化合物的中间体; 制造这种化合物的方法; 和治疗与MMP，肿瘤坏死因子（或“TNF”）和/或聚集蛋白聚糖酶活性，特别是病理学病症有关的病症的方法。

7. 发明申请

WO0063195A8 NOVEL HETEROCYCLIC AMINO CARBONYL DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：用作氮氧化物合成酶抑制剂的新型杂环氨基羰基衍生物
公开(公告)号：WO0063195A8
公开(公告)日：2001-03-22
申请号：PCT/US0008735
申请日：2000-04-17
申请人： SEARLE & CO , WEBBER R KEITH , RUEPPEL MELVIN L , HANSEN DONALD W JR , HALLINAN E ANN , HAGEN TIMOTHY J , PITZELE BARNETT S
发明人： WEBBER R KEITH , RUEPPEL MELVIN L , HANSEN DONALD W JR , HALLINAN E ANN , HAGEN TIMOTHY J , PITZELE BARNETT S
IPC分类号： C07D239/54 , C07D243/04 , C07D271/06 , C07D271/07 , C07D273/00 , C07D273/06 , C07D273/08 , C07D285/00 , C07D285/15 , C07D291/02 , C07D291/04 , C07D291/06 , C07D403/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D487/04 , C07F9/6584 , C07F9/6587 , A61K31/33 , A61K31/675 , A61K31/695 , A61P9/00 , C07F7/18
CPC分类号： C07D291/04 , C07D239/54 , C07D243/04 , C07D271/07 , C07D273/00 , C07D273/06 , C07D285/15 , C07D291/02 , C07D291/06 , C07D403/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D487/04 , C07F9/65844 , C07F9/6587
摘要： The current invention discloses novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors
摘要翻译：本发明公开了用作一氧化氮合酶抑制剂的新型杂环氨基羰基衍生物

8. 发明申请

WO1997003947A1 PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE 审中-公开
标题翻译：乙基3S- [[4 - [[4-（氨基亚氨基）苯基]氨基] -1,4-二氧代丁基]氨基] -4-戊酸的制备方法
公开(公告)号：WO1997003947A1
公开(公告)日：1997-02-06
申请号：PCT/US1996010658
申请日：1996-07-12
申请人： G.D. SEARLE & CO. , BABIAK, Kevin, A. , BABU, Srinivasan , BEHLING, James, R. , BOYS, Mark, L. , CAIN-JANICKI, Kimberly, J. , DOUBLEDAY, Wendell, W. , FARID, Payman , HAGEN, Timothy, J. , HALLINAN, E., Ann , HANSEN, Donald, W., Jr. , KORTE, Donald, E. , MC LAUGHLIN, Kathleen, T. , MEDICH, John, R. , NUGENT, Sean, T. , ORLOVSKI, Vlasdislav , PARK, Jung, M. , PETERSON, Karen, B. , PILIPAUSKAS, Daniel, R. , PITZELE, Barnett, S. , TSYMBALOV, Sofya , STAHL, Glenn, L.
发明人： G.D. SEARLE & CO.
IPC分类号： C07C249/12
CPC分类号： C07C227/12 , C07C227/34 , C07C257/18
摘要： The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)-phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate and pharmaceutically acceptable acid addition salt thereof which comprises treating (trimethylsilyl)acetylene sequentially with n-butyllitium and 4-formylmorpholine followed by acid hydrolysis to give 3-(trimethylsilyl)-2-propynal; treating 3-(trimethylsilyl)-2-propynal with lithium bis(trimethylsilyl)amide to give in situ N,3-bis(trimethylsilyl)-2-propyn-1-imine; condensation of N,3-bis(trimethylsilyl)-2-propyn-1-imine with lithium t-butyl acetate to give (+/-)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate; treating (+/-)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate- with p-toluenesulfonic acid to give (+/-)1,1-dimethylethyl 3-amin-5-(trimethylsilyl)-4-pentynoate, mono p-toluenesulfonic acid salt, treatment of resulting salt with ethanol in the presence of p-toluenesulfonic acid to give (+/-)ethyl 3-amino-5-(trimethylsilyl)-4-pentynoate; desilylation of (+/-)ethyl 3-amino-5-(trimethylsilyl)-4-pentynoate to give in situ (+/-)ethyl 3-amino-4-pentynoate; resolution of (+/-)ethyl 3-amino-4-pentynoate using (R)-(-)-mandelic acid and treatment of the resolved product with gaseous hydrochloric acid to give ethyl 3S-amino-4-pentynoate, monohydrochloride; coupling the ethyl 3S-amino-4-pentynoate, monohydrochloride to 4-[[4-(aminoiminomethyl)phenyl]amino]-4-oxobutanoic acid, monohydrochloride in the presence of isobutyl chloroformate and N-methylmorpholine to give ethyl 3S-[[4-[[4-(aminoiminomehtyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate, monohydrochloride.
摘要翻译：本发明涉及制备3S - [[4 - [[4-（氨基亚氨基甲基） - 苯基]氨基] -1,4-二氧代丁基]氨基] -4-戊酸乙酯和药学上可接受的酸加成盐的新方法其包括依次用正丁基鎓和4-甲酰基吗啉处理（三甲基甲硅烷基）乙炔，然后酸水解，得到3-（三甲基甲硅烷基）-2-丙炔醛; 用双（三甲基甲硅烷基）氨基锂处理3-（三甲基甲硅烷基）-2-丙炔醛，得到原位N，3-二（三甲基甲硅烷基）-2-丙炔-1-亚胺; N，3-二（三甲基甲硅烷基）-2-丙炔-1-亚胺与乙酸叔丁酯的缩合得到3-氨基-5-（三甲基甲硅烷基）-4-戊炔酸（+/-）1,1-二甲基乙酯; 用对甲苯磺酸处理（+/-）3-氨基-5-（三甲基甲硅烷基）-4-戊酸乙酯（+/-）1,1-二甲基乙基酯，得到3-氨基-5-（三甲基甲硅烷基）-4-戊酸酯，单对甲苯磺酸盐，在对甲苯磺酸存在下用乙醇处理所得的盐，得到（+/-）3-氨基-5-（三甲基甲硅烷基）-4-戊酸乙酯; （+/-）乙基3-氨基-5-（三甲基甲硅烷基）-4-戊酸乙酯脱甲硅烷基，得到原位（+/-）3-氨基-4-戊酸乙酯; 使用（R） - （ - ） - 扁桃酸分解（+/-）乙基3-氨基-4-戊炔酸，并用气态盐酸处理分离产物，得到3S-氨基-4-戊酸乙酯，一盐酸盐; 将3S-氨基-4-戊酸乙酯，一盐酸盐在氯甲酸异丁酯和N-甲基吗啉存在下，将4 - [[4-（氨基亚氨基甲基）苯基]氨基] -4-氧代丁酸单盐酸盐偶合，得到3S- [ 4 - [[4-（氨基亚氨基甲基）苯基]氨基] -1,4-二氧代丁基]氨基] -4-戊酸乙酯，一盐酸盐。

9. 发明申请

WO1996015120A1 AMINOTETRAZOLE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：用作氮氧化物合成酶抑制剂的氨基三唑衍生物
公开(公告)号：WO1996015120A1
公开(公告)日：1996-05-23
申请号：PCT/US1995014001
申请日：1995-11-08
申请人： G.D. SEARLE & CO. , HALLINAN, E., Ann , HANSEN, Donald, W., Jr. , TSYMBALOV, Sofya
发明人： G.D. SEARLE & CO.
IPC分类号： C07D257/06
CPC分类号： C07D239/42 , C07D231/40 , C07D233/88 , C07D249/14 , C07D257/06 , C07D277/18 , C07D277/46
摘要： Compounds having formula (I) and pharmaceutically acceptable salts thereof, wherein B is NR R , wherein R is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl and aryl, and R is selected from a 3 to 8 member heterocyclyl radical in which at least one member of the ring is carbon and in which 1 to about 4 members are heteroatoms independently selected from oxygen, nitrogen and sulfur and said heterocyclyl radical may be optionally substituted, useful as nitric oxide synthase inhibitors.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐，其中B为NR 5 R 11，其中R 5选自氢，低级烷基，低级烯基，低级炔基和芳基，和 R 11选自3至8个杂环基，其中至少一个环的成员是碳，并且其中1至约4个成员是独立地选自氧，氮和硫的杂原子，并且所述杂环基可以是任选的取代，可用作一氧化氮合酶抑制剂。

10. 发明申请

WO1995011231A1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：氨氮衍生物作为氮氧化物合成酶抑制剂有用
公开(公告)号：WO1995011231A1
公开(公告)日：1995-04-27
申请号：PCT/US1994011832
申请日：1994-10-20
申请人： G. D. SEARLE & CO. , HANSEN, Donald, W., Jr. , CURRIE, Mark, G. , HALLINAN, E., Ann , FOK, Kam, F. , HAGEN, Timothy, J. , BERGMANIS, Arija, A. , KRAMER, Steven, W. , LEE, Len, F. , METZ, Suzanne , MOORE, William, M. , PETERSON, Karen, B. , PITZELE, Barnett, S. , SPANGLER, Dale, P. , WEBBER, R., Keith , TOTH, Mihaly, V. , TRIVEDI, Mahima , TJOENG, Foe, S.
发明人： G. D. SEARLE & CO.
IPC分类号： C07D207/22
CPC分类号： C07D213/06 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , C07D207/22 , C07D209/44 , C07D211/72 , C07D211/74 , C07D215/38 , C07D217/22 , C07D221/22 , C07D221/24 , C07D223/12 , C07D225/02 , C07D233/46 , C07D239/12 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06 , C07D405/06
摘要： The current invention discloses useful pharmaceutical compositions containing amidino derivatives of formula (I) as nitric oxide synthase inhibitors.
摘要翻译：本发明公开了含有式（I）的脒基衍生物作为一氧化氮合酶抑制剂的有用的药物组合物。

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