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1. 发明申请

WO2011071259A3 METHOD FOR CULTURING MYCOPLASMA CONTAMINATION-FREE CELLS AND METHOD FOR REMOVING MYCOPLASMA CONTAMINATION OF CELLS 审中-公开
标题翻译：培养霉菌无污染细胞的方法和消除细胞的巨噬细胞污染的方法
公开(公告)号：WO2011071259A3
公开(公告)日：2011-11-10
申请号：PCT/KR2010008342
申请日：2010-11-24
申请人： CELLSAFE CO LTD , HAN JAE-JIN
发明人： HAN JAE-JIN
IPC分类号： C12N1/38 , C07D309/10 , C12N1/14
CPC分类号： C12N5/0602 , C12N5/0018 , C12N2500/76
摘要： The present invention provides a method for culturing cells, which is able to prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, the present invention provides a method for removing mycoplasma contamination of the cells, comprising a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.
摘要翻译：本发明提供一种培养细胞的方法，其通过使用通过培养具有蚜虫生产力的菌株获得的生物质提取物培养细胞来防止支原体污染的可能性，所述生物质提取物优选为诸如Amphidinium klebsii，Amphididinium carterae等的菌株属于鞭毛体，或使用从提取物中获得的部分; 以及通过使用两性霉素衍生物培养被支原体污染的细胞来去除细胞的支原体污染的方法。此外，本发明提供了一种去除细胞支原体污染的方法，其包括单细胞分离酶溶液处理和细胞聚集体去除的组合。

2. 发明申请

WO2006011719A1 N-SUBSTITUTED-SULFAMOYLBENZOIC ACID DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N-取代的磺酰苯甲酸衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2006011719A1
公开(公告)日：2006-02-02
申请号：PCT/KR2005/002257
申请日：2005-07-13
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
发明人： KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
IPC分类号： C07D413/12
CPC分类号： C07D295/135 , C07D413/12 , C07D413/14
摘要： The present invention relates to N -substituted-sulfamoylbenzoic acid derivatives useful as an antiviral agent, and more particularly the present invention relates to novel N -substituted-sulfamoylbenzoic acid derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The N -substituted-sulfamoylbenzoic acid derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的N-取代氨磺酰基苯甲酸衍生物，更具体地说，本发明涉及对丙型肝炎病毒（HCV）和药学上复制具有优异抑制作用的新型N-取代氨磺酰基苯甲酸衍生物其可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的N-取代氨磺酰基苯甲酸衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

3. 发明申请

WO2010085091A3 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C, COMPRISING THE ROOTS EXTRACT OF PLATYCODON GRANDIFLORUM OR PLATYCODON GRANDIFLORUM SAPONIN COMPONENTS 审中-公开
标题翻译：用于预防或治疗丙型肝炎的药物组合物，包含巨大葛根或巨大葛根素皂苷元组份的根提取物
公开(公告)号：WO2010085091A3
公开(公告)日：2010-11-25
申请号：PCT/KR2010000376
申请日：2010-01-21
申请人： B & C BIOPHARM CO LTD , KIM JONG WOO , LEE SANG WOOK , HAN JAE JIN , PARK SANG JIN , SHIN JUNG CHEUL , YANG JAE WON , LEE YOUNG CHUN , PARK BYOUNG KEUN
发明人： KIM JONG WOO , LEE SANG WOOK , HAN JAE JIN , PARK SANG JIN , SHIN JUNG CHEUL , YANG JAE WON , LEE YOUNG CHUN , PARK BYOUNG KEUN
IPC分类号： A61K36/346 , A61P31/12
CPC分类号： A61K36/346 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition for preventing or treating Hepatitis C, comprising the roots extract of Platycodon grandiflorum and/or saponin components in Platycodon grandiflorum useful as an antiviral agent. The composition of the present invention has no harm to human and inhibits the proliferation of Hepatitis C virus, so that it can be effectively used as a preventive or therapeutic agent for Hepatitis C.
摘要翻译：本发明涉及用于预防或治疗丙型肝炎的药物组合物，其包含可用作抗病毒剂的桔梗中的桔梗和/或皂苷成分的根提取物。本发明的组合物对人体无害并且抑制丙型肝炎病毒的增殖，因此可以有效地用作丙型肝炎的预防或治疗剂。

4. 发明申请

WO2007061254A1 GENISTEIN DERIVATIVES AND ANTI-FUNGAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：基因衍生物和含有该衍生物的抗真菌组合物
公开(公告)号：WO2007061254A1
公开(公告)日：2007-05-31
申请号：PCT/KR2006/004979
申请日：2006-11-24
申请人： B & C BIOPHARM. CO., LTD. , KIM, Jong Woo , HAN, Jae Jin , PARK, Eul Yong , SUH, Joo Won , YOON, Tae Mi , KIM, Won Gon , KWON, Hyung Jin
发明人： KIM, Jong Woo , HAN, Jae Jin , PARK, Eul Yong , SUH, Joo Won , YOON, Tae Mi , KIM, Won Gon , KWON, Hyung Jin
IPC分类号： C07D405/12
CPC分类号： C07H17/07
摘要： Genistein derivative compound, method for producing the same from Kitasatospora kifunensis strain, anti-fungal composition containing the same and Kitasatospora kifunensis MJM-341 (accession number: KCCM- 10710P) are disclosed. The compound of the invention has excellent anti-fungal activity and low toxicity, which is useable as anti-fungal medicine.
摘要翻译：染料木黄素衍生物化合物，其生产方法由北起氏菌属菌株，含有该菌株的抗真菌组合物和北卡多西菌属MJM-341（登录号：KCCM-10710P）。本发明化合物具有优异的抗真菌活性和低毒性，可用作抗真菌药物。

5. 发明申请

WO2006137706A1 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 6-（4-取代的苯胺基）吡嗪衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2006137706A1
公开(公告)日：2006-12-28
申请号：PCT/KR2006/002416
申请日：2006-06-22
申请人： B & C BIOPHARM. CO., LTD. , KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
发明人： KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
IPC分类号： C07D413/14 , A61K31/00 , A61P31/12
CPC分类号： C07D239/48 , C07D403/12 , C07D417/12
摘要： 6-(4-substituted-anilino)pyrimidine derivatives represented by Formula 1 having an excellent inhibitory effect on replication of Hepatitis C virus (HCV) or pharmaceutically acceptable salts thereof, a method for preparing thereof and an antiviral pharmaceutical composition comprising the same. The novel 6-(4-substituted- anilino)pyrimidine derivatives represented by Formula 1 have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and low toxicity thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：具有对丙型肝炎病毒（HCV）复制的抑制作用优异的式1表示的6-（4-取代苯胺基）嘧啶衍生物或其药学上可接受的盐，其制备方法和含有该丙烯酰胺的抗病毒药物组合物。由式1表示的新型6-（4-取代 - 苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，低毒性，因此可有利地用作丙型肝炎的治疗或预防剂。

6. 发明申请

WO2004108068A3 4-[4-(4-MORPHOLINO)ANILINO]PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 4- [4-（4-吗啉基）苯胺基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108068A3
公开(公告)日：2005-02-17
申请号：PCT/KR2004001297
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/12 , A61K20060101
CPC分类号： C07D239/47
摘要： The present invention relates to 4-[4-(4-morpholino)anilino]pyrimidine derivatives useful as an antiviral agent, and more particularly novel 4-[4-(4-morpholino)anilino]pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula I: in which R1 represents C1-C4 straight or branched alkoxy group, -NR2R3 group or 4-(R4)-piperazin-l-yl group; R2 represents hydrogen or C1-C4 straight or branched alkyl group; R3 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C1-C4 straight or branched alkyl group substituted by C2-C6 straight or branched dialkylamino group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; R4 represents C1-C4 straight or branched alkoxycarbonylmethyl group, carboxymethyl group or -CH2-CO-NH-R5 group; and R5 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C3-C6 cycloalkyl group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 4-[4-(4-morpholino)anilino]pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型4- [4-（4-吗啉代）苯胺基]嘧啶衍生物由下式I表示的丙型肝炎病毒（HCV）：其中R1表示C1-C4直链或支链烷氧基，-NR2R3基或4-（R4） - 哌嗪-1-基; R2表示氢或C1-C4直链或支链烷基; R3表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C2-C6直链或支链二烷基氨基取代的C1-C4直链或支链烷基或被杂环取代的C1-C4直链或支链烷基环; R4表示C1-C4直链或支链烷氧基羰基甲基，羧甲基或-CH2-CO-NH-R5基团; R5表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，C3-C6环烷基或被杂环取代的C1-C4直链或支链烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

7. 发明申请

WO2004108068A2 4-[4-(4-MORPHOLINO)ANILINO]PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 4- [4-（4-吗啉基）苯胺基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108068A2
公开(公告)日：2004-12-16
申请号：PCT/KR2004/001297
申请日：2004-06-01
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
发明人： KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
IPC分类号： A61K
CPC分类号： C07D239/47
摘要： The present invention relates to 4-[4-(4-morpholino)anilino]pyrimidine derivatives useful as an antiviral agent, and more particularly novel 4-[4-(4-morpholino)anilino]pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula I: in which R 1 represents C 1 -C 4 straight or branched alkoxy group, -NR 2 R 3 group or 4-(R 4 )-piperazin-l-yl group; R 2 represents hydrogen or C 1 -C 4 straight or branched alkyl group; R 3 represents C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched hydroxyalkyl group, C 1 -C 4 straight or branched alkyl group substituted by C 2 -C 6 straight or branched dialkylamino group or C 1 -C 4 straight or branched alkyl group substituted by heterocyclic ring; R 4 represents C 1 -C 4 straight or branched alkoxycarbonylmethyl group, carboxymethyl group or -CH 2 -CO-NH-R 5 group; and R 5 represents C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched hydroxyalkyl group, C 3 -C 6 cycloalkyl group or C 1 -C 4 straight or branched alkyl group substituted by heterocyclic ring; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 4-[4-(4-morpholino)anilino]pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型4- [4-（4-吗啉代）苯胺基]嘧啶衍生物由下式I表示的丙型肝炎病毒（HCV）：其中R1表示C1-C4直链或支链烷氧基，-NR2R3基或4-（R4） - 哌嗪-1-基; R2表示氢或C1-C4直链或支链烷基; R3表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C2-C6直链或支链二烷基氨基取代的C1-C4直链或支链烷基或被杂环取代的C1-C4直链或支链烷基环; R4表示C1-C4直链或支链烷氧基羰基甲基，羧甲基或-CH2-CO-NH-R5基团; R5表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，C3-C6环烷基或被杂环取代的C1-C4直链或支链烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

8. 发明申请

WO2011136513A3 BONE-TRANSPLANT OR BONE-FILLING COMPOSITION COMPRISING A DIHYDROXYBENZOIC ACID DERIVATIVE 审中-公开
标题翻译：含有二羟基苯甲酸衍生物的骨髓移植物或骨填充组合物
公开(公告)号：WO2011136513A3
公开(公告)日：2012-03-22
申请号：PCT/KR2011002975
申请日：2011-04-25
申请人： CELLSAFE CO LTD , HAN JAE-JIN
发明人： HAN JAE-JIN
IPC分类号： A61F2/28 , A61C8/00 , A61F2/30 , C07C65/05
CPC分类号： A61C8/0006 , A61L27/50 , A61L2430/02 , A61L2430/12 , C07C65/03 , C07C69/84
摘要： Provided is a bone-transplant or bone-filling composition, which comprises a dihydroxybenzoic acid derivative which has been newly demonstrated to increase the activity of osteoblasts and so induce bone formation.
摘要翻译：提供了一种骨移植或骨填充组合物，其包含已被新证实增加成骨细胞活性并因此诱导骨形成的二羟基苯甲酸衍生物。

9. 发明申请

WO2010085091A2 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C, COMPRISING THE ROOTS EXTRACT OF PLATYCODON GRANDIFLORUM OR PLATYCODON GRANDIFLORUM SAPONIN COMPONENTS 审中-公开
标题翻译：用于预防或治疗HEPATITIS C的药物组合物，包括平板ON ON UM UM THE THE THE ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS
公开(公告)号：WO2010085091A2
公开(公告)日：2010-07-29
申请号：PCT/KR2010/000376
申请日：2010-01-21
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong Woo , LEE, Sang Wook , HAN, Jae Jin , PARK, Sang Jin , SHIN, Jung Cheul , YANG, Jae Won , LEE, Young Chun , PARK, Byoung Keun
发明人： KIM, Jong Woo , LEE, Sang Wook , HAN, Jae Jin , PARK, Sang Jin , SHIN, Jung Cheul , YANG, Jae Won , LEE, Young Chun , PARK, Byoung Keun
IPC分类号： A61K36/346 , A61P31/12
CPC分类号： A61K36/346 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition for preventing or treating Hepatitis C, comprising the roots extract of Platycodon grandiflorum and/or saponin components in Platycodon grandiflorum useful as an antiviral agent. The composition of the present invention has no harm to human and inhibits the proliferation of Hepatitis C virus, so that it can be effectively used as a preventive or therapeutic agent for Hepatitis C.
摘要翻译：本发明涉及一种用于预防或治疗丙型肝炎的药物组合物，其包含用作抗病毒剂的桔梗中的桔梗和/或皂角苷组分的根提取物。本发明的组合物对人体无害，抑制丙型肝炎病毒的增殖，因此可有效地用作丙型肝炎的预防或治疗剂。

10. 发明申请

WO2004108719A9 2-[2-(4-MORPHOLINO)ETHYLAMINO]PYRIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 2- [2-（4-吗啉基）乙基氨基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108719A9
公开(公告)日：2005-07-28
申请号：PCT/KR2004001298
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/14 , C07D213/74
CPC分类号： C07D213/74
摘要： The present invention relates to 2-[2-(4-morpholino)ethylamino]pyridine derivatives useful as an antiviral agent, and more particularly novel 2-[2-(4-morpholino)ethylamino]pyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula (I) in which R1 and R2 represent respectively C1-C4 straight or branched alkyl group, C1-C4 straight or branched alkoxy group, methylthio group, trifluoromethyl group, halogen atom, or hydrogen atom, and X represents oxygen atom or sulfur atom; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 2-[2-(4-morpholino)ethylamino]pyridine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的2- [2-（4-吗啉代）乙氨基]吡啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型2- [2-（4-吗啉代）乙氨基]吡啶衍生物由下式（I）表示的丙烯酸类病毒（HCV），其中R1和R2分别表示C1-C4直链或支链烷基，C1-C4直链或支链烷氧基，甲硫基，三氟甲基，卤素原子，或氢原子，X表示氧原子或硫原子; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的2- [2-（4-吗啉代）乙氨基]吡啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

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