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1. 发明申请

WO2009134091A3 METHOD FOR MANUFACTURING UNIFORM SIZE POLYMERIC NANOPARTICLES CONTAINING POORLY SOLUBLE DRUGS 审中-公开
标题翻译：制造含有不溶性药物的均匀聚合物纳米颗粒的方法
公开(公告)号：WO2009134091A3
公开(公告)日：2010-02-11
申请号：PCT/KR2009002289
申请日：2009-04-30
申请人： KOREA RES INST OF BIOSCIENCE , CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
发明人： CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
IPC分类号： B82B3/00
CPC分类号： A61K9/1652 , A61K9/5153 , A61K31/235 , A61K31/343 , A61K31/513 , A61K31/519 , A61K31/5415 , A61K31/573 , A61K31/585 , A61K31/704 , A61K31/7048 , B01D65/00 , C08J3/03 , Y10S516/929
摘要： The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.
摘要翻译：本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将生物可降解聚合物溶解在非挥发性物质中的第一步骤极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小且均匀的聚合物纳米颗粒可生物降解聚合物和难溶物质的溶液，并使用低机械能条件和在乳化过程中分批添加分散体。本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐稳定地释放并保持在恒定的密度。

2. 发明申请

WO2009134092A3 POORLY SOLUBLE DRUG-CONTAINING RELEASE-CONTROLLED POLYMERIC NANOPARTICLE FORMULATION 审中-公开
标题翻译：不溶解药物释放控制的聚合物纳米颗粒配方
公开(公告)号：WO2009134092A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009002291
申请日：2009-04-30
申请人： KOREA RES INST OF BIOSCIENCE , CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
发明人： CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
IPC分类号： A61K9/51 , A61K9/00 , A61K9/127 , A61K47/00
CPC分类号： A61K9/5153
摘要： The present invention relates to a release-controlled polymeric nanoparticle formulation containing biphenyl-dimethyl-dicarboxylate, a poorly soluble drug, and more particularly, to a nano-sized polymer formulation having a particle size distribution of narrow range, in which the biphenyl-dimethyl-dicarboxylate, a poorly soluble drug, is impregnated in biodegradable polymer and the surface of the formulation is coated with an emulsifier. The polymeric nanoparticle formulation according to the present invention can be effectively used in the treatment of hepatic disease since the formulation enhances the dissolution rate of biphenyl-dimethyl-dicarboxylate which is a poorly soluble drug to increase bioavailability, and releases drugs gradually to keep the drugs at a constant density in blood over a long period of time. The polymeric nanoparticle formulation of the present invention may prevent an excessive use of biphenyl-dimethyl-dicarboxylate caused due to the low dissolution rate in a body and low bioavailability of conventional formulations containing biphenyl-dimethyl-dicarboxylate.
摘要翻译：本发明涉及含有联苯二甲酸二甲酯（一种难溶性药物）的释放控制聚合物纳米颗粒制剂，更具体地说，涉及一种具有窄范围的粒径分布的纳米尺寸聚合物制剂，其中联苯基 - 二甲基二羧酸盐，一种难溶性药物，被浸渍在可生物降解的聚合物中，制剂的表面用乳化剂包衣。本发明的聚合物纳米颗粒制剂可以有效地用于肝脏疾病的治疗，因为该配方增加联苯基 - 二甲酸二甲酯的溶出速率，其是难溶性药物以提高生物利用度，并逐渐释放药物以保持药物在长时间的血液中以恒定的密度。本发明的聚合物纳米颗粒制剂可以防止由于体内低溶解速率和含有联苯二甲酸二甲酯的常规制剂的低生物利用度引起的联苯二甲酸二甲酯的过量使用。

3. 发明申请

WO2009051337A1 PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：含有量子纳米粒子的全氟烷纳米乳液及其制备方法
公开(公告)号：WO2009051337A1
公开(公告)日：2009-04-23
申请号：PCT/KR2008/004821
申请日：2008-08-20
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHUNG, Bong Hyun , LIM, Yong Taik , CHOI, Bang Sil , HAN, Jung Hyun
发明人： CHUNG, Bong Hyun , LIM, Yong Taik , CHOI, Bang Sil , HAN, Jung Hyun
IPC分类号： B82B3/00
CPC分类号： C09K11/565 , C09K11/02 , C09K11/883
摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanopaiticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
摘要翻译：本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地说涉及一种多功能全氟碳纳米乳液的制备方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

4. 发明申请

WO2009028825A3 POLYMER PARTICLES FOR NIR/MR BIMODAL MOLECULAR IMAGING AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用于NIR / MR双模分子成像的聚合物颗粒及其制备方法
公开(公告)号：WO2009028825A3
公开(公告)日：2009-04-23
申请号：PCT/KR2008004820
申请日：2008-08-20
申请人： KOREA RES INST OF BIOSCIENCE , CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
发明人： CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
IPC分类号： C08J3/12
CPC分类号： C08J5/005 , A61K49/0002 , A61K49/0034 , A61K49/0067 , A61K49/0093 , A61K49/1824 , B82Y30/00 , C08J3/12 , C08J3/2053 , C08J3/215 , C08J2367/02 , G01R33/0213 , G01R33/1269 , G01R33/281 , G01R33/4808 , G01R33/5601
摘要： The present invention relates to polymer particles showing magnetic properties and fluorescent properties simultaneously and a preparation method thereof. More specifically, relates to polymer particles for near infrared (NIR)/magnetic resonance (MR) bimodal molecular imaging, contain a magnetic nanomaterial and an NIR fluorescent material, and a preparation method thereof. The disclosed polymer particles show magnetic properties and fluorescent properties simultaneously, and thus are useful as contrast agents for NIR/MR bimodal molecular imaging.
摘要翻译：本发明涉及同时显示磁性和荧光特性的聚合物颗粒及其制备方法。更具体地，涉及用于近红外（NIR）/磁共振（MR）双峰分子成像的聚合物颗粒，其包含磁性纳米材料和NIR荧光材料及其制备方法。所公开的聚合物颗粒同时显示磁性和荧光特性，因此可用作NIR / MR双峰分子成像的对比剂。

5. 发明申请

WO2009020334A3 POROUS POLYMER PARTICLES IMMOBILIZED WITH CHARGED MOLECULES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：带有带电荷分子的多孔聚合物颗粒及其制备方法
公开(公告)号：WO2009020334A3
公开(公告)日：2009-04-23
申请号：PCT/KR2008004540
申请日：2008-08-05
申请人： KOREA RES INST OF BIOSCIENCE , CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
发明人： CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
IPC分类号： C08J3/12
CPC分类号： A61K9/5031 , A61K49/0034 , A61K49/0054 , A61K49/0056 , A61K49/0089 , C08J3/12 , C08J2367/04
摘要： The present invention relates to porous polymer particles containing a charged molecule immobilized therein and a method for preparing the same. According to the disclosed invention, porous particles can be prepared using a biocompatible polymer and, at the same time, a charged molecule can be immobilized in the pores of the porous particles, such that various charged molecules can be loaded in the porous particles. In addition, various kinds of drugs or functional materials can be loaded into the porous particles of the present invention by electrostatic attraction and absorption or adsorption by a capillary phenomenon occurring due to porous properties.
摘要翻译：本发明涉及含有固定在其中的带电荷分子的多孔聚合物颗粒及其制备方法。根据所公开的发明，可以使用生物相容性聚合物制备多孔颗粒，并且同时可以将带电分子固定在多孔颗粒的孔中，使得各种带电分子可以装载在多孔颗粒中。此外，各种药物或功能材料可以通过静电吸引和吸收或由于多孔性质引起的毛细管现象吸附而装载到本发明的多孔颗粒中。

6. 发明申请

WO2010117199A3 COENZYME Q10 NANOPARTICLES, PREPARATION METHOD THEREOF AND COMPOSITION CONTAINING SAID NANOPARTICLES 审中-公开
标题翻译： COENZYME Q10纳米颗粒，其制备方法和含有纳米颗粒的组合物
公开(公告)号：WO2010117199A3
公开(公告)日：2011-03-03
申请号：PCT/KR2010002112
申请日：2010-04-06
申请人： KOREA RES INST OF BIOSCIENCE , CHUNG BONG HYUN , HAN JUNG HYUN
发明人： CHUNG BONG HYUN , HAN JUNG HYUN
IPC分类号： A61K31/122 , A23L1/305 , A61K8/66 , A61K47/42 , A61P17/18
CPC分类号： A61K31/122 , A23L33/15 , A23V2002/00 , A61K9/0014 , A61K9/127 , A61K9/145 , A61K9/146 , A61K47/10 , A23V2250/314
摘要： The present invention relates to coenzyme Q10 nanoparticles, a preparation method thereof and a composition containing the nanoparticles. According to the present invention, coenzyme Q10 can be dissolved in a water-miscible organic solvent alone, easily made in a nanoparticulated and soluble form through simple stirring which is a low-energy condition, and dispersion-stabilized by amino acids or proteins. As the coenzyme Q10 is dissolved in nanoscale size, absorption rate increases. As amino acids and proteins can be delivered together with the nanoparticles, the effective use of coenzyme Q10 in food, cosmetics and medicine is also possible.
摘要翻译：本发明涉及辅酶Q10纳米颗粒，其制备方法和含有纳米颗粒的组合物。根据本发明，辅酶Q10可以单独溶解在与水可混溶的有机溶剂中，容易通过简单搅拌制成纳米颗粒和可溶形式，这是一种低能量条件，并被氨基酸或蛋白质分散稳定。由于辅酶Q10溶解于纳米尺寸，吸收率增加。由于氨基酸和蛋白质可以与纳米颗粒一起递送，所以在食品，化妆品和医药中有效使用辅酶Q10也是可行的。

7. 发明申请

WO2009028825A2 POLYMER PARTICLES FOR NIR/MR BIMODAL MOLECULAR IMAGING AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用于NIR / MR双模分子成像的聚合物颗粒及其制备方法
公开(公告)号：WO2009028825A2
公开(公告)日：2009-03-05
申请号：PCT/KR2008/004820
申请日：2008-08-20
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHUNG, Bong Hyun , LIM, Yong Taik , HAN, Jung Hyun
发明人： CHUNG, Bong Hyun , LIM, Yong Taik , HAN, Jung Hyun
IPC分类号： C08J3/12
CPC分类号： C08J5/005 , A61K49/0002 , A61K49/0034 , A61K49/0067 , A61K49/0093 , A61K49/1824 , B82Y30/00 , C08J3/12 , C08J3/2053 , C08J3/215 , C08J2367/02 , G01R33/0213 , G01R33/1269 , G01R33/281 , G01R33/4808 , G01R33/5601
摘要： The present invention relates to polymer particles showing magnetic properties and fluorescent properties simultaneously and a preparation method thereof. More specifically, relates to polymer particles for near infrared (NIR)/magnetic resonance (MR) bimodal molecular imaging, contain a magnetic nanomaterial and an NIR fluorescent material, and a preparation method thereof. The disclosed polymer particles show magnetic properties and fluorescent properties simultaneously, and thus are useful as contrast agents for NIR/MR bimodal molecular imaging.
摘要翻译：本发明涉及同时显示磁性和荧光性能的聚合物颗粒及其制备方法。更具体地，涉及包含磁性纳米材料和NIR荧光材料的用于近红外（NIR）/磁共振（MR）双峰分子成像的聚合物颗粒及其制备方法。所公开的聚合物颗粒同时显示磁性和荧光性质，因此可用作NIR / MR双峰分子成像的造影剂。

8. 发明申请

WO2009020334A2 POROUS POLYMER PARTICLES IMMOBILIZED WITH CHARGED MOLECULES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用充电分子固定的多孔聚合物颗粒及其制备方法
公开(公告)号：WO2009020334A2
公开(公告)日：2009-02-12
申请号：PCT/KR2008/004540
申请日：2008-08-05
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHUNG, Bong Hyun , LIM, Yong Taik , HAN, Jung Hyun
发明人： CHUNG, Bong Hyun , LIM, Yong Taik , HAN, Jung Hyun
IPC分类号： C08J3/12
CPC分类号： A61K9/5031 , A61K49/0034 , A61K49/0054 , A61K49/0056 , A61K49/0089 , C08J3/12 , C08J2367/04
摘要： The present invention relates to porous polymer particles containing a charged molecule immobilized therein and a method for preparing the same. According to the disclosed invention, porous particles can be prepared using a biocompatible polymer and, at the same time, a charged molecule can be immobilized in the pores of the porous particles, such that various charged molecules can be loaded in the porous particles. In addition, various kinds of drugs or functional materials can be loaded into the porous particles of the present invention by electrostatic attraction and absorption or adsorption by a capillary phenomenon occurring due to porous properties.
摘要翻译：本发明涉及含有固定在其中的带电分子的多孔聚合物颗粒及其制备方法。根据所公开的发明，可以使用生物相容性聚合物制备多孔颗粒，并且同时可以将带电分子固定在多孔颗粒的孔中，使得各种带电分子可以负载在多孔颗粒中。此外，通过由于多孔性质而发生的毛细管现象的静电吸引和吸收，可以将各种药物或功能材料装载到本发明的多孔颗粒中。

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