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1. 发明申请

WO2007062142A2 METHOD FOR IDENTIFYING BIOMARKERS ASSOCIATED WITH CANCER 审中-公开
标题翻译：识别与癌症相关的生物标志物的方法
公开(公告)号：WO2007062142A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/045244
申请日：2006-11-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HALPERIN, Jose, A. , WAGNER, Gerhard , CHOREV, Michael
发明人： HALPERIN, Jose, A. , WAGNER, Gerhard , CHOREV, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57426 , G01N33/57484
摘要： The present invention relates to methods for diagnosing cancer in an organism by obtaining a biological sample from the organism, detecting a level of biomarker in the biological sample, and diagnosing the organism with cancer based on the level of biomarker detected.
摘要翻译：本发明涉及通过从生物体获得生物样品，检测生物样品中生物标志物的水平，并根据检测到的生物标志物的水平来诊断具有癌症的生物体来诊断生物体内的癌症的方法。

2. 发明申请

WO2006078942A3 REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION 审中-公开
标题翻译：通过抑制EIF4E-EIF4G相互作用来调控蛋白质合成
公开(公告)号：WO2006078942A3
公开(公告)日：2007-04-19
申请号：PCT/US2006002093
申请日：2006-01-20
申请人： HARVARD COLLEGE , WAGNER GERHARD , CHOREV MICHAEL , MOERKE NATHAN JOHN , AKTAS HUSEYIN , HALPERIN JOSE
发明人： WAGNER GERHARD , CHOREV MICHAEL , MOERKE NATHAN JOHN , AKTAS HUSEYIN , HALPERIN JOSE
IPC分类号： A61K31/426 , A61K31/515 , A61P35/00 , C07D277/46 , C07D277/56 , G01N33/50
CPC分类号： C07D277/28 , A61K31/426 , A61K31/515 , C07D237/20 , C07D277/46 , C07D277/50 , C07D277/56 , G01N33/5011 , G01N33/6872 , G01N33/6875 , G01N2500/00
摘要： A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
摘要翻译：与非肿瘤细胞相比抑制肿瘤细胞增殖的组合物和方法。还描述了与蛋白质的帽无关翻译相比，筛选抑制帽依赖性翻译的组合物的方法。

3. 发明申请

WO2006086098A3 MASS SPECTROMETRIC METHODS AND PRODUCTS 审中-公开
标题翻译：质谱方法和产品
公开(公告)号：WO2006086098A3
公开(公告)日：2007-01-18
申请号：PCT/US2006000310
申请日：2006-01-06
申请人： HARVARD COLLEGE , HALPERIN JOSE
发明人： HALPERIN JOSE
IPC分类号： G01N33/68 , C07K5/08
CPC分类号： C07K14/70596 , C07K5/081 , G01N33/6872
摘要： The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
摘要翻译：本发明涉及用于质谱法的测定，诊断，试剂盒和测定组分以及确定受试者中糖基化CD59水平的其它方法。

4. 发明申请

WO2009073252A3 METHODS AND COMPOSITIONS FOR DETERMINING CHOLESTEROL-REDUCING PROPERTIES OF COMPOUNDS 审中-公开
标题翻译：用于测定化合物的胆固醇减少性质的方法和组合物
公开(公告)号：WO2009073252A3
公开(公告)日：2010-01-07
申请号：PCT/US2008068286
申请日：2008-06-26
申请人： HARVARD COLLEGE , HALPERIN JOSE A , ATKAS HUSEYIN
发明人： HALPERIN JOSE A , ATKAS HUSEYIN
IPC分类号： A01N65/00 , C12Q1/66
CPC分类号： G01N33/5023
摘要： The present invention relates to compositions and methods for detecting the ability of a food substance, nutritional supplement, therapeutic agent or disease preventive agent to decrease, increase or otherwise modulate cholesterol levels in a cell and/or animal.
摘要翻译：本发明涉及用于检测食物，营养补充剂，治疗剂或疾病预防剂降低，增加或以其他方式调节细胞和/或动物胆固醇水平的能力的组合物和方法。

5. 发明申请

WO2010078329A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PATHOGENIC DISEASES 审中-公开
标题翻译：治疗病原性疾病的方法和组合
公开(公告)号：WO2010078329A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069692
申请日：2009-12-29
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , QIN, Xuebin , HU, Weiguo , HALPERIN, Jose, A.
发明人： QIN, Xuebin , HU, Weiguo , HALPERIN, Jose, A.
IPC分类号： A61K39/42 , A61K39/12
CPC分类号： C07K16/1063 , A61K39/42 , C07K14/70596 , C12N7/00 , C12N2740/15051 , Y02A50/423 , A61K2300/00
摘要： The invention features methods of inducing antibody-mediated virolysis in a subject infected with an hCD59 or hCD55 expressing pathogen (e.g., HIV-1).
摘要翻译：本发明的特征在于感染hCD59或表达hCD55的病原体（例如，HIV-1）的受试者中诱导抗体介导的病毒溶解的方法。

6. 发明申请

WO2006078942A2 REGULATION OF PROTEIN SYNTHESIS 审中-公开
标题翻译：蛋白质合成调控
公开(公告)号：WO2006078942A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/002093
申请日：2006-01-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WAGNER, Gerhard , CHOREV, Michael , MOERKE, Nathan, John , AKTAS, Huseyin , HALPERIN, Jose
发明人： WAGNER, Gerhard , CHOREV, Michael , MOERKE, Nathan, John , AKTAS, Huseyin , HALPERIN, Jose
CPC分类号： C07D277/28 , A61K31/426 , A61K31/515 , C07D237/20 , C07D277/46 , C07D277/50 , C07D277/56 , G01N33/5011 , G01N33/6872 , G01N33/6875 , G01N2500/00
摘要： A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
摘要翻译：与非肿瘤细胞相比抑制肿瘤细胞增殖的组合物和方法。还描述了与蛋白质的帽无关翻译相比，筛选抑制帽依赖性翻译的组合物的方法。

7. 发明申请

WO2022241236A2 METHODS AND REAGENTS FOR PROTEIN ANALYSIS 审中-公开
公开(公告)号：WO2022241236A2
公开(公告)日：2022-11-17
申请号：PCT/US2022/029227
申请日：2022-05-13
申请人： CHOREV, Michael , HALPERIN, Jose A. , MELLITUS, LLC
发明人： CHOREV, Michael , HALPERIN, Jose A.
IPC分类号： G01N33/50 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/58 , G01N33/68 , C07K14/705
摘要： The disclosure includes methods of detecting glycated CD59 in samples using capture and detection antibodies to glycated and non-glycated CD59 epitopes, respectively, followed by detection of resulting complexes. Included are methods for detection of the detection antibody. Also included are related methods of screening, monitoring, and diagnosing subjects with diabetes-related indications and kits for carrying out such methods.

8. 发明申请

WO2012109538A3 SURROGATES OF POST-TRANSLATIONALLY MODIFIED PROTEINS AND USES THEREOF 审中-公开
标题翻译：翻译后修饰蛋白质的现象及其用途
公开(公告)号：WO2012109538A3
公开(公告)日：2012-11-22
申请号：PCT/US2012024645
申请日：2012-02-10
申请人： HARVARD COLLEGE , CHOREV MICHAEL , HALPERIN JOSE A
发明人： CHOREV MICHAEL , HALPERIN JOSE A
IPC分类号： C07K14/435 , C07K16/18 , G01N33/533 , G01N33/574
CPC分类号： G01N33/6893 , C07K14/70596 , C07K16/2896 , C07K16/44 , G01N33/564 , G01N33/6872 , G01N2333/70596 , G01N2440/00 , G01N2440/38 , G01N2800/042
摘要： The present invention provides compounds that are surrogates of post-translationally modified proteins and uses thereof. Numerous diseases are associated with post- translationally modified proteins that are difficult to obtain in homogenous form and in quantities needed for immunization and use as convenient standards, calibrators, and/or reference compounds that facilitate the detection and analysis of endogenous post- translationally modified proteins. The surrogate compounds of the invention typically comprise antigenic epitopes (one of which carries a post-translational modification) that are tethered by a flexible and hydrophilic linker. The resulting compound behaves like a surrogate of the post-translationally modified protein because it preserves the character of the included antigens and allows recognition by specific antibodies targeting the individual antigens. The surrogate compounds may be prepared by covalently joining two or more polypeptide epitopes using one or more linkers, wherein at least one of the epitopes comprises a post-translational modification. In one aspect, the surrogate compounds of the invention comprise a C-terminal epitope and a glycated epitope of human CD59. The inventive methods allow quantification of the levels of glycated CD59 in the serum in human subjects, particularly those with diabetes or pre-diabetes. This technological platform of post-translationally modified protein surrogates can be applied to other diseases associated with post-translationally modified proteins (e.g., autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus). In another aspect, the invention provides antibodies that bind specifically to the compounds of the invention and methods for producing such antibodies.
摘要翻译：本发明提供了作为翻译后修饰的蛋白质的替代物的化合物及其用途。许多疾病与翻译后修饰的蛋白质相关联，其难以以均匀的形式获得，并且以免疫和使用所需的量作为方便的标准品，校准物和/或参考化合物，促进内源性翻译后修饰的蛋白质的检测和分析。本发明的替代化合物通常包含被柔性和亲水接头连接的抗原表位（其中一个携带翻译后修饰）。所得化合物表现为翻译后修饰的蛋白质的替代物，因为其保留所包含的抗原的特征，并允许通过针对各个抗原的特异性抗体进行识别。替代化合物可以通过使用一种或多种接头共价连接两个或多个多肽表位来制备，其中至少一个表位包含翻译后修饰。一方面，本发明的替代化合物包含人CD59的C-末端表位和糖基化表位。本发明的方法允许定量人受试者，特别是糖尿病或前期糖尿病患者血清中糖基化CD59的水平。翻译后修饰的蛋白质替代物的这种技术平台可以应用于与翻译后修饰的蛋白质（例如自身免疫性疾病如多发性硬化症，类风湿性关节炎和系统性红斑狼疮）相关的其它疾病。另一方面，本发明提供了与本发明化合物特异性结合的抗体以及用于产生此类抗体的方法。

9. 发明申请

WO2010138820A3 N,N-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION 审中-公开
标题翻译： N，N-二芳基化合物和N，N'-二异丙基脲化合物作为翻译启动的抑制剂
公开(公告)号：WO2010138820A3
公开(公告)日：2011-01-27
申请号：PCT/US2010036584
申请日：2010-05-28
申请人： HARVARD COLLEGE , AKTAS HUSEYIN , HALPERIN JOSE A , CHOREV MICHAEL
发明人： AKTAS HUSEYIN , HALPERIN JOSE A , CHOREV MICHAEL
IPC分类号： A61K31/20 , A61K31/17
CPC分类号： C07C275/30 , A61K31/5377 , C07C275/34 , C07C275/38 , C07C275/40 , C07C2601/02 , C07C2602/08 , C07D213/75 , C07D213/81 , C07D215/06 , C07D231/56 , C07D233/36 , C07D237/30 , C07D239/34 , C07D239/42 , C07D249/14 , C07D261/14 , C07D271/12 , C07D277/18 , C07D277/66 , C07D285/14 , C07D295/088 , C07D295/135 , C07D295/192 , C07D307/88 , C07D317/66 , C07D319/08 , C07D333/20 , C07D333/38 , C07D405/12 , C07D409/04
摘要： Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N'-diarylureas and/or N,N'-diarylthiourea compounds are described.
摘要翻译：提供了抑制翻译起始的组合物和方法。用于治疗（1）细胞增殖性疾病的组合物，方法和试剂盒，（2）非增殖性，退行性病症，（3）病毒感染和/或（4）与病毒感染相关的病症，使用N，N'-二芳基脲和 /或N，N'-二芳基硫脲化合物。

10. 发明申请

WO2010138820A2 N,N-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION 审中-公开
标题翻译： N，N-二芳基化合物和N，N'-二异丙基脲化合物作为翻译启动的抑制剂
公开(公告)号：WO2010138820A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036584
申请日：2010-05-28
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , AKTAS, Huseyin , HALPERIN, Jose, A. , CHOREV, Michael
发明人： AKTAS, Huseyin , HALPERIN, Jose, A. , CHOREV, Michael
IPC分类号： A61K31/5377
CPC分类号： C07C275/30 , A61K31/5377 , C07C275/34 , C07C275/38 , C07C275/40 , C07C2601/02 , C07C2602/08 , C07D213/75 , C07D213/81 , C07D215/06 , C07D231/56 , C07D233/36 , C07D237/30 , C07D239/34 , C07D239/42 , C07D249/14 , C07D261/14 , C07D271/12 , C07D277/18 , C07D277/66 , C07D285/14 , C07D295/088 , C07D295/135 , C07D295/192 , C07D307/88 , C07D317/66 , C07D319/08 , C07D333/20 , C07D333/38 , C07D405/12 , C07D409/04
摘要： Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N'-diarylureas and/or N,N'-diarylthiourea compounds are described.
摘要翻译：提供了抑制翻译起始的组合物和方法。用于治疗（1）细胞增殖性疾病的组合物，方法和试剂盒，（2）非增殖性，退行性病症，（3）病毒感染和/或（4）与病毒感染相关的病症，使用N，N'-二芳基脲和 /或N，N'-二芳基硫脲化合物。

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