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1. 发明申请

WO2003105772A2 ANALOGS OF PARATHYROID HORMONE AND PTH-RELATED PROTEIN AS BONE ANABOLIC AGENTS 审中-公开
标题翻译：作为骨质疏松剂的PARATHYROID HORMONE和PTH相关蛋白的模拟物
公开(公告)号：WO2003105772A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018890
申请日：2003-06-13
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC. , CHOREV, Michael , ROSENBLATT, Michael
发明人： CHOREV, Michael , ROSENBLATT, Michael
IPC分类号： A61K
CPC分类号： C07K14/635 , A61K38/00
摘要： The invention provides novel parathyroid hormone analogs and parathyroid hormones-related protein analogs. The invention also provides methods of using these analogs to treat osteoporosis, promote the formation of bone, and inhibit bone loss.
摘要翻译：本发明提供新型甲状旁腺激素类似物和甲状旁腺激素相关蛋白类似物。本发明还提供了使用这些类似物来治疗骨质疏松症，促进骨形成和抑制骨丢失的方法。

2. 发明申请

WO1995000166A1 PHARMACEUTICAL COMPOSITIONS FOR STIMULATING RECONSTRUCTION OF HEMOPOIETIC MICROENVIRONMENT 审中-公开
标题翻译：用于刺激重建微生态环境的药物组合物
公开(公告)号：WO1995000166A1
公开(公告)日：1995-01-05
申请号：PCT/GB1994001309
申请日：1994-06-17
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael , BAB, Itai , MUHLRAD, Andras , CHOREV, Michael , SHTEYER, Arie , SLAVIN, Shimon , MANSUR, Nura , GUREVITCH, Olga
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael
IPC分类号： A61K37/36
CPC分类号： C07K14/51 , A61K38/00 , Y10S530/84 , Y10S530/841
摘要： The invention relates to a pharmaceutical composition for stimulating reconstruction of hemopoietic microenvironment comprising a therapeutically effective amount of a peptide having an amino acide sequence Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Try-Gly-Phe-Gly-Gly- (OGP), or conservative amino acid substitution or deletion thereof, or an oligopeptide having molecular weight of from 200 to 2,000 wherein the four C-terminal amino acid residues are identical with those of the said OGP, with the penultimate Gly optionally replaced by His, or a mixture thereof and a pharmaceutically acceptable carrier. A method of stimulating reconstruction of hemopoietic microenvironment in a mammal which comprises administering to said mammal a therapeutically effective amount of a peptide having an amino acid sequence Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly (OGP), or conservative amino acid substitution or deletion thereof, or an oligopeptide having molecular weight of from 200 to 2,000 wherein the four C-terminal amino acid residues are identical with those of said OGP, with the penultimates Gly optionally replaced by His, or a mixture thereof.
摘要翻译：本发明涉及用于刺激造血微环境重建的药物组合物，其包含治疗有效量的具有氨基酸序列Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Try-Gly-Phe- Gly-Gly-（OGP）或其保守氨基酸取代或缺失，或分子量为200至2,000的寡肽，其中四个C-末端氨基酸残基与所述OGP的氨基酸残基相同，其中倒数第二任选地被His替代，或其混合物和药学上可接受的载体。一种刺激哺乳动物造血微环境重建的方法，其包括向所述哺乳动物施用治疗有效量的具有氨基酸序列Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly -Phe-Gly-Gly（OGP）或其保守氨基酸取代或缺失，或分子量为200至2,000的寡肽，其中四个C末端氨基酸残基与所述OGP的氨基酸残基相同， Gly任选被His取代，或其混合物。

3. 发明申请

WO1994020529A1 OSTEOGENIC GROWTH OLIGOPEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：营养生长寡核苷酸和含有它们的药物组合物
公开(公告)号：WO1994020529A1
公开(公告)日：1994-09-15
申请号：PCT/GB1994000416
申请日：1994-03-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael , BAB, Itai , MUHLRAD, Andras , CHOREV, Michael , SHTEYER, Arie , GREENBERG, Zvi , MANSUR, Nura
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael
IPC分类号： C07K05/10
CPC分类号： C07K14/51 , A61K38/00
摘要： The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred oligopeptides according to the invention comprise the amino acid sequences Tyr-Gly-Phe-His-Gly and Gly-Phe-Gly-Gly. The invention further relates to pharmaceutical compositions for the stimulation of formation of osteoblastic of fibroblastic cells, enhanced bone formation in osteogenic pathological conditions, fracture repair, healing of wounds, intraosseous implants and bone supplementation, or other conditions requiring enhanced bone formation cells comprising a therapeutically effective amount of an oligopeptide according to the invention.
摘要翻译：本发明涉及对分子量在200和2,000之间的成骨细胞和/或成纤维细胞具有刺激活性的生物化学纯的寡肽。根据本发明的优选的寡肽包含氨基酸序列Tyr-Gly-Phe-His-Gly和Gly-Phe-Gly-Gly。本发明进一步涉及用于刺激成纤维细胞成骨细胞形成的药物组合物，增强成骨细胞病理状态下的骨形成，骨折修复，伤口愈合，骨内植入物和补骨，或需要增强的骨形成细胞的其它条件，其包括治疗有效量的根据本发明的寡肽。

4. 发明申请

WO2012006068A2 COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION 审中-公开
标题翻译：用于抑制细胞增殖的化合物
公开(公告)号：WO2012006068A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/042139
申请日：2011-06-28
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHOREV, Michael , AKTAS, Bertal Huseyin , HALPERIN, José A. , WAGNER, Gerhard
发明人： CHOREV, Michael , AKTAS, Bertal Huseyin , HALPERIN, José A. , WAGNER, Gerhard
IPC分类号： C07D417/02
CPC分类号： C07D277/84 , C07D233/88 , C07D263/48 , C07D277/30 , C07D277/42 , C07D277/50 , C07D417/04 , C07D417/10 , C07D417/12 , C07D513/04
摘要： Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.
摘要翻译：提供了用于抑制翻译的组合物和方法。用于治疗（1）细胞增殖性疾病的组合物，方法和试剂盒，（2）非增殖性，退行性病症，（3）病毒感染，（4）与病毒感染相关的病症和/或（5）非增殖性代谢紊乱例如II型糖尿病，其中使用本文公开的化合物对翻译起始的抑制是有益的。

5. 发明申请

WO2007062142A2 METHOD FOR IDENTIFYING BIOMARKERS ASSOCIATED WITH CANCER 审中-公开
标题翻译：识别与癌症相关的生物标志物的方法
公开(公告)号：WO2007062142A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/045244
申请日：2006-11-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HALPERIN, Jose, A. , WAGNER, Gerhard , CHOREV, Michael
发明人： HALPERIN, Jose, A. , WAGNER, Gerhard , CHOREV, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57426 , G01N33/57484
摘要： The present invention relates to methods for diagnosing cancer in an organism by obtaining a biological sample from the organism, detecting a level of biomarker in the biological sample, and diagnosing the organism with cancer based on the level of biomarker detected.
摘要翻译：本发明涉及通过从生物体获得生物样品，检测生物样品中生物标志物的水平，并根据检测到的生物标志物的水平来诊断具有癌症的生物体来诊断生物体内的癌症的方法。

6. 发明申请

WO2006078942A3 REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION 审中-公开
标题翻译：通过抑制EIF4E-EIF4G相互作用来调控蛋白质合成
公开(公告)号：WO2006078942A3
公开(公告)日：2007-04-19
申请号：PCT/US2006002093
申请日：2006-01-20
申请人： HARVARD COLLEGE , WAGNER GERHARD , CHOREV MICHAEL , MOERKE NATHAN JOHN , AKTAS HUSEYIN , HALPERIN JOSE
发明人： WAGNER GERHARD , CHOREV MICHAEL , MOERKE NATHAN JOHN , AKTAS HUSEYIN , HALPERIN JOSE
IPC分类号： A61K31/426 , A61K31/515 , A61P35/00 , C07D277/46 , C07D277/56 , G01N33/50
CPC分类号： C07D277/28 , A61K31/426 , A61K31/515 , C07D237/20 , C07D277/46 , C07D277/50 , C07D277/56 , G01N33/5011 , G01N33/6872 , G01N33/6875 , G01N2500/00
摘要： A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
摘要翻译：与非肿瘤细胞相比抑制肿瘤细胞增殖的组合物和方法。还描述了与蛋白质的帽无关翻译相比，筛选抑制帽依赖性翻译的组合物的方法。

7. 发明申请

WO1997032594A1 SYNTHETIC PEPTIDES AND PSEUDOPEPTIDES HAVING OSTEOGENIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：具有生物活性的合成肽和药物组合物及含有它们的药物组合物
公开(公告)号：WO1997032594A1
公开(公告)日：1997-09-12
申请号：PCT/IL1997000087
申请日：1997-03-10
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , BAB, Itai , GAZIT, Dan , YU-CHEN, Chen , MUHLRAD, Andras , SHTEYER, Arie , CHOREV, Michael
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K38/03
CPC分类号： C07K5/1008 , A61K38/00 , C07K5/0806 , C07K5/126 , C07K14/51
摘要： The invention relates to synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP (10-14) which may be linear or cyclic, and which are capable of enhancing bone cell proliferation and bone formation. Further, the present invention relates to pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.
摘要翻译：本发明涉及成骨生长多肽（OGP）和OGP（10-14）的合成假肽衍生物，其可以是线性或环状的，并且能够增强骨细胞增殖和骨形成。此外，本发明涉及包含本发明的至少一种假肽衍生物作为活性成分的药物组合物和这些假肽衍生物在制备用于刺激成骨细胞或成纤维细胞形成的药物组合物中的用途，增强骨形成骨质疏松的病理状况，修复骨折，愈合伤口，骨内植入物移植，逆转骨质疏松症的骨丢失等需要增强骨细胞形成的病症。

8. 发明申请

WO2012109538A2 SURROGATES OF POST-TRANSLATIONALLY MODIFIED PROTEINS AND USES THEREOF 审中-公开
标题翻译：翻译后修饰的蛋白质的去除剂及其用途
公开(公告)号：WO2012109538A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024645
申请日：2012-02-10
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHOREV, Michael , HALPERNIN, Jose, A.
发明人： CHOREV, Michael , HALPERNIN, Jose, A.
IPC分类号： C07K14/435 , C07K16/18 , G01N33/533 , G01N33/574
CPC分类号： G01N33/6893 , C07K14/70596 , C07K16/2896 , C07K16/44 , G01N33/564 , G01N33/6872 , G01N2333/70596 , G01N2440/00 , G01N2440/38 , G01N2800/042
摘要： The present invention provides compounds that are surrogates of post-translationally modified proteins and uses thereof. Numerous diseases are associated with post- translationally modified proteins that are difficult to obtain in homogenous form and in quantities needed for immunization and use as convenient standards, calibrators, and/or reference compounds that facilitate the detection and analysis of endogenous post- translationally modified proteins. The surrogate compounds of the invention typically comprise antigenic epitopes (one of which carries a post-translational modification) that are tethered by a flexible and hydrophilic linker. The resulting compound behaves like a surrogate of the post-translationally modified protein because it preserves the character of the included antigens and allows recognition by specific antibodies targeting the individual antigens. The surrogate compounds may be prepared by covalently joining two or more polypeptide epitopes using one or more linkers, wherein at least one of the epitopes comprises a post-translational modification. In one aspect, the surrogate compounds of the invention comprise a C-terminal epitope and a glycated epitope of human CD59. The inventive methods allow quantification of the levels of glycated CD59 in the serum in human subjects, particularly those with diabetes or pre-diabetes. This technological platform of post-translationally modified protein surrogates can be applied to other diseases associated with post-translationally modified proteins (e.g., autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus). In another aspect, the invention provides antibodies that bind specifically to the compounds of the invention and methods for producing such antibodies.
摘要翻译：本发明提供了作为翻译后修饰蛋白替代物的化合物及其用途。许多疾病与翻译后修饰的蛋白质相关，所述蛋白质难以以均匀形式和免疫所需的量获得，并且用作便利检测和分析内源性翻译后修饰的蛋白质的便利标准物，校准物和/或参考化合物。本发明的替代化合物通常包含通过柔性和亲水性连接子连接的抗原表位（其中一个携带翻译后修饰）。生成的化合物表现得像翻译后修饰的蛋白质的替代物，因为它保留了包含的抗原的特征并且允许通过靶向单个抗原的特异性抗体识别。替代化合物可以通过使用一个或多个接头共价连接两个或更多个多肽表位来制备，其中至少一个表位包含翻译后修饰。在一个方面，本发明的替代化合物包含人CD59的C端表位和糖化表位。本发明的方法可以量化人受试者血清中糖化CD59的水平，特别是那些患有糖尿病或糖尿病前期的人。翻译后修饰的蛋白质替代物的这种技术平台可以应用于与翻译后修饰的蛋白质（例如，自身免疫性疾病，例如多发性硬化症，类风湿性关节炎和系统性红斑狼疮）相关的其他疾病。另一方面，本发明提供了与本发明化合物特异性结合的抗体和生产这种抗体的方法。

9. 发明申请

WO2006078942A2 REGULATION OF PROTEIN SYNTHESIS 审中-公开
标题翻译：蛋白质合成调控
公开(公告)号：WO2006078942A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/002093
申请日：2006-01-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WAGNER, Gerhard , CHOREV, Michael , MOERKE, Nathan, John , AKTAS, Huseyin , HALPERIN, Jose
发明人： WAGNER, Gerhard , CHOREV, Michael , MOERKE, Nathan, John , AKTAS, Huseyin , HALPERIN, Jose
CPC分类号： C07D277/28 , A61K31/426 , A61K31/515 , C07D237/20 , C07D277/46 , C07D277/50 , C07D277/56 , G01N33/5011 , G01N33/6872 , G01N33/6875 , G01N2500/00
摘要： A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
摘要翻译：与非肿瘤细胞相比抑制肿瘤细胞增殖的组合物和方法。还描述了与蛋白质的帽无关翻译相比，筛选抑制帽依赖性翻译的组合物的方法。

10. 发明申请

WO03011313A8 OSTEOGENIC GROWTH OLIGOPEPTIDES AS STIMULANTS OF HEMATOPOIESIS 审中-公开
标题翻译：作为生殖细胞增生的生长发育障碍
公开(公告)号：WO03011313A8
公开(公告)日：2004-04-08
申请号：PCT/IL0100700
申请日：2001-07-29
申请人： YISSUM RES DEV CO , BAB ITAI , CHOREV MICHAEL , SHTEYER ARYE , MUHLRAD ANDRAS , MANSUR NURA , GUREVITCH OLGA , GREENBERG ZVI , ROSINI SERGIO , TRASCIATTI SILVIA , PETRINI MARIO
发明人： BAB ITAI , CHOREV MICHAEL , SHTEYER ARYE , MUHLRAD ANDRAS , MANSUR NURA , GUREVITCH OLGA , GREENBERG ZVI , ROSINI SERGIO , TRASCIATTI SILVIA , PETRINI MARIO
IPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/07 , A61K38/08 , A61K38/22 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P41/00 , A61P43/00 , C12N5/0789 , C12N5/00 , C12N5/08
CPC分类号： A61K38/08 , A61K38/07 , A61K2035/124 , C12N5/0647 , C12N2501/998
摘要： The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analagous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.
摘要翻译：本发明涉及一种药物组合物，其包含与OGP的C末端部分相同或相似的寡肽作为有效成分，对造血细胞的产生具有刺激活性。使用的优选的寡肽是Tyr-Gly-Phe-Gly-Gly，Tyr-Gly-Phe-His-Gly，Gly-Phe-Gly-Gly或Met-Tyr-Gly-Phe-Gly-Gly。更具体地，这些寡肽增强了骨髓移植的植入，造血重建，骨髓再生和周边干细胞动员，优选化疗或照射后。本发明还提供了治疗和使用这些寡肽在制备药物组合物中的方法。

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