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1. 发明专利

CA96338A ARTIFICAIL FUEL 未知
公开(公告)号：CA96338A
公开(公告)日：1905-11-28
申请号：CA96338D
申请日：1905-08-22
申请人： ENGLE PERCY , HALEY JOHN , ENGLE ANDREW
发明人： ENGLE ANDREW

2. 发明专利

CA292466A METHOD OF COVERING ARTICLES WITH CELLULOID 未知
公开(公告)号：CA292466A
公开(公告)日：1929-08-27
申请号：CA292466D
申请人： HALEY JOHN MICHAEL
发明人： HALEY JOHN MICHAEL

3. 发明专利

CA202336A FLUSHING DEVICE FOR SEWERS 未知
公开(公告)号：CA202336A
公开(公告)日：1920-07-27
申请号：CA202336D
申请人： THOMAS ROYAL HERMAN , HALEY JOHN WESLEY , FLETCHER JOHN A
发明人： FLETCHER JOHN A , HALEY JOHN WESLEY , THOMAS ROYAL HERMAN

4. 发明专利

GB189802637A Improvements in Railway Sleepers, Mine Timber, and the like. 未知
公开(公告)号：GB189802637A
公开(公告)日：1898-03-12
申请号：GB189802637D
申请日：1898-02-01
申请人： WILLIAMS HENRY FAIRFAX , HALEY JOHN JUSTICE
发明人： WILLIAMS HENRY FAIRFAX , HALEY JOHN JUSTICE
摘要： 2637. Williams, H. F., and Haley, J. J. Feb. 1. Sleepers for railways are built up of a wooden box A filled with layers of wood B and asphalt or similar cementing - material which also acts as a preservative.

5. 发明申请

WO2009111067A9 METHODS FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT MESENCHYMAL -LIKE TUMOR CELLS OR THEIR FORMATION 审中-公开
标题翻译：鉴定抑制MESENCHYMAL-LUM肿瘤细胞或其形成的药物的方法
公开(公告)号：WO2009111067A9
公开(公告)日：2009-12-23
申请号：PCT/US2009001456
申请日：2009-03-06
申请人： OSI PHARM INC , HALEY JOHN D , THOMSON STUART , KAN JULIE , SHAABAN SALAM A
发明人： HALEY JOHN D , THOMSON STUART , KAN JULIE , SHAABAN SALAM A
IPC分类号： G01N33/574
CPC分类号： G01N33/5011 , G01N2333/475 , G01N2333/485 , G01N2333/495 , G01N2333/525
摘要： The present invention provides tumor cell preparations for use as models of the EMT process for use in the identification of anti-cancer agents, wherein said tumor cell preparations comprise cells of the epithelial tumor cell line H358, which are stimulated by receptor ligands to induce EMT, or which have been engineered to inducibly express a protein that stimulates EMT. The present invention also provides methods of identifying potential anti-cancer agents by using such tumor cell preparations to identify agents that inhibit EMT, stimulate MET, or inhibit the growth of mesenchymal-like cells. Such agents should be particularly useful when used in conjunction with other anti-cancer drugs such as EGFR and IGF-IR kinase inhibitors, which appear to be less effective at inhibiting tumor cells that have undergone an EMT.
摘要翻译：本发明提供用作鉴定抗癌剂的EMT方法的模型的肿瘤细胞制剂，其中所述肿瘤细胞制剂包含受体配体刺激以诱导EMT的上皮肿瘤细胞系H358的细胞，或已被设计成可诱导地表达刺激EMT的蛋白质。本发明还提供了通过使用这样的肿瘤细胞制剂鉴定潜在的抗癌剂的方法来鉴定抑制EMT，刺激MET或抑制间充质细胞生长的药剂。当与其它抗癌药物如EGFR和IGF-1R激酶抑制剂联合使用时，这些药剂应该特别有用，这对于抑制已经经历EMT的肿瘤细胞来说效果较差。

6. 发明申请

WO2007076449A3 BIOMEDIA APPARATUS AND METHOD OF USE 审中-公开
标题翻译：生物医学设备和使用方法
公开(公告)号：WO2007076449A3
公开(公告)日：2007-12-06
申请号：PCT/US2006062506
申请日：2006-12-21
申请人： BIOPROCESS TECHNOLOGIES LTD , HALEY JOHN W III
发明人： HALEY JOHN W III
IPC分类号： C02F3/00
CPC分类号： C02F3/103 , B01D39/083 , B01D39/086 , B01D2239/02 , B01D2239/0609 , B01D2239/065 , B01D2239/10 , C02F3/04 , C02F2103/28 , Y02W10/15 , Y10T428/2929 , Y10T428/2931 , Y10T428/2933 , Y10T428/2976
摘要： A biomedia apparatus comprising an elongated central core and a plurality of loops positioned along the central core adapted to collect organisms from water. The biomedia apparatus may further comprise at least one reinforcing member associated with the central core. In one embodiment, the biomedia apparatus is utilized in a trickle tower to treat wastewater. In another embodiment, the biomedia apparatus is utilized outside a power plant to minimize spat that is drawn into the plant through water intake valves.
摘要翻译：一种生物介质装置，包括细长的中央核心和沿中央核心定位的多个环圈，适于从水中收集生物体。生物介质装置可以进一步包括至少一个与中央芯相关联的加强构件。在一个实施例中，生物介质装置用于滴流塔中以处理废水。在另一个实施方案中，生物介质装置在发电厂外使用，以使通过进水阀吸入设备的sp液最小化。

7. 发明申请

WO2006101925A2 BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITORS 审中-公开
标题翻译：生物标志物预防抗癌生长因子受体激酶激酶抑制剂
公开(公告)号：WO2006101925A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009403
申请日：2006-03-16
申请人： OSI PHARM INC , GENENTECH INC , HALEY JOHN D , GRIFFIN GRAEME , AMLER LUKAS C , EBERHARD DAVID A , YAUCH ROBERT L
发明人： HALEY JOHN D , GRIFFIN GRAEME , AMLER LUKAS C , EBERHARD DAVID A , YAUCH ROBERT L
IPC分类号： G01N33/574 , C12Q1/48 , G01N33/74
CPC分类号： A61K31/517 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2800/52
摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by EGFR kinase inhibitors are also provided.
摘要翻译：本发明提供用于预测EGFR激酶抑制剂治疗癌症患者的有效性的诊断和预后方法。提供了用于预测肿瘤细胞生长对EGFR激酶抑制剂抑制的敏感性的方法，包括通过测定上皮和/或间质生物标志物的表达水平来评估肿瘤细胞是否经历了上皮间质转化（EMT），其中已经经历EMT的肿瘤细胞对EGFR激酶抑制剂的抑制基本上较不敏感。还提供了用于治疗结合上述方法的EGFR激酶抑制剂的癌症患者的改进方法。另外，提供了用于鉴定预测肿瘤对EGFR激酶抑制剂的反应性的新生物标志物的方法。此外，还提供了用于鉴定恢复已经经历EMT的肿瘤细胞对EGFR激酶抑制剂抑制的敏感性的药剂的方法。

8. 发明申请

WO2009045389A2 BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE INHIBITORS 审中-公开
标题翻译：生物标志物预测抗胰岛素样生长因子-1受体激酶抑制剂的抗癌反应
公开(公告)号：WO2009045389A2
公开(公告)日：2009-04-09
申请号：PCT/US2008011299
申请日：2008-09-29
申请人： OSI PHARM INC , BUCK ELIZABETH A , HALEY JOHN D
发明人： BUCK ELIZABETH A , HALEY JOHN D
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/5023 , G01N33/57484 , G01N2333/4703 , G01N2800/52
摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by IGF-1R kinase inhibitors. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to IGF-1R kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by IGF-1R kinase inhibitors are also provided. pErk, HER3 and pHER are also demonstrated to be effective biomarkers for predicting sensitivity of tumor cells to IGF-1R kinase inhibitors.
摘要翻译：本发明提供了用于预测用IGF-1R激酶抑制剂治疗癌症患者的有效性的诊断和预后方法。提供了用于预测肿瘤细胞生长对IGF-1R激酶抑制剂的抑制的敏感性的方法，包括通过确定上皮和/或间充质生物标志物的表达水平来评估肿瘤细胞是否已经经历上皮至间质转化（EMT）其中已经经历EMT的肿瘤细胞对IGF-1R激酶抑制剂的抑制显着较不敏感。还提供了包含上述方法的用IGF-1R激酶抑制剂治疗癌症患者的改进方法。另外，提供了用于鉴定预测肿瘤对IGF-1R激酶抑制剂的响应性的新生物标志物的方法。此外，还提供了用于鉴定恢复经历EMT的肿瘤细胞对IGF-1R激酶抑制剂的抑制的敏感性的试剂的方法。 pErk，HER3和pHER也被证明是预测肿瘤细胞对IGF-1R激酶抑制剂敏感性的有效生物标志物。

9. 发明申请

WO2008127718A2 BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITORS 审中-公开
标题翻译：生物标志物对表皮生长因子受体激酶抑制剂的抗癌反应预测
公开(公告)号：WO2008127718A2
公开(公告)日：2008-10-23
申请号：PCT/US2008/004818
申请日：2008-04-14
申请人： OSI PHARMACEUTICALS, INC. , HALEY, John , THOMSON, Stuart , PETTI, Filippo
发明人： HALEY, John , THOMSON, Stuart , PETTI, Filippo
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/6893 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2800/52
摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by EGFR kinase inhibitors are also provided.
摘要翻译：本发明提供了用于预测用EGFR激酶抑制剂治疗癌症患者的有效性的诊断和预后方法。提供了用于预测肿瘤细胞生长对EGFR激酶抑制剂的抑制的敏感性的方法，包括通过确定上皮和/或间充质生物标志物的表达水平来评估肿瘤细胞是否已经经历上皮至间质转化（EMT），其中经历EMT的肿瘤细胞对EGFR激酶抑制剂的抑制作用明显较不敏感。还提供了包含上述方法的用EGFR激酶抑制剂治疗癌症患者的改进方法。另外，提供了用于鉴定预测肿瘤对EGFR激酶抑制剂的响应性的新生物标志物的方法。此外，还提供了用于鉴定恢复已经经历EMT的肿瘤细胞对EGFR激酶抑制剂的抑制的敏感性的试剂的方法。

10. 发明申请

WO2007113522A1 CABLE INSTALLATION 审中-公开
标题翻译：电缆安装
公开(公告)号：WO2007113522A1
公开(公告)日：2007-10-11
申请号：PCT/GB2007/001182
申请日：2007-04-02
申请人： BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY , BARKER, Philip, Alfred , MUNNINGS, Christopher, Nigel , HALEY, John, Michael
发明人： BARKER, Philip, Alfred , MUNNINGS, Christopher, Nigel , HALEY, John, Michael
IPC分类号： G02B6/48 , G02B6/44
CPC分类号： G02B6/4442 , G02B6/4451 , G02B6/4457
摘要： A method of protecting a weak point along a cable (34), the cable being subject to stress, comprising the steps of (i) selecting a section of the cable between a source of the strain and up to and including the weak point, (ii) using the section of the cable to form a cable configuration comprising a pair of coils, by - putting a twist in the cable by winding the cable in a first direction to form a first coil, and - taking the twist out of the cable by winding the cable in a second direction to form a second coil, and (iii) securing under tension the cable configuration formed.
摘要翻译：一种沿着电缆（34）保护弱点的方法，所述电缆受到应力，包括以下步骤：（i）在所述应变源之间选择直到并包括所述弱点的所述电缆的一部分（ ii）使用电缆的部分形成包括一对线圈的电缆结构，通过在第一方向上缠绕电缆以将线缆缠绕在电缆中以形成第一线圈，以及 - 将电缆从电缆中扭出通过沿第二方向缠绕电缆以形成第二线圈，并且（iii）在张力下固定所形成的电缆配置。

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