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1. 发明申请

US20140000307A1 ACCESSIBLE COOLING SYSTEM, ESPECIALLY FOR CRYOPRESERVING BIOLOGICAL SAMPLES, AND METHOD FOR THE OPERATION THEREOF 审中-公开
标题翻译：可靠的冷却系统，特别适用于生物生物样品的制备及其操作方法
公开(公告)号：US20140000307A1
公开(公告)日：2014-01-02
申请号：US13983342
申请日：2012-02-01
申请人： Guenter R. Fuhr , Heiko Zimmermann , Bernd R. Kranz , Tomm Schmidt
发明人： Guenter R. Fuhr , Heiko Zimmermann , Bernd R. Kranz , Tomm Schmidt
IPC分类号： F25D3/10
CPC分类号： F25D3/10 , F25D3/102 , F25D25/00 , F25D29/001
摘要： A cooling system (1), especially for cryopreserving biological samples (2), comprises a cooling chamber (100) delimited by a bottom area (110), side walls (120), and a top area (130), and a cooling device (200) for cooling the cooling chamber (100) using liquid nitrogen (220). The bottom area (110) is designed for direct cooling using the liquid nitrogen, and the cooling chamber (100) is dimensioned such that an operator (3) can access and move around in the cooling chamber (100). The bottom area (110) has a platform (111) which is permeable to vapor of the liquid nitrogen (220) and forms a support zone for the operator (3). Methods for operating the cooling system are also described.
摘要翻译：特别是用于冷冻保存生物样品（2）的冷却系统（1）包括由底部区域（110），侧壁（120）和顶部区域（130）限定的冷却室（100），以及冷却装置（200），用于使用液氮（220）冷却所述冷却室（100）。底部区域110被设计用于使用液氮进行直接冷却，并且冷却室100的尺寸设计成使得操作者（3）能够在冷却室100中进入和移动。底部区域（110）具有能够渗透液氮（220）的蒸气的平台（111），并形成操作者（3）的支撑区域。还描述了用于操作冷却系统的方法。

2. 发明申请

US20130305438A1 PROTECTIVE SUIT FOR USE IN A COOLING CHAMBER 有权
标题翻译：用于冷却室的保护套件
公开(公告)号：US20130305438A1
公开(公告)日：2013-11-21
申请号：US13983268
申请日：2012-02-01
申请人： Guenter R. Fuhr , Heiko Zimmermann , Klaus-Peter Hoffmann
发明人： Guenter R. Fuhr , Heiko Zimmermann , Klaus-Peter Hoffmann
IPC分类号： A62B17/00
CPC分类号： A62B17/00 , A41D13/0051 , A41D19/01535 , A62B17/005 , H05B3/34 , H05B3/84 , H05B2203/022 , H05B2203/033 , H05B2203/036
摘要： A protective suit (100), especially for an operator (1) in a cooling chamber that is cooled using liquid nitrogen or vapor of the liquid nitrogen comprises a body suit (10) which has a thermally insulating, gas-tight cover material (20) and is designed to accommodate the operator (1), and a heating device (30) which is connected to the body suit (10) and is designed to heat the interior of the protective suit (100). A glove (70) which is made of a thermally insulating glove material (71) and includes a glove heater (77) is also described.
摘要翻译：特别是对于使用液氮或液氮的蒸气冷却的冷却室中的操作者（1）的防护服（100）包括：身体套装（10），其具有隔热，气密的覆盖材料（20 ），并且被设计成容纳操作者（1），以及加热装置（30），其连接到身体衣服（10）并被设计成加热防护服（100）的内部。还描述了由绝热手套材料（71）制成并且包括手套加热器（77）的手套（70）。

3. 发明授权

US08451138B2 Cryogenic storage device comprising a transponder 有权
标题翻译：低温存储设备包括应答器
公开(公告)号：US08451138B2
公开(公告)日：2013-05-28
申请号：US13158046
申请日：2011-06-10
申请人： Heiko Zimmermann , Guenter R. Fuhr , Rolf Hagedorn
发明人： Heiko Zimmermann , Guenter R. Fuhr , Rolf Hagedorn
IPC分类号： G01N1/42 , C12N1/00 , C12Q3/00 , G08C17/04
CPC分类号： G01N1/42 , A01N1/02 , A01N1/0263 , B01L3/545 , B01L2300/022 , F25D29/001 , F25D2700/08 , G01N35/00732 , G01N35/00871 , G01N2035/00782 , G06K7/0008 , G06K19/0723 , G06K19/07758
摘要： A method for operating a cryostorage device (100), especially for biological samples, is described which comprises a sample carrier (10) to receive at least one sample (11) and a data storage (20), wherein data are inductively transmitted from the data storage device (20) into a wireless transmission channel (40) and/or conversely using a resonant circuit (30) connected to the data storage device (20).
摘要翻译：描述了一种用于操作特别是用于生物样品的冷冻保存装置（100）的方法，其包括用于接收至少一个样品（11）和数据存储器（20）的样品载体（10），其中数据从数据存储装置（20）进入无线传输通道（40）和/或相反地使用连接到数据存储装置（20）的谐振电路（30）。

4. 发明申请

US20120079990A1 METHOD AND APPARATUS FOR CONSERVING DEEP-SEA ORGANISMS 有权
标题翻译：用于保护深海有机体的方法和装置
公开(公告)号：US20120079990A1
公开(公告)日：2012-04-05
申请号：US13319182
申请日：2010-06-14
申请人： Guenter R. Fuhr , Heiko Zimmermann , Charli Kruse , Robert Lemor
发明人： Guenter R. Fuhr , Heiko Zimmermann , Charli Kruse , Robert Lemor
IPC分类号： A01N1/02 , A01M23/00 , A01K61/00
CPC分类号： A01K63/02 , A01N1/00 , A01N1/0221 , A01N1/0252 , A01N1/0284
摘要： The invention relates to a method for conserving at least one biological deep-sea organism (1) comprising the steps of collecting the biological organism (1) in a deep-sea trapping device (110); cooling the biological organism (1) with a cooling device (120), wherein the biological organism (1) is put in a frozen condition; and moving the frozen biological organism (1), preferably with the trapping device (110), to a normal-pressure environment. The invention further relates to a conservation apparatus (100) for conserving at least one biological deep-sea organism (1).
摘要翻译：本发明涉及一种用于保存至少一种生物深海生物体的方法（1），包括以下步骤：在深海捕获装置（110）中收集生物体（1）; 用冷却装置（120）冷却生物体（1），其中所述生物体（1）处于冷冻状态; 以及将所述冷冻生物体（1）优选地与所述捕集装置（110）一起移动到常压环境。本发明还涉及一种用于保存至少一种生物深海生物（1）的保存装置（100）。

5. 发明申请

US20110277486A1 CRYOGENIC STORAGE DEVICE COMPRISING A TRANSPONDER 有权
标题翻译：包含TRANSPONDER的低温储存装置
公开(公告)号：US20110277486A1
公开(公告)日：2011-11-17
申请号：US13158046
申请日：2011-06-10
申请人： Heiko ZIMMERMANN , Guenter R. FUHR , Rolf HAGEDORN
发明人： Heiko ZIMMERMANN , Guenter R. FUHR , Rolf HAGEDORN
IPC分类号： F17C13/02
CPC分类号： G01N1/42 , A01N1/02 , A01N1/0263 , B01L3/545 , B01L2300/022 , F25D29/001 , F25D2700/08 , G01N35/00732 , G01N35/00871 , G01N2035/00782 , G06K7/0008 , G06K19/0723 , G06K19/07758
摘要： A method for operating a cryostorage device (100), especially for biological samples, is described which comprises a sample carrier (10) to receive at least one sample (11) and a data storage (20), wherein data are inductively transmitted from the data storage device (20) into a wireless transmission channel (40) and/or conversely using a resonant circuit (30) connected to the data storage device (20).
摘要翻译：描述了一种用于操作特别是用于生物样品的冷冻保存装置（100）的方法，其包括用于接收至少一个样品（11）和数据存储器（20）的样品载体（10），其中数据从数据存储装置（20）进入无线传输通道（40）和/或相反地使用连接到数据存储装置（20）的谐振电路（30）。

6. 发明申请

US20130198529A1 SAMPLE CARRIER UNIT HAVING SAMPLE DATA ENCRYPTION AND METHOD FOR USE THEREOF 审中-公开
标题翻译：具有样本数据加密的样本载体单元及其使用方法
公开(公告)号：US20130198529A1
公开(公告)日：2013-08-01
申请号：US13878218
申请日：2011-10-10
申请人： Guenter R. Fuhr , Heiko Zimmermann , Haiko Wick , Frank Ihmig
发明人： Guenter R. Fuhr , Heiko Zimmermann , Haiko Wick , Frank Ihmig
IPC分类号： G06F21/60
CPC分类号： G06F21/602 , A01N1/0268 , B01L1/50 , B01L3/545 , B01L2300/02 , B01L2300/022 , B01L2300/024
摘要： A sample carrier unit (100), in particular for biological samples, is described which comprises a sample uptake unit (10) which is equipped for taking up at least one sample, a data storage unit (20) which is equipped for the storage of sample data that relate to the at least one sample, and to a key storage unit (30) having at least one key store (31, 32, 33), wherein the key storage unit (30) is equipped for storing key data in the at least one key store (31, 32, 33). At least one key store (31, 32, 33) of the key storage unit (30) can be arranged so as to be separable from the sample carrier unit (100). In addition, a data processing unit (200) which is configured for coupling to the sample carrier unit (100) and a method for processing sample data are described, which sample data are encrypted using at least one cryptological key which is stored in the key storage unit (30).
摘要翻译：描述了一种特别用于生物样品的样品载体单元（100），其包括装备用于吸收至少一个样品的样品摄取单元（10），用于储存至少一个样品的数据存储单元（20）与所述至少一个样本相关的样本数据以及具有至少一个密钥存储器（31,32,33）的密钥存储单元（30），其中所述密钥存储单元（30）被配备用于存储关键数据至少一个密钥库（31,32,33）。密钥存储单元（30）的至少一个密钥存储器（31,32,33）可以布置成可以与样本载体单元（100）分离。此外，描述被配置为耦合到采样载体单元（100）的数据处理单元（200）和用于处理采样数据的方法，使用存储在密钥中的至少一个加密密钥来加密采样数据存储单元（30）。

7. 发明申请

US20110219788A1 CRYOGENIC STORAGE DEVICE 有权
标题翻译：低温储存装置
公开(公告)号：US20110219788A1
公开(公告)日：2011-09-15
申请号：US13129870
申请日：2009-11-09
申请人： Heiko Zimmermann , Uwe Schoen , Guenter R. Fuhr , Dirk Leuthold , Marianne Belke
发明人： Heiko Zimmermann , Uwe Schoen , Guenter R. Fuhr , Dirk Leuthold , Marianne Belke
IPC分类号： F25D13/06 , F25B49/00
CPC分类号： A01N1/0252 , F25B2700/04 , F25D3/102 , F25D3/11 , F25D29/001 , F25D2600/02 , F25D2700/12 , F25D2700/16 , G01N1/42 , G01N2035/00435
摘要： The invention relates to a cryogenic storage device and to a method for operating a cryogenic storage device, particularly for cryogenic storage of biological samples, comprising a sample carrying device that is set up to accommodate samples, a cryogenic container that is set up to accommodate the sample carrying device, a container cooling device with which the cryogenic container can be cooled, an intermediate storage container that is set up for intermediate storage of the sample carrying device, a transport device with which the sample carrying device can be moved between the cryogenic container and the intermediate storage container and a sensor device with which at least one operating parameter of the cryogenic storage device can be registered. The transport device is set up to be activated in dependence on an output signal from the sensor device upon registering a predetermined operating condition of the cryogenic storage device, so that the sample carrying device is moved from the cryogenic container to the intermediate storage container. Additionally or alternatively, an intermediate storage cooling device that is set up for cooling the intermediate storage container can be activated in dependence on an output signal of the sensor device.
摘要翻译：本发明涉及一种低温存储装置和一种用于操作低温存储装置的方法，特别是用于生物样品的低温储存的方法，包括设置用于容纳样品的样品携带装置，设置为容纳样品运送装置，用于冷冻低温容器的容器冷却装置，设置用于样品运送装置的中间储存的中间储存容器，运送装置，使样品运送装置能够在低温容器以及可以登记低温储存装置的至少一个操作参数的中间储存容器和传感器装置。传送装置被设置为在登记低温存储装置的预定操作条件时依赖于来自传感器装置的输出信号被激活，使得样品携带装置从低温容器移动到中间储存容器。另外或替代地，可以根据传感器装置的输出信号激活设置用于冷却中间存储容器的中间存储冷却装置。

8. 发明申请

US20110020933A1 METHOD AND DEVICE FOR RECEIVING BIOLOGICAL CELLS FROM A STEM CELL CULTURE 审中-公开
标题翻译：用于从干细胞培养物接收生物细胞的方法和装置
公开(公告)号：US20110020933A1
公开(公告)日：2011-01-27
申请号：US12671534
申请日：2008-07-25
申请人： Charli Kruse , Guenter R. Fuhr
发明人： Charli Kruse , Guenter R. Fuhr
IPC分类号： C12N5/074
CPC分类号： C12M33/14 , C12M33/00
摘要： A method for receiving biological cells (1, 2) from a cell culture (3) includes the steps: cultivation of the cell culture on a main substrate (10), cell transfer from the main substrate (10) onto at least one receiving substrate (20, 20.1, 20.2, 20.3, 20.4 . . . ), wherein the cells (1, 2) move onto the at least one receiving substrate (20, 20.1, 20.2, 20.3, 20.4 . . . ) by natural cell locomotion, and a cultivation of the cells (1, 2) is provided on the at least one receiving substrate (20, 20.1, 20.2, 20.3, . . . ), and separation of the main substrate (10) and of the at least one receiving substrate (20, 20.1, 20.2, 20.3, 20.4 . . . ) from one another. Also described is a substrate arrangement (100) for providing biological cells (1, 2) of a cell culture (3).
摘要翻译：从细胞培养物（3）接收生物细胞（1,2）的方法包括以下步骤：在主衬底（10）上培养细胞培养物，将细胞从主衬底（10）转移到至少一个接收衬底（20,20.1,20.2,20.3,20.4 ...），其中细胞（1,2）通过天然细胞运动移动到至少一个接收衬底（20,20.1,20.2,20.3,20.4 ...）上，并且在所述至少一个接收基板（20,20.1,20.2,20.3等）上设置所述单元（1,2）的培养，并且分离所述主基板（10）和所述至少一个接收衬底（20,20.1,20.2,20.3,20.4 ...）彼此。还描述了一种用于提供细胞培养物（3）的生物细胞（1,2）的底物装置（100）。

9. 发明申请

US20100062529A1 APPARATUS AND METHOD FOR THE DEPOSITION OF BIOLOGICAL MATERIAL IN A TARGET SUBSTRATE 有权
标题翻译：目标物质沉积生物材料的装置和方法
公开(公告)号：US20100062529A1
公开(公告)日：2010-03-11
申请号：US12514338
申请日：2008-01-28
申请人： Heiko Zimmermann , Guenter R. Fuhr
发明人： Heiko Zimmermann , Guenter R. Fuhr
IPC分类号： C12N5/00 , C12M1/00
CPC分类号： C12M35/08 , C12M35/00 , C12M41/12
摘要： Disclosed is a deposition apparatus (100) which is designed to deposit frozen biological material (1) in a target substrate (2) and includes a charging device (10) and a driving device (20). The charging device (10) is designed to supply the biological material (1) to the driving device (20) while the driving device (20) is designed to apply a driving force to the biological material (1). In order to apply the driving force, the driving device (20) is formed such that the biological material (1) can penetrate into the target substrate (2) under the effect of the driving force. Also disclosed are an injector cartridge which is designed to provide frozen biological material in a deposition apparatus as well as a method for depositing biological material (1) in a target substrate (2).
摘要翻译：公开了一种沉积设备（100），其设计成将冷冻的生物材料（1）沉积在目标基底（2）中，并包括充电装置（10）和驱动装置（20）。充电装置（10）被设计成将生物材料（1）供应到驱动装置（20），同时驱动装置（20）被设计成向生物材料（1）施加驱动力。为了施加驱动力，驱动装置（20）形成为使得生物材料（1）能够在驱动力的作用下渗透到目标基板（2）中。还公开了一种被设计成在沉积设备中提供冷冻生物材料的注射器盒以及用于在生物材料（1）中沉积到靶基底（2）中的方法。

10. 发明授权

US09851304B2 Method and device for monitoring a cryopreserved biological sample 有权
公开(公告)号：US09851304B2
公开(公告)日：2017-12-26
申请号：US13988558
申请日：2011-10-26
申请人： Guenter R. Fuhr , Heiko Zimmermann , Frank Stracke , Daniel Doerr
发明人： Guenter R. Fuhr , Heiko Zimmermann , Frank Stracke , Daniel Doerr
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , G01N21/658
摘要： The invention relates to a method for monitoring a cryopreserved biological sample (1), comprising the steps of providing the biological sample (1) in a cryopreserved state, measuring at least one Raman spectroscopic sample characteristic by means of a Raman spectroscopic measuring apparatus (10, 20), comparing the at least one sample characteristic with a reference characteristic by means of an evaluating apparatus (30), and providing a state characteristic that depends on the result of the comparison and that is characteristic of a storage state of the biological sample (1). The invention further relates to a monitoring device for cryopreserved samples, in particular for performing said method.

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