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1. 发明授权

US06932979B2 Soluble, gum-containing, coated chewable tablet 有权
标题翻译：可溶，含胶，涂层咀嚼片
公开(公告)号：US06932979B2
公开(公告)日：2005-08-23
申请号：US10407134
申请日：2003-04-07
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely
IPC分类号： A23G3/00 , A23G3/02 , A23G3/38 , A23G3/42 , A23G3/54 , A61K9/00 , A61K9/20
CPC分类号： A23G3/42 , A23G3/0289 , A23G3/38 , A23G3/54 , A61K9/0056
摘要： The soluble, rubber-containing, coated chewable tablet contains chewable components, syrup components and fat or wax components and optionally fillers. It can be prepared by a process in which pulverulent chewable components are mixed with the molten fat or wax components. The mixture, with the addition of at least one syrup component, then becomes a crumbly material, which is then cooled to below 0° C., then milled to a particle size of not more than 5 mm and, after cooling to below 10° C., compressed to give tablets which are coated in a known manner. The finished product—due to compression of the cooled granules—presumably has a partially granular structure in which the moisture has been initially immobilized by the low temperature. After compression, this moisture becomes mobile as a result of heating (in particular during the coating process) and migrates or diffuses—initially at the surface—into the water-soluble ingredients present. These are partially dissolved and give a highly viscous, thixotropic, chewable material.
摘要翻译：可溶的含橡胶的涂覆的咀嚼片含有咀嚼成分，糖浆组分和脂肪或蜡组分以及任选的填充剂。可以通过将粉状咀嚼成分与熔融脂肪或蜡成分混合的方法来制备。加入至少一种糖浆组分的混合物然后变成易碎的材料，然后将其冷却至0℃以下，然后研磨至不大于5mm的粒度，冷却至10℃以下 C.压缩得到以已知方式包衣的片剂。由于冷却的颗粒的压缩，最终产品可能具有部分颗粒状结构，其中水分最初被低温固定。在压缩之后，由于加热（特别是在涂布过程中），这种水分变得可移动，并且迁移或扩散 - 最初在表面进入存在的水溶性成分。这些部分溶解并产生高粘度，触变性，咀嚼材料。

2. 发明授权

US06497900B2 Effervescent base 有权
标题翻译：泡腾基地
公开(公告)号：US06497900B2
公开(公告)日：2002-12-24
申请号：US09529343
申请日：2000-05-24
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
IPC分类号： A61K946
CPC分类号： A61K9/0007
摘要： The effervescent base for the preparation of effervescent tablets and effervescent granules consists of at least one acidic and one gas-evolving component, the former of which is formed by a mixture of (predominantly) monosodium tartrate and (possibly) disodium tartrate, and optionally tartaric acid. The effervescent base is prepared by mixing tartaric acid with sodium bicarbonate and sodium carbonate containing water of crystallization and slowly reacting the mixture at a temperature increasing to about 50° C., after which further sodium carbonate containing water of crystallization is admixed and is allowed to react up to a temperature of about 60° C., and drying is then carried out, preferably in vacuo, the mixture is mixed with further, now anhydrous sodium carbonate and the product is optionally pressed to give tablets. The base may additionally comprise an acid sensitive or an alkali-sensitive pharmaceutically active substance.
摘要翻译：用于制备泡腾片和泡腾颗粒的泡腾基底由至少一种酸性和一种气体逸出组分组成，前者由（主要）酒石酸单钠和（可能）酒石酸二钠）和任选的酒石酸酸。通过将酒石酸与碳酸氢钠和含有结晶水的碳酸钠混合制备起泡底物，并将混合物在升高至约50℃的温度下缓慢反应，然后混合另外含有结晶水的含碳酸钠，并使其反应至约60℃的温度，然后进行干燥，优选在真空中，将混合物与另外的无水碳酸钠混合，任选地将产物压制得到片剂。碱可以另外包含酸敏感或碱敏感的药物活性物质。

3. 发明授权

US5064656A Uncoated pharmaceutical reaction tablet 失效
标题翻译：未经处理的药物反应片
公开(公告)号：US5064656A
公开(公告)日：1991-11-12
申请号：US574585
申请日：1990-08-28
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely
IPC分类号： A61K9/20 , A61K9/46
CPC分类号： A61K9/0007
摘要： An uncoated compressed tablet which is used for the preparation of an orally applicable aqueous suspension or solution of a pharmaceutically active substance contains a mixture of the pharmaceutically active substance, a swelling disintegrant and an effervescent system. The weight ratio of the disintegrant to the effervescent system is from 0.1:1 to 4:1.
摘要翻译：用于制备口服适用的水性悬浮液或药物活性物质溶液的未包衣的压制片剂包含药物活性物质，溶胀崩解剂和泡腾系统的混合物。崩解剂与泡腾系统的重量比为0.1：1至4：1。

4. 发明授权

US4968517A Method for preparing an effervescent granulate, an effervescent granulate made accordingly 失效
标题翻译：制备泡腾颗粒的方法，相当于泡腾颗粒
公开(公告)号：US4968517A
公开(公告)日：1990-11-06
申请号：US221788
申请日：1988-08-16
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Ruediger Wolf
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Ruediger Wolf
IPC分类号： A23L2/40 , A61K9/46
CPC分类号： A23L2/40 , A61K9/0007
摘要： The present invention relates to the formation of an effervescent granulate which contains carnitine. The granulate is formed by combining an edible organic acid with an alkaline carbonate or an alkaline earth metal carbonate to form a preliminary reaction solution. After the addition of salt, the crystals are stirred and dried and then finally combined with carnitine.
摘要翻译： PCT No.PCT / EP87 / 00618 Sec。 371日期1988年8月16日 102（e）日期1988年8月16日PCT提交1987年10月21日PCT公布。出版物WO88 / 02993 日期：1988年5月5日。本发明涉及含有肉碱的泡腾颗粒的形成。通过将可食用有机酸与碱性碳酸盐或碱土金属碳酸盐结合形成预反应溶液形成颗粒。加入盐后，将晶体搅拌并干燥，然后最终与肉碱组合。

5. 发明授权

US4911930A Process and means for the heat treatment of powdery or granulate material 失效
标题翻译：用于粉末或颗粒材料的热处理的方法和方法
公开(公告)号：US4911930A
公开(公告)日：1990-03-27
申请号：US297405
申请日：1989-01-17
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely
IPC分类号： A61J3/02 , A61J3/06 , A61K9/00 , A61K9/16 , A61K9/46 , A61K31/19 , B01J2/00 , B01J2/10 , B01J2/12 , B01J2/16 , B01J3/00 , F26B7/00
CPC分类号： B01J2/16 , A61K9/0007 , B01J2/10 , F26B7/00
摘要： Solid, loose particulate materials are treated with vaporizable agent in a process chamber. The materials are combined with a mixture of hot gas and vapor in order to condense finely subdivided amounts of the treatment agent on the material. After a suitable time of reaction, the condensed material is partially removed from the treated material so that the pressure in the process chamber is reduced at least to the point at which the treatment agent partially evaporates, whereupon the portion which has revaporized is extracted from the process chamber. This cycle of introduction and removal of the treating agent is preferably repeated in a program-controlled operation until the desired result is achieved and a product which is suitably agglomerated is obtained. In the present process, particulate material in powder or granule form is agitated and heat-treated in a closed drum, by stirring agents and surface treated by a hot gas flow forced over or through the charge of the material and then extracted intermittently by a vacuum pump. The air is heated and vaporized so that the vapor does not condense on the charge material.
摘要翻译：固体，松散的颗粒材料在处理室中用可蒸发剂处理。将这些材料与热气体和蒸气的混合物组合以便将精细细分的量的处理剂冷凝在材料上。在适当的反应时间之后，将冷凝材料从经处理的材料中部分地除去，使得处理室中的压力至少降低到处理剂部分蒸发的程度，随后从其中提取已再汽化的部分处理室。处理剂的引入和除去的这个循环优选在程序控制操作中重复，直到达到所需的结果，并且获得适当聚集的产物。在本方法中，粉末或颗粒形式的颗粒材料在封闭的鼓中通过搅拌剂进行搅拌和热处理，并通过强制的热气流进行表面处理，或通过该材料的电荷进行表面处理，然后通过真空间歇地提取泵。空气被加热和蒸发，使得蒸气不会在充电材料上冷凝。

6. 发明授权

US4678661A Effervescent composition and method of making same 失效
标题翻译：泡腾组合物及其制造方法
公开(公告)号：US4678661A
公开(公告)日：1987-07-07
申请号：US880081
申请日：1986-06-30
申请人： Gerhard Gergely , Thomas Gergely , Irmgard Gergely
发明人： Gerhard Gergely , Thomas Gergely , Irmgard Gergely
IPC分类号： A23L2/40 , A61K9/46 , A61K33/10
CPC分类号： A61K9/0007 , A23L2/40 , A61K33/10 , Y10S514/819
摘要： Effervescent granulates, particularly for the manufacture of effervescent tablets, comprising at least one solid, crystalline edible organic acid and at least one carbonate which releases carbon dioxide upon reaction with the organic acid, the acid crystals comprising a coating which contains calcium carbonate adhering to the surface of the acid crystals by means of a bonding layer formed by a reaction at the interface with the crystal of a calcium carbonate coating material. The coating is built up in multi-layers and includes at least two carbonate layers, the layer which is bonded essentially to the acid crystal being composed of calcium carbonate with the succeeding layers adhering to the carbonate layer by means of a bonding layer formed by reaction of the acid and the carbonate. The invention also deals with methods of manufacture as well as fields of use for the new effervescent granulates.
摘要翻译：泡腾颗粒，特别是用于制造泡腾片剂，其包含至少一种固体，结晶可食用有机酸和至少一种与有机酸反应释放二氧化碳的碳酸盐，所述酸晶体包含含有碳酸钙的涂层，通过在与碳酸钙涂层材料的结晶的界面处的反应形成的结合层，形成酸晶体的表面。该涂层是多层构成的，并且包括至少两个碳酸盐层，该层基本上与由碳酸钙组成的酸性晶体结合，后续层通过由反应形成的粘合层粘附到碳酸盐层的酸和碳酸盐。本发明还涉及新的泡腾颗粒的制造方法和使用领域。

7. 发明授权

US06190697B1 Effervescent formulation containing plant extract 有权
标题翻译：含有植物提取物的泡腾制剂
公开(公告)号：US06190697B1
公开(公告)日：2001-02-20
申请号：US09178639
申请日：1998-10-26
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
IPC分类号： A61K946
CPC分类号： A61K9/0007 , A61K36/00 , A61K2300/00
摘要： The effervescent formulation elation in the form of granules or of a tablet contains, in addition to the effervescent base, at least one water-soluble or at least suspendable plant extract whose particles are coated with at least one oily, fatty or waxy substance. At least one emulsifier and/or at least one antifoam may be present in the coating and/or as a further component of the mixture, in particular applied as a further component of the mixture to a pharmaceutically permissible filler as carrier. The individual phases are prepared by a procedure in which the plant extract or the filler is heated—preferably in a granulator, in particular in a vacuum granulator—and wet or mixed with a melt or solution of the oily, fatty or waxy substance or at least one emulsifier and/or at least one antifoam and then dried—preferably in a vacuum—and sieved to the desired particle size.
摘要翻译：颗粒或片剂形式的泡腾剂配方除了泡腾基质之外还含有至少一种水溶性或至少可悬浮的植物提取物，其颗粒被至少一种油性，脂肪或蜡状物质包被。至少一种乳化剂和/或至少一种消泡剂可以存在于涂层和/或作为混合物的另外的组分中，特别是作为混合物的另外的组分被用作药学上允许的填料作为载体。各个阶段通过其中植物提取物或填料加热的方法制备，优选在造粒机中，特别是在真空制粒机中，并且与油，脂肪或蜡质物质的熔体或溶液一起湿润或混合，或在至少一种乳化剂和/或至少一种消泡剂，然后干燥，优选在真空中并筛分至所需粒度。

8. 发明授权

US5888544A Effervescent system for effervescent tablets and effervescent granules 失效
标题翻译：泡腾系统泡腾片和泡腾颗粒
公开(公告)号：US5888544A
公开(公告)日：1999-03-30
申请号：US867446
申请日：1997-06-02
申请人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
发明人： Gerhard Gergely , Irmgard Gergely , Thomas Gergely , Stefan Gergely
IPC分类号： A23L2/00 , A23L1/00 , A23L2/40 , A61K9/46 , C01B32/60
CPC分类号： A61K9/0007
摘要： The effervescent system for effervescent tablets and/or effervescent granules contains, on the one hand, particles of a solid, edible, organic acid and, on the other hand, particles of at least one alkali metal bicarbonate, of which at least 1, preferably from 2 to 4, but at most 10, preferably at most 8, % by weight are superficially converted into dry alkali metal carbonate free of water of crystallization. The acid particles, preferably citric acid particles, can be covered in a manner known per se by partial reaction with at least one carbonate and/or bicarbonate, preferably from about 20 to 40% by weight thereof. The conversion mentioned is carried out by a procedure in which commercial alkali metal bicarbonate particles are heated in a vacuum vessel at less than 40, preferably less than 20, in particular less than 10, mbar at above 60.degree. C., preferably between 80.degree. C. and 120.degree. C., in particular at about 100.degree. C., and are cooled to below 60.degree. C., preferably to below 50.degree. C., after a time predetermined by the desired layer thickness, while maintaining the vacuum. The alkali metal carbonate particles evolve only a little CO.sub.2 even on storage at elevated temperature, and the formation of free salicylic acid (fSA) from any acetylsalicylic acid mixed with the effervescent system remains very small.
摘要翻译：泡腾片和/或泡腾颗粒的泡腾系统一方面包含固体，可食用的有机酸的颗粒，另一方面含有至少一种碱金属碳酸氢盐的颗粒，其中至少1个，优选 2至4，但至多10，优选至多8重量％表面转化为不含结晶水的干碱金属碳酸盐。酸性颗粒，优选柠檬酸颗粒可以以本身已知的方式用至少一种碳酸盐和/或碳酸氢盐，优选约20至40重量％的部分反应来包覆。所述的转化是通过以下步骤进行的：其中商业碱金属碳酸氢盐颗粒在真空容器中以低于40℃，优选小于20℃，特别是小于10℃，高于60℃，优选80℃加热。在120℃，特别是约100℃下，在保持真空的同时，经预定的期望层厚度，冷却至低于60℃，优选低于50℃。碱金属碳酸盐颗粒即使在升高的温度下储存也仅释放少量二氧化碳，并且与泡腾体系混合的任何乙酰水杨酸的游离水杨酸（fSA）的形成仍然非常小。

9. 发明授权

US4737366A Chewing gum and production method thereof 失效
标题翻译：口香糖及其生产方法
公开(公告)号：US4737366A
公开(公告)日：1988-04-12
申请号：US913662
申请日：1986-08-26
申请人： Gerhard Gergely , Thomas Gergely , Irmgard Gergely
发明人： Gerhard Gergely , Thomas Gergely , Irmgard Gergely
IPC分类号： A23G4/00 , A23G3/02 , A23G4/02 , A23G4/04 , A23G4/06 , A23G4/08 , A23G4/20 , A61K9/00 , A61K9/68 , A23G3/30
CPC分类号： A23G4/06 , A23G3/0289 , A23G4/02 , A23G4/043 , A23G4/08 , A23G4/20 , A61K9/0058
摘要： A chewing gum which consists of a chewing gum base, fats or waxes, fillers, additives and active substances, the chewing gum base being present in a particle size of 0.2 to 1 mm, together with the fillers, additives and active substances, in the matrix of fats and waxes. The tablet form is preferably coated with a tablet coating. Production is effected by separately comminuting the chewing gum base on the one hand and the matrix on the other hand at low temperatures, mixing the two types of granules and then pressing the mixture on a cooled tableting press. Finally, the tablets are coated with a covering layer and slowly heated to 40.degree.-45.degree. C.
摘要翻译： PCT No.PCT / EP85 / 00735 Sec。 371日期1986年8月26日第 102（e）日期1986年8月26日PCT 1985年12月21日PCT PCT。公开号WO86 / 03967 日期：1986年7月17日。由口香糖基料，脂肪或蜡，填料，添加剂和活性物质组成的口香糖，口香糖基料的粒径为0.2-1毫米，添加剂和活性物质，在脂肪和蜡的基质中。片剂形式优选用片剂包衣包衣。一方面通过单独粉碎口香糖基料和另一方面在低温下进行生产，混合两种类型的颗粒，然后在冷却的压片机上压制该混合物。最后，将片剂涂覆覆盖层并缓慢加热至40-45℃。

10. 发明授权

US4560282A Apparatus for mixing and granulating powdery substances with a sifting device attached by means of a valve closure 失效
标题翻译：用于通过阀关闭连接的筛分装置混合和制粒粉状物质的装置
公开(公告)号：US4560282A
公开(公告)日：1985-12-24
申请号：US572964
申请日：1984-01-23
申请人： Gerhard Gergely
发明人： Gerhard Gergely
IPC分类号： B01F15/00 , B01J2/10 , B01F7/08 , B01F15/02
CPC分类号： B01J2/10 , B01F15/00954
摘要： The present invention is directed to a sifting device that is attached to a granulating apparatus. The sifting device includes a disk valve which can be shut, allowing the sifting device to be cleaned apart from the granulating apparatus, without detaching the sifting device from the granulating apparatus.
摘要翻译：本发明涉及一种附着在造粒装置上的筛选装置。筛选装置包括可关闭的盘阀，允许筛分装置与造粒装置分离，而不将筛分装置从造粒装置分离。

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