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1. 发明授权

US08350020B2 Compositions and methods related to mRNA translational enhancer elements 有权
公开(公告)号：US08350020B2
公开(公告)日：2013-01-08
申请号：US12316581
申请日：2008-12-11
申请人： Vincent P. Mauro , Gerald M. Edelman , Wei Zhou
发明人： Vincent P. Mauro , Gerald M. Edelman , Wei Zhou
IPC分类号： C07H21/04 , C12N15/63 , C12N15/85 , C12P21/00
摘要： Provided are mRNA translational enhancer elements (TEEs), e.g., SEQ ID NOs:1-35. Also provided are translational enhancer polynucleotides that comprise one or more of the specific TEEs exemplified herein or their variants, homologs or functional derivatives. Further provided are expression vectors comprising such TEEs or translational enhancer polynucleotides, as well as host cells and expression systems that harbor such vectors.

2. 发明申请

US20110047109A1 Brain-Based Device Having a Cerebellar Model for Predictive Motor Control 有权
标题翻译：具有用于预测电机控制的小脑模型的基于脑的装置
公开(公告)号：US20110047109A1
公开(公告)日：2011-02-24
申请号：US12914596
申请日：2010-10-28
申请人： Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
发明人： Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
IPC分类号： B25J9/00 , G06F15/18
CPC分类号： G05B13/04 , G05B13/026 , G06N3/008 , G06N3/049
摘要： A mobile brain-based device (BBD) includes a mobile platform with sensors and effectors, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.
摘要翻译：基于移动脑的设备（BBD）包括具有传感器和效果器的移动平台，其由模拟神经系统引导，模拟神经系统是用于预测运动控制的大脑小脑区域的类似物，以确定与真实世界的交互环境。模拟神经系统具有包括脑前核（PN），浦肯野细胞（PC），深小脑核（DCN）和下橄榄（IO）的神经区域，用于预测在现实环境中运动期间BBD的转向和速度控制。 BBD经过培训和测试，模拟神经系统基于延迟资格追踪学习规则学习和执行控制功能。

3. 发明授权

US07519452B2 Mobile brain-based device for use in a real world environment 有权
标题翻译：用于现实世界环境中的基于移动大脑的设备
公开(公告)号：US07519452B2
公开(公告)日：2009-04-14
申请号：US11105019
申请日：2005-04-13
申请人： Anil K. Seth , Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
发明人： Anil K. Seth , Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
IPC分类号： G06F15/18 , G06N3/00 , G06F15/00 , G05B19/04
CPC分类号： G06F15/18 , G06F3/015 , G06K9/629 , G06N3/004 , G06N3/049 , G16H50/50
摘要： A mobile brain-based device BBD includes a mobile base equipped with sensors and effectors (Neurally Organized Mobile Adaptive Device or NOMAD), which is guided by a simulated nervous system that is an analogue of cortical and sub-cortical areas of the brain required for visual processing, decision-making, reward, and motor responses. These simulated cortical and sub-cortical areas are reentrantly connected and each area contains neuronal units representing both the mean activity level and the relative timing of the activity of groups of neurons. The brain-based device BBD learns to discriminate among multiple objects with shared visual features, and associated “target” objects with innately preferred auditory cues. Globally distributed neuronal circuits that correspond to distinct objects in the visual field of NOMAD 10 are activated. These circuits, which are constrained by a reentrant neuroanatomy and modulated by behavior and synaptic plasticity, result in successful discrimination of objects. The brain-based device BBD is moveable, in a rich real-world environment involving continual changes in the size and location of visual stimuli due to self-generated or autonomous, movement, and shows that reentrant connectivity and dynamic synchronization provide an effective mechanism for binding the features of visual objects so as to reorganize object features such as color, shape and motion while distinguishing distinct objects in the environment.
摘要翻译：基于移动脑的设备BBD包括配备有传感器和效应器（神经有机移动自适应装置或NOMAD）的移动基座，其由模拟神经系统引导，该模拟神经系统是脑的皮质和皮质下皮区域的类似物，视觉处理，决策，奖励和运动反应。这些模拟的皮质和皮质区域是可重复连接的，每个区域包含表示神经元组的平均活动水平和相对时间的神经元单位。基于脑的设备BBD学习使用共享的视觉特征和相关联的“目标”对象与具有本来优选的听觉线索的多个对象之间进行区分。对应于NOMAD 10的视野中的不同物体的全球分布的神经元电路被激活。这些由折返性神经解剖学限制并由行为和突触可塑性调节的电路导致对象的成功辨别。基于大脑的设备BBD可以在丰富的现实环境中移动，包括由于自我生成或自主运动引起的视觉刺激的大小和位置的持续变化，并且表明可重入连接性和动态同步为绑定视觉对象的特征，以便重新组织对象特征，如颜色，形状和运动，同时区分环境中的不同对象。

4. 发明授权

US07468275B2 Synthetic internal ribosome entry sites and methods of identifying same 失效
标题翻译：合成内部核糖体进入位点及其鉴定方法
公开(公告)号：US07468275B2
公开(公告)日：2008-12-23
申请号：US10182327
申请日：2001-01-26
申请人： Vincent P. Mauro , Gerald M. Edelman , Stephen A. Chappell , Geoffrey Owens , Jason K. Pinkstaff , Leslie Krushel , Wei Zhou
发明人： Vincent P. Mauro , Gerald M. Edelman , Stephen A. Chappell , Geoffrey Owens , Jason K. Pinkstaff , Leslie Krushel , Wei Zhou
IPC分类号： C12N15/63 , C12N15/85 , C12N5/10 , C07H21/02 , C07H21/04 , A61K48/00
CPC分类号： C12N15/1034 , C12N15/79
摘要： Synthetic and isolated translational regulatory elements, including oligonucleotides that have translational enhancing activity, internal ribosome entry site (IRES) activity, or translational inhibitory activity, and multimers of such translational regulatory elements are provided. In addition, compositions that include such translational regulatory elements are provided, as are methods of using the translational regulatory elements.
摘要翻译：提供合成和分离的翻译调节元件，包括具有翻译增强活性的寡核苷酸，内部核糖体进入位点（IRES）活性或翻译抑制活性，以及这些翻译调节元件的多聚体。此外，提供包括这种翻译调控元件的组合物，以及使用翻译调节元件的方法。

5. 发明申请

US20120173020A1 MOBILE BRAIN-BASED DEVICE FOR USE IN A REAL WORLD ENVIRONMENT 审中-公开
标题翻译：用于实际世界环境的基于移动电脑的设备
公开(公告)号：US20120173020A1
公开(公告)日：2012-07-05
申请号：US13308296
申请日：2011-11-30
申请人： Anil K. Seth , Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
发明人： Anil K. Seth , Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
IPC分类号： G06F15/18
CPC分类号： G06N20/00 , G06F3/015 , G06K9/629 , G06N3/004 , G06N3/049 , G16H50/50
摘要： A mobile brain-based device BBD includes a mobile base equipped with sensors and effectors (Neurally Organized Mobile Adaptive Device or NOMAD), which is guided by a simulated nervous system that is an analogue of cortical and sub-cortical areas of the brain required for visual processing, decision-making, reward, and motor responses. The brain-based device BBD learns to discriminate among multiple objects with shared visual features, and associated “target” objects with innately preferred auditory cues. The brain-based device BBD is moveable, in a rich real-world environment involving continual changes in the size and location of visual stimuli due to self-generated or autonomous, movement, and shows that reentrant connectivity and dynamic synchronization provide an effective mechanism for binding the features of visual objects so as to reorganize object features such as color, shape and motion while distinguishing distinct objects in the environment.
摘要翻译：基于移动脑的设备BBD包括配备有传感器和效应器（神经有机移动自适应装置或NOMAD）的移动基座，其由模拟神经系统引导，该模拟神经系统是大脑所需的皮层和皮质下皮质区域的类似物视觉处理，决策，奖励和运动反应。基于脑的设备BBD学习使用共享的视觉特征和相关联的“目标”对象与具有本来优选的听觉线索的多个对象之间进行区分。基于大脑的设备BBD可以在丰富的现实环境中移动，包括由于自我生成或自主运动引起的视觉刺激的大小和位置的持续变化，并且表明可重入连接性和动态同步为绑定视觉对象的特征，以便重新组织对象特征，如颜色，形状和运动，同时区分环境中的不同对象。

6. 发明授权

US08131658B2 Brain-based device having a cerebellar model for predictive motor control 有权
标题翻译：具有用于预测性运动控制的小脑模型的基于脑的装置
公开(公告)号：US08131658B2
公开(公告)日：2012-03-06
申请号：US12914596
申请日：2010-10-28
申请人： Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
发明人： Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
IPC分类号： G06N5/00
CPC分类号： G05B13/04 , G05B13/026 , G06N3/008 , G06N3/049
摘要： A mobile brain-based device (BBD) includes a mobile platform with sensors and effectors, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.
摘要翻译：基于移动脑的设备（BBD）包括具有传感器和效果器的移动平台，其由模拟神经系统引导，模拟神经系统是用于预测运动控制的大脑小脑区域的类似物，以确定与真实世界的交互环境。模拟神经系统具有包括脑前核（PN），浦肯野细胞（PC），深小脑核（DCN）和下橄榄（IO）的神经区域，用于预测在现实环境中运动期间BBD的转向和速度控制。 BBD经过培训和测试，模拟神经系统基于延迟资格追踪学习规则学习和执行控制功能。

7. 发明授权

US07827124B2 Brain-based device having a cerebellar model for predictive motor control 有权
标题翻译：具有用于预测性运动控制的小脑模型的基于脑的装置
公开(公告)号：US07827124B2
公开(公告)日：2010-11-02
申请号：US11646930
申请日：2006-12-27
申请人： Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
发明人： Jeffrey L. McKinstry , Gerald M. Edelman , Jeffrey L. Krichmar
IPC分类号： G06N5/00
CPC分类号： G05B13/04 , G05B13/026 , G06N3/008 , G06N3/049
摘要： A mobile brain-based device (BBD) includes a mobile platform with sensors and effectors, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.
摘要翻译：基于移动脑的设备（BBD）包括具有传感器和效果器的移动平台，其由模拟神经系统引导，模拟神经系统是用于预测运动控制的大脑小脑区域的类似物，以确定与真实世界的交互环境。模拟神经系统具有包括脑前核（PN），浦肯野细胞（PC），深小脑核（DCN）和下橄榄（IO）的神经区域，用于预测在现实环境中运动期间BBD的转向和速度控制。 BBD经过培训和测试，模拟神经系统基于延迟资格追踪学习规则学习和执行控制功能。

8. 发明授权

US09068197B2 Translation enhancer-element dependent vector systems 有权
标题翻译：翻译增强子元素相关向量系统
公开(公告)号：US09068197B2
公开(公告)日：2015-06-30
申请号：US11509293
申请日：2006-08-23
申请人： Vincent P. Mauro , Gerald M. Edelman , Wei Zhou
发明人： Vincent P. Mauro , Gerald M. Edelman , Wei Zhou
IPC分类号： C12N15/00 , C07H21/02 , C07H21/04 , C12N15/85 , C12N15/10 , C12N15/67
CPC分类号： C12N15/1051 , C12N15/1086 , C12N15/67 , C12N15/85 , C12N2800/107 , C12N2830/002 , C12N2840/105 , C12N2840/20 , C12N2840/203
摘要： A translation enhancer-driven positive feedback vector system is disclosed which is designed to facilitate identification of a Translational Enhancer Element (TEE) and to provide a means for overexpression of gene products. The system exploits both transcriptional and translational approaches to control the expression levels of genes and/or gene products. Methods are also disclosed for screening libraries of random nucleotide sequences to identify translational elements and for overproduction of proteins, which have uses in both research and industrial environments.
摘要翻译：公开了翻译增强子驱动的正反馈向量系统，其被设计为便于识别翻译增强子元件（TEE）并提供用于过表达基因产物的手段。该系统利用转录和翻译方法来控制基因和/或基因产物的表达水平。还公开了用于筛选随机核苷酸序列文库的方法，以鉴定翻译元件和蛋白质的过量产生，其在研究和工业环境中都有用途。

9. 发明授权

US08785611B2 Compositions and methods related to mRNA translational enhancer elements 失效
标题翻译：与mRNA翻译增强子元件相关的组成和方法
公开(公告)号：US08785611B2
公开(公告)日：2014-07-22
申请号：US12316581
申请日：2008-12-11
申请人： Vincent P. Mauro , Gerald M. Edelman , Wei Zhou
发明人： Vincent P. Mauro , Gerald M. Edelman , Wei Zhou
IPC分类号： C07H21/04 , C12N15/63 , C12N15/85 , C12P21/00
CPC分类号： C12N15/85 , C12N15/1051 , C12N15/67
摘要： Provided are mRNA translational enhancer elements (TEEs), e.g., SEQ ID NOs:1-35. Also provided are translational enhancer polynucleotides that comprise one or more of the specific TEEs exemplified herein or their variants, homologs or functional derivatives. Further provided are expression vectors comprising such TEEs or translational enhancer polynucleotides, as well as host cells and expression systems that harbor such vectors.
摘要翻译：提供mRNA翻译增强子元件（TEE），例如SEQ ID NO：1-35。还提供了包含本文示例的一种或多种特异性TEE或其变体，同系物或功能性衍生物的翻译增强子多核苷酸。还提供了包含这样的TEE或翻译增强子多核苷酸的表达载体，以及含有这些载体的宿主细胞和表达系统。

10. 发明授权

US08583286B2 Hybrid control device 有权
标题翻译：混合控制装置
公开(公告)号：US08583286B2
公开(公告)日：2013-11-12
申请号：US13439702
申请日：2012-04-04
申请人： Jason G. Fleischer , Botond Szatmáry , Donald B. Hutson , Douglas A. Moore , James A. Snook , Gerald M. Edelman , Jeffrey L. Krichmar
发明人： Jason G. Fleischer , Botond Szatmáry , Donald B. Hutson , Douglas A. Moore , James A. Snook , Gerald M. Edelman , Jeffrey L. Krichmar
IPC分类号： G06N3/04 , G05B13/00 , G06E1/00 , G05B15/02
CPC分类号： G06N3/0427 , G05B13/027 , G05B15/02 , G05B2219/39292 , G05B2219/39385 , G06K9/00664
摘要： A brain-based device (BBD) for moving in a real-world environment has sensors that provide data about the environment, actuators to move the BBD, and a hybrid controller which includes a neural controller having a simulated nervous system being a model of selected areas of the human brain and a non-neural controller based on a computational algorithmic network. The neural controller and non-neural controller interact with one another to control movement of the BBD.
摘要翻译：用于在现实环境中移动的基于脑的设备（BBD）具有提供关于环境的数据的传感器，用于移动BBD的致动器，以及包括具有模拟神经系统的神经控制器的混合控制器，所述神经控制器是被选择的模型人脑的区域和基于计算算法网络的非神经控制器。神经控制器和非神经控制器相互作用以控制BBD的运动。

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