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1. 发明授权

US08015623B2 Belt extender 有权
标题翻译：皮带延长器
公开(公告)号：US08015623B2
公开(公告)日：2011-09-13
申请号：US12405981
申请日：2009-03-17
申请人： George E. Lee , Erik Philip Ericksen
发明人： George E. Lee , Erik Philip Ericksen
IPC分类号： A41F3/02
CPC分类号： A41F9/002
摘要： A belt extender for installation on a belt with a removable buckle comprising a main body with a first end and a second end, a metal tab fixedly attached to and extending from a first end of the main body of the belt extender, and a longitudinal slot roughly centrally disposed on the main body of the belt extender. The main body folds over itself at a fold line that extends through the center of the longitudinal slot and is secured in place with snap fasteners to create a folded end. A belt buckle comprising a tongue and a frame is installed on the folded end of the belt extender by sliding the frame of the belt buckle over the second end of the belt extender and inserting the tongue through the longitudinal slot prior to folding. The metal tab is inserted into a longitudinal slot on the buckle end of the belt strap and rotated so that the main body of the belt extender is aligned with the belt strap on the buckle end of the belt.
摘要翻译：一种带状延伸器，用于安装在具有可拆卸带扣的带上的带子延伸器，该带子包括具有第一端和第二端的主体，固定地附接到带延伸器的主体的第一端并从其延伸的金属接头，大致中心地布置在带延伸器的主体上。主体折叠在折叠线上，折线延伸穿过纵向槽的中心，并用紧固件固定就位以产生折叠端。通过将带扣的框架滑动在带延伸器的第二端上并且在折叠之前将舌片插入纵向槽中，将包括舌和框架的带扣安装在带延伸器的折叠端上。将金属片插入带束带的带扣端部的纵向狭槽中并旋转，使得带延伸器的主体与带的带扣端部上的带束带对准。

2. 发明授权

US07125903B1 Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists 失效
标题翻译：噻吩异恶唑基和噻吩基吡唑基 - 苯氧基取代的丙基衍生物，可用作D4拮抗剂
公开(公告)号：US07125903B1
公开(公告)日：2006-10-24
申请号：US10088250
申请日：2000-09-13
申请人： David M. Fink , Brian S. Freed , Nicholas J. Hrib , Raymond W. Kosley, Jr. , George E. Lee , Gregory H. Merriman , Barbara S. Rauckman
发明人： David M. Fink , Brian S. Freed , Nicholas J. Hrib , Raymond W. Kosley, Jr. , George E. Lee , Gregory H. Merriman , Barbara S. Rauckman
IPC分类号： A61K31/42 , A61K31/415 , C07D261/00 , C07D231/00
CPC分类号： C07D495/04
摘要： The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
摘要翻译：这些化合物是类似噻吩并恶唑基和噻吩基吡唑基 - 苯氧基取代的丙基衍生物，可用作D 4 N 4拮抗剂。所述化合物可用于治疗通过抑制D 4受体介导的医学病症。这些病症包括例如注意力缺陷多动障碍，强迫症，精神病，药物滥用，物质依赖性，帕金森病，帕金森综合征，迟发性麻痹症，杜氏综合征，行为障碍和反对性反抗障碍。本发明的另一方面是提供药物组合物，中间体和制备所述类化合物的方法。

3. 发明授权

US4496732A Stereoselective reduction of 2- or 3-substituted 4-piperidones with sodium borohydride 失效
标题翻译：用硼氢化钠对2-或3-取代的4-哌啶酮进行立体选择性还原
公开(公告)号：US4496732A
公开(公告)日：1985-01-29
申请号：US474856
申请日：1983-03-14
申请人： George E. Lee , Thomas B. K. Lee
发明人： George E. Lee , Thomas B. K. Lee
IPC分类号： C07D211/44 , C07D211/46
CPC分类号： C07D211/46 , C07D211/44
摘要： A stereoselective reduction of 2- or 3-substituted 4-piperidones of the formula ##STR1## where R.sub.1 is hydrogen, loweralkyl or benzyl and R.sub.2 is methyl or ethyl, to the di-equatorial isomer of the corresponding 4-piperidinol is described. Said reduction is conducted by use of sodium borohydride in a protic solvent medium at a temperature substantially lower than ambient temperature in the presence of an effective amount of an inorganic acid. Under favorable reaction conditions, the stereoselectivity of the reduction is so high that simple crystallization of the reaction product affords the pure isomer in a commercially acceptable and advantageous process.
摘要翻译：描述了相应的4-哌啶醇的二 - 赤藓醇异构体的2-或3-取代的4-取代的4-取代的4-取代的哌嗪酮，其中R1是氢，低级烷基或苄基，R2是甲基或乙基。所述还原通过在有效量的无机酸存在下，在质子溶剂介质中使用硼氢化钠在基本上低于环境温度的温度下进行。在有利的反应条件下，还原的立体选择性非常高，使得在商业上可接受和有利的方法中，反应产物的简单结晶提供纯异构体。

4. 发明授权

US4374067A Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates 失效
标题翻译：用于制备4-苯基-1,3-苯并二氮杂的中间体及其制备方法
公开(公告)号：US4374067A
公开(公告)日：1983-02-15
申请号：US333965
申请日：1981-12-23
申请人： Thomas B. K. Lee , George E. Lee
发明人： Thomas B. K. Lee , George E. Lee
IPC分类号： C07C67/00 , C07C209/00 , C07C209/62 , C07C211/49 , C07C231/00 , C07C231/10 , C07C231/12 , C07C233/07 , C07C233/25 , C07C233/43 , C07C239/08 , C07C271/28 , C07C301/00 , C07C303/28 , C07C309/63 , C07D243/04 , C07C143/68 , C07C103/127 , C07C125/06
CPC分类号： C07D243/04 , C07C233/07
摘要： The invention relates to compounds of the formula ##STR1## where Y is --OH; halogen; ##STR2## R.sub.1 SO.sub.3 --, where R.sub.1 is a straight chain or branched chain alkyl group having 1 to 5 carbon atoms, or aryl; and R.sub.2 is --C(CH.sub.3).sub.3 or --O--C(CH.sub.3).sub.3. Processes for preparing the compounds are provided. The compounds are useful as intermediates in the preparation of 4-phenyl-1,3-benzodiazepins, which exhibit activity as antidepressants, analgetics and anticonvulsants.
摘要翻译：本发明涉及式（I）的化合物，其中Y是-OH; 卤素; R1S3-，其中R1是具有1-5个碳原子的直链或支链烷基或芳基; 并且R 2是-C（CH 3）3或-O-C（CH 3）3。提供了制备化合物的方法。该化合物可用作制备4-苯基-1,3-苯并二氮杂的中间体，其表现出抗抑郁药，止痛药和抗惊厥药的作用。

5. 发明授权

US1535231A Auxiliary melting device 失效
公开(公告)号：US1535231A
公开(公告)日：1925-04-28
申请号：US56869522
申请日：1922-06-16
申请人： GEORGE E LEE COMPANY
发明人： LEE GEORGE E
IPC分类号： B41B11/52
CPC分类号： B41B11/52 , Y10T137/7287

6. 发明授权

US1228794A Device for controlling supply of heat to an auxiliary heating device. 失效
标题翻译：用于控制供热给辅助加热装置的装置。
公开(公告)号：US1228794A
公开(公告)日：1917-06-05
申请号：US7814416
申请日：1916-02-14
申请人： GEORGE E LEE COMPANY
发明人： LEE GEORGE E
CPC分类号： B41B11/82 , Y10T137/7287

7. 发明授权

US1228793A Fuel-regulating device. 失效
标题翻译：燃油调节装置。
公开(公告)号：US1228793A
公开(公告)日：1917-06-05
申请号：US1914819676
申请日：1914-02-19
申请人： GEORGE E LEE COMPANY
发明人： LEE GEORGE E
CPC分类号： B41B11/82 , Y10T137/7287

8. 发明授权

US1208587A Heat control for linotype melting-pots. 失效
标题翻译： LINOTYPE MELTING POTS热控制。
公开(公告)号：US1208587A
公开(公告)日：1916-12-12
申请号：US3134315
申请日：1915-06-01
申请人： GEORGE E LEE COMPANY
发明人： LEE GEORGE E
CPC分类号： F26B3/305 , A24B1/02

9. 发明授权

US5498726A Preparation of physostigmine carbamate derivatives from physostigmine 失效
标题翻译：从毒扁豆碱制备毒扁豆碱氨基甲酸酯衍生物
公开(公告)号：US5498726A
公开(公告)日：1996-03-12
申请号：US216238
申请日：1994-03-22
申请人： George E. Lee , Thomas B. K. Lee , Donna M. Borek
发明人： George E. Lee , Thomas B. K. Lee , Donna M. Borek
IPC分类号： A61K31/40 , A61P25/04 , A61P25/28 , C07D20060101 , C07D487/04 , C07D487/00
CPC分类号： C07D487/04
摘要： This application relates to a new process for the preparation of a product of the formula ##STR1## wherein R, R.sup.1, R.sup.2, X and m are as defined within, which process comprises preparing treating a compound such as physostigmine to form eseroline which is then treated with an appropriate compound or its equivalent. Acetic acid is added to the reaction mixture after the formation of eseroline.
摘要翻译：本申请涉及制备式（I）的产物的新方法，其中R，R 1，R 2，X和m如上所定义，该方法包括制备治疗化合物如毒扁豆素以形成eseroline 然后用合适的化合物或其等同物处理。在形成eseroline后，将乙酸加入到反应混合物中。

10. 发明授权

US5053513A Method of reducing a carbonyl containing acridine 失效
标题翻译：减少含有亚油酸的方法
公开(公告)号：US5053513A
公开(公告)日：1991-10-01
申请号：US500967
申请日：1990-03-29
申请人： Thomas B. K. Lee , George E. Lee , George S. K. Wong , Donna M. Borek , Keith E. Goehring
发明人： Thomas B. K. Lee , George E. Lee , George S. K. Wong , Donna M. Borek , Keith E. Goehring
IPC分类号： B01J23/40 , C07B61/00 , C07D219/08 , C07D219/10 , C07D221/16
CPC分类号： C07D219/10
摘要： A method of reducing a carbonyl containing acridine of the formula ##STR1## where n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, trifluoromethyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl and R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl, is disclosed.

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