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1. 发明申请

US20070084999A1 Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry 有权
标题翻译：电喷雾增强高场不对称离子迁移谱法的方法和装置
公开(公告)号：US20070084999A1
公开(公告)日：2007-04-19
申请号：US11436213
申请日：2006-05-18
申请人： Raanan Miller , Erkinjon Nazarov , Gary Eiceman , Evgeny Krylov
发明人： Raanan Miller , Erkinjon Nazarov , Gary Eiceman , Evgeny Krylov
IPC分类号： H01J49/00
CPC分类号： H01J49/165 , B01L3/502753 , G01N27/624 , G01N30/7206 , H01J49/0018
摘要： A field asymmetric ion mobility spectrometer apparatus and system including a sample preparation and introduction section, a head for delivery of ions from a sample, an ion filtering section, an output part, and an electronics part wherein the filter section includes surfaces defining a flow path, further including ion filter electrodes facing each other over the flow path that enables the flow of ions derived from the sample between the electrodes and wherein the electronics part applies controlling signals to the electrodes for generating a filter field for filtering the flow of ions in the flow path while being compensated to pass desired ion species out of the filter.
摘要翻译：一种场非对称离子迁移谱仪装置和系统，包括样品制备和引入部分，用于从样品输送离子的头，离子过滤部分，输出部分和电子部件，其中过滤部分包括限定流路进一步包括在流动路径上彼此面对的离子过滤器电极，其能够从电极之间的样品流出的离子流，并且其中电子部件向电极施加控制信号，以产生用于过滤离子的流过的过滤器场流动路径，同时被补偿以将期望的离子种类从过滤器中流出。

2. 发明申请

US20050121607A1 Method and apparatus for plasma generation 有权
标题翻译：用于等离子体产生的方法和装置
公开(公告)号：US20050121607A1
公开(公告)日：2005-06-09
申请号：US10894861
申请日：2004-07-19
申请人： Raanan Miller , Erkinjon Nazarov , Evgeny Krylov , Gary Eiceman , John Wright , Stephen Kendig , C. Morris , Douglas Cameron
发明人： Raanan Miller , Erkinjon Nazarov , Evgeny Krylov , Gary Eiceman , John Wright , Stephen Kendig , C. Morris , Douglas Cameron
IPC分类号： H01J49/12 , H01J49/40
CPC分类号： G01N27/624 , H05H1/2406 , H05H2001/2456
摘要： An RF-driven plasma source, including a pair of spaced-apart plasma electrodes, wherein the electrodes act as plates of a capacitor, the gas electrically discharges and creates a plasma of both positive and negative ions, in a clean process that enables efficient sample analysis, with preferred isolated sample photo-ionization, reduced-power operation and also including signal detection with modulated drive electronics.
摘要翻译：一种RF驱动的等离子体源，包括一对间隔开的等离子体电极，其中电极用作电容器的平板，气体在清洁过程中进行放电并产生正离子和负离子的等离子体，从而能够实现有效的样品分析，采用优选的孤立样品光电离，降低功率运行，并且还包括带有调制驱动电子器件的信号检测。

3. 发明申请

US20050051719A1 Systems for differential ion mobility analysis 有权
标题翻译：差示离子迁移率分析系统
公开(公告)号：US20050051719A1
公开(公告)日：2005-03-10
申请号：US10797466
申请日：2004-03-10
申请人： Raanan Miller , Erkinjon Nazarov , Angela Zapata , Cristina Davis , Gary Eiceman , Anthony Bashall
发明人： Raanan Miller , Erkinjon Nazarov , Angela Zapata , Cristina Davis , Gary Eiceman , Anthony Bashall
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： G01N27/624 , G01N27/622 , G01N27/64
摘要： Disclosed herein are systems, methods and apparatus, for detection and identification of analytes in a volatilized or volatilizable sample, using the mobility-based signature that is produced when the volatilized sample is passed through a differential ion mobility spectrometry (DMS) device.
摘要翻译：本文公开了用于在挥发或可挥发的样品中检测和鉴定分析物的系统，方法和装置，使用当挥发的样品通过差示离子迁移谱（DMS）装置时产生的基于移动性的签名。

4. 发明申请

US20050029443A1 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry 有权
公开(公告)号：US20050029443A1
公开(公告)日：2005-02-10
申请号：US10932986
申请日：2004-09-02
申请人： Raanan Miller , Erkinjon Nazarov , Gary Eiceman , Evgeny Krylov , Boris Tadjikov
发明人： Raanan Miller , Erkinjon Nazarov , Gary Eiceman , Evgeny Krylov , Boris Tadjikov
IPC分类号： G01N27/62 , B01D59/44 , G01N27/64 , G01N30/64 , G01N30/72 , H01J49/06 , H01J49/10 , H01J49/40 , H01J49/42 , H01J49/00
CPC分类号： G01N27/624 , G01N27/62 , G01N27/64 , G01N30/7206 , G01N2030/0095 , H01J49/0018 , H01J49/0022
摘要： Method and apparatus for chromatographic high field asymmetric waveform ion mobility spectrometry, including a gas chromatographic analyzer section intimately coupled with an ionization section, an ion filter section, and an ion detection section, in which the sample compounds are at least somewhat separated prior to ionization, and ion filtering proceeds in a planar chamber under influence of high field asymmetric periodic signals, with detection integrated into the flow path, for producing accurate, real-time, orthogonal data for identification of a broad range of chemical compounds.

5. 发明授权

US07863562B2 Method and apparatus for digital differential ion mobility separation 有权
标题翻译：用于数字差分离子迁移率分离的方法和装置
公开(公告)号：US07863562B2
公开(公告)日：2011-01-04
申请号：US11812886
申请日：2007-06-22
申请人： Hermann Wollnik , Gary Eiceman , Dimitrios Papanastasiou
发明人： Hermann Wollnik , Gary Eiceman , Dimitrios Papanastasiou
IPC分类号： H01J49/42
CPC分类号： G01N27/624
摘要： A method for differential mobility separation of ions using digital-drive based high voltage fast switching electronics. The digital waveform delivered to the spectrometer is characterized by at least two substantially rectangular pulses of different amplitude and polarity. The control circuitry allows for waveform frequency, duty cycle and pulse amplitudes to be varied independently. Balanced as well as unbalanced asymmetric waveforms can be designed for optimum differential mobility separation of ions. The digital drive is designed for differential mobility spectrometers including parallel plate and segmented plate multipoles of planar symmetry, as well as multipoles of cylindrical symmetry, which may optionally be arranged in series. The use of the digital drive establishes alternating electric fields during which the displacement as a result of ion oscillation is determined by mobility coefficients.
摘要翻译：使用基于数字驱动的高压快速开关电子器件进行离子差分迁移分离的方法。传送到光谱仪的数字波形的特征在于具有不同幅度和极性的至少两个基本矩形的脉冲。控制电路允许波形频率，占空比和脉冲幅度独立变化。可以设计平衡和不平衡非对称波形，以实现离子的最佳差分迁移率分离。数字驱动器设计用于差动迁移率光谱仪，包括平面板和平面对称的分段板多极体，以及圆柱对称的多极，其可以可选地串联布置。使用数字驱动器建立交变电场，在此期间由离子振荡引起的位移由迁移率系数决定。

6. 发明申请

US20070176092A1 Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations 有权
标题翻译：使用各种分析仪配置增强离子迁移率样品分析的方法和设备
公开(公告)号：US20070176092A1
公开(公告)日：2007-08-02
申请号：US11594505
申请日：2006-11-07
申请人： Raanan Miller , Evgeny Krylov , Erkinjon Nazarov , Gary Eiceman , John Wright
发明人： Raanan Miller , Evgeny Krylov , Erkinjon Nazarov , Gary Eiceman , John Wright
IPC分类号： H01J49/00
CPC分类号： G01N27/624 , H01J49/004
摘要： A system for analyzing one or more ion species of a sample including a first ion mobility filter associated with a first flow path for passing first ions of the sample, a second ion mobility filter associated with a second flow path for passing second ions of the sample, a first outlet from the first flow path for passing a portion of the first ions from the first flow path to the second flow path, and a first outlet from the second flow path for removing neutral particles from the second flow path where the first outlet from the second flow path is upstream of the second ion mobility filter in relation to the ion flow in the second flow path.
摘要翻译：一种用于分析样品的一种或多种离子种类的系统，包括与用于通过样品的第一离子的第一流动路径相关联的第一离子迁移率过滤器，与第二流动路径相关联的第二离子迁移过滤器，用于使样品的第二离子来自第一流路的第一出口，用于将第一离子的一部分从第一流动路径传递到第二流动路径;以及来自第二流动路径的第一出口，用于从第二流动路径去除中性粒子，其中第一出口第二流路相对于第二流路中的离子流在第二离子迁移率过滤器的上游。

7. 发明申请

US20060237669A1 Method and apparatus for plasma generation 有权
公开(公告)号：US20060237669A1
公开(公告)日：2006-10-26
申请号：US11471854
申请日：2006-06-21
申请人： Raanan Miller , Erkinjon Nazarov , Evgeny Krylov , Gary Eiceman , John Wright , Stephen Kendig , C. Morris , Douglas Cameron
发明人： Raanan Miller , Erkinjon Nazarov , Evgeny Krylov , Gary Eiceman , John Wright , Stephen Kendig , C. Morris , Douglas Cameron
IPC分类号： G01J3/10 , H05G2/00
CPC分类号： G01N27/624 , H05H1/2406 , H05H2001/2456
摘要： An RF-driven plasma source, including a pair of spaced-apart plasma electrodes, wherein the electrodes act as plates of a capacitor, the gas electrically discharges and creates a plasma of both positive and negative ions, in a clean process that enables efficient sample analysis, with preferred isolated sample photo-ionization, reduced-power operation and also including signal detection with modulated drive electronics.

8. 发明申请

US20060237642A1 Explosives detection using differential mobility spectrometry 有权
公开(公告)号：US20060237642A1
公开(公告)日：2006-10-26
申请号：US11471826
申请日：2006-06-20
申请人： Raanan Miller , Erkinjon Nazarov , David Wheeler , Quan Shi , John Wright , Gary Eiceman
发明人： Raanan Miller , Erkinjon Nazarov , David Wheeler , Quan Shi , John Wright , Gary Eiceman
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , G01N33/22 , H01J49/0018
摘要： The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.

9. 发明申请

US20060060768A1 System for collection of data and identification of unknown ion species in an electric field 有权
公开(公告)号：US20060060768A1
公开(公告)日：2006-03-23
申请号：US11190691
申请日：2005-07-26
申请人： Lawrence Kaufman , Raanan Miller , Erkinjon Nazarov , Evgeny Krylov , Gary Eiceman
发明人： Lawrence Kaufman , Raanan Miller , Erkinjon Nazarov , Evgeny Krylov , Gary Eiceman
IPC分类号： H01J49/00
CPC分类号： H01J49/42
摘要： An apparatus for identification of chemical species by measurement of mobility as a function of high electric field and for generating unique compound-dependent signatures based on ion mobility at a plurality of peak RF voltages for a given compensation. The resulting detection data is compared against a library of data in order to identify a detected chemical species.

10. 发明申请

US20050167583A1 Methods and apparatus for enhanced ion based sample detection using selective pre-separation and amplification 有权
标题翻译：使用选择性预分离和扩增的增强离子样品检测的方法和装置
公开(公告)号：US20050167583A1
公开(公告)日：2005-08-04
申请号：US11015413
申请日：2004-12-17
申请人： Raanan Miller , Erkinjon Nazarov , Lawrence Kaufman , Gary Eiceman
发明人： Raanan Miller , Erkinjon Nazarov , Lawrence Kaufman , Gary Eiceman
IPC分类号： B01D59/44 , H01J49/04
CPC分类号： G01N27/624
摘要： The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification.
摘要翻译：本发明一般涉及基于离子迁移率的系统，用于分析样品的方法和装置，更具体地涉及样品预分离和扩增。

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