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1. 发明申请

WO2009083211A2 PHARMACEUTICAL COMPOUND FOR THE PROPHYLAXIS AND/OR SYMPTOMATIC TREATMENT OF CYSTIC FIBROSIS 审中-公开
标题翻译：药物组合物，囊性纤维化的预防和/或对症治疗
公开(公告)号：WO2009083211A2
公开(公告)日：2009-07-09
申请号：PCT/EP2008010996
申请日：2008-12-22
申请人： CYCNAD GMBH & CO KG , GULBINS ERICH
发明人： GULBINS ERICH
CPC分类号： A61K9/0078 , A61K31/00
摘要： The invention relates to a pharmaceutical compound for the prophylaxis and/or symptomatic treatment of cystic fibrosis, particularly for the prophylaxis and/or treatment of infections and/or infection illnesses manifesting with cystic fibrosis, having at least one anti-depressive and preferable at least one dispersion agent and/or at least one pharmaceutically tolerated carrier material.
摘要翻译：本发明涉及用于预防和/或囊性纤维化的对症治疗的药物组合物，特别是用于在囊性纤维化感染和/或感染性疾病发生的预防和/或治疗，其包含至少一种抗抑郁剂和优选至少一种分散剂和/或至少一种药学上可接受的载体材料。

2. 发明申请

WO1997011103A1 DISPERSIONS CONTAINING POLYURETHANES WITH CARBONYL GROUPS IN THE KETO FUNCTION 审中-公开
标题翻译：分散体含聚氨酯在ketofunction羰基
公开(公告)号：WO1997011103A1
公开(公告)日：1997-03-27
申请号：PCT/EP1996004031
申请日：1996-09-13
申请人： BASF AKTIENGESELLSCHAFT , KOKEL, Nicolas , RAU, Maria, Gyopar , ETTL, Roland , LARBIG, Harald , MELDER, Johann-Peter , GULBINS, Erich , WIRTH, Thomas
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08G18/08
CPC分类号： C14C11/006 , C08G18/0823 , C08G18/12 , C08G18/3825 , C08G18/5039 , C08G18/833 , C08G18/3228
摘要： The invention concerns aqueous dispersions containing a polyurethane (A), containing structural units derived from compounds of formula (I), in which the substituents have the following meanings: R , R , R each designate hydrogen, C1-C24 alkyl or C6 - C24 alkenyl; R designates hydrogen; R , R a) together designate C4-C10 alkane-diyl, b) each designate C2-C10 alkyl, C5-C8 cycloalkyl or C7-C20 aralkyl, c) each designate a hydroxyl-terminated poly(C2-C4 alkylene oxide), or d) designate an R or R group with the meaning given in (a) to (c) and the other group designating hydrogen or a group of formula (II), in which X designates C2-C6 alkane-diyl; and R has the same meaning as R or R with the exception that R is not a group of formula II, R and R carrying a total of between 2 and 5 hydroxyl groups bonded to aliphatic carbon atoms; and R and/or R optionally carrying 1 or 2 aromatically bonded hydroxyl groups or 1 nitrile, tertiary amino, carboxylic acid or sulphonic acid group which are optionally present in the form of their salts.
摘要翻译：包含含有从式（I）的化合物的结构单元的聚氨酯（A），其中取代基具有以下含义的水性分散体：R t <1>，R <2>，R <3>各自是氢， C1至C24的烷基或C6至C24链烯基; [R <4>氢; [R <5> - [R <6>一个）一起C4-C10链烷，b）分别是C2至C10烷基，C5-C8的环烷基或C 7至C 20 - 芳烷基，c）是各自为羟基封端的聚（C2至C4环氧烷）中，d）基团R <5>或R <6>中所定义的（a）至c（同上），并且另一个基团为氢或式的基团（II），其中X C2至C6烷二基且R <7>是等效于R <5>或R <6>，不同之处在于R <7>并不意味着一个式的基团（II），其中R <5> 且R <6>穿总共2至5连接到脂族碳原子，羟基基团和，如果合适的话，基团R <5>和/或R <6> 1或2个芳族键合羟基基团或1腈，叔氨基，羧酸或磺酸基团，其存在任选地为其盐的形式，有助于。

3. 发明申请

WO2004017949A2 PROPHYLAXE UND THERAPIE VON INFEKTIONSERKRANKUNGEN 审中-公开
标题翻译：传染病预防和处理情况
公开(公告)号：WO2004017949A2
公开(公告)日：2004-03-04
申请号：PCT/EP2003/009254
申请日：2003-08-21
申请人： GULBINS, Erich
发明人： GULBINS, Erich
IPC分类号： A61K31/00
CPC分类号： A61K31/137 , A61K31/55 , Y02A50/463
摘要： Die Erfindung betrifft die Verwendung von Hemmstoffen der sauren Sphingomyelinase und/oder von Hemmstoffen von Produkten der durch dieses Enzym katalysierten Reaktion zur Prophylaxe und/oder Therapie von Infektionskrankheiten und/oder Krankheiten, deren Verlauf durch Infektionen beeinflusst wird. Bei den genannten Produkten handelt es sich insbesondere um Ceramid. Als Hemmstoffe sind in besonderer Weise neutralisierende Antikörper und/oder Antidepressiva bevorzugt, insbesondere trizyklische und/oder tetrazyklische Antidepressiva.
摘要翻译：本发明涉及使用酸性鞘磷脂酶和/或由感染性疾病和/或该过程中被感染的疾病影响的预防和/或治疗这种酶反应催化的反应的产物抑制剂的抑制剂。所提到的产品尤其是神经酰胺。作为抑制剂的中和抗体和/或抗抑郁剂是特别优选的，特别是三环类和/或四环类抗抑郁药。

4. 发明申请

WO0217950A8 DETECTING AND INFLUENCING THE EXPRESSION OR FUNCTION OF CD95/CD95L IN INFECTIONS 审中-公开
标题翻译：检测和感染表达或功能的CD95 / CD95L的影响及其应对
公开(公告)号：WO0217950A8
公开(公告)日：2003-09-18
申请号：PCT/EP0109889
申请日：2001-08-28
申请人： LANG FLORIAN , GULBINS ERICH
发明人： LANG FLORIAN , GULBINS ERICH
IPC分类号： A61K38/17 , A61K38/00 , A61K31/70 , A61P31/04
CPC分类号： A61K38/1709

5. 发明申请

WO2019084117A1 IMPLANT COATINGS AND PROCESS FOR MANUFACTURING IMPLANT COATINGS 审中-公开
公开(公告)号：WO2019084117A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057282
申请日：2018-10-24
申请人： UNIVERSITY OF CINCINNATI , SEITZ, Aaron , EDWARDS, Michael , GULBINS, Erich , GOBBLE, Ryan
发明人： SEITZ, Aaron , EDWARDS, Michael , GULBINS, Erich , GOBBLE, Ryan
IPC分类号： A01N25/02 , A61K9/08 , A61L31/16
CPC分类号： A61L27/54 , A01N25/34 , A61L31/16 , A61L2300/406 , A61L2300/606 , A61L2420/02 , A01N37/18 , A01N43/22 , A01N43/90
摘要： Methods for applying a coating to a surface of a substrate for inhibition and prevention of implant-associated complications (including implant-associated infections), methods for inhibiting and preventing implant-associated complications (including implant-associated infections), implant-associated infection inhibiting coatings, and coated devices are provided. Coating processes include a) providing a saturated or supersaturated solution of an antibiotic in a fast-evaporating or medium-evaporating organic solvent; b) coating the surface of the substrate with at least one application of solution, each application followed directly by a solvent evaporation period.

6. 发明申请

WO2004017949A3 PROPHYLAXIS AND TREATMENT OF INFECTIOUS DISEASES 审中-公开
标题翻译：预防和阿米替林传染病防治，或丙咪嗪地昔帕明或或或AN FGF ANTICERAMID抗体或环糊精或制霉菌素或菲律
公开(公告)号：WO2004017949A3
公开(公告)日：2004-04-29
申请号：PCT/EP0309254
申请日：2003-08-21
申请人： GULBINS ERICH
发明人： GULBINS ERICH
IPC分类号： A61K31/137 , A61K31/55 , A61P31/00
CPC分类号： A61K31/137 , A61K31/55
摘要： The invention relates to the use of inhibitors of acid sphingomyelinase and/or inhibitors of products of the reaction catalysed by said enzyme, for the prophylaxis and/or treatment of infectious diseases and/or diseases which are influenced by infections during the course thereof. The cited products especially include ceramide. Preferably neutralising antibodies and/or anti-depressants, especially tricyclic and/or tetracyclic anti-depressants, are used as inhibitors.
摘要翻译：本发明涉及使用酸性鞘磷脂酶和/或由感染性疾病和/或该过程中被感染的疾病影响的预防和/或治疗这种酶反应催化的反应的产物抑制剂的抑制剂。所提到的产品尤其是神经酰胺。作为抑制剂的中和抗体和/或抗抑郁剂是特别优选的，特别是三环类和/或四环类抗抑郁药。

7. 发明申请

WO2017100580A1 SPHINGOLIPID COATINGS AND PROCESS FOR MANUFACTURING SPHINGOLIPID COATINGS EFFECTIVE FOR INHIBITING BIOFILM FORMATION 审中-公开
标题翻译：用于制造螺型油漆涂层的螺型油漆涂料和方法有效地抑制生物膜形成
公开(公告)号：WO2017100580A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065838
申请日：2016-12-09
申请人： SEITZ, Aaron , EDWARDS, Michael J. , GULBINS, Erich
发明人： SEITZ, Aaron , EDWARDS, Michael J. , GULBINS, Erich
IPC分类号： A61K38/00 , A61K9/00 , A23J7/00
CPC分类号： A61L29/16 , A61L2300/22 , A61L2300/404
摘要： Methods for applying a sphingolipid aggregate coating to a surface of a substrate for inhibition and prevention of biofilm growth, methods for inhibiting and preventing biofilms, biofilm-inhibiting coatings and coated devices are provided. Coating processes include suspending an amount of sphingolipid in a medium-to-fast-evaporating organic solvent; b) applying energy to the suspension sufficient to create a colloidal dispersion of sphingolipid in the solvent; c) heating the dispersion sufficient to create a solution; and d) coating the surface of the substrate with at least one application of solution, each application followed directly by a complete solvent evaporation period. The resulting coatings exhibit aggregate architectures particularly effective for inhibition and prevention of biofilms.
摘要翻译：提供了用于将鞘脂聚集物涂层施用于基质表面以抑制和防止生物膜生长的方法，用于抑制和防止生物膜，生物膜抑制涂层和涂布装置的方法。涂覆方法包括将一定量的鞘脂悬浮在介质至快速蒸发的有机溶剂中; b）向悬浮液施加足以在溶剂中产生鞘脂的胶态分散体的能量; c）加热足以产生溶液的分散体; 和d）用至少一次溶液涂布涂布基材表面，每次涂布后直接进行完全溶剂蒸发期。所得到的涂层表现出对抑制和预防生物膜特别有效的聚集体结构。

8. 发明申请

WO2009083211A3 PHARMAZEUTISCHE ZUSAMMENSETZUNG ZUR PROPHYLAXE UND/ODER SYMPTOMATISCHEN BEHANDLUNG VON ZYSTISCHER FIBROSE 审中-公开
公开(公告)号：WO2009083211A3
公开(公告)日：2009-07-09
申请号：PCT/EP2008/010996
申请日：2008-12-22
申请人： CYCNAD GMBH & CO. KG , GULBINS, Erich
发明人： GULBINS, Erich
IPC分类号： A61K9/00 , A61K31/00
摘要： Die Erfindung betrifft eine pharmazeutische Zusammensetzung zur Prophylaxe und/oder symptomatischen Behandlung von zystischer Fibrose, insbesondere zur Prophylaxe und/oder Behandlung von bei zystischer Fibrose auftretenden Infektionen und/oder Infektionserkrankungen, umfassend zumindest ein Antidepressivum und vorzugsweise zumindest ein Dispersionsmittel und/oder zumindest ein pharmazeutisch verträgliches Trägermaterial.

9. 发明申请

WO0051578A3 USE OF CERAMIDES FOR THE TREATMENT OF CYSTIC FIBROSIS 审中-公开
标题翻译：治疗使用神经酰胺囊性纤维化
公开(公告)号：WO0051578A3
公开(公告)日：2001-01-04
申请号：PCT/EP0001682
申请日：2000-02-29
申请人： LANG FLORIAN , GULBINS ERICH , LEPPLE WIENHUES
发明人： LANG FLORIAN , GULBINS ERICH , LEPPLE-WIENHUES
IPC分类号： A61K31/00 , A61K31/16 , A61P11/00
CPC分类号： A61K31/7032
摘要： The invention relates to the use of ceramides and/or substances which contain ceramides as a building block. Said ceramides and substances are used for the treatment of cystic fibrosis. The ceramides are especially C2 and/or C6 ceramides. The invention also relates to the use of the above-mentioned substances for the treatment of diseases which are linked to a disturbed regulation of transport processes at membranes.
摘要翻译：本发明涉及使用神经酰胺和/或使用的含有神经酰胺作为构建块为囊性纤维化的治疗物质。神经酰胺是，特别是C2和/或C6-神经酰胺。此外，为了由本发明所涵盖的疾病的治疗中使用上述物质与运输过程对膜紊乱调节有关。

10. 发明授权

EP1531826B1 ANTIDEPRESSIVA ZUR PROPHYLAXE UND THERAPIE VON ZYSTISCHER FIBROSE 有权转让
标题翻译：抗抑郁药囊性纤维化的预防和治疗
公开(公告)号：EP1531826B1
公开(公告)日：2011-05-11
申请号：EP03792402.4
申请日：2003-08-21
申请人： Gulbins, Erich, Prof. Dr. , Adams, Claus, Prof. Dr.
发明人： Gulbins, Erich
IPC分类号： A61K31/55 , A61P31/00 , A61K31/135
CPC分类号： A61K31/137 , A61K31/55 , Y02A50/463
摘要： The invention relates to the use of inhibitors of acid sphingomyelinase and/or inhibitors of products of the reaction catalysed by said enzyme, for the prophylaxis and/or treatment of infectious diseases and/or diseases which are influenced by infections during the course thereof. The cited products especially include ceramide. Preferably neutralising antibodies and/or anti-depressants, especially tricyclic and/or tetracyclic anti-depressants, are used as inhibitors.

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