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1. 发明专利

GB2480242A A vacuum insulation panel 未知
公开(公告)号：GB2480242A
公开(公告)日：2011-11-16
申请号：GB201007747
申请日：2010-05-10
申请人： GREY JONATHAN
发明人： GREY JONATHAN
IPC分类号： E04B1/80 , E04C2/20 , E04C2/34
摘要： A vacuum insulation panel 2 comprises a first layer 4, an intermediate connecting layer 6 and a second layer 8. The first and second layers 4, 8 are each formed by a generally planar base 7, 9 having an internal side and an external side, and formations 12, 14 extending from the internal side of the base 7, 9. The intermediate connecting layer 6 comprises a generally planar base 11 with formations 16 extending generally perpendicularly from both sides corresponding to the formations 12 and 14 of the first and second layers 4, 8. The first layer is provided with an array of apertures 10 on the base 7. The formations are arranged such that they connect together to define substantially circular chambers 20 having outer cavities (22) around them within a matrix of generally square cells 30. Air is evacuated from the chambers 20 and cavities 22 through the apertures 10. By evacuating all possible areas of the vacuum insulation panel 2, heat loss and sound transmission is reduced to a minimum. The panel 2 is then sealed airtight by sealing the apertures 10.

2. 发明专利

GB201007747D0 A vacuum insulation panel 未知
公开(公告)号：GB201007747D0
公开(公告)日：2010-06-23
申请号：GB201007747
申请日：2010-05-10
申请人： GREY JONATHAN

3. 发明申请

WO2011109551A3 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
公开(公告)号：WO2011109551A3
公开(公告)日：2012-01-19
申请号：PCT/US2011026916
申请日：2011-03-02
申请人： CALCIMEDICA INC , VELICELEBI GONUL , STAUDERMAN KENNETH A , WHITTEN JEFFREY P , CAO JIANGUO , WANG ZHIJUN , ROGERS EVAN , DYCK BRIAN , GREY JONATHAN
发明人： VELICELEBI GONUL , STAUDERMAN KENNETH A , WHITTEN JEFFREY P , CAO JIANGUO , WANG ZHIJUN , ROGERS EVAN , DYCK BRIAN , GREY JONATHAN
IPC分类号： C07D471/04 , A61K31/428 , A61K31/437 , A61P19/02 , A61P37/00 , C07D333/38 , C07D417/12
CPC分类号： C07D409/12 , C07D333/38 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

4. 发明申请

WO2011139489A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
标题翻译：调节细胞内钙的化合物
公开(公告)号：WO2011139489A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/031992
申请日：2011-04-11
申请人： CALCIMEDICA INC. , WHITTEN, Jeffrey, P. , PEI, Yazhong , CAO, Jianguo , WANG, Zhijun , ROGERS, Evan , DYCK, Brian , GREY, Jonathan
发明人： WHITTEN, Jeffrey, P. , PEI, Yazhong , CAO, Jianguo , WANG, Zhijun , ROGERS, Evan , DYCK, Brian , GREY, Jonathan
IPC分类号： C07D405/04 , C07D405/14 , C07D213/81 , C07D213/72 , A61K31/443 , A61K31/44 , A61P29/00
CPC分类号： C07D213/74 , C07D213/75 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D493/10 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store- operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

5. 发明申请

WO2004080411A3 MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISTS AND COMPOSITIONS AND METHODS RELATED THERETO 审中-公开
标题翻译：梅兰宁 - 集中激素受体拮抗剂及其相关组合物和方法
公开(公告)号：WO2004080411A3
公开(公告)日：2004-12-16
申请号：PCT/US2004007260
申请日：2004-03-08
申请人： NEUROCRINE BIOSCIENCES INC , GOODFELLOW VAL , ROWBOTTOM MARTIN , DYCK BRIAN P , TAMIYA JUNKO , ZHANG MINGZHU , GREY JONATHAN , VICKERS TROY , KIANKARIMI MEHRAK , WADE WARREN , HUDSON SARAH CLOUGH
发明人： GOODFELLOW VAL , ROWBOTTOM MARTIN , DYCK BRIAN P , TAMIYA JUNKO , ZHANG MINGZHU , GREY JONATHAN , VICKERS TROY , KIANKARIMI MEHRAK , WADE WARREN , HUDSON SARAH CLOUGH
IPC分类号： A61K20060101 , A61K31/4025 , C07D207/16 , C07D405/14 , C07D409/14 , C07D413/14
CPC分类号： C07D207/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, R5, and R6 are as defined herein. Pharmaceutical compositions containing a compound of this invention, as well as methods relating to the use thereof, are also disclosed.
摘要翻译：公开的黑色素浓集激素（MCH）受体拮抗剂可用于治疗基于MCH受体的疾病如肥胖症。本发明化合物具有以下结构式（I）：包括其立体异构体和药学上可接受的盐，其中n，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义。还公开了含有本发明化合物的药物组合物以及涉及其使用的方法。

6. 发明申请

WO2012170931A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
标题翻译：调节细胞内钙的化合物
公开(公告)号：WO2012170931A2
公开(公告)日：2012-12-13
申请号：PCT/US2012/041725
申请日：2012-06-08
申请人： CALCIMEDICA, INC. , WHITTEN, Jeffrey P. , GREY, Jonathan , CAO, Jianguo , WANG, Zhijun , ROGERS, Evan
发明人： WHITTEN, Jeffrey P. , GREY, Jonathan , CAO, Jianguo , WANG, Zhijun , ROGERS, Evan
IPC分类号： A61K31/36 , A61K31/435 , A61K31/4155 , A61P1/16 , A61P13/12
CPC分类号： C07D405/04 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/506 , C07D213/74 , C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/10 , C07D417/04 , C07D491/04 , C07D491/056
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

7. 发明申请

WO2012027710A3 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
公开(公告)号：WO2012027710A3
公开(公告)日：2012-05-18
申请号：PCT/US2011049424
申请日：2011-08-26
申请人： CALCIMEDICA INC , WHITTEN JEFFREY P , PEI YAZHONG , CAO JIANGUO , WANG ZHIJUN , ROGERS EVAN , DYCK BRIAN , GREY JONATHAN
发明人： WHITTEN JEFFREY P , PEI YAZHONG , CAO JIANGUO , WANG ZHIJUN , ROGERS EVAN , DYCK BRIAN , GREY JONATHAN
IPC分类号： C07D417/14 , A61K31/423 , A61K31/427 , A61P3/10 , A61P19/10 , A61P29/00 , C07D413/04 , C07D417/04
CPC分类号： C07D413/04 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/007 , A61K9/02 , A61K9/4866 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store- operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

8. 发明申请

WO2010027875A3 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
公开(公告)号：WO2010027875A3
公开(公告)日：2010-06-10
申请号：PCT/US2009055090
申请日：2009-08-26
申请人： CALCIMEDICA INC , VELICELEBI GONUL , STAUDERMAN KENNETH A , WHITTEN JEFFREY P , PEI YAZHONG , CAO JIANGUO , WANG ZHIJUN , ROGERS EVAN , DYCK BRIAN , GREY JONATHAN
发明人： VELICELEBI GONUL , STAUDERMAN KENNETH A , WHITTEN JEFFREY P , PEI YAZHONG , CAO JIANGUO , WANG ZHIJUN , ROGERS EVAN , DYCK BRIAN , GREY JONATHAN
IPC分类号： C07D409/02 , A61K31/415 , A61P19/00 , A61P19/02 , A61P25/28 , C07D231/56 , C07D277/60 , C07D413/12 , C07D495/04
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

9. 发明申请

WO2012170951A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
公开(公告)号：WO2012170951A2
公开(公告)日：2012-12-13
申请号：PCT/US2012/041752
申请日：2012-06-08
申请人： CALCIMEDICA, INC. , WHITTEN, Jeffrey P. , GREY, Jonathan , CAO, Jianguo , WANG, Zhijun , ROGERS, Evan
发明人： WHITTEN, Jeffrey P. , GREY, Jonathan , CAO, Jianguo , WANG, Zhijun , ROGERS, Evan
CPC分类号： C07D277/42 , C07D263/48 , C07D277/54 , C07D409/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

10. 发明申请

WO2012040511A3 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
公开(公告)号：WO2012040511A3
公开(公告)日：2012-03-29
申请号：PCT/US2011/052834
申请日：2011-09-22
申请人： CALCIMEDICA, INC. , CAO, Jianguo , WHITTEN, Jeffrey, P. , PEI, Yazhong , WANG, Zhijun , ROGERS, Evan , GREY, Jonathan
发明人： CAO, Jianguo , WHITTEN, Jeffrey, P. , PEI, Yazhong , WANG, Zhijun , ROGERS, Evan , GREY, Jonathan
IPC分类号： C07D421/04 , C07D421/12 , C07D421/14 , A61K31/095 , A61P29/00 , A61P9/00
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store- operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

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