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1. 发明公开

EP3311173A2 METHODS OF CHARACTERISING CANCER 审中-公开
标题翻译：表征癌症的方法
公开(公告)号：EP3311173A2
公开(公告)日：2018-04-25
申请号：EP16736399.3
申请日：2016-06-20
申请人： Herd, Thomas Mole , Greenfield, Robert Scott
发明人： Herd, Thomas Mole , Greenfield, Robert Scott
IPC分类号： G01N33/68 , G01N33/86
CPC分类号： G01N33/86 , G01N33/57488 , G01N2333/7454
摘要： The present invention concerns the use of immunoassays for the characterisation, diagnosis, screening and monitoring of cancer and other diseases. In particular said immunoassays involve the use of polyclonal and monoclonal antibodies against different regions in tissue factor, particularly urinary tissue factor, and methods for generating the same. Preferably said antibodies are specific for the tissue factor signal transduction peptide region (anti-TF-STP antibodies). In particular, the present invention relates to antibodies and the use thereof which are specific for phosphorylated isoforms of TF-STP. The invention further concerns use of these anti-TF-STP antibodies to quantitate TF-STP isoformsin biological fluids, in particular urine. Also described herein is the use ofsaid antibodies in immunoassays for the characterisation, diagnosis, screening and monitoring of cancer and other diseases, specificpolyclonal and monoclonal antibodies against different regions in tissue factor, and methods for generating the same.

2. 发明申请

WO2012052762A1 QUANTITATION OF URINARY TISSUE FACTOR FOR THE DIAGNOSIS AND SCREENING OF CANCER 审中-公开
标题翻译：泌尿系统诊断和筛查筛查因素的定量分析
公开(公告)号：WO2012052762A1
公开(公告)日：2012-04-26
申请号：PCT/GB2011/052026
申请日：2011-10-19
申请人： C-TERM DIAGNOSTICS LIMITED , HERD, Thomas Mole , GREENFIELD, Robert
发明人： HERD, Thomas Mole , GREENFIELD, Robert
IPC分类号： G01N33/574
CPC分类号： G01N33/574
摘要： We provide a novel technological approach for quantitation of c-terminal fragment of uTF for the purpose of quantitation, diagnosis and population screening of cancer. We provide a rationale for measuring c-terminal fragment, methods for making assays, monoclonal and polyclonal antibodies, together with accepted methods of sample preparation. Taken together these proposals and ideas constitute a novel approach for diagnosis and population screening for cancers using urine from cancer patients. In addition we believe that our approach may be useful in the diagnosis of other pathological conditions.
摘要翻译：我们提供了一种新颖的技术方法来定量uTF的c-末端片段，以便定量，诊断和癌症的群体筛选。我们提供测量c-末端片段，测定方法，单克隆抗体和多克隆抗体以及接受的样品制备方法的基本原理。总结这些提案和想法构成了使用癌症患者尿液的癌症诊断和人群筛选的新方法。此外，我们认为我们的方法可能有助于诊断其他病理状况。

3. 发明申请

WO2006046108A3 DIAGNOSIS OF MALE INFERTILITY BY MEASURING TISSUE FACTOR PATHWAY INHIBITOR 审中-公开
标题翻译：测量组织因子途径抑制剂对男性不育的诊断
公开(公告)号：WO2006046108A3
公开(公告)日：2006-07-20
申请号：PCT/IB2005003172
申请日：2005-10-24
申请人： AMERICAN DIAGNOSTICA INC , LWALEED BASHIR , COOPER ALAN , GREENFIELD ROBERT
发明人： LWALEED BASHIR , COOPER ALAN , GREENFIELD ROBERT
IPC分类号： A61K38/16 , C12N15/09 , C12Q1/37 , C12Q1/56 , G01N33/86
CPC分类号： G01N33/689 , G01N2333/8114 , G01N2800/367
摘要： Human semen contains Tissue Factor (TF, Thromboplastin, CD142) and a natural inhibitor of the TF-dependent pathway, Tissue Factor Pathway Inhibitor (TFPI) in seminal plasma, swim-up sperm and prostasomes. TFPI levels were significantly higher in normal men as compared to sub-fertile (p
摘要翻译：人精液中含有组织因子（TF，Thromboplastin，CD142）和TF依赖性途径的天然抑制剂，精浆中的组织因子途径抑制剂（TFPI），游泳精子和prostasomes。与亚生育力（p <0.01）或输精管切除术受试者相比，正常男性的TFPI水平显着更高（p <0.001）。描述了体外实践的诊断方法，包括从男性受试者获得精液样品并确定其中的TFPI水平。然后将其与参考水平进行比较。如果测量值低于参考水平，则表明受试者的生育力水平较低。还描述了用于执行所述诊断方法的试剂盒。

4. 发明申请

WO2016203053A3 METHODS OF CHARACTERISING CANCER 审中-公开
标题翻译：表征癌症的方法
公开(公告)号：WO2016203053A3
公开(公告)日：2017-02-09
申请号：PCT/EP2016064219
申请日：2016-06-20
申请人： HERD THOMAS MOLE , GREENFIELD ROBERT SCOTT
发明人： HERD THOMAS MOLE , GREENFIELD ROBERT SCOTT
IPC分类号： G01N33/68 , G01N33/86
CPC分类号： G01N33/86 , G01N33/57488 , G01N2333/7454
摘要： The present invention concerns the use of immunoassays for the characterisation, diagnosis, screening and monitoring of cancer and other diseases. In particular said immunoassays involve the use of polyclonal and monoclonal antibodies against different regions in tissue factor, particularly urinary tissue factor, and methods for generating the same. Preferably said antibodies are specific for the tissue factor signal transduction peptide region (anti-TF-STP antibodies). In particular, the present invention relates to antibodies and the use thereof which are specific for phosphorylated isoforms of TF-STP. The invention further concerns use of these anti-TF-STP antibodies to quantitate TF-STP isoformsin biological fluids, in particular urine. Also described herein is the use ofsaid antibodies in immunoassays for the characterisation, diagnosis, screening and monitoring of cancer and other diseases, specificpolyclonal and monoclonal antibodies against different regions in tissue factor, and methods for generating the same.
摘要翻译：本发明涉及使用免疫测定法来表征，诊断，筛选和监测癌症和其它疾病。所述免疫测定法尤其涉及针对组织因子，特别是尿组织因子中的不同区域的多克隆和单克隆抗体及其生成方法。优选地，所述抗体对于组织因子信号转导肽区（抗TF-STP抗体）是特异性的。特别地，本发明涉及对TF-STP的磷酸化同种型特异性的抗体及其用途。本发明还涉及使用这些抗TF-STP抗体来定量TF-STP异型体生物流体，特别是尿液。本文还描述了免疫测定中使用的抗体用于表征，诊断，筛选和监测癌症和其它疾病，针对组织因子中不同区域的特异性多克隆抗体和单克隆抗体及其生成方法。

5. 发明申请

WO2009045412A3 METHODS OF TREATMENT USING MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULES 审中-公开
公开(公告)号：WO2009045412A3
公开(公告)日：2009-04-09
申请号：PCT/US2008/011330
申请日：2008-10-01
申请人： AMERICAN DIAGNOSTICA, INC. , THE UNIVERSITY OF TOLEDO , JANKUN, Jerzy , SKRZYPCZAK-JANKUN, Ewa , SELMAN, Steven, H. , GREENFIELD, Robert, S.
发明人： JANKUN, Jerzy , SKRZYPCZAK-JANKUN, Ewa , SELMAN, Steven, H. , GREENFIELD, Robert, S.
IPC分类号： A61K38/57 , A61K38/48 , A61P7/04
摘要： The present invention generally relates to methods of treating bleeding diseases and disorders and to promote wound healing. The methods comprises administering a procoagulant, preferably factor VII a, and a modified plasminogen activator inhibitor type-1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of the PAI-1 molecule. The invention also relates to methods of treating respiratory diseases using a modified PAI-1 molecule.

6. 发明申请

WO2007065261A1 PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS 审中-公开
标题翻译：疟原虫激活剂抑制剂-1抑制剂
公开(公告)号：WO2007065261A1
公开(公告)日：2007-06-14
申请号：PCT/CA2006/001990
申请日：2006-12-07
申请人： AMERICAN DIAGNOSTICA INC. , TRIFONOV, Latchezar S. , VAUGEOIS, Jean , GAIKWAD, Bhavna , GREENFIELD, Robert S.
发明人： TRIFONOV, Latchezar S. , VAUGEOIS, Jean , GAIKWAD, Bhavna , GREENFIELD, Robert S.
IPC分类号： C07D409/04 , A61K31/496 , C07D295/135 , C07D333/60 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/06 , C07D409/12
CPC分类号： C07D311/16 , C07C271/28 , C07D213/74 , C07D233/56 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/06 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Inhibitors of plasminogen activator inhibitor-1 (PAI-I) are provided, which may also act as anti cancer agents, of formulae (I-V).
摘要翻译：提供了纤溶酶原激活物抑制剂-1（PAI-1）的抑制剂，其也可用作式（I-V）的抗癌剂。

7. 发明申请

WO2006046108A2 DIAGNOSIS OF MALE INFERTILITY BY MEASURING TISSUE FACTOR PATHWAY INHIBITOR 审中-公开
标题翻译：通过测定组织因子途径抑制剂对男性感染的诊断
公开(公告)号：WO2006046108A2
公开(公告)日：2006-05-04
申请号：PCT/IB2005/003172
申请日：2005-10-24
申请人： AMERICAN DIAGNOSTICA INC. , LWALEED, Bashir , COOPER, Alan , GREENFIELD, Robert
发明人： LWALEED, Bashir , COOPER, Alan , GREENFIELD, Robert
IPC分类号： C12Q1/37
CPC分类号： G01N33/689 , G01N2333/8114 , G01N2800/367
摘要： Human semen contains Tissue Factor (TF, Thromboplastin, CD142) and a natural inhibitor of the TF-dependent pathway, Tissue Factor Pathway Inhibitor (TFPI) in seminal plasma, swim-up sperm and prostasomes. TFPI levels were significantly higher in normal men as compared to sub-fertile (p
摘要翻译：人精液含有组织因子（TF，凝血激酶原，CD142）和TF依赖途径的天然抑制剂，精浆中的组织因子途径抑制剂（TFPI），游泳精子和前列腺体。正常人（P <0.01）或输精管切除术者（P <0.001）相比，正常人的TFPI水平显着升高。描述了体外实践的诊断方法，其包括从男性受试者获得精液样品并确定其中的TFPI水平。然后将其与参考级别进行比较。如果测量值低于参考水平，则表明该受试者的生育能力较低。还描述了用于执行所述诊断方法的试剂盒。

8. 发明申请

WO2004020976A3 DIAGNOSTIC ASSAY FOR THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR (TAFI) 审中-公开
标题翻译：用于血小板活化纤维蛋白溶解抑制剂（TAFI）的诊断测定
公开(公告)号：WO2004020976A3
公开(公告)日：2004-08-12
申请号：PCT/US0327061
申请日：2003-08-29
申请人： AMERICAN DIAGNOSTICA INC , GREENFIELD ROBERT S , AN SEONG SOO A
发明人： GREENFIELD ROBERT S , AN SEONG SOO A
IPC分类号： C12Q1/37 , C12Q1/56 , G01N33/574 , G01N33/68 , G01N33/86 , C12Q1/00 , G01N33/53 , G01N33/573
CPC分类号： C12Q1/37 , C12Q1/56 , G01N33/57415 , G01N33/57426 , G01N33/6893 , G01N33/86 , G01N2333/81 , G01N2800/085 , G01N2800/224 , G01N2800/226 , G01N2800/32
摘要： The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFIa or TAFIai), or a derivative or variant thereof, but not the TAFI proenzyme (TAFI) or the N-terminal activation peptide of TAFI.
摘要翻译：本发明涉及用于选择性测量35kD形式的凝血酶激活性纤维蛋白溶解抑制剂（TAFIa或TAFIai）或其衍生物或变体，而不是TAFI酶原（TAFI）或N-末端活化肽 TAFI。

9. 发明申请

WO2007065261B1 PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS 审中-公开
公开(公告)号：WO2007065261B1
公开(公告)日：2007-08-16
申请号：PCT/CA2006001990
申请日：2006-12-07
申请人： AMERICAN DIAGNOSTICA INC , TRIFONOV LATCHEZAR S , VAUGEOIS JEAN , GAIKWAD BHAVNA , GREENFIELD ROBERT S
发明人： TRIFONOV LATCHEZAR S , VAUGEOIS JEAN , GAIKWAD BHAVNA , GREENFIELD ROBERT S
IPC分类号： C07D409/04 , A61K31/496 , C07D295/135 , C07D333/60 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/06 , C07D409/12
CPC分类号： C07D311/16 , C07C271/28 , C07D213/74 , C07D233/56 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/06 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Inhibitors of plasminogen activator inhibitor-1 (PAI-I) are provided, which may also act as anti cancer agents, of formulae (I-V).
摘要翻译：提供了还可以作为式（I-V）的抗癌剂的纤溶酶原激活物抑制剂-1（PAI-1）的抑制剂。

10. 发明申请

WO2007051314A1 CURCUMINOID COMPOUNDS FOR INHIBITING PLASMINOGEN ACTIVATOR INHIBITOR-1 审中-公开
标题翻译：用于抑制促胰岛素激动剂抑制剂-1的CURCUMINOID化合物
公开(公告)号：WO2007051314A1
公开(公告)日：2007-05-10
申请号：PCT/CA2006/001817
申请日：2006-11-07
申请人： AMERICAN DIAGNOSTICA INC. , TRIFONOV, Latchezar, S. , VAUGEOIS, Jean , GAIKWAD, Bhavna , GREENFIELD, Robert, S.
发明人： TRIFONOV, Latchezar, S. , VAUGEOIS, Jean , GAIKWAD, Bhavna , GREENFIELD, Robert, S.
IPC分类号： C07C49/255 , A61K31/085 , A61K31/343 , A61K31/496 , C07C59/90 , C07D295/10
CPC分类号： C07C49/255 , C07C45/74 , C07C49/248 , C07C65/40 , C07C69/712 , C07C317/24 , C07C323/22 , C07D213/38 , C07D213/74 , C07D295/135 , C07D295/205 , C07D307/80 , C07D333/34
摘要： Pharmaceutical compounds which are analogs of curcumin [bis-l,7-(4-hydroxy-3-methoxyphenyl)-hepta-l,6-diene-3,5dione] which act as inhibitors of plasminogen activator inhibitor- 1 (PAI-I) and thus are useful in the treatment and the prophylactic of various thrombotic related disease conditions, including deep vein thrombosis, coronary artery disease, pulmonary fibrosis and polycystic ovary syndrome
摘要翻译：作为姜黄素[双-1,7-（4-羟基-3-甲氧基苯基） - 庚-1,6-二烯-3,5二酮]类似物的药物化合物，其作为纤溶酶原激活物抑制剂-1（PAI-1 ），因此可用于各种血栓相关疾病的治疗和预防，包括深静脉血栓形成，冠状动脉疾病，肺纤维化和多囊卵巢综合征

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