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1. 发明专利

CA2523754A1 CONTOURED CONCRETE FORM 未知
公开(公告)号：CA2523754A1
公开(公告)日：2007-03-08
申请号：CA2523754
申请日：2005-10-18
申请人： COOPER ALAN
发明人： COOPER ALAN
IPC分类号： E04G11/04
摘要： The present invention relates to ICF (Insulated Concrete Form) building technology, offering an enhancement to existing practices by presenting a structure and method that enables concrete to be placed and shaped at any angle. In addition, the present invention provides a structure and method th at offers aesthetic alternatives to flat surfaces characteristic of existing concrete forming building techniques.

2. 发明专利

CA942732A TEMPORARY WALL SUPPORT 未知
公开(公告)号：CA942732A
公开(公告)日：1974-02-26
申请号：CA104942
申请日：1971-02-10
申请人： COOPER ALAN B
发明人： COOPER ALAN B

3. 发明专利

AR006053A1 ALOJAMIENTO ELASTOMÉRICO PARA DESCARGADORES DE SOBRETENSIONES. 未知
公开(公告)号：AR006053A1
公开(公告)日：1999-07-21
申请号：ARP970100822
申请日：1997-02-28
申请人： COOPER ALAN
IPC分类号： H01B17/32 , H01C7/12 , H01B17/42 , H01T4/04
摘要： Un alojamiento elastomérico para aparatos incluye un manguito que tiene una porción central tubular y campanas radiantes. El manguito está moldeado enuna primer configuración y, cuando la porción central es estirada radialmente, adopta una segundaconfiguración en la que las campanasadoptan una configuración dispuesta hacia abajo. Las campanas en la segunda configuración, incluyen una superficie superior que tiene una formatroncocónica en general. El alojamiento puede estar hec ho utilizandotécnicas de moldeo convencionales, que requiere substancialmente menos material quesi el alojamiento fuera moldeado directamente en la segunda configuración deseada.

4. 发明申请

WO2012030685A3 INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS 审中-公开
标题翻译：吲哚衍生物可用作ERK抑制剂
公开(公告)号：WO2012030685A3
公开(公告)日：2012-06-07
申请号：PCT/US2011049483
申请日：2011-08-29
申请人： SCHERING CORP , DENG YONGQI , SHIPPS GERALD W JR , LO SIE-MUN , ZHU LIANG , COOPER ALAN B , MUPPALLA KIRAN
发明人： DENG YONGQI , SHIPPS GERALD W JR , LO SIE-MUN , ZHU LIANG , COOPER ALAN B , MUPPALLA KIRAN
IPC分类号： A61K31/416
CPC分类号： A61K31/541 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/113
摘要： The present invention provides a compound of the Formula I: Formula I or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, R4, X, m and n are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供了式I化合物或其药学上可接受的盐，溶剂合物或酯，其中R，R 1，R 2，R 3，R 4，X，m和n如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用它们治疗癌症的方法。

5. 发明申请

WO2011163330A1 NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS 审中-公开
标题翻译：新型杂环化合物作为ERK抑制剂
公开(公告)号：WO2011163330A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041396
申请日：2011-06-22
申请人： MERCK SHARP & DOHME CORP. , SCHERING CORPORATION , DENG, Yongqi , ZHU, Liang , SHIPPS, Gerald, W., Jr. , LO, Sie-Mun , SUN, Binyuan , HUANG, Xiaohua , BEINSTOCK, Corey , COOPER, Alan, B. , GAO, Xiaolei , YAO, Xin , ZHU, Hugh, Y. , KELLY, Joseph, M. , BOGA, Sobhana Babu , ALHASSAN, Abdul-Basit , TAGAT, Jayaram, R. , MANSOOR, Umar Faruk , WILSON, Kevin , O'BOYLE, Brendan, M. , DANIELS, Matthew , SCHELL, Adam , SILIPHAIVANH, Phieng , FISCHER, Christian
发明人： DENG, Yongqi , ZHU, Liang , SHIPPS, Gerald, W., Jr. , LO, Sie-Mun , SUN, Binyuan , HUANG, Xiaohua , BEINSTOCK, Corey , COOPER, Alan, B. , GAO, Xiaolei , YAO, Xin , ZHU, Hugh, Y. , KELLY, Joseph, M. , BOGA, Sobhana Babu , ALHASSAN, Abdul-Basit , TAGAT, Jayaram, R. , MANSOOR, Umar Faruk , WILSON, Kevin , O'BOYLE, Brendan, M. , DANIELS, Matthew , SCHELL, Adam , SILIPHAIVANH, Phieng , FISCHER, Christian
IPC分类号： A01N43/56 , C07D231/56 , C07D209/48 , C07D235/04
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1856
摘要： The present invention provides a compound of the Formula I:(Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供了式I化合物：（式I应在此插入）或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2和R 3如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

6. 发明申请

WO2009005872A3 AUTOTHERMAL HYDROGEN STORAGE AND DELIVERY SYSTEMS 审中-公开
公开(公告)号：WO2009005872A3
公开(公告)日：2009-01-08
申请号：PCT/US2008/060471
申请日：2008-04-16
申请人： AIR PRODUCTS AND CHEMICALS, INC. , PEZ, Guido, Peter , COOPER, Alan, Charles , SCOTT, Aaron, Raymond
发明人： PEZ, Guido, Peter , COOPER, Alan, Charles , SCOTT, Aaron, Raymond
IPC分类号： C01B3/22 , C01B3/26
摘要： Processes are provided for the storage and release of hydrogen by means of dehydrogenation of hydrogen carrier compositions where at least part of the heat of dehydrogenation is provided by a hydrogen-reversible selective oxidation of the carrier. Autothermal generation of hydrogen is achieved wherein sufficient heat is provided to sustain the at least partial endothermic dehydrogenation of the carrier at reaction temperature. The at least partially dehydrogenated and at least partially selectively oxidized liquid carrier is regenerated in a catalytic hydrogenation process where apart from an incidental employment of process heat, gaseous hydrogen is the primary source of reversibly contained hydrogen and the necessary reaction energy.

7. 发明申请

WO2009005872A2 AUTOTHERMAL HYDROGEN STORAGE AND DELIVERY SYSTEMS 审中-公开
标题翻译：自动加热储氢系统
公开(公告)号：WO2009005872A2
公开(公告)日：2009-01-08
申请号：PCT/US2008060471
申请日：2008-04-16
申请人： AIR PROD & CHEM , PEZ GUIDO PETER , COOPER ALAN CHARLES , SCOTT AARON RAYMOND
发明人： PEZ GUIDO PETER , COOPER ALAN CHARLES , SCOTT AARON RAYMOND
CPC分类号： C01B3/22 , C01B3/26 , C01B2203/0277 , C01B2203/0405 , C01B2203/0838 , C01B2203/1064 , C01B2203/1211 , C01B2203/1252
摘要： Processes are provided for the storage and release of hydrogen by means of dehydrogenation of hydrogen carrier compositions where at least part of the heat of dehydrogenation is provided by a hydrogen-reversible selective oxidation of the carrier. Autothermal generation of hydrogen is achieved wherein sufficient heat is provided to sustain the at least partial endothermic dehydrogenation of the carrier at reaction temperature. The at least partially dehydrogenated and at least partially selectively oxidized liquid carrier is regenerated in a catalytic hydrogenation process where apart from an incidental employment of process heat, gaseous hydrogen is the primary source of reversibly contained hydrogen and the necessary reaction energy.
摘要翻译：提供了通过氢载体组合物的脱氢来储存和释放氢的方法，其中至少部分脱氢热由载体的氢可逆选择性氧化提供。实现氢气的自热生成，其中提供足够的热量以在反应温度下维持载体的至少部分吸热脱氢。至少部分脱氢的和至少部分选择性氧化的液体载体在催化氢化过程中再生，除了偶然使用过程热量外，气态氢是可逆地包含的氢的主要来源和必需的反应能量。

8. 发明申请

WO2008155568A1 WATER-STABLE COMPOUNDS, CATALYSTS AND CATALYSED REACTIONS 审中-公开
标题翻译：水稳定化合物，催化剂和催化反应
公开(公告)号：WO2008155568A1
公开(公告)日：2008-12-24
申请号：PCT/GB2008/050450
申请日：2008-06-16
申请人： JOHNSON MATTHEY PLC , TULLOCH, Arran Alexander Dickon , COOPER, Alan , DUNCAN, Robert Hume
发明人： TULLOCH, Arran Alexander Dickon , COOPER, Alan , DUNCAN, Robert Hume
IPC分类号： B01J31/02
CPC分类号： B01J31/2243 , B01J31/2247 , B01J2231/342 , B01J2231/42 , B01J2231/70 , B01J2531/31 , B01J2531/46 , B01J2531/48 , B01J2531/842 , B01J2531/96
摘要： The invention provides a method of carrying out a Lewis-acid catalysed organic reaction in the presence of a Lewis acid catalyst comprising a metal-organic compound having the following formula: M(HO(CR 1 R 2 )z)a(O(CR 1 R 2 )z)bY-(CR 3 R 4 )χ-Y((CR 1 R 2 )zO)c((CR 1 R 2 )zOH)d.nR 5 OH (Formula I) in which: M is a metal atom, preferably titanium, zirconium, hafnium or iron (III) Y is selected from P and N, but is very preferably N; each R 1 , R 2 , R 3 and R 4 is independently selected from H, alkyl, aryl, substituted alkyl or substituted aryl, R 5 is hydrogen, an alkyl group, a hydroxy-functionalised alkyl group, a polyoxyalkylmoiety, R 6 O or R 7 COO where R 6 and R 7 may each represent H, alkyl, aryl or alkyl-aryl; d and a are each O or 1, b and c are each 1 or 2, b + c = the valency of M, a+b+c+d = 4, each z is independently 1,2, 3 or 4; x represents the least number of C atoms between the Y atoms and is 2 or 3 and n is a number in the range from 0 to 4. The metal-organic compound forms a stable hydrate in water which retains Lewis-acid catalytic properties.
摘要翻译：本发明提供一种在路易斯酸催化剂存在下进行路易斯酸催化的有机反应的方法，该路易斯酸催化剂包含具有下式的金属有机化合物：M（HO（CR 1 R 2）z）a（O（CR 1 R 2）z ）bY-（CR 3 R 4）2 - （CR 1 R 2）z O）c（（CR 1 R 2）z OH）d.nR 5 OH（式I）其中：M是金属原子，优选钛，锆，铪或铁选自P和N，但非常优选N; 每个R 1，R 2，R 3和R 4独立地选自H，烷基，芳基，取代的烷基或取代的芳基，R 5是氢，烷基，羟基官能化的烷基，聚氧烷基摩尔，R 10或R 7 COO，其中R 6和R 7可以各自代表H，烷基，芳基或烷基 - 芳基; d和a分别为O或1，b和c各自为1或2，b + c = M的化合价，a + b + c + d = 4，每个z独立地为1,2,3或4; x表示Y原子之间的C原子数最少，为2或3，n为0至4的数。该金属有机化合物在水中形成稳定的水合物，保留路易斯酸催化性能。

9. 发明申请

WO2007070398A1 POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS 审中-公开
标题翻译：作为ERK抑制剂的多环吲哚衍生物
公开(公告)号：WO2007070398A1
公开(公告)日：2007-06-21
申请号：PCT/US2006/046959
申请日：2006-12-11
申请人： SCHERING CORPORATION , COOPER, Alan , DENG, Yongqi , SHIPPS, Gerald, W., Jr. , SHIH, Neng-yang , ZHU, Hugh , SUN, Robert , KELLY, Joseph , DOLL, Ronald , NAN, Yang , WANG, Tong , DESAI, Jagdish , WANG, James , DONG, Youhao , MADISON, Vincent, S. , LI, Xiao , HRUZA, Alan , SIDDIQUI, M., Arshad , SAMATAR, Ahmed , PALIWAL, Sunil , TSUI, Hon-Chung , CELEBI, Azim, A. , WU, Yiji , BOGA, Sobhana, Babu
发明人： COOPER, Alan , DENG, Yongqi , SHIPPS, Gerald, W., Jr. , SHIH, Neng-yang , ZHU, Hugh , SUN, Robert , KELLY, Joseph , DOLL, Ronald , NAN, Yang , WANG, Tong , DESAI, Jagdish , WANG, James , DONG, Youhao , MADISON, Vincent, S. , LI, Xiao , HRUZA, Alan , SIDDIQUI, M., Arshad , SAMATAR, Ahmed , PALIWAL, Sunil , TSUI, Hon-Chung , CELEBI, Azim, A. , WU, Yiji , BOGA, Sobhana, Babu
IPC分类号： C07D231/56 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/506 , A61K31/427 , A61K31/428 , A61K31/496 , A61P35/00 , C07D417/14 , C07D403/14
CPC分类号： C07D405/14 , C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了式1.0的ERK抑制剂及其药学上可接受的盐和溶剂化物。 Q是可以具有桥或稠合环的哌啶或哌嗪环。哌啶环可以在环中具有双键。所有其他取代基如本文所定义。还公开了使用式1.0化合物治疗癌症的方法。

10. 发明申请

WO2006046108A2 DIAGNOSIS OF MALE INFERTILITY BY MEASURING TISSUE FACTOR PATHWAY INHIBITOR 审中-公开
标题翻译：通过测定组织因子途径抑制剂对男性感染的诊断
公开(公告)号：WO2006046108A2
公开(公告)日：2006-05-04
申请号：PCT/IB2005/003172
申请日：2005-10-24
申请人： AMERICAN DIAGNOSTICA INC. , LWALEED, Bashir , COOPER, Alan , GREENFIELD, Robert
发明人： LWALEED, Bashir , COOPER, Alan , GREENFIELD, Robert
IPC分类号： C12Q1/37
CPC分类号： G01N33/689 , G01N2333/8114 , G01N2800/367
摘要： Human semen contains Tissue Factor (TF, Thromboplastin, CD142) and a natural inhibitor of the TF-dependent pathway, Tissue Factor Pathway Inhibitor (TFPI) in seminal plasma, swim-up sperm and prostasomes. TFPI levels were significantly higher in normal men as compared to sub-fertile (p
摘要翻译：人精液含有组织因子（TF，凝血激酶原，CD142）和TF依赖途径的天然抑制剂，精浆中的组织因子途径抑制剂（TFPI），游泳精子和前列腺体。正常人（P <0.01）或输精管切除术者（P <0.001）相比，正常人的TFPI水平显着升高。描述了体外实践的诊断方法，其包括从男性受试者获得精液样品并确定其中的TFPI水平。然后将其与参考级别进行比较。如果测量值低于参考水平，则表明该受试者的生育能力较低。还描述了用于执行所述诊断方法的试剂盒。

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