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1. 发明申请

WO2012178101A3 COMPOSITIONS AND METHODS TO REMOVE GENETIC MARKERS USING COUNTER-SELECTION 审中-公开
标题翻译：使用计数器选择移除基因标记的组合物和方法
公开(公告)号：WO2012178101A3
公开(公告)日：2013-04-04
申请号：PCT/US2012043868
申请日：2012-06-22
申请人： JOULE UNLTD TECHNOLOGIES INC , XU YU , GREEN BRIAN D
发明人： XU YU , GREEN BRIAN D
IPC分类号： C12N1/13 , C12N15/74
CPC分类号： C12N15/74
摘要： The present disclosure provides compositions and methods for genetic marker removal in cyanobacteria. Cyanobacteria are developed having a genetic marker capable of being selected against in the presence of a negatively selective condition, resulting in removal of a positively selective marker (e.g., an antibiotic resistance marker) from the host cell.
摘要翻译：本公开提供了用于在蓝细菌中去除遗传标记的组合物和方法。开发具有能够在负选择性条件存在下被选择的遗传标记的蓝细菌，导致从宿主细胞中去除阳性选择性标记（例如，抗生素抗性标记）。

2. 发明申请

WO2012178101A2 COMPOSITIONS AND METHODS TO REMOVE GENETIC MARKERS USING COUNTER-SELECTION 审中-公开
标题翻译：使用计数器选择移除基因标记的组合物和方法
公开(公告)号：WO2012178101A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043868
申请日：2012-06-22
申请人： JOULE UNLIMITED TECHNOLOGIES, INC. , XU, Yu , GREEN, Brian, D.
发明人： XU, Yu , GREEN, Brian, D.
IPC分类号： C12N15/31
CPC分类号： C12N15/74
摘要： The present disclosure provides compositions and methods for genetic marker removal in cyanobacteria. Cyanobacteria are developed having a genetic marker capable of being selected against in the presence of a negatively selective condition, resulting in removal of a positively selective marker (e.g., an antibiotic resistance marker) from the host cell.
摘要翻译：本公开提供了用于在蓝细菌中去除遗传标记的组合物和方法。开发具有能够在负选择性条件存在下被选择的遗传标记的蓝细菌，导致从宿主细胞中去除阳性选择性标记（例如抗生素抗性标记）。

3. 发明申请

WO2009111513A1 ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST 审中-公开
标题翻译：工程化二氧化碳固定微生物生产基于碳的产品
公开(公告)号：WO2009111513A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/035937
申请日：2009-03-03
申请人： JOULE BIOTECHNOLOGIES, INC. , BERRY, David, A. , ROBERTSON, Dan, E. , SKRALY, Frank, A. , GREEN, Brian, D. , RIDLEY, Christian, P. , KOSURI, Sriram , REPPAS, Nikos, B. , SHOLL, Martha , AFEYAN, Noubar, B.
发明人： BERRY, David, A. , ROBERTSON, Dan, E. , SKRALY, Frank, A. , GREEN, Brian, D. , RIDLEY, Christian, P. , KOSURI, Sriram , REPPAS, Nikos, B. , SHOLL, Martha , AFEYAN, Noubar, B.
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译：本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。

4. 发明申请

WO2009049179A1 METHOD FOR SELECTIVELY REMOTING WINDOWS 审中-公开
标题翻译：选择性地切换窗口的方法
公开(公告)号：WO2009049179A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079541
申请日：2008-10-10
申请人： CITRIX SYSTEMS, INC. , GREEN, Brian, D.
发明人： GREEN, Brian, D.
IPC分类号： G06F3/14
CPC分类号： G06F3/1454 , G06F9/452 , G09G5/14 , G09G2340/10
摘要： Methods and apparatus for the display of an image at a remote computer, where the image includes a graphical object to be at least partially omitted from the image displayed at the remote computer. Different regions of the desktop are identified and processed by different capture methods, in such a way as to achieve the desired result while keeping the computational cost low. Applications include the sharing of a local user's desktop with remote users without sharing a local user interface.
摘要翻译：用于在远程计算机上显示图像的方法和装置，其中所述图像包括要从远程计算机上显示的图像中至少部分省略的图形对象。通过不同的捕获方法识别和处理桌面的不同区域，以便在保持计算成本低的同时实现期望的结果。应用程序包括与远程用户共享本地用户的桌面，而不需要共享本地用户界面。

5. 发明申请

WO2005044979A3 GLYCOSYLATION ENZYMES AND SYSTEMS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：糖化酶和系统及其制备和使用方法
公开(公告)号：WO2005044979A3
公开(公告)日：2009-04-09
申请号：PCT/US2004025015
申请日：2004-08-04
申请人： DIVERSA CORP , TREFZER AXEL , GREEN BRIAN D , BIBB MERVYN , MASON DYLAN
发明人： TREFZER AXEL , GREEN BRIAN D , BIBB MERVYN , MASON DYLAN
IPC分类号： C12N1/20 , C07H21/04 , C12N20060101 , C12P19/26 , C12P21/00 , C12P21/02
CPC分类号： C12P21/005 , A01N43/90
摘要： The invention provides a novel technology for glycosylation of natural products using novel genetically engineered strains of bacteria. These in vivo glycosylation systems of the invention express a heterologous glycosyltransferase and deoxysugar pathway that are capable of glycosylating a suitable substrate, which can be added to a culture broth. The invention also provides novel compounds glycosylated by these novel genetically engineered strains (the in vivo glycosylation systems of the invention), including novel peptides, mixed polyketide-peptides, or polyketides, including novel macrolides, e.g., glycosylated spinosyn derivatives, glycosylated derivatives of antibiotics such as erythromycin, tetracycline, rifampicin, glycosylated derivatives of anti-tumor drugs such as daunorubicin, mithramycin, derivatives of immunosuppressants such as rapamycin, FK520, FK506, glycosylated derivatives of anti-fungals such as amphotericin, glycosylated derivatives of antibacterials such as tylosin, glycosylated derivatives of antiparasitics such as avermectin, glycosylated derivatives of insecticides such as spinosyn, and methods for making these compounds using the in vivoglycosylation systems of the invention.
摘要翻译：本发明提供了一种使用新型遗传工程菌株进行天然产物糖基化的新技术。本发明的这些体内糖基化体系表达能够糖基化合适底物的异源糖基转移酶和脱氧糖通路，其可加入到培养液中。本发明还提供了通过这些新型遗传工程菌株（本发明的体内糖基化体系）糖基化的新型化合物，包括新型肽，混合聚酮化合物肽或聚酮化合物，包括新型大环内酯类，例如糖基化多杀菌素衍生物，抗生素糖基化衍生物例如红霉素，四环素，利福平，抗肿瘤药物如柔红霉素，霉素霉素，免疫抑制剂如雷帕霉素的衍生物，FK520，FK506，抗真菌剂如两性霉素的糖基化衍生物，抗菌药的糖基化衍生物如泰乐菌素，抗寄生虫的糖基化衍生物，例如除虫菌素，杀虫剂的糖基化衍生物如多杀菌素，以及使用本发明的生物活性糖基化体系制备这些化合物的方法。

6. 发明申请

WO2005044979A2 GLYCOSYLATION ENZYMES AND SYSTEMS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：糖化酶和系统及其制备和使用方法
公开(公告)号：WO2005044979A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/025015
申请日：2004-08-04
申请人： DIVERSA CORPORATION , TREFZER, Axel , GREEN, Brian, D. , BIBB, Mervyn , MASON, Dylan
发明人： TREFZER, Axel , GREEN, Brian, D. , BIBB, Mervyn , MASON, Dylan
IPC分类号： C12N
CPC分类号： C12P21/005 , A01N43/90
摘要： The invention provides a novel technology for glycosylation of natural products using novel genetically engineered strains of bacteria. These in vivo glycosylation systems of the invention express a heterologous glycosyltransferase and deoxysugar pathway that are capable of glycosylating a suitable substrate, which can be added to a culture broth. The invention also provides novel compounds glycosylated by these novel genetically engineered strains (the in vivo glycosylation systems of the invention), including novel peptides, mixed polyketide-peptides, or polyketides, including novel macrolides, e.g., glycosylated spinosyn derivatives, glycosylated derivatives of antibiotics such as erythromycin, tetracycline, rifampicin, glycosylated derivatives of anti-tumor drugs such as daunorubicin, mithramycin, derivatives of immunosuppressants such as rapamycin, FK520, FK506, glycosylated derivatives of anti-fungals such as amphotericin, glycosylated derivatives of antibacterials such as tylosin, glycosylated derivatives of antiparasitics such as avermectin, glycosylated derivatives of insecticides such as spinosyn, and methods for making these compounds using the in vivo glycosylation systems of the invention.
摘要翻译：本发明提供了一种使用新型遗传工程菌株进行天然产物糖基化的新技术。本发明的这些体内糖基化体系表达能够糖基化合适底物的异源糖基转移酶和脱氧糖通路，其可加入到培养液中。本发明还提供了通过这些新型遗传工程菌株（本发明的体内糖基化体系）糖基化的新型化合物，包括新型肽，混合聚酮化合物肽或聚酮化合物，包括新型大环内酯类，例如糖基化多杀菌素衍生物，抗生素糖基化衍生物例如红霉素，四环素，利福平，抗肿瘤药物如柔红霉素，霉素霉素，免疫抑制剂如雷帕霉素的衍生物，FK520，FK506，抗真菌剂如两性霉素的糖基化衍生物，抗菌药的糖基化衍生物如泰乐菌素，抗寄生虫的糖基化衍生物如除虫菌素，杀虫剂的糖基化衍生物如多杀菌素，以及使用本发明的体内糖基化系统制备这些化合物的方法。

7. 发明申请

WO0070056A9 CHLORAMPHENICOL BIOSYNTHETIC PATHWAY AND GENE CLUSTER CHARACTERIZATION 审中-公开
公开(公告)号：WO0070056A9
公开(公告)日：2001-11-29
申请号：PCT/US0013394
申请日：2000-05-15
申请人： DIVERSA CORP , PARADKAR ASHISH , SHORT JAY M , MATHUR ERIC J , GREEN BRIAN D
发明人： PARADKAR ASHISH , SHORT JAY M , MATHUR ERIC J , GREEN BRIAN D
IPC分类号： C12N15/10 , C12N15/52 , C12P13/02 , C12Q1/68
CPC分类号： C12P13/02 , C12N15/1034 , C12N15/52
摘要： The present invention provides a chloramphenicol gene cluster and methods of use thereof. Such gene clusters are useful for production of chloramphenicol.
摘要翻译：本发明提供氯霉素基因簇及其使用方法。这样的基因簇可用于生产氯霉素。

8. 发明申请

WO2012040361A3 METHODS AND COMPOSITIONS FOR LIMITING VIABILITY OF A MODIFIED HOST CELL OUTSIDE OF DESIGNATED PROCESS CONDITIONS 审中-公开
标题翻译：用于限制指定过程条件外修改的主机单元的可行性的方法和组合
公开(公告)号：WO2012040361A3
公开(公告)日：2014-03-27
申请号：PCT/US2011052606
申请日：2011-09-21
申请人： JOULE UNLTD TECHNOLOGIES INC , CHURCH GEORGE , SKRALY FRANK ANTHONY , GREEN BRIAN D , HARRISON JACOB CARTER
发明人： CHURCH GEORGE , SKRALY FRANK ANTHONY , GREEN BRIAN D , HARRISON JACOB CARTER
IPC分类号： C12N1/12 , C12N1/20
CPC分类号： C12N15/63 , C07K14/435 , C12N13/00
摘要： The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
摘要翻译：本发明提供了用于在指定的工艺条件之外抑制修饰的宿主细胞增殖的方法和组合物。公开了当暴露于受控环境外的自然条件时提供具有降低的活力的宿主细胞的组合物和方法。

9. 发明申请

WO2011011464A3 CONSTRUCTS AND METHODS FOR EFFICIENT TRANSFORMATION OF MICRO-ORGANISMS FOR PRODUCTION OF CARBON-BASED PRODUCTS OF INTEREST 审中-公开
标题翻译：有效转化微生物用于生产基于碳的产品的结构和方法
公开(公告)号：WO2011011464A3
公开(公告)日：2011-04-07
申请号：PCT/US2010042667
申请日：2010-07-20
申请人： JOULE UNLTD INC , REPPAS NIKOS B , GREEN BRIAN D
发明人： REPPAS NIKOS B , GREEN BRIAN D
IPC分类号： C12P1/00 , C12N1/20
CPC分类号： C12N15/74 , C12N9/0006 , C12N9/88 , C12P7/065 , Y02E50/17
摘要： Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon- based products of interest are provided.
摘要翻译：提供了改进的用于提高嗜热宿主细胞转化用于生产感兴趣的碳基产物和生产基于碳的产品的方法的效率的构建体。

10. 发明申请

WO2012040361A2 METHODS AND COMPOSITIONS FOR LIMITING VIABILITY OF A MODIFIED HOST CELL OUTSIDE OF DESIGNATED PROCESS CONDITIONS 审中-公开
标题翻译：用于限制指定过程条件外修改的主机单元的可行性的方法和组合
公开(公告)号：WO2012040361A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052606
申请日：2011-09-21
申请人： JOULE UNLIMITED TECHNOLOGIES, INC. , CHURCH, George , SKRALY, Frank, Anthony , GREEN, Brian, D. , HARRISON, Jacob, Carter
发明人： CHURCH, George , SKRALY, Frank, Anthony , GREEN, Brian, D. , HARRISON, Jacob, Carter
IPC分类号： C12N15/79 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/13 , C12N1/19 , C12N1/15
CPC分类号： C12N15/63 , C07K14/435 , C12N13/00
摘要： The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
摘要翻译：本发明提供了用于在指定的工艺条件之外抑制修饰的宿主细胞增殖的方法和组合物。公开了当暴露于受控环境外的自然条件时提供具有降低的活力的宿主细胞的组合物和方法。

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