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1. 发明专利

TW201305204A 中和性抗－ＣＣＬ２０抗體审中-公开
简体标题：中和性抗－ＣＣＬ２０抗体
公开(公告)号：TW201305204A
公开(公告)日：2013-02-01
申请号：TW100142487
申请日：2011-11-18
申请人：今井俊夫 , IMAI, TOSHIO , 克林布拉德 , KLINE, BRAD , 河野鐵 , KAWANO, TETSU , 葛拉索魯吉 , GRASSO, LUIGI , 坂本佳正 , SAKAMOTO, YOSHIMASA , 史彼戴爾傑瑞德 , SPIDEL, JARED , 西村美由希 , NISHIMURA, MIYUKI , 村本賢三 , MURAMOTO, KENZO , 堀添達央 , HORIZOE, TATSUO
发明人：今井俊夫 , IMAI, TOSHIO , 克林布拉德 , KLINE, BRAD , 河野鐵 , KAWANO, TETSU , 葛拉索魯吉 , GRASSO, LUIGI , 坂本佳正 , SAKAMOTO, YOSHIMASA , 史彼戴爾傑瑞德 , SPIDEL, JARED , 西村美由希 , NISHIMURA, MIYUKI , 村本賢三 , MURAMOTO, KENZO , 堀添達央 , HORIZOE, TATSUO
IPC分类号： C07K16/24 , C07K16/46 , C12N15/12 , A61K39/395 , A61P17/00 , A61P19/02
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要：本發明係關於一種新穎的人類化、嵌合及鼠類抗體，其對於人類CC趨化因子配體20(CCL20)具有結合特異性。本發明進一步關於該等抗體之重鏈及輕鏈。本發明亦關於包含編碼該等抗體之重鏈及/或輕鏈之序列的分離核酸、重組載體及宿主細胞，及關於一種製備該等抗體之方法。本發明之抗-CCL20抗體可用於治療性應用中，供治療例如發炎性病症及自體免疫病症及癌症。
简体摘要：本发明系关于一种新颖的人类化、嵌合及鼠类抗体，其对于人类CC趋化因子配体20(CCL20)具有结合特异性。本发明进一步关于该等抗体之重链及轻链。本发明亦关于包含编码该等抗体之重链及/或轻链之串行的分离核酸、重组载体及宿主细胞，及关于一种制备该等抗体之方法。本发明之抗-CCL20抗体可用于治疗性应用中，供治疗例如发炎性病症及自体免疫病症及癌症。

2. 发明公开

EP1285303A1 SYSTEM ZUR ERZEUGUNG EINES VIRTUELLEN DISPLAYS 有权
标题翻译：系统用于生成虚拟DISPLAYS
公开(公告)号：EP1285303A1
公开(公告)日：2003-02-26
申请号：EP01945216.8
申请日：2001-05-30
申请人： Grasso, Luigi
发明人： Grasso, Luigi
IPC分类号： G02B27/01 , G06F3/00 , H04Q7/32
CPC分类号： G06F3/012 , G06F1/1626 , G06F1/1632 , G06F1/1666 , G06F3/021 , G06F3/0221 , G06F3/0231
摘要： The invention relates to a system for generating a virtual display comprising the following: an input means (9) for inputting user-specifiable data and/or instructions; a processing unit (5) connected to the input means (9), and; a mobile display device (6), which is connected to the processing unit (5) and which is provided for generating at least one virtual display. The processing unit (5) is configured for outputting a signal for generating an image in the virtual display in accordance with the user-specifiable instructions of the input means (9) and with the relative position of the display device (6) to an arbitrarily selectable reference point. Said reference point is specified by the user and is independent from the image. Alternatively or in addition thereto, the processing unit (5) can be configured for fetching, via a mobile telephone (4), image data in accordance with the user-specifiable instructions and, with the aid of the image data, for outputting a signal for generating an image in the virtual display.

3. 发明公开

EP1259628A1 METHODS FOR GENERATING HYPERMUTABLE YEAST 有权
标题翻译：用于生产FAST酵母突变
公开(公告)号：EP1259628A1
公开(公告)日：2002-11-27
申请号：EP01911013.9
申请日：2001-02-21
申请人： The Johns Hopkins UNiversity School of Medicine , Nicolaides, Nicholas, C. , Sass, Philip, M. , Grasso, Luigi , Vogelstein, Bert , Kinzler, Kenneth
发明人： NICOLAIDES, Nicholas, C. , SASS, Philip, M. , GRASSO, Luigi , VOGELSTEIN, Bert , KINZLER, Kenneth, W.
IPC分类号： C12N15/81 , C12N5/10 , C12N15/01
CPC分类号： C12N15/81
摘要： Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be rendered genetically stable by restoring the mismatch repair system to proper functionality.

4. 发明公开

EP2640744A2 NEUTRALIZING ANTI-CCL20 ANTIBODIES 审中-公开
标题翻译：和抗体CCL20的
公开(公告)号：EP2640744A2
公开(公告)日：2013-09-25
申请号：EP11841462.2
申请日：2011-11-18
申请人： Imai, Toshio , Kline, James Bradford , Kawano, Tetsu , Grasso, Luigi , Sakamoto, Yoshimasa , Spidel, Jared , Nishimura, Miyuki , Muramoto, Kenzo , Horizoe, Tatsuo
发明人： Imai, Toshio , Kline, James Bradford , Kawano, Tetsu , Grasso, Luigi , Sakamoto, Yoshimasa , Spidel, Jared , Nishimura, Miyuki , Muramoto, Kenzo , Horizoe, Tatsuo
IPC分类号： C07K16/00 , A61K39/395 , C07H21/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

5. 发明授权

EP1285303B1 SYSTEM ZUR ERZEUGUNG EINES VIRTUELLEN DISPLAYS 有权
标题翻译：系统用于生成虚拟DISPLAYS
公开(公告)号：EP1285303B1
公开(公告)日：2004-12-29
申请号：EP01945216.8
申请日：2001-05-30
申请人： Grasso, Luigi
发明人： Grasso, Luigi
IPC分类号： G02B27/01 , G06F3/00 , H04Q7/32
CPC分类号： G06F3/012 , G06F1/1626 , G06F1/1632 , G06F1/1666 , G06F3/021 , G06F3/0221 , G06F3/0231
摘要： The invention relates to a system for generating a virtual display comprising the following: an input means (9) for inputting user-specifiable data and/or instructions; a processing unit (5) connected to the input means (9), and; a mobile display device (6), which is connected to the processing unit (5) and which is provided for generating at least one virtual display. The processing unit (5) is configured for outputting a signal for generating an image in the virtual display in accordance with the user-specifiable instructions of the input means (9) and with the relative position of the display device (6) to an arbitrarily selectable reference point. Said reference point is specified by the user and is independent from the image. Alternatively or in addition thereto, the processing unit (5) can be configured for fetching, via a mobile telephone (4), image data in accordance with the user-specifiable instructions and, with the aid of the image data, for outputting a signal for generating an image in the virtual display.

6. 发明公开

EP1430123A2 A METHOD FOR GENERATING HYPERMUTABLE ORGANISMS 有权
标题翻译：方法ZUR HERSTELLUNG HYPERMUTAGENISIERTER ORGANISMEN
公开(公告)号：EP1430123A2
公开(公告)日：2004-06-23
申请号：EP01935403.4
申请日：2001-05-14
申请人： The Johns Hopkins University , Morphotek Inc. , Nicolaides, Nicholas, C. , Sass, Philip, M. , Grasso, Luigi , Vogelstein, Bert , Kinzler, Kenneth
发明人： NICOLAIDES, Nicholas, C. , SASS, Philip, M. , GRASSO, Luigi , VOGELSTEIN, Bert , KINZLER, Kenneth, W.
IPC分类号： C12N15/10 , C12N15/01 , C12Q1/68 , A01K67/027
摘要： PROBLEM TO BE SOLVED: To provide a method for rendering cells hypermutable, and hypermutable cell lines altered genetically and phenotypically.SOLUTION: The invention relates to use of dominant negative alleles of human mismatch repair genes to generate hypermutable cells and organisms; the use of introducing genes into cells and transgenic animals by which new cell lines and animal varieties with new and useful properties can be prepared more efficiently than by relying on the natural rate of mutation; and use of mutagens for enhancing a rate of further augmented mutation.
摘要翻译：要解决的问题：提供一种使细胞变性可变的方法，以及基因和表型改变的超可变细胞系。解决方案：本发明涉及人错配修复基因的显性阴性等位基因用于产生超可变细胞和生物体; 将基因导入细胞和转基因动物中，通过其可以比通过依赖于自然的突变率更有效地制备具有新的和有用的性质的新的细胞系和动物品种; 并使用诱变剂提高进一步增强突变率。

7. 发明授权

EP1430123B1 A METHOD FOR GENERATING HYPERMUTABLE ORGANISMS 有权
标题翻译：一种生成超级生物的方法
公开(公告)号：EP1430123B1
公开(公告)日：2018-01-03
申请号：EP01935403.4
申请日：2001-05-14
申请人： The Johns Hopkins University , Morphotek, Inc. , Nicolaides, Nicholas, C. , Sass, Philip, M. , Grasso, Luigi , Vogelstein, Bert , Kinzler, Kenneth
发明人： NICOLAIDES, Nicholas, C. , SASS, Philip, M. , GRASSO, Luigi , VOGELSTEIN, Bert , KINZLER, Kenneth, W.
IPC分类号： C12N15/10 , C12N15/01 , C12Q1/68 , A01K67/027 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a method for rendering cells hypermutable, and hypermutable cell lines altered genetically and phenotypically.SOLUTION: The invention relates to use of dominant negative alleles of human mismatch repair genes to generate hypermutable cells and organisms; the use of introducing genes into cells and transgenic animals by which new cell lines and animal varieties with new and useful properties can be prepared more efficiently than by relying on the natural rate of mutation; and use of mutagens for enhancing a rate of further augmented mutation.

8. 发明公开

EP1515176A1 System zur Erzeugung eines virtuellen Displays 审中-公开
标题翻译：系统zur Erzeugung eines virtuellen显示
公开(公告)号：EP1515176A1
公开(公告)日：2005-03-16
申请号：EP04029603.0
申请日：2001-05-30
申请人： Grasso, Luigi
发明人： Grasso, Luigi
IPC分类号： G02B27/01 , G06F3/00 , H04Q7/32
CPC分类号： G06F3/012 , G06F1/1626 , G06F1/1632 , G06F1/1666 , G06F3/021 , G06F3/0221 , G06F3/0231
摘要： Die Erfindung betrifft ein mobiles System zur Erzeugung eines virtuellen Displays für ein Mobiltelefon (4), das folgendes umfaßt: ein Eingabemittel (9) zur Eingabe von benutzerbestimmbaren Daten und/oder Befehlen; eine mit dem Eingabemittel (9) verbundene Verarbeitungseinheit (5); und eine mit der Verarbeitungseinheit (5) verbundene mobile Displayvorrichtung (6) zur Erzeugung mindestens eines virtuellen Displays; wobei die Verarbeitungseinheit (5) ausgebildet ist, ein Signal zur Erzeugung eines Bildes im virtuellen Display in Übereinstimmung mit den benutzerbestimmbaren Befehlen des Eingabemittels (9) und der relativen Stellung der Displayvorrichtung (6) zu einem willkürlich auswählbaren absoluten Bezugspunkt auszugeben, der vom Benutzer bestimmt wird, wobei das System ausgebildet ist, das Bild im virtuellen Display solange zu erzeugen, bis die Displayvorrichtung (6) bezüglich des willkürlich auswählbaren Bezugspunkts einen vorbestimmten Raumwinkelbereich einnimmt, wobei das System weiterhin ausgebildet ist, das Bild im virtuellen Display abzuschalten, wenn die Displayvorrichtung (6) den vorbestimmten Raumwinkelbereich verläßt, und wobei das System weiterhin ausgebildet ist, das Bild in einem Teilbereich (25) der Displayvorrichtung (6) zu erzeugen, so dass außerhalb des Teilbereichs (25) der Displayvorrichtung (6) dem Benutzer ein Außenbild zur Verfügung steht.
摘要翻译：处理器（5）被配置为根据用户在输入单元（9）处指定的命令来输出产生虚拟显示中的图像的信号; 和显示器（6）相对于任意选择的参考的位置。参考点是用户选择的，与图像无关。

9. 发明申请

WO2012068540A3 NEUTRALIZING ANTI-CCL20 ANTIBODIES 审中-公开
标题翻译：中性抗CCL20抗体
公开(公告)号：WO2012068540A3
公开(公告)日：2012-09-27
申请号：PCT/US2011061525
申请日：2011-11-18
申请人： IMAI TOSHIO , KLINE BRAD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURMOTO KENZO , HORIZOE TASTUO
发明人： IMAI TOSHIO , KLINE BRAD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURMOTO KENZO , HORIZOE TASTUO
IPC分类号： C07K16/00 , A61K39/395 , C07H21/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The disclosure provides humanized, chimeric and murine antibodies that specificity bind to the human CC chemokine ligand 20 (CCL20). The disclosure further provides heavy chains and light chains of the antibodies, as well as isolated nucleic acids, recombinant vectors and host cells that comprise a sequence encoding a heavy chain and/or light chain of the antibodies. Further disclosed are methods of using the anti-CCL20 antibodies for treating disorders including inflammatory and autoimmune disorders as well as cancers.
摘要翻译：本公开提供特异性结合人CC趋化因子配体20（CCL20）的人源化，嵌合和鼠抗体。本公开还提供了抗体的重链和轻链，以及包含编码抗体的重链和/或轻链的序列的分离的核酸，重组载体和宿主细胞。进一步公开的是使用抗CCL20抗体治疗包括炎性和自身免疫疾病以及癌症的疾病的方法。

10. 发明申请

WO2012054654A2 ANTI-FOLATE RECEPTOR ALPHA ANTIBODY GLYCOFORMS 审中-公开
标题翻译：抗叶酸受体α抗体糖蛋白
公开(公告)号：WO2012054654A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056966
申请日：2011-10-19
申请人： MORPHOTEK, INC. , SASS, Philip M. , NICOLAIDES, Nicholas , GRASSO, Luigi , ROUTHIER, Eric , GU, Wei , YOUNG, Jason , YAO, Jun
发明人： SASS, Philip M. , NICOLAIDES, Nicholas , GRASSO, Luigi , ROUTHIER, Eric , GU, Wei , YOUNG, Jason , YAO, Jun
IPC分类号： C12Q1/68 , G01N27/00 , G01R33/30
CPC分类号： C07K16/28 , C07K16/00 , C07K2317/41 , C07K2317/732 , C07K2317/77
摘要： The invention provides anti-FRA antibodies with novel N-linked neutral glycan profiles in that the relative amounts of one or more neutral glycans are increased or decreased compared to anti- FRA antibodies produced under reference cell culture conditions. The invention further provides anti-FRA antibodies with altered binding to FRA, altered antibody-dependent cellular cytotoxicity (ADCC) and/or altered rate and/or efficiency of internalization in a cell expressing FRA. In related aspects, the invention provides cell cultures comprising an anti-FRA antibody of the invention, a cell isolated from such a culture, kits and compositions comprising an anti-FRA antibody of the invention, methods of producing an anti-FRA antibody of the invention and diagnostic and therapeutic uses of an anti-FRA antibody of the invention.
摘要翻译：本发明提供了具有新的N-连接的中性聚糖谱的抗FRA抗体，因为与参考细胞培养条件下产生的抗FRA抗体相比，一种或多种中性聚糖的相对量增加或减少。本发明进一步提供了抗FRA抗体，其具有改变的FRA结合，改变的抗体依赖性细胞毒性（ADCC）和/或改变的表达FRA的细胞中的内化速率和/或效率。在相关方面，本发明提供了包含本发明的抗FRA抗体的细胞培养物，从这样的培养物中分离的细胞，包含本发明的抗FRA抗体的试剂盒和组合物，产生抗FRA抗体的方法发明以及本发明的抗FRA抗体的诊断和治疗用途。

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