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1. 发明专利

AU2011329647A1 Neutralizing anti-CCL20 antibodies 未知
公开(公告)号：AU2011329647A1
公开(公告)日：2013-05-02
申请号：AU2011329647
申请日：2011-11-18
申请人： SAKAMOTO YOSHIMASA , KAWANO TETSU , GRASSO LUIGI , MURMOTO KENZO , KLINE BRAD , NISHIMURA MIYUKI , SPIDEL JARED , IMAI TOSHIO , HORIZOE TASTUO
发明人： IMAI TOSHIO , KLINE BRAD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURMOTO KENZO , HORIZOE TASTUO
IPC分类号： C07K16/00 , A61K39/395 , A61P19/02 , A61P19/10 , A61P29/00 , A61P31/20 , A61P35/00 , C07H21/04 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/071 , C12N5/10 , C12N15/13 , C12N15/63 , C12P21/08
摘要： The disclosure provides humanized, chimeric and murine antibodies that specificity bind to the human CC chemokine ligand 20 (CCL20). The disclosure further provides heavy chains and light chains of the antibodies, as well as isolated nucleic acids, recombinant vectors and host cells that comprise a sequence encoding a heavy chain and/or light chain of the antibodies. Further disclosed are methods of using the anti-CCL20 antibodies for treating disorders including inflammatory and autoimmune disorders as well as cancers.

2. 发明申请

WO2012068540A3 NEUTRALIZING ANTI-CCL20 ANTIBODIES 审中-公开
标题翻译：中性抗CCL20抗体
公开(公告)号：WO2012068540A3
公开(公告)日：2012-09-27
申请号：PCT/US2011061525
申请日：2011-11-18
申请人： IMAI TOSHIO , KLINE BRAD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURMOTO KENZO , HORIZOE TASTUO
发明人： IMAI TOSHIO , KLINE BRAD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURMOTO KENZO , HORIZOE TASTUO
IPC分类号： C07K16/00 , A61K39/395 , C07H21/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The disclosure provides humanized, chimeric and murine antibodies that specificity bind to the human CC chemokine ligand 20 (CCL20). The disclosure further provides heavy chains and light chains of the antibodies, as well as isolated nucleic acids, recombinant vectors and host cells that comprise a sequence encoding a heavy chain and/or light chain of the antibodies. Further disclosed are methods of using the anti-CCL20 antibodies for treating disorders including inflammatory and autoimmune disorders as well as cancers.
摘要翻译：本公开提供特异性结合人CC趋化因子配体20（CCL20）的人源化，嵌合和鼠抗体。本公开还提供了抗体的重链和轻链，以及包含编码抗体的重链和/或轻链的序列的分离的核酸，重组载体和宿主细胞。进一步公开的是使用抗CCL20抗体治疗包括炎性和自身免疫疾病以及癌症的疾病的方法。

3. 发明专利

MA34738B1 NEUTRALISATION D'ANTICORPS ANTI-CCL20 未知
公开(公告)号：MA34738B1
公开(公告)日：2013-12-03
申请号：MA36013
申请日：2013-06-14
申请人： HORIZOE TASTUO , IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO
发明人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
IPC分类号： C07K16/00 , A61K39/395 , C07H21/04
摘要： La présente invention concerne de nouveaux anticorps humanisés, chimères et murins ayant une spécificité de liaison au ligand 20 de la chimiokine CC humaine (CCL20). La présente invention concerne en outre des chaînes lourdes et des chaînes légères desdits anticorps. L'invention concerne également des acides nucléiques isolés, des vecteurs recombinants et des cellules hôtes comprenant une séquence codant pour une chaîne lourde et/ou une chaîne légère desdits anticorps, et un procédé de préparation desdits anticorps. Les anticorps anti-CCL20 de l'invention peuvent être utilisés dans des applications thérapeutiques destinées à traiter, par exemple, des troubles inflammatoires et autoimmuns et le cancer.

4. 发明专利

CO6761352A2 Anticuerpos neutralizadores anti-ccl20 未知
公开(公告)号：CO6761352A2
公开(公告)日：2013-09-30
申请号：CO13145744
申请日：2013-06-19
申请人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
发明人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
IPC分类号： C07K16/00
摘要： Nuevos anticuerpos humanizados, quiméricos y murinos que presentan especificidad de unión por el ligando de la quimioquina humana CC 20 (CCL2O). Cadenas pesadas y cadenas livianas de dichos anticuerpos. Ácidos nucleicos aislados, vectores recombinantes y células huésped que comprenden una secuencia que codifica una cadena pesada y/o una cadena liviana de dichos anticuerpos. Método para preparar dichos anticuerpos. Los anticuerpos anti-CCL2O de la invención pueden usarse en aplicaciones terapéuticas, por ejemplo, para tratar los trastornos inflamatorios y autoinmunes y el cáncer.

5. 发明专利

CA2818548A1 NEUTRALIZING ANTI-CCL20 ANTIBODIES 未知
公开(公告)号：CA2818548A1
公开(公告)日：2012-05-24
申请号：CA2818548
申请日：2011-11-18
申请人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
发明人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
IPC分类号： C12N15/13 , A61K39/395 , C07K16/24 , C07K16/46 , C12N15/63 , C12P21/08
摘要： The disclosure provides humanized, chimeric and murine antibodies that specificity bind to the human CC chemokine ligand 20 (CCL20). The disclosure further provides heavy chains and light chains of the antibodies, as well as isolated nucleic acids, recombinant vectors and host cells that comprise a sequence encoding a heavy chain and/or light chain of the antibodies. Further disclosed are methods of using the anti-CCL20 antibodies for treating disorders including inflammatory and autoimmune disorders as well as cancers.

6. 发明专利

AU2011329647B2 Neutralizing anti-CCL20 antibodies 未知
公开(公告)号：AU2011329647B2
公开(公告)日：2015-10-22
申请号：AU2011329647
申请日：2011-11-18
申请人： GRASSO LUIGI , HORIZOE TATSUO , IMAI TOSHIO , KAWANO TETSU , KLINE JAMES BRADFORD , MURAMOTO KENZO , NISHIMURA MIYUKI , SAKAMOTO YOSHIMASA , SPIDEL JARED
发明人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
IPC分类号： C07K16/00 , A61K39/395 , A61P19/02 , A61P19/10 , A61P29/00 , A61P31/20 , A61P35/00 , C07H21/04 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/071 , C12N5/10 , C12N15/13 , C12N15/63 , C12P21/08
摘要： The disclosure provides humanized, chimeric and murine antibodies that specificity bind to the human CC chemokine ligand 20 (CCL20). The disclosure further provides heavy chains and light chains of the antibodies, as well as isolated nucleic acids, recombinant vectors and host cells that comprise a sequence encoding a heavy chain and/or light chain of the antibodies. Further disclosed are methods of using the anti-CCL20 antibodies for treating disorders including inflammatory and autoimmune disorders as well as cancers.

7. 发明专利

ZA201303571B NEUTRALIZING ANTI-CCL20 ANTIBODIES 未知
公开(公告)号：ZA201303571B
公开(公告)日：2014-12-23
申请号：ZA201303571
申请日：2013-05-16
申请人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
发明人： IMAI TOSHIO , KLINE JAMES BRADFORD , KAWANO TETSU , GRASSO LUIGI , SAKAMOTO YOSHIMASA , SPIDEL JARED , NISHIMURA MIYUKI , MURAMOTO KENZO , HORIZOE TATSUO
IPC分类号： A61K20060101 , C07H20060101 , C07K20060101
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

8. 发明申请

WO2005032589A8 PREVENTION AND TREATMENT FOR GVHD 审中-公开
标题翻译： GVHD的预防和治疗
公开(公告)号：WO2005032589A8
公开(公告)日：2005-06-16
申请号：PCT/JP2004014277
申请日：2004-09-29
申请人： JAPAN SCIENCE & TECH AGENCY , EISAI CO LTD , MATSUSHIMA KOUJI , UEHA SATOSHI , IMAI TOSHIO
发明人： MATSUSHIMA KOUJI , UEHA SATOSHI , IMAI TOSHIO
IPC分类号： A61K45/06 , A61P37/06 , C07K16/24 , G01N33/50 , G01N33/564 , G01N33/68 , A61K45/00 , A61K39/395 , G01N33/15
CPC分类号： G01N33/6872 , A61K45/06 , A61K2039/505 , C07K16/24 , C07K2317/70 , G01N33/505 , G01N33/564 , G01N2800/245
摘要： It is intended to provide a method of specifically and preventively or therapeutically avoiding organ injury in graft-versus-host disease (GVHD), a preventive or a remedy therefor and a method of screening the preventive or the remedy. Organ injury in GVHD can be prevented and thus GVHD can be selectively treated and prevented by inhibiting the interaction between fractalkine and a chemokine receptor CX3CR1 expressed in donor CD8 T cells and specifically inhibiting the infiltration of the CD8 T cells into organs such as the intestinal tract. The interaction between fractalkine and the chemokine receptor CX3CR1 can be inhibited by, for example, the method using antifractalkine antibody. A method of screening a substance having an effect of preventing or treating organ injury in GVHD by using the mechanism of specifically inhibiting the infiltration of the CD8 T cells into organs such as the intestinal tract.
摘要翻译：旨在提供一种特异性和预防性或治疗性避免移植物抗宿主病（GVHD）中的器官损伤的方法，其预防或治疗方法以及筛选预防或治疗方法。通过抑制fractalkine与供体CD8 T细胞中表达的趋化因子受体CX3CR1之间的相互作用并特异性抑制CD8 T细胞向肠道等器官的浸润，可以预防GVHD器官损伤，从而可以选择性治疗和预防GVHD 。例如，通过使用抗福尔马克碱抗体的方法可以抑制fractalkine和趋化因子受体CX3CR1之间的相互作用。通过使用特异性抑制CD8T细胞向肠道等器官的浸润的机制，筛选具有预防或治疗GVHD的器官损伤的效果的物质的方法。

9. 发明专利

MX2013005532A ANTICUERPOS ANTI-LIGANDO DE QUIMIOCINA CC 20 (CCL20) NEUTRALIZANTES. 未知
公开(公告)号：MX2013005532A
公开(公告)日：2013-09-26
申请号：MX2013005532
申请日：2011-11-18
申请人： IMAI TOSHIO
发明人： NISHIMURA MIYUKI , IMAI TOSHIO , GRASSO LUIGI , KLINE JAMES BRADFORD , KAWANO TETSU , SAKAMOTO YOSHIMASA , SPIDEL JARED , MURAMOTO KENSO , HORIZOE TATSUO
IPC分类号： A61K39/395 , C07H21/04 , C07K16/00
摘要： La presente invención se refiere a anticuerpos humanizados, quiméricos y de murino novedosos que tienen especificidad de unión por el ligando de quimiocina CC 20 de humano (CCL20). La presente invención se refiere además a cadenas pesadas y cadenas ligeras de los anticuerpos. La invención también se refiere a ácidos nucleicos aislados, vectores recombinantes y células hospedantes que comprenden una secuencia la cual codifica una cadena pesada y/o una cadena ligera de los anticuerpos y a un método para preparar los anticuerpos. Los anticuerpos anti-CCL20 de la invención se puede utilizar en aplicaciones terapéuticas para tratar, por ejemplo, trastornos inflamatorios y autoinmunes y el cáncer.

10. 发明专利

JP2000238894A AUXILIARY TOOL FOR CORKSCREW OF HELICAL DRILL 失效
公开(公告)号：JP2000238894A
公开(公告)日：2000-09-05
申请号：JP9327199
申请日：1999-02-23
申请人： IMAI NORIFUMI , IMAI MASARU , IMAI TOSHIO
发明人： IMAI NORIFUMI , IMAI TOSHIO
IPC分类号： B67B7/04
摘要： PROBLEM TO BE SOLVED: To remove a cork just by revolving a handle with a helical drill on its lower section. SOLUTION: An insert die 3 is screwed into a main body 2 by screws 6 provided on both of them, and clutch sections 5 are formed on the upper section of the insert die 3 and the lower section of a handle 1, and when the handle 1 is revolved, first a helical drill 4 is bitten into a cork, and then when the upper clutch section 5 reaches the lower clutch section, the biting of the cork is completed, and the handle 1 and the insert die 3 are revolved simultaneously. The revolution of the insert die 3 is moved to the oblique upper while being revolved by the guide of a screw 6 of the main body 2, and the cork into which the helical drill 4 is bitten is moved in a same manner, and the cork is removed slowly by the small force, and the helical drill 4 is set in the state of being pulled while revolving the work toward oblique upper, and the damage to the cork is small, and the end of the helical drill 4 is not protruded from the bottom of the cork.

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