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1. 发明申请

WO2001083750A3 DENDRITIC CELL CO-STIMULATOR MOLECULES 审中-公开
公开(公告)号：WO2001083750A3
公开(公告)日：2001-11-08
申请号：PCT/US2001/013430
申请日：2001-04-27
申请人： THE JOHNS HOPKINS UNIVERSITY , PARDOLL, Drew, M. , TSUCHIYA, Haruo , GORSKI, Kevin, S. , TSENG, Su-Yi
发明人： PARDOLL, Drew, M. , TSUCHIYA, Haruo , GORSKI, Kevin, S. , TSENG, Su-Yi
IPC分类号： C12N15/12
摘要： A costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.

2. 发明申请

WO0183750A2 NEW DENDRITIC CELL CO-STIMULATORY MOLECULES 审中-公开
标题翻译：新型细胞共刺激分子
公开(公告)号：WO0183750A2
公开(公告)日：2001-11-08
申请号：PCT/US0113430
申请日：2001-04-27
申请人： UNIV JOHNS HOPKINS , PARDOLL DREW M , TSUCHIYA HARUO , GORSKI KEVIN S , TSENG SU YI
发明人： PARDOLL DREW M , TSUCHIYA HARUO , GORSKI KEVIN S , TSENG SU-YI
IPC分类号： C12N15/09 , A61K35/14 , A61K35/76 , A61K38/00 , A61K39/39 , A61K39/395 , A61K48/00 , A61P35/00 , A61P37/04 , A61P37/06 , C07K14/705 , C07K14/725 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/08 , A61K38/17 , C12N15/62
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

3. 发明申请

WO0183750A9 DENDRITIC CELL CO-STIMULATOR MOLECULES 审中-公开
标题翻译： DENDRITIC细胞共刺激分子
公开(公告)号：WO0183750A9
公开(公告)日：2003-07-03
申请号：PCT/US0113430
申请日：2001-04-27
申请人： UNIV JOHNS HOPKINS , PARDOLL DREW M , TSUCHIYA HARUO , GORSKI KEVIN S , TSENG SU-YI
发明人： PARDOLL DREW M , TSUCHIYA HARUO , GORSKI KEVIN S , TSENG SU-YI
IPC分类号： C12N15/09 , A61K35/14 , A61K35/76 , A61K38/00 , A61K39/39 , A61K39/395 , A61K48/00 , A61P35/00 , A61P37/04 , A61P37/06 , C07K14/705 , C07K14/725 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/08 , A61K38/17 , A61K39/00 , C12N15/62
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

4. 发明申请

WO2005077048A2 IMMUNE MODULATION BY REGULATING EXPRESSION OF THE “MINOR” GENE IN IMMUNE DENDRITIC CELLS 审中-公开
标题翻译：通过调节免疫细胞中“微量”基因表达的免疫调节
公开(公告)号：WO2005077048A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/004060
申请日：2005-02-09
申请人： THE JOHNS HOPKINS UNIVERSITY , PARDOLL, Drew , WHARTENBY, Katharine, A. , GORSKI, Kevin, S. , CHAN, Camie
发明人： PARDOLL, Drew , WHARTENBY, Katharine, A. , GORSKI, Kevin, S. , CHAN, Camie
IPC分类号： A61K39/00 , C12N5/0784 , C12N15/113
CPC分类号： A61K39/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0639 , C12N15/1138 , C12N2310/14 , C12N2501/38 , C12N2501/48
摘要： Mitogen induced nuclear orphan receptor (MINOR) is described as inducing apoptosis in dendritic cells (DCs). Downregulation of its expression results in a downregulation of apoptosis. A novel approach of inhibiting DC apoptosis is described employing small interfering RNA (siRNA) that targets MINOR. Improved DC-based vaccines exhibiting longer lifespan of DCs, increased potency of DCs, and enhanced immunogenicity are described.
摘要翻译：丝裂原诱导的核孤儿受体（MINOR）被描述为诱导树突状细胞（DC）的细胞凋亡。其表达的下调导致细胞凋亡的下调。使用针对MINOR的小干扰RNA（siRNA）描述抑制DC凋亡的新方法。描述了改进的DC表现出更长使用寿命的DC疫苗，增加DC的效力和增强的免疫原性。

5. 发明申请

WO2007149802A3 FORMULATION FOR DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开
标题翻译：免疫调节剂的配制
公开(公告)号：WO2007149802A3
公开(公告)日：2008-04-10
申请号：PCT/US2007071433
申请日：2007-06-18
申请人： 3M INNOVATIVE PROPERTIES CO , GORSKI KEVIN S , ORTIZ RONNIE , STOESZ JAMES D , ZARRAGA ISIDRO ANGELO E
发明人： GORSKI KEVIN S , ORTIZ RONNIE , STOESZ JAMES D , ZARRAGA ISIDRO ANGELO E
IPC分类号： A61K9/06 , A61K39/39
CPC分类号： A61K9/06 , A61K9/0019 , A61K9/0024 , A61K2039/55511
摘要： The present invention provides pharmaceutical compositions that include an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel. In another aspect, the present invention also provides a method of eliciting an antigen-specific immune response in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to generate an immune response in the subject against the antigen. In yet another aspect, the present invention also provides a method of treating a condition in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to ameliorate at least one symptom or clinical sign of the condition.
摘要翻译：本发明提供药物组合物，其包含IRM-PEG复合物和抗原，一起配制在热反应凝胶中。另一方面，本发明还提供在受试者中引发抗原特异性免疫应答的方法。通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应性凝胶中，其数量有效地在受试者中针对抗原产生免疫应答。在另一方面，本发明还提供了治疗受试者的病症的方法。通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应凝胶中，其量可以有效地改善至少一种症状或临床症状。

6. 发明申请

WO2007149802A2 FORMULATION FOR DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开
标题翻译：免疫调节剂的配制
公开(公告)号：WO2007149802A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/071433
申请日：2007-06-18
申请人： 3M INNOVATIVE PROPERTIES COMPANY , GORSKI, Kevin S. , ORTIZ, Ronnie , STOESZ, James D. , ZARRAGA, Isidro Angelo E.
发明人： GORSKI, Kevin S. , ORTIZ, Ronnie , STOESZ, James D. , ZARRAGA, Isidro Angelo E.
IPC分类号： A61K9/06 , A61K39/39
CPC分类号： A61K9/06 , A61K9/0019 , A61K9/0024 , A61K2039/55511
摘要： The present invention provides pharmaceutical compositions that include an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel. In another aspect, the present invention also provides a method of eliciting an antigen-specific immune response in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to generate an immune response in the subject against the antigen. In yet another aspect, the present invention also provides a method of treating a condition in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to ameliorate at least one symptom or clinical sign of the condition.
摘要翻译：本发明提供药物组合物，其包含IRM-PEG复合物和抗原，一起配制在热反应凝胶中。另一方面，本发明还提供在受试者中引发抗原特异性免疫应答的方法。通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应性凝胶中，其数量有效地在受试者中针对抗原产生免疫应答。在另一方面，本发明还提供了治疗受试者的病症的方法。通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应凝胶中，其量可以有效地改善至少一种症状或临床症状。

7. 发明申请

WO2005077048A3 IMMUNE MODULATION BY REGULATING EXPRESSION OF THE "MINOR" GENE IN IMMUNE DENDRITIC CELLS 审中-公开
标题翻译：通过调节免疫细胞中“微量”基因表达的免疫调节
公开(公告)号：WO2005077048A3
公开(公告)日：2006-08-10
申请号：PCT/US2005004060
申请日：2005-02-09
申请人： UNIV JOHNS HOPKINS , PARDOLL DREW , WHARTENBY KATHARINE A , GORSKI KEVIN S , CHAN CAMIE
发明人： PARDOLL DREW , WHARTENBY KATHARINE A , GORSKI KEVIN S , CHAN CAMIE
IPC分类号： C12Q1/68 , A01N43/04 , A61K31/07 , A61K39/00 , C07H21/04 , C12N5/0784 , C12N15/113
CPC分类号： A61K39/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0639 , C12N15/1138 , C12N2310/14 , C12N2501/38 , C12N2501/48
摘要： Mitogen induced nuclear orphan receptor (MINOR) is described as inducing apoptosis in dendritic cells (DCs). Downregulation of its expression results in a downregulation of apoptosis. A novel approach of inhibiting DC apoptosis is described employing small interfering RNA (siRNA) that targets MINOR. Improved DC-based vaccines exhibiting longer lifespan of DCs, increased potency of DCs, and enhanced immunogenicity are described.
摘要翻译：丝裂原诱导的核孤儿受体（MINOR）被描述为诱导树突状细胞（DC）的细胞凋亡。其表达的下调导致细胞凋亡的下调。使用针对MINOR的小干扰RNA（siRNA）描述抑制DC凋亡的新方法。描述了改进的DC表现出更长寿命的DCs，增加DC的效力和增强的免疫原性的疫苗。

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