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1. 发明公开

EP0687270A1 OSTEOGENIC GROWTH OLIGOPEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 失效转让
标题翻译：成骨生长寡肽和含有它们的药物组合物
公开(公告)号：EP0687270A1
公开(公告)日：1995-12-20
申请号：EP94908419.0
申请日：1994-03-04
申请人： YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , GOLDIN, Douglas Michael
发明人： BAB, Itai , MUHLRAD, Andras , CHOREV, Michael , SHTEYER, Arie , GREENBERG, Zvi , MANSUR, Nura
IPC分类号： A61K38 , A61P19 , A61P43 , C07K5 , C07K7 , C07K14 , C12N15
CPC分类号： C07K14/51 , A61K38/00
摘要： The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred oligopeptides according to the invention comprise the amino acid sequences Tyr-Gly-Phe-His-Gly and Gly-Phe-Gly-Gly. The invention further relates to pharmaceutical compositions for the stimulation of formation of osteoblastic of fibroblastic cells, enhanced bone formation in osteogenic pathological conditions, fracture repair, healing of wounds, intraosseous implants and bone supplementation, or other conditions requiring enhanced bone formation cells comprising a therapeutically effective amount of an oligopeptide according to the invention.

2. 发明专利

CA2157506C OSTEOGENIC GROWTH OLIGOPEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：CA2157506C
公开(公告)日：2007-12-04
申请号：CA2157506
申请日：1994-03-04
申请人： GOLDIN DOUGLAS MICHAEL , YISSUM RES DEV CO
发明人： BAB ITAI , MUHLRAD ANDRAS , CHOREV MICHAEL , SHTEYER ARIE , GREENBERG ZVI , MANSUR NURA
IPC分类号： A61K38/00 , C07K7/06 , A61K38/07 , A61K38/08 , A61K38/22 , A61P17/02 , A61P19/00 , A61P19/08 , A61P43/00 , C07K1/22 , C07K1/36 , C07K5/08 , C07K5/10 , C07K5/103 , C07K14/51 , C12N15/06
摘要： The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred oligopeptides according to the invention comprise the amino acid sequences Tyr--Gly-Phe-His-Gly and Gly-Phe-Gly-Gly. The invention further relates to pharmaceutical compositions for the stimulation of formation of osteoblastic of fibroblastic cells, enhanced bone formation in osteogenic pathological conditions, fracture repair, healing of wounds, intraosseous implants and bone supplementation, or other conditions requirin g enhanced bone formation cells comprising a therapeutically effective amount of an oligopeptide according to the invention.

3. 发明专利

AU6974994A Pharmaceutical compositions for stimulating reconstruction of hemopoietic microenvironment 未知
公开(公告)号：AU6974994A
公开(公告)日：1995-01-17
申请号：AU6974994
申请日：1994-06-17
申请人： GOLDIN DOUGLAS MICHAEL , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIV OF JERUSALEM
发明人： BAB ITAI , MUHLRAD ANDRAS , CHOREV MICHAEL , SHTEYER ARIE , SLAVIN SHIMON , MANSUR NURA , GUREVITCH OLGA
IPC分类号： A61K38/00 , C07K14/51 , A61K37/36 , C07K7/08 , C07K15/00
摘要： A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction. OGP, identified from regenerating bone marrow, has an amino acid sequence of Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly.

5. 发明专利

DE69424657D1 未知
公开(公告)号：DE69424657D1
公开(公告)日：2000-06-29
申请号：DE69424657
申请日：1994-03-04
申请人： YISSUM RES DEV CO , GOLDIN DOUGLAS MICHAEL
发明人： BAB ITAI , MUHLRAD ANDRAS , CHOREV MICHAEL , SHTEYER ARIE , GREENBERG ZVI , MANSUR NURA
IPC分类号： A61K38/00 , A61K38/22 , A61P19/00 , A61P43/00 , C07K5/08 , C07K5/10 , C07K7/06 , C07K14/51 , C12N15/06 , C07K7/08

6. 发明申请

WO1995000166A1 PHARMACEUTICAL COMPOSITIONS FOR STIMULATING RECONSTRUCTION OF HEMOPOIETIC MICROENVIRONMENT 审中-公开
标题翻译：用于刺激重建微生态环境的药物组合物
公开(公告)号：WO1995000166A1
公开(公告)日：1995-01-05
申请号：PCT/GB1994001309
申请日：1994-06-17
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael , BAB, Itai , MUHLRAD, Andras , CHOREV, Michael , SHTEYER, Arie , SLAVIN, Shimon , MANSUR, Nura , GUREVITCH, Olga
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael
IPC分类号： A61K37/36
CPC分类号： C07K14/51 , A61K38/00 , Y10S530/84 , Y10S530/841
摘要： The invention relates to a pharmaceutical composition for stimulating reconstruction of hemopoietic microenvironment comprising a therapeutically effective amount of a peptide having an amino acide sequence Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Try-Gly-Phe-Gly-Gly- (OGP), or conservative amino acid substitution or deletion thereof, or an oligopeptide having molecular weight of from 200 to 2,000 wherein the four C-terminal amino acid residues are identical with those of the said OGP, with the penultimate Gly optionally replaced by His, or a mixture thereof and a pharmaceutically acceptable carrier. A method of stimulating reconstruction of hemopoietic microenvironment in a mammal which comprises administering to said mammal a therapeutically effective amount of a peptide having an amino acid sequence Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly (OGP), or conservative amino acid substitution or deletion thereof, or an oligopeptide having molecular weight of from 200 to 2,000 wherein the four C-terminal amino acid residues are identical with those of said OGP, with the penultimates Gly optionally replaced by His, or a mixture thereof.
摘要翻译：本发明涉及用于刺激造血微环境重建的药物组合物，其包含治疗有效量的具有氨基酸序列Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Try-Gly-Phe- Gly-Gly-（OGP）或其保守氨基酸取代或缺失，或分子量为200至2,000的寡肽，其中四个C-末端氨基酸残基与所述OGP的氨基酸残基相同，其中倒数第二任选地被His替代，或其混合物和药学上可接受的载体。一种刺激哺乳动物造血微环境重建的方法，其包括向所述哺乳动物施用治疗有效量的具有氨基酸序列Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly -Phe-Gly-Gly（OGP）或其保守氨基酸取代或缺失，或分子量为200至2,000的寡肽，其中四个C末端氨基酸残基与所述OGP的氨基酸残基相同， Gly任选被His取代，或其混合物。

7. 发明申请

WO1994020529A1 OSTEOGENIC GROWTH OLIGOPEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：营养生长寡核苷酸和含有它们的药物组合物
公开(公告)号：WO1994020529A1
公开(公告)日：1994-09-15
申请号：PCT/GB1994000416
申请日：1994-03-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael , BAB, Itai , MUHLRAD, Andras , CHOREV, Michael , SHTEYER, Arie , GREENBERG, Zvi , MANSUR, Nura
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael
IPC分类号： C07K05/10
CPC分类号： C07K14/51 , A61K38/00
摘要： The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred oligopeptides according to the invention comprise the amino acid sequences Tyr-Gly-Phe-His-Gly and Gly-Phe-Gly-Gly. The invention further relates to pharmaceutical compositions for the stimulation of formation of osteoblastic of fibroblastic cells, enhanced bone formation in osteogenic pathological conditions, fracture repair, healing of wounds, intraosseous implants and bone supplementation, or other conditions requiring enhanced bone formation cells comprising a therapeutically effective amount of an oligopeptide according to the invention.
摘要翻译：本发明涉及对分子量在200和2,000之间的成骨细胞和/或成纤维细胞具有刺激活性的生物化学纯的寡肽。根据本发明的优选的寡肽包含氨基酸序列Tyr-Gly-Phe-His-Gly和Gly-Phe-Gly-Gly。本发明进一步涉及用于刺激成纤维细胞成骨细胞形成的药物组合物，增强成骨细胞病理状态下的骨形成，骨折修复，伤口愈合，骨内植入物和补骨，或需要增强的骨形成细胞的其它条件，其包括治疗有效量的根据本发明的寡肽。

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