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1. 发明专利

JP2012184245A Method for purifying highly anionic protein 有权
标题翻译：用于纯化高亲和蛋白的方法
公开(公告)号：JP2012184245A
公开(公告)日：2012-09-27
申请号：JP2012107204
申请日：2012-05-09
申请人： Genetics Inst Llc , ジェネティクスインスティテュート,エルエルシー
发明人： COFFMAN JONATHAN L , FOSTER WILLIAM BARRY , GERMAIN BONNIE J , SUN SHUJUN , ROBINSON JEFFREY J
IPC分类号： C07K1/16 , C07K14/00 , C07K1/14 , C07K1/18 , C07K1/20 , C07K14/705 , C07K19/00
CPC分类号： C07K1/20 , C07K1/18 , C07K1/36 , C07K14/70596 , C07K2319/00 , C07K2319/30
摘要： PROBLEM TO BE SOLVED: To provide a method for isolation and purification of a highly anionic target protein such as a sulfated protein.SOLUTION: The method for purifying the highly anionic target protein comprises (1) a step to contact an ion-exchange chromatograph with a specimen and bond the target protein to a substrate, (2) a step to wash the substrate with a first washing solution under a condition to keep a plurality of proteinaceous and non-proteinaceous impurities in the specimen from bonding to the substrate or wash off the impurities from the substrate while leaving the highly anionic target protein in a state bonded to the substrate, (3) a step to elute the specimen with a first elution solution containing a salt solution having high molar concentration and (4) a step to collect the eluted specimen containing the purified anionic target protein. The sulfated protein has five or more sulfation sites, for example, six sulfation sites on N-terminal tyrosine residues such as PSGL-1 (P-selectin glycoprotein ligand).
摘要翻译：待解决的问题：提供高度阴离子靶蛋白如硫酸化蛋白质的分离纯化方法。解决方案：高纯度阴离子靶蛋白的纯化方法包括（1）将离子交换色谱与样品接触并将靶蛋白结合到基底上的步骤，（2）用在将样品中的多种蛋白质和非蛋白质杂质保持在与基底结合的状态下或者从衬底中洗去杂质的同时将高度阴离子靶蛋白留下至与基底结合的状态下，将第一洗涤溶液（3 ）用含有高摩尔浓度的盐溶液的第一洗脱溶液洗脱样品的步骤和（4）收集含有纯化的阴离子靶蛋白的洗脱样品的步骤。硫酸化蛋白质具有五个或更多个硫酸化位点，例如N末端酪氨酸残基如PSGL-1（P-选择素糖蛋白配体）上的六个硫酸化位点。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2011105751A Pd-1, receptor of b7-4 and use of the same 审中-公开
标题翻译： PD-1，B7-4受体及其用途
公开(公告)号：JP2011105751A
公开(公告)日：2011-06-02
申请号：JP2011015534
申请日：2011-01-27
申请人： Dana-Farber Cancer Inst Inc , Genetics Inst Llc , ジェネティクスインスティテュート,エルエルシー , ダナ−ファーバーキャンサーインスティテュート,インコーポレイテッドDana−Farber Cancer Institute, Incorporated
发明人： WOOD CLIVE , FREEMANN GORDON J
IPC分类号： A61K45/00 , G01N33/50 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/06 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P15/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/06 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/06 , A61P33/12 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P41/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N33/15 , G01N33/566
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/06 , A61K2039/55516 , C07K14/70503 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N2333/70503 , G01N2500/04 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide an agent which modulates a signaling via PD-1. SOLUTION: PD-1 is identified as a receptor of B7-4. B7-4 can inhibit the activation of an immunocyte when it is bonded to an inhibitory receptor on an immunocyte. Therefore, modulation of immune response is induced by modulating costimulatory or inhibitory signal of the immunocyte by administrating an agent which modulates PD-1, B7-4 and interaction between B7-4 and PD-1. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供通过PD-1调制信令的代理。解决方案：PD-1被鉴定为B7-4的受体。当免疫细胞与免疫细胞上的抑制性受体结合时，B7-4可以抑制免疫细胞的活化。因此，通过施用调节PD-1，B7-4和B7-4与PD-1之间的相互作用的药剂调节免疫细胞的共刺激或抑制信号来诱导免疫应答的调节。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2010195794A Use of follistatin to modulate gdf-8 and bmp-11 审中-公开
标题翻译：使用氟西汀来调节GDF-8和BMP-11
公开(公告)号：JP2010195794A
公开(公告)日：2010-09-09
申请号：JP2010061242
申请日：2010-03-17
申请人： Genetics Inst Llc , ジェネティクスインスティテュート,エルエルシー
发明人： WOOD CLIVE R , FITZ LORI JO
IPC分类号： A61K38/00 , C12N5/10 , A61K38/17 , A61P13/02 , A61P21/00 , A61P21/02 , A61P21/04 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C07K14/51 , C12N5/00 , C12N15/09
CPC分类号： A61K38/1709
摘要： PROBLEM TO BE SOLVED: To provide a composition for treating muscle-associated diseases containing follistatin or its functional fragment.
SOLUTION: A method is to block the influence over cell of protein chosen from a group consisting of a growth and differentiation factor 8 (GDF-8), and bone morphogenetic protein 11 (BMP-11), and includes medicating cell with the follistatin of an effective amount for diseases relevant to the influence of GDF-8 or BMP-11 over nerve or muscle.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于治疗含有卵泡抑素或其功能片段的肌肉相关疾病的组合物。解决方案：一种方法是阻止从生长和分化因子8（GDF-8）和骨形态发生蛋白11（BMP-11）组成的组中选择的蛋白质细胞的影响，包括治疗细胞与与GDF-8或BMP-11对神经或肌肉的影响相关的疾病的有效量的卵泡抑素。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009046512A Method and composition for inhibiting tumor growth and enhancing immune response 审中-公开
标题翻译：抑制肿瘤生长和增强免疫应答的方法和组合
公开(公告)号：JP2009046512A
公开(公告)日：2009-03-05
申请号：JP2008262301
申请日：2008-10-08
申请人： Genetics Inst Llc , Government Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services , ザガバメントオブザユナイテッドステイツアズレプリゼンテッドバイザセクレタリーオブザデパートメントオブヘルスアンドヒューマンサービシーズ , ジェネティクスインスティテュート,エルエルシー
发明人： BERZOFSKY JAY A , TERABE MASAKI , DONALDSON DEBRA D , MATSUI SO , NOBEN-TRAUTH NANCY , PAUL WILLIAM E
IPC分类号： A61K45/00 , A61K47/34 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/385 , A61K39/39 , A61K39/395 , A61K48/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/02 , A61P37/04 , C07K14/54 , C07K16/24 , C07K16/28
CPC分类号： C07K16/244 , A61K38/1793 , A61K38/208 , A61K39/39 , A61K2039/505 , A61K2039/55516 , A61K2039/55538 , C07K16/2812 , C07K2319/30 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a method and a composition for enhancing an immune response.
SOLUTION: The method and composition for enhancing an immune response in a subject comprises administering an inhibitor of IL-13 or an inhibitor of an NK-T cell to the subject. This method can be used to prevent growth of a tumor in the subject (e.g., to inhibit tumor recurrence or metastasis). The method can also be used to enhance a response to a vaccine in a subject. The method is based in part on the discovery that administration of an inhibitor of IL-13 to a subject or disrupting NK-T cell function in a subject inhibits recurrence of the tumor.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供用于增强免疫应答的方法和组合物。解决方案：用于增强受试者的免疫应答的方法和组合物包括向受试者施用IL-13抑制剂或NK-T细胞抑制剂。该方法可用于预防受试者中肿瘤的生长（例如抑制肿瘤复发或转移）。该方法还可用于增强对受试者中疫苗的反应。该方法部分地基于以下发现：对受试者施用IL-13抑制剂或破坏受试者的NK-T细胞功能抑制肿瘤的复发。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2008131942A Human ctla-8 and uses of ctla-8-related proteins 有权
标题翻译：人CTLA-8和CTLA-8相关蛋白的用途
公开(公告)号：JP2008131942A
公开(公告)日：2008-06-12
申请号：JP2007301924
申请日：2007-11-21
申请人： Genetics Inst Llc , ジェネティクスインスティテュート,エルエルシー
发明人： JACOBS KENNETH , KELLEHER KERRY , CARLIN MCKEOUGH , GOLDMAN SAMUEL , PITTMAN DEBRA , MI SHA , NEBEN STEVEN , GIANNOTTI JOANN , GOLDEN-FLEET MARGARET
IPC分类号： C12N15/09 , A61K31/00 , A61K35/12 , A61K38/00 , A61K48/00 , A61P7/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47 , C07K14/54 , C07K16/24 , C12N5/10 , C12N15/12 , C12N15/24 , C12P21/02
CPC分类号： C07K14/54 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide new methods for identifying novel cytokines and other secretion factors and to isolate polynucleotides encoding them, and to provide uses of the cytokines. SOLUTION: Polynucleotides encoding human CTLA-8 and human CTLA-8 polypeptides are disclosed. The inhibition of angiogenesis, inhibition of proliferation of vascular endothelial cells, inhibition of tumor growth, inhibition of angiogenesis-dependent tissue growth, proliferation of myeloid cells or progenitors, proliferation of erythroid cells or progenitors, proliferation of lymphoid cells or progenitors, induction of IFNγ production, the induction of IL-3 production and induction of GM-CSF production are effectively carried out in a subject by using the polynucleotides and the polypeptides. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供用于鉴定新的细胞因子和其他分泌因子并分离编码它们的多核苷酸的新方法，并提供细胞因子的用途。解决方案：公开了编码人CTLA-8和人CTLA-8多肽的多核苷酸。抑制血管发生，抑制血管内皮细胞增殖，抑制肿瘤生长，抑制血管生成依赖性组织生长，髓细胞或祖细胞增殖，红细胞或祖细胞增殖，淋巴细胞或祖细胞增殖，诱导IFNγ 通过使用多核苷酸和多肽，在受试者中有效地进行生产，IL-3产生的诱导和GM-CSF产生的诱导。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2008099695A P-selectin ligand protein 审中-公开
标题翻译： P-SELECTIN LIGAND蛋白
公开(公告)号：JP2008099695A
公开(公告)日：2008-05-01
申请号：JP2007271396
申请日：2007-10-18
申请人： Genetics Inst Llc , ジェネティクスインスティテュート,エルエルシー
发明人： LARSEN GLENN R , SAKO DIANNE S , CHANG XIAO-JIA , VELDMAN GEERTRUIDA M , CUMMING DALE , KUMAR RAVINDRA , SHAW GRAY
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61P29/00 , A61P35/04 , C07K14/19 , C07K14/47 , C07K14/51 , C07K14/52 , C07K14/54 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/64 , C12N15/12 , C12P21/02
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/51 , C07K14/52 , C07K14/5431 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C07K2319/00 , C07K2319/24 , C12N9/10 , C12N9/1051 , C12N9/6454 , C12N2770/36222
摘要： PROBLEM TO BE SOLVED: To provide a P-selectin ligand sugar protein, a DNA sequence encoding the protein and a host cell transformed by the DNA sequence and to provide a method for producing the P-selectin ligand protein. SOLUTION: The present invention provides the fused protein containing (a) a first amino acid sequence which is a P-selectin ligand protein containing a specific amino acid sequence and (b) a second amino acid sequence derived from an antibody or a sequence of a protein other than P-selectin ligand, the DNA sequence encoding the protein, and the host cell, and provides the method for producing the P-selectin ligand protein. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供P-选择蛋白配体糖蛋白，编码该蛋白质的DNA序列和由该DNA序列转化的宿主细胞，并提供一种生产P-选择蛋白配体蛋白的方法。解决方案：本发明提供了含有（a）第一氨基酸序列的融合蛋白，所述第一氨基酸序列是含有特定氨基酸序列的P-选择蛋白配体蛋白，和（b）源自抗体或除了选择蛋白配体之外的蛋白质的序列，编码蛋白质的DNA序列和宿主细胞，并提供生产P-选择蛋白配体蛋白的方法。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2007262090A Highly concentrated, lyophilized, and liquid factor ix formulation 有权
标题翻译：高浓度，LYOPHILIZED和液体因子IX配方
公开(公告)号：JP2007262090A
公开(公告)日：2007-10-11
申请号：JP2007180835
申请日：2007-07-10
申请人： Genetics Inst Llc , ジェネティクスインスティテュート,エルエルシー
发明人： WEBB CHANDRA , BUSH LAWRENCE , SCHAUB ROBERT G
IPC分类号： A61K38/43 , A61K47/00 , A61K9/19 , A61K38/48 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/34 , A61P7/04
CPC分类号： A61K38/4846 , A61K9/0019 , A61K47/12 , A61K47/183 , A61K47/26 , C12Y304/21022
摘要： PROBLEM TO BE SOLVED: To provide new, highly concentrated, lyophilized, and liquid factor IX formulations containing the factor IX.
SOLUTION: This composition comprises factor IX, arginine, and a buffering agent selected from the group consisting of citrate, maleic acid, histidine, trisethanolamine and diethanolamine, and a member selected from the group consisting of sucrose and mannitol.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供含有因子IX的新的，高度浓缩的，冻干的和液体因子IX制剂。解决方案：该组合物包含因子IX，精氨酸和选自柠檬酸盐，马来酸，组氨酸，三乙醇胺和二乙醇胺的缓冲剂，以及选自蔗糖和甘露糖醇的成员。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2005312457A Bmp-12, bmp-13 and tendon-inducing compositions thereof 有权
标题翻译： BMP-12，BMP-13和TENDON诱导组合物
公开(公告)号：JP2005312457A
公开(公告)日：2005-11-10
申请号：JP2005168624
申请日：2005-06-08
申请人： Genetics Inst Llc , Univ Harvard , ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニーGenetics Institute,Llc , プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ
发明人： CELESTE ANTHONY J , WOZNEY JOHN M , ROSEN VICKI A , WOLFMAN NEIL M , THOMSEN GERALD H , MELTON DOUGLAS A
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61L27/22 , A61L27/36 , A61P1/02 , A61P5/00 , A61P19/04 , A61P43/00 , C07H21/04 , C07K14/51 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要： PROBLEM TO BE SOLVED: To identify a novel family of proteins useful for a compositions having a tendon/ligament-like tissue-inducing activity and useful for the induction of tendon/ligament-like tissue formation and repair. SOLUTION: Novel bone morphogenetic proteins, BMP-12 and BMP-13, have been cloned. Disclosed are compositions comprising these proteins each having a tendon/ligament-like tissue-inducing activity. The compositions are useful for treatment of tendinitis or deficiency of other tendon or ligament and for repair of related tissue. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：鉴定可用于具有腱/类韧带组织诱导活性并可用于诱导肌腱/韧带样组织形成和修复的组合物的新型蛋白质家族。解决方案：克隆了新型骨形态发生蛋白BMP-12和BMP-13。公开了包含这些蛋白质的组合物，其各自具有肌腱/类韧带组织诱导活性。该组合物可用于治疗腱炎或其他腱或韧带的缺陷以及相关组织的修复。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2004073208A Osteolytic composition 审中-公开
公开(公告)号：JP2004073208A
公开(公告)日：2004-03-11
申请号：JP2003341026
申请日：2003-09-30
申请人： Genetics Inst Llc , ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニーGenetics Institute,Llc
发明人： WANG ELIZABETH A , WOZNEY JOHN M , ROSEN VICKI A , CELESTE ANTHONY J
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K47/02 , A61K47/34 , A61K47/42 , A61P1/02 , A61P3/02 , A61P5/00 , A61P17/02 , A61P19/02 , A61P19/08 , A61P43/00 , C07K14/00 , C07K14/51 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To provide a material having sufficient soft bone and/or hard bone osteogenetic ability so as to effectively perform inducing soft bone and/or hard bone osteogensis, wound healing, tissue restoration and the like. SOLUTION: The proteins exhibiting charactors of BMP-5, BMP-6 or BMP-7 are provided, a method for producing the proteins is provided and a medicinal composition containing the proteins and for inducing hard bone and/or soft bone ostogenesis, wound healing, tissue restoration and the like is provided. COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2004002464A Bone morphogenetic protein-9 composition 审中-公开
公开(公告)号：JP2004002464A
公开(公告)日：2004-01-08
申请号：JP2003284907
申请日：2003-08-01
申请人： Genetics Inst Llc , ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニーGenetics Institute,Llc
发明人： WOZNEY JOHN M , CELESTE ANTHONY J
IPC分类号： A61K38/00 , A61K47/02 , A61K47/34 , A61K47/42 , A61L27/00 , A61P1/02 , A61P17/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/51 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号： C07K14/51 , A61K38/00 , C07K2319/02
摘要： PROBLEM TO BE SOLVED: To provide a new protein inducing a formation of a bone and a cartilage, and also to provide a phamaceutical composition containing the same protein. SOLUTION: This bone pharmaceutical composition is composed of a bone morphogenetic protein-9 protein and a carrier allowable in medicine. COPYRIGHT: (C)2004,JPO

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