基本信息:
- 专利标题: Human ctla-8 and uses of ctla-8-related proteins
- 专利标题(中):人CTLA-8和CTLA-8相关蛋白的用途
- 申请号:JP2007301924 申请日:2007-11-21
- 公开(公告)号:JP2008131942A 公开(公告)日:2008-06-12
- 发明人: JACOBS KENNETH , KELLEHER KERRY , CARLIN MCKEOUGH , GOLDMAN SAMUEL , PITTMAN DEBRA , MI SHA , NEBEN STEVEN , GIANNOTTI JOANN , GOLDEN-FLEET MARGARET
- 申请人: Genetics Inst Llc , ジェネティクス インスティテュート,エルエルシー
- 专利权人: Genetics Inst Llc,ジェネティクス インスティテュート,エルエルシー
- 当前专利权人: Genetics Inst Llc,ジェネティクス インスティテュート,エルエルシー
- 优先权: US50403295 1995-07-19; US51401495 1995-08-11
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K31/00 ; A61K35/12 ; A61K38/00 ; A61K48/00 ; A61P7/00 ; A61P9/00 ; A61P35/00 ; A61P37/00 ; A61P43/00 ; C07K14/47 ; C07K14/54 ; C07K16/24 ; C12N5/10 ; C12N15/12 ; C12N15/24 ; C12P21/02
摘要:
PROBLEM TO BE SOLVED: To provide new methods for identifying novel cytokines and other secretion factors and to isolate polynucleotides encoding them, and to provide uses of the cytokines. SOLUTION: Polynucleotides encoding human CTLA-8 and human CTLA-8 polypeptides are disclosed. The inhibition of angiogenesis, inhibition of proliferation of vascular endothelial cells, inhibition of tumor growth, inhibition of angiogenesis-dependent tissue growth, proliferation of myeloid cells or progenitors, proliferation of erythroid cells or progenitors, proliferation of lymphoid cells or progenitors, induction of IFNγ production, the induction of IL-3 production and induction of GM-CSF production are effectively carried out in a subject by using the polynucleotides and the polypeptides. COPYRIGHT: (C)2008,JPO&INPIT
摘要(中):
要解决的问题:提供用于鉴定新的细胞因子和其他分泌因子并分离编码它们的多核苷酸的新方法,并提供细胞因子的用途。 解决方案:公开了编码人CTLA-8和人CTLA-8多肽的多核苷酸。 抑制血管发生,抑制血管内皮细胞增殖,抑制肿瘤生长,抑制血管生成依赖性组织生长,髓细胞或祖细胞增殖,红细胞或祖细胞增殖,淋巴细胞或祖细胞增殖,诱导IFNγ 通过使用多核苷酸和多肽,在受试者中有效地进行生产,IL-3产生的诱导和GM-CSF产生的诱导。 版权所有(C)2008,JPO&INPIT
公开/授权文献:
- JP4319686B2 Human · ctla-8 and ctla-8- associated protein applications 公开/授权日:2009-08-26