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1. 发明申请

WO2003076650A1 METHOD FOR IDENTIFYING ENZYMES WITH ACTIVITY ON INSOLUBLE SUBSTRATES 审中-公开
标题翻译：用于在不溶性底物上鉴定活性的酶的方法
公开(公告)号：WO2003076650A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/007116
申请日：2003-03-05
申请人： GENENCOR INTERNATIONAL, INC. , GEBERT, Mark, S. , KELLIS, James, T, Jr. , SCHELLENBERGER, Volker , YOON, Mee-Young
发明人： GEBERT, Mark, S. , KELLIS, James, T, Jr. , SCHELLENBERGER, Volker , YOON, Mee-Young
IPC分类号： C12Q1/00
CPC分类号： C12Q1/34 , C12Q1/00 , C12Q1/37 , C12Y301/01074 , G01N2333/21 , G01N2500/20
摘要： A high throughput method for screening for enzymes having activity on insoluble substrates includes grinding the substrates to form a powder or particulate substrate which may be filtered to form a uniform sample that may be aliquoted into conventional multiple assay plates or tubes.
摘要翻译：用于筛选在不溶性底物上具有活性的酶的高通量方法包括研磨底物以形成粉末或颗粒基质，其可以被过滤以形成均匀的样品，其可以等分到常规的多个测定板或管中。

2. 发明申请

WO2003000625A3 HIGHLY IMPACT-RESISTANT GRANULES 审中-公开
公开(公告)号：WO2003000625A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/019518
申请日：2002-06-20
申请人： GENENCOR INTERNATIONAL, INC. , BECKER, Nathaniel, T. , GEBERT, Mark, S. , MAZEAUD, Isabelle
发明人： BECKER, Nathaniel, T. , GEBERT, Mark, S. , MAZEAUD, Isabelle
IPC分类号： C12N11/14
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.

3. 发明申请

WO2007112273A2 OXIDATIVE PROTECTION OF LIPID LAYER BIOSENSORS 审中-公开
标题翻译：润滑层生物传感器的氧化保护
公开(公告)号：WO2007112273A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064680
申请日：2007-03-22
申请人： MCAULIFFE, Joseph C. , GEBERT, Mark S. , CASCAO-PEREIRA, Luis G.
发明人： MCAULIFFE, Joseph C. , GEBERT, Mark S. , CASCAO-PEREIRA, Luis G.
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54393 , G01N2405/00
摘要： The present invention provides methods and composition related to lipid layers with increased stability to oxidative degradation. In one embodiment, the invention provides lipid layers comprising antioxidant inclusion molecules that permit biosensors with increased performance and functional lifetime due to increased oxidative protection. In addition to these lipid-layer compositions, the present invention provides methods for further protection of lipid layers from oxidation. These methods include application of solutions and coatings comprising barrier compounds (e.g., trehalose), storage under anaerobic conditions (e.g., with inert gases), storage with oxidant scavengers (e.g., dessicants and catalysts), and packaging with barrier materials (e.g., mylar, polyethylene) that prevent oxidant exposure.
摘要翻译：本发明提供了与氧化降解的稳定性增加的与脂质层相关的方法和组合。在一个实施方案中，本发明提供包含抗氧化剂包含分子的脂质层，其允许生物传感器由于增加的氧化保护而具有增加的性能和功能寿命。除了这些脂质层组合物之外，本发明还提供进一步保护脂质层免于氧化的方法。这些方法包括应用包含阻挡化合物（例如海藻糖）的溶液和涂层，在厌氧条件下（例如，用惰性气体）储存，与氧化剂清除剂（例如，干燥剂和催化剂）的储存以及与阻隔材料（例如聚酯薄片）的包装，聚乙烯），防止氧化剂暴露。

4. 发明申请

WO2005028604A1 SILICA DERIVED SOL-GELS SENSITIVE TO WATER CONTENT CHANGE 审中-公开
标题翻译：二氧化硅衍生的溶胶对水含量变化敏感
公开(公告)号：WO2005028604A1
公开(公告)日：2005-03-31
申请号：PCT/US2004/030990
申请日：2004-09-17
申请人： GENENCOR INTERNATIONAL, INC. , SOUTHERN ILLINOIS UNIVERSITY , BECKER, Nathaniel, Todd , BAKUL, Dave, C. , DESHPANDE, Kiranmayi , GEBERT, Mark, S. , MCAULIFFE, Joseph, C. , SMITH, Wyatt, Charles
发明人： BECKER, Nathaniel, Todd , BAKUL, Dave, C. , DESHPANDE, Kiranmayi , GEBERT, Mark, S. , MCAULIFFE, Joseph, C. , SMITH, Wyatt, Charles
IPC分类号： C11D3/20
CPC分类号： B01J13/0056 , C11D3/162 , C11D3/386 , C11D17/003
摘要： The present invention provides an enzyme-containing sol-gel composition wherein one or more enzymes are stably entrapped within the gels and are released from the gels in responsive to an increase in environmental water percentage (by weight). The enzyme-containing sol-gels are prepared from starting materials comprising one or more aminoalkylsilane precursors such as bis(trialkoxyalkylsilane)amine, bis(trialkoxyalkylsilane)alkylenediamine, bis(dialkyldialkoxysilane)amine, and aminoalkyltrialkoxysilane, and one or more alkoxysilane precursors such as dialkyldialkoxysilane and alkyltrialkoxysilane. The present invention further provides a liquid detergent, a liquid soap or a shampoo formulation comprising an enzyme-entrapped sol-gel system, wherein the enzymes are released upon dilution of the formulation in water. The silica gel matrices not only improve the thermal stability of enzymes but also prevent the enzyme denaturation due to proteolysis/autolysis or interference from other components of the formulation.
摘要翻译：本发明提供了一种含酶溶胶凝胶组合物，其中一种或多种酶稳定地包埋在凝胶内并且响应于环境水百分数（重量）的增加而从凝胶中释放出来。由含有一种或多种氨基烷基硅烷前体的起始材料制备含酶溶胶凝胶，例如双（三烷氧基烷基硅烷）胺，双（三烷氧基烷基硅烷）亚烷基二胺，双（二烷基二烷氧基硅烷）胺和氨基烷基三烷氧基硅烷，以及一种或多种烷氧基硅烷前体如二烷基二烷氧基硅烷和烷基三烷氧基硅烷。本发明还提供了一种液体洗涤剂，液体皂或包含酶包被溶胶 - 凝胶系统的洗发剂制剂，其中在将制剂稀释在水中时释放酶。硅胶基质不仅提高了酶的热稳定性，而且防止了由于蛋白水解/自溶或制剂中其他组分的干扰引起的酶变性。

5. 发明申请

WO2003101404A2 PREPARATIONS FOR TOPICAL SKIN USE AND TREATMENT 审中-公开
标题翻译：用于局部皮肤使用和治疗的准备
公开(公告)号：WO2003101404A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/007411
申请日：2003-03-11
申请人： DOW CORNING CORPORATION , GENENCOR INTERNATIONAL, INC. , BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
发明人： BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
IPC分类号： A61K
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/7007 , A61K9/7069 , A61K38/465 , A61K38/482 , A61L26/0019 , A61L26/0066 , A61L2300/254 , A61L2300/602 , A61L2300/622 , C08L83/04
摘要： The present invention is related to topical preparations for release of an active agent and to methods of making and using the topical preparations. The preparations may have an internal phase dispersed within an external phase. The internal phase may be a hydrophilic carrier and an active agent. The external phase may be a silicone matrix. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：本发明涉及用于释放活性剂的局部制剂以及制备和使用局部制剂的方法。制剂可能具有分散在外部相中的内相。内相可以是亲水载体和活性剂。外部相可以是硅树脂基质。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交的理解是不会用于解释或限制权利要求的范围或含义。

6. 发明申请

WO2009102770A1 SMALL ENZYME-CONTAINING GRANULES 审中-公开
标题翻译：含小包含颗粒
公开(公告)号：WO2009102770A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/033766
申请日：2009-02-11
申请人： DANISCO US INC., GENENCOR DIVISION , BECKER, Nathaniel T. , CHRISTENSEN, Robert I. , GEBERT, Mark S. , VAHA-VAHE, Antti Pekka
发明人： BECKER, Nathaniel T. , CHRISTENSEN, Robert I. , GEBERT, Mark S. , VAHA-VAHE, Antti Pekka
IPC分类号： C12N9/98 , C11D3/386 , C12N9/42 , A23K1/165 , D06M16/00
CPC分类号： C12N9/98 , A23K20/189 , C11D3/38645 , C11D17/0039 , C12N9/2437 , C12N11/14 , C12Y302/01004
摘要： The invention provides small enzyme-containing granules having an inorganic salt core and an enzyme-containing layer coated over the core, and methods for producing such granules. The majority of the enzyme granules are less than 300 μm in diameter. The granules are suitable for incorporation into compositions such as cleaning, textile processing, and animal feed compositions.
摘要翻译：本发明提供了具有无机盐核心和包覆在芯上的含酶层的小的含酶颗粒，以及用于生产这种颗粒的方法。大部分酶颗粒的直径小于300μm。这些颗粒适用于掺入组合物如清洁，纺织加工和动物饲料组合物中。

7. 发明申请

WO2007112273A3 OXIDATIVE PROTECTION OF LIPID LAYER BIOSENSORS 审中-公开
标题翻译：润滑层生物传感器的氧化保护
公开(公告)号：WO2007112273A3
公开(公告)日：2008-07-03
申请号：PCT/US2007064680
申请日：2007-03-22
申请人： MCAULIFFE JOSEPH C , GEBERT MARK S , CASCAO-PEREIRA LUIS G
发明人： MCAULIFFE JOSEPH C , GEBERT MARK S , CASCAO-PEREIRA LUIS G
IPC分类号： G01N33/53 , C12M1/34 , G01N1/28
CPC分类号： G01N33/54393 , G01N2405/00
摘要： The present invention provides methods and composition related to lipid layers with increased stability to oxidative degradation. In one embodiment, the invention provides lipid layers comprising antioxidant inclusion molecules that permit biosensors with increased performance and functional lifetime due to increased oxidative protection. In addition to these lipid-layer compositions, the present invention provides methods for further protection of lipid layers from oxidation. These methods include application of solutions and coatings comprising barrier compounds (e.g., trehalose), storage under anaerobic conditions (e.g., with inert gases), storage with oxidant scavengers (e.g., dessicants and catalysts), and packaging with barrier materials (e.g., mylar, polyethylene) that prevent oxidant exposure.
摘要翻译：本发明提供了与氧化降解的稳定性增加的与脂质层相关的方法和组合。在一个实施方案中，本发明提供包含抗氧化剂包含分子的脂质层，其允许生物传感器由于增加的氧化保护而具有增加的性能和功能寿命。除了这些脂质层组合物之外，本发明还提供进一步保护脂质层免于氧化的方法。这些方法包括应用包含阻挡化合物（例如海藻糖）的溶液和涂层，在厌氧条件下（例如，用惰性气体）储存，与氧化剂清除剂（例如，干燥剂和催化剂）的储存以及与阻隔材料（例如聚酯薄片）的包装，聚乙烯），防止氧化剂暴露。

8. 发明申请

WO2004058933A1 MECHANICALLY ROBUST PLASTICIZED GRANULES 审中-公开
标题翻译：机械稳定的塑料颗粒
公开(公告)号：WO2004058933A1
公开(公告)日：2004-07-15
申请号：PCT/US2003/041638
申请日：2003-12-24
申请人： GENENCOR INTERNATIONAL, INC. , BECKER, Nathaniel, T. , GREEN, Thomas, S. , GEBERT, Mark, S. , MAZEAUD, Isabelle
发明人： BECKER, Nathaniel, T. , GREEN, Thomas, S. , GEBERT, Mark, S. , MAZEAUD, Isabelle
IPC分类号： C11D17/00
CPC分类号： C11D11/0088 , A61K8/0241 , A61K8/66 , A61K2800/56 , A61K2800/624 , A61K2800/63 , A61Q19/10 , B01J2/006 , C11D3/38672 , C11D17/0039
摘要： The present invention provides a mechanically robust, water-soluble or water dispersible, low-dust granule comprising an active ingredient, a polymer coating, and an impregnated plasticizer within the granule, and methods for obtaining the same.
摘要翻译：本发明提供一种机械稳定的水溶性或水分散性低灰尘颗粒，其包含颗粒内的活性成分，聚合物涂层和浸渍的增塑剂，以及获得该颗粒的方法。

9. 发明申请

WO0204923A3 REPEATED IMPACT APPARATUS AND METHOD FOR CHARACTERIZING GRANULE STRENGTH 审中-公开
标题翻译：重复冲击装置和表征颗粒强度的方法
公开(公告)号：WO0204923A3
公开(公告)日：2002-07-18
申请号：PCT/US0141294
申请日：2001-07-06
申请人： GENENCOR INT , GEBERT MARK S , PITCHUMANI RAMANAN , BEEKMAN WILLEM J , MEESTERS GABRIEL M H , SCARLETT BRIAN , BECKER NATHANIEL T
发明人： GEBERT MARK S , PITCHUMANI RAMANAN , BEEKMAN WILLEM J , MEESTERS GABRIEL M H , SCARLETT BRIAN , BECKER NATHANIEL T
IPC分类号： G01N3/00 , G01N3/56 , G01N15/02 , G01N33/00
CPC分类号： G01N3/56 , G01N3/565 , G01N15/0272 , G01N2015/0261 , G01N2015/0288 , G01N2033/0091 , G01N2203/0005 , G01N2203/0037
摘要： The present invention provides methods and devices for measuring granule impact strength and granule attrition rates by vibrating a small container of granules at a well-controlled amplitude in order to inflict reproducible damage to the granules. Damage to the granules is measured as a function of time and amplitude and attrition rates are measured in terms of dust generate per number of collisions versus mass of the granules. The measurements obtained yield a highly reproducible means for characterizing granule attrition, attrition rates, and fragmentation.
摘要翻译：本发明提供了通过以良好控制的振幅振动小容器的颗粒来测量颗粒冲击强度和颗粒磨损率的方法和装置，以便对颗粒造成可重复的损害。根据时间和幅度来测量颗粒的损害，并且根据每次碰撞产生的粉尘相对于颗粒的质量来测量磨损率。所获得的测量结果表现出高度可重复的用于表征颗粒磨损，磨损率和碎裂的方法。

10. 发明申请

WO2005025548A1 TOPICAL PREPARATIONS COMPRISING A HYDROPHILIC CARRIER AND A SILICONE MATRIX 审中-公开
标题翻译：包含水文载体和硅胶基质的主题制备
公开(公告)号：WO2005025548A1
公开(公告)日：2005-03-24
申请号：PCT/US2004/026218
申请日：2004-08-13
申请人： DOW CORNING CORPORATION , GENENCOR INTERNATIONAL, INC. , BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
发明人： BOTT, Richard, R. , GEBERT, Mark, S. , KLYKKEN, Paal, Christian , MAZEAUD, Isabelle , THOMAS, Xavier, Jean-Paul
IPC分类号： A61K9/70
CPC分类号： A61K9/7069 , A61K9/0014 , A61K9/7007 , A61K38/465 , A61K38/482 , A61K47/02 , A61K47/24 , A61K47/34 , A61L26/0019 , A61L26/0066 , A61L2300/254 , A61L2300/602 , A61L2300/622 , C08L83/04
摘要： Topical preparations for release of an active agent to remove necrotic tissue and to methods of making and using the topical preparations are provided. The preparations may have an internal phase dispersed within an external phase. The internal phase may be a hydrophilic carrier and an active agent. The external phase may be a silicone matrix.
摘要翻译：提供用于释放活性剂以除去坏死组织的局部制剂以及制备和使用局部制剂的方法。制剂可能具有分散在外部相中的内相。内相可以是亲水载体和活性剂。外部相可以是硅树脂基质。

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