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1. 发明申请

WO2007112273A2 OXIDATIVE PROTECTION OF LIPID LAYER BIOSENSORS 审中-公开
标题翻译：润滑层生物传感器的氧化保护
公开(公告)号：WO2007112273A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064680
申请日：2007-03-22
申请人： MCAULIFFE, Joseph C. , GEBERT, Mark S. , CASCAO-PEREIRA, Luis G.
发明人： MCAULIFFE, Joseph C. , GEBERT, Mark S. , CASCAO-PEREIRA, Luis G.
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54393 , G01N2405/00
摘要： The present invention provides methods and composition related to lipid layers with increased stability to oxidative degradation. In one embodiment, the invention provides lipid layers comprising antioxidant inclusion molecules that permit biosensors with increased performance and functional lifetime due to increased oxidative protection. In addition to these lipid-layer compositions, the present invention provides methods for further protection of lipid layers from oxidation. These methods include application of solutions and coatings comprising barrier compounds (e.g., trehalose), storage under anaerobic conditions (e.g., with inert gases), storage with oxidant scavengers (e.g., dessicants and catalysts), and packaging with barrier materials (e.g., mylar, polyethylene) that prevent oxidant exposure.
摘要翻译：本发明提供了与氧化降解的稳定性增加的与脂质层相关的方法和组合。在一个实施方案中，本发明提供包含抗氧化剂包含分子的脂质层，其允许生物传感器由于增加的氧化保护而具有增加的性能和功能寿命。除了这些脂质层组合物之外，本发明还提供进一步保护脂质层免于氧化的方法。这些方法包括应用包含阻挡化合物（例如海藻糖）的溶液和涂层，在厌氧条件下（例如，用惰性气体）储存，与氧化剂清除剂（例如，干燥剂和催化剂）的储存以及与阻隔材料（例如聚酯薄片）的包装，聚乙烯），防止氧化剂暴露。

2. 发明申请

WO2010056653A2 PROTEASES COMPRISING ONE OR MORE COMBINABLE MUTATIONS 审中-公开
标题翻译：包含一个或多个组合突变的标签
公开(公告)号：WO2010056653A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/063837
申请日：2009-11-10
申请人： DANISCO US INC. , CASCAO-PEREIRA, Luis G. , ESTELL, David A. , KELLIS, JR., James T.
发明人： CASCAO-PEREIRA, Luis G. , ESTELL, David A. , KELLIS, JR., James T.
IPC分类号： C11D3/386 , C12N9/54 , C12N15/09
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38663 , C11D3/38681 , C12N15/52 , C12Y304/21062
摘要： The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.
摘要翻译：本发明提供工程蛋白酶变体。特别地，蛋白酶变体在选定的表面位置包含影响酶的电荷和/或疏水性的可组合突变，以在所选择的应用中增强所得变体酶的至少一种所需性质。还提供了包含蛋白酶变体的组合物及其使用方法。

3. 发明申请

WO2012151534A1 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS 审中-公开
标题翻译：包含丝氨酸蛋白酶变体的组合物和方法
公开(公告)号：WO2012151534A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036608
申请日：2012-05-04
申请人： DANISCO US INC. , THE PROCTER & GAMBLE COMPANY , AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, JR., James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, JR., James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
IPC分类号： C12N9/54 , C12N15/57
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
摘要翻译：本发明提供丝氨酸蛋白酶变体，更具体地是从其产生的枯草杆菌蛋白酶变体。具体而言，与参考丝氨酸蛋白酶相比，本发明提供丝氨酸蛋白酶变体，更具体地具有一个或多个取代的枯草杆菌蛋白酶变体。此外，本发明提供了包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体中的至少一种的清洁组合物。

4. 发明申请

WO2009149200A2 COMPOSITIONS AND METHODS COMPRISING VARIANT MICROBIAL PROTEASES 审中-公开
标题翻译：包含变异微生物蛋白质的组合物和方法
公开(公告)号：WO2009149200A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046156
申请日：2009-06-03
申请人： DANISCO US INC. , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , ESTELL, David A. , KELLIS, JR., James T.
发明人： BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , ESTELL, David A. , KELLIS, JR., James T.
IPC分类号： C12N9/54 , A23K1/165
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more properties of a protein. The present invention also provides variant subtilisins suitable for various uses.
摘要翻译：本发明提供蛋白质工程方法。具体地说，本发明提供了使用位点评估库来设计优化蛋白质的两个或多个性质的文库的方法。本发明还提供适用于各种用途的变体枯草杆菌蛋白酶。

5. 发明申请

WO2010056640A2 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS 审中-公开
标题翻译：包含丝氨酸蛋白酶变体的组合物和方法
公开(公告)号：WO2010056640A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/063808
申请日：2009-11-10
申请人： DANISCO US INC. , AEHLE, Wolfgang , CASCAO-PEREIRA, Luis G. , ESTELL, David A. , GOEDEGEBUUR, Frits , KELLIS, James T., Jr. , POULOSE, Ayrookaran J. , SCHMIDT, Brian F.
发明人： AEHLE, Wolfgang , CASCAO-PEREIRA, Luis G. , ESTELL, David A. , GOEDEGEBUUR, Frits , KELLIS, James T., Jr. , POULOSE, Ayrookaran J. , SCHMIDT, Brian F.
IPC分类号： C11D3/386 , C12N9/54
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38636 , C11D3/38645 , C11D3/38654 , C12N9/50 , C12N9/54 , C12Y304/21062
摘要： The present invention provides methods for protein engineering and serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译：本发明提供蛋白质工程方法和丝氨酸蛋白酶变体。具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。

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