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2. 发明申请

WO1991013093A1 CLONING AND PRODUCTION OF HUMAN VON WILLEBRAND FACTOR GPIb BINDING DOMAIN POLYPEPTIDES AND METHODS OF USING SAME 审中-公开
标题翻译：克隆和生产人类WILLEBRAND因子GPIb结合域多聚体及其使用方法
公开(公告)号：WO1991013093A1
公开(公告)日：1991-09-05
申请号：PCT/US1991001416
申请日：1991-03-01
申请人： BIO-TECHNOLOGY GENERAL CORP. , GARFINKEL, Leonard , RICHTER, Tamar
发明人： BIO-TECHNOLOGY GENERAL CORP.
IPC分类号： C07K13/00
CPC分类号： C07K14/755 , A61K38/00
摘要： The subject invention provides non-glycosylated, biologically active polypeptides which comprise the vWF (von Willebrand Factor) GP1b binding domain. These polypeptides may be used to inhibit platelet adhesion and aggregation in the treatment of subjects with conditions such as cerebrovascular disorders and cardiovascular disorders. This invention also provides expression plasmids encoding these polypeptides as well as methods of producing by transforming a bacterial cell and recovering such polypeptides. In addition, the subject invention provides methods of treating and preventing cerebrovascular, cardiovascular and other disorders using these polypeptides to inhibit platelet aggregation.
摘要翻译：本发明提供了包含vWF（血管性血友病因子）GP1b结合结构域的非糖基化的生物活性多肽。这些多肽可用于在治疗具有诸如脑血管障碍和心血管疾病的病症的受试者时抑制血小板粘附和聚集。本发明还提供了编码这些多肽的表达质粒以及通过转化细菌细胞并回收此类多肽来产生的方法。此外，本发明提供了使用这些多肽来治疗和预防脑血管，心血管和其它病症以抑制血小板聚集的方法。

3. 发明申请

WO2015112482A1 METHOD AND APPARATUS TO RESTORE A TOOTH IMPLANT IMPAIRED BY PERI-IMPLANTITIS 审中-公开
标题翻译：方法和装置，以恢复受到植入物侵害的牙植入物
公开(公告)号：WO2015112482A1
公开(公告)日：2015-07-30
申请号：PCT/US2015/011994
申请日：2015-01-20
申请人： GARFINKEL, Leonard M.
发明人： GARFINKEL, Leonard M.
IPC分类号： A61C8/00 , A61C13/12 , A61C13/38
CPC分类号： A61C8/0006 , A61C8/00 , A61C8/0009 , A61C8/0068 , A61C8/0074 , A61C8/008 , A61C8/0089 , A61C2008/0046
摘要： The invention is for the repair of a traditional implant previously installed, the implant being of the kind currently manufactured by many implant companies. The invention includes a method and apparatus used to repair a diseased tooth implant having peri-implantitis. A soft thin titanium alloy sleeve having an exterior treated surface for enhancing osseo-integration is used for implant surface restoration. The sleeve is initially installed on a dowel. The dowel is necessary to support the thin soft deformable sleeve at all times to prevent its collapse or being crushed. The dowel is also necessary to accomplish the transfer of the sleeve onto the implant surface. The diseased implant is restored by a new surface that enhances osseo-integration provided by the surface restoration sleeve.
摘要翻译：本发明用于修复先前安装的传统植入物，植入物是目前由许多种植体公司制造的植入物。本发明包括用于修复具有植入周围炎的患病牙植入物的方法和装置。具有用于增强骨整合的外部处理表面的软的薄钛合金套筒用于植入物表面恢复。套筒最初安装在定位销上。榫头必须始终支撑薄软的可变形套筒，以防止其塌陷或被压扁。钉子也是实现将套筒转移到植入物表面上所必需的。患病植入物由增强由表面修复套筒提供的骨整合的新表面恢复。

4. 发明申请

WO2003040686A3 DOSING AND ADMINISTRATION OF THERAPEUTIC MICRO-ORGANS IN LIVING SUBJECTS AND DEVICES AND METHODS FOR SAME 审中-公开
公开(公告)号：WO2003040686A3
公开(公告)日：2003-05-15
申请号：PCT/IL2002/000877
申请日：2002-11-05
申请人： MEDGENICS, INC. , PEARLMAN, Andrew, L. , BELLOMO, Stephen, F. , LIPPIN, Itzhak , ALMON, Einat , PIVA, Guillermo, A. , GARFINKEL, Leonard, I. , ROSENBERG, Lior , SHAVITT, Menachem, D.
发明人： PEARLMAN, Andrew, L. , BELLOMO, Stephen, F. , LIPPIN, Itzhak , ALMON, Einat , PIVA, Guillermo, A. , GARFINKEL, Leonard, I. , ROSENBERG, Lior , SHAVITT, Menachem, D.
IPC分类号： G01N33/00
摘要： A method of determining the amount of a therapeutic micro-organ to be implanted in a patient, the method comprising: determining a secretion level of a therapeutic agent by a quantity of the micro-organ in vitro; estimating a relationship between in vitro secretions and in vivo serum levels of the therapeutic agent; and determining an amount of therapeutic micro-organ to be implanted, based on the determined secretion level and the estimated relationship.

5. 发明申请

WO2003039382A3 SYSTEM FOR PROCESSING TISSUE 审中-公开
公开(公告)号：WO2003039382A3
公开(公告)日：2003-05-15
申请号：PCT/IL2002/000880
申请日：2002-11-05
申请人： MEDGENICS, INC. , PEARLMAN, Andrew, L. , BELLOMO, Stephen, F. , GARFINKEL, Leonard, I. , PIVA, Guillermo, A. , SHAVITT, Menachem, D. , ROSENBERG, Lior , LIPPIN, Itzhak , BUKHMAN, Mordechay , ALMON, Einat , SHER, Niv
发明人： PEARLMAN, Andrew, L. , BELLOMO, Stephen, F. , GARFINKEL, Leonard, I. , PIVA, Guillermo, A. , SHAVITT, Menachem, D. , ROSENBERG, Lior , LIPPIN, Itzhak , BUKHMAN, Mordechay , ALMON, Einat , SHER, Niv
IPC分类号： A61B17/322
摘要： A micro-organ processing system, comprising: a plurality of operational modules, each said module performing all or part of a process of producing said micro-organ from a tissue sample; and means for transferring the tissue sample or micro-organ from one module to a next module in the process, via ports in the modules, without removal of the tissue sample from the modules.

6. 发明申请

WO2003006669A3 EFFICIENT METHODS FOR ASSESSING AND VALIDATING CANDIDATE PROTEIN-BASED THERAPEUTIC MOLECULES ENCODED BY NUCLEIC ACID SEQUENCES OF INTEREST 审中-公开
公开(公告)号：WO2003006669A3
公开(公告)日：2003-01-23
申请号：PCT/IL2002/000549
申请日：2002-07-07
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MEDGENICS, INC. , GARFINKEL, Leonard, I. , PEARLMAN, Andrew, L. , MITRANI, Eduardo, N.
发明人： GARFINKEL, Leonard, I. , PEARLMAN, Andrew, L. , MITRANI, Eduardo, N.
IPC分类号： A01N63/00
摘要： A method of determining at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of a recombinant gene product in vivo, the method comprises (a) obtaining at least one micro-organ explant from a donor subject, the micro-organ explant comprising a population of cells, the micro-organ explant maintaining a microarchitecture of an organ from which it is derived and at the same time having dimensions selected so as to allow diffusion of adequate nutrients and gases to cells in the micro-organ explant and diffusion of cellular waste out of the micro-organ explant so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of the waste in the micro-organ explant, at least some cells of the population of cells of the micro-organ explant expressing and secreting at least one recombinant gene product; (b) implanting the at least one micro-organ explant in a recipient subject; and (c) determining the at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of the recombinant gene product in the recipient subject.

7. 发明申请

WO2003039382A2 CLOSED AUTOMATED SYSTEM FOR TISSUE-BASED PROTEIN THERAPY 审中-公开
标题翻译：封闭式自动化系统，用于组织蛋白质治疗
公开(公告)号：WO2003039382A2
公开(公告)日：2003-05-15
申请号：PCT/IL2002/000880
申请日：2002-11-05
申请人： MEDGENICS, INC. , PEARLMAN, Andrew, L. , BELLOMO, Stephen, F. , GARFINKEL, Leonard, I. , PIVA, Guillermo, A. , SHAVITT, Menachem, D. , ROSENBERG, Lior , LIPPIN, Itzhak , BUKHMAN, Mordechay , ALMON, Einat , SHER, Niv
发明人： PEARLMAN, Andrew, L. , BELLOMO, Stephen, F. , GARFINKEL, Leonard, I. , PIVA, Guillermo, A. , SHAVITT, Menachem, D. , ROSENBERG, Lior , LIPPIN, Itzhak , BUKHMAN, Mordechay , ALMON, Einat , SHER, Niv
IPC分类号： A61B17/322
CPC分类号： C12M21/08 , A61B17/322 , A61B2017/3225 , A61K35/36 , A61K38/1816 , A61K38/212 , A61K47/6901 , C12M35/08 , C12M45/02 , A61K2300/00
摘要： A micro-organ processing system, comprising: a plurality of operational modules, each said module performing all or part of a process of producing said micro-organ from a tissue sample; and means for transferring the tissue sample or micro-organ from one module to a next module in the process, via ports in the modules, without removal of the tissue sample from the modules.
摘要翻译：一种微器官处理系统，包括：多个操作模块，每个所述模块执行从组织样本产生所述微器官的过程的全部或部分; 以及用于通过模块中的端口将组织样本或微器官从一个模块转移到该过程中的下一个模块的装置，而不从模块中移除组织样本。

8. 发明申请

WO03006669A2 EFFICIENT METHODS FOR ASSESSING AND VALIDATING CANDIDATE PROTEIN-BASED THERAPEUTIC MOLECULES ENCODED BY NUCLEIC ACID SEQUENCES OF INTEREST 审中-公开
标题翻译：用于评估和验证核苷酸基因治疗分子的有效方法由核酸酸序列编码
公开(公告)号：WO03006669A2
公开(公告)日：2003-01-23
申请号：PCT/IL0200549
申请日：2002-07-07
申请人： YISSUM RES DEV CO , MEDGENICS INC , GARFINKEL LEONARD I , PEARLMAN ANDREW L , MITRANI EDUARDO N
发明人： GARFINKEL LEONARD I , PEARLMAN ANDREW L , MITRANI EDUARDO N
IPC分类号： C12N15/10 , C12Q
CPC分类号： C12N15/1079 , C12N15/1034 , C12N15/1055
摘要： A method of determining at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of a recombinant gene product in vivo, the method comprises (a) obtaining at least one micro-organ explant from a donor subject, the micro-organ explant comprising a population of cells, the micro-organ explant maintaining a microarchitecture of an organ from which it is derived and at the same time having dimensions selected so as to allow diffusion of adequate nutrients and gases to cells in the micro-organ explant and diffusion of cellular waste out of the micro-organ explant so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of the waste in the micro-organ explant, at least some cells of the population of cells of the micro-organ explant expressing and secreting at least one recombinant gene product; (b) implanting the at least one micro-organ explant in a recipient subject; and (c) determining the at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of the recombinant gene product in the recipient subject.
摘要翻译：一种确定体内重组基因产物的至少一种定量或定性药理，生理和/或治疗，参数或作用的方法，所述方法包括（a）从供体受试者获得至少一种微器官外植体，所述微观 - 包含细胞群的组织外植体，所述微器官外植体保持其来源的器官的微结构，并且同时具有选择的尺寸，以允许足够的营养物和气体扩散到微器官中的细胞细胞废弃物从微器官外植体中的外植和扩散，以便最小化细胞毒性和伴随死亡，这是由于营养不良和微器官外植体中的废物积累不足，微生物细胞群体的至少一些细胞表达和分泌至少一种重组基因产物的外植体; （b）将至少一个微器官外植体植入受体受试者; 和（c）确定重组基因产物在受体受试者中的至少一种定量或定性的药理学，生理学和/或治疗学参数或作用。

9. 发明申请

WO03040686A2 DOSING AND ADMINISTRATION OF THERAPEUTIC MICRO-ORGANS IN LIVING SUBJECTS AND DEVICES AND METHODS FOR SAME 审中-公开
标题翻译：治疗性微生物在生活物种和装置中的施用和施用及其方法
公开(公告)号：WO03040686A2
公开(公告)日：2003-05-15
申请号：PCT/IL0200877
申请日：2002-11-05
申请人： MEDGENICS INC , PEARLMAN ANDREW L , BELLOMO STEPHEN F , LIPPIN ITZHAK , ALMON EINAT , PIVA GUILLERMO A , GARFINKEL LEONARD I , ROSENBERG LIOR , SHAVITT MENACHEM D
发明人： PEARLMAN ANDREW L , BELLOMO STEPHEN F , LIPPIN ITZHAK , ALMON EINAT , PIVA GUILLERMO A , GARFINKEL LEONARD I , ROSENBERG LIOR , SHAVITT MENACHEM D
IPC分类号： A61B17/322 , A61K9/00 , A61K38/21 , A61K47/48 , A61K48/00 , A61P37/00 , C12N5/02 , G01N
CPC分类号： C12M21/08 , A61B17/322 , A61B2017/3225 , A61K35/36 , A61K38/1816 , A61K38/212 , A61K47/6901 , C12M35/08 , C12M45/02 , A61K2300/00
摘要： A method of determining the amount of a therapeutic micro-organ to be implanted in a patient, the method comprising: determining a secretion level of a therapeutic agent by a quantity of the micro-organ in vitro; estimating a relationship between in vitro secretions and in vivo serum levels of the therapeutic agent; and determining an amount of therapeutic micro-organ to be implanted, based on the determined secretion level and the estimated relationship.
摘要翻译：一种确定要植入患者的治疗性微器官的量的方法，所述方法包括：通过体外测定微量器官的量的治疗剂的分泌水平; 估计体内分泌物与治疗剂的体内血清水平之间的关系; 并根据确定的分泌水平和所估计的关系确定待植入的治疗性微器官的量。

10. 发明申请

WO1994025582A1 METHOD OF ENHANCING THROMBOLYSIS 审中-公开
标题翻译：增加血栓形成的方法
公开(公告)号：WO1994025582A1
公开(公告)日：1994-11-10
申请号：PCT/US1994004418
申请日：1994-04-22
申请人： BIO-TECHNOLOGY GENERAL CORP. , GARFINKEL, Leonard , GORECKI, Marian , PANET, Amos
发明人： BIO-TECHNOLOGY GENERAL CORP.
IPC分类号： C12N09/64
CPC分类号： C07K14/755 , A61K38/37 , A61K38/49 , A61K31/60 , A61K2300/00
摘要： A method is provided for the use of a fragment of von Willebrand Factor (vWF) comprising the platelet glycoprotein Ib (GPIb) binding domain in conjunction with known therapies to obtain enhanced protection against thrombosis, improved thrombolysis, and a decreased likelihood of reocclusion following thrombolytic treatment. Additionally, a method is provided for the use of the vWF fragment and aspirin to prevent complications following traumatic vascular damage.
摘要翻译：提供了一种使用包含血小板糖蛋白Ib（GPIb）结合结构域的血管性血友病因子（vWF）片段与已知疗法结合的方法，以获得增强的抗血栓形成的保护作用，改善溶栓治疗以及血栓溶解后再闭塞的可能性降低治疗。另外，提供了一种使用vWF片段和阿斯匹林来预防创伤性血管损伤后并发症的方法。

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