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1. 发明申请

WO2003060062A3 METHODS OF INDUCING DIFFERENTIATION IN STEM CELLS, METHODS OF GENERATING TISSUE USING SCAFFOLD MATRICES DERIVED FROM MICRO-ORGANS AND STEM CELLS, METHODS OF PRODUCING ADULT STEM CELLS AND METHODS OF CONTINUOUSLY GENERATING STEM CELLS BY IMPLANTATION OF MICRO-ORGANS AS SOURCES OF STEM CELLS 审中-公开
公开(公告)号：WO2003060062A3
公开(公告)日：2003-07-24
申请号：PCT/IL2003/000037
申请日：2003-01-14
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MITRANI, Eduardo, N.
发明人： MITRANI, Eduardo, N.
IPC分类号： A01N63/00
摘要： Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided.

2. 发明申请

WO2003035851A1 IN VITRO MICRO-ORGANS, AND USES RELATED THERETO 审中-公开
标题翻译：在VITRO微型机器人，以及相关的使用
公开(公告)号：WO2003035851A1
公开(公告)日：2003-05-01
申请号：PCT/IL2001/000976
申请日：2001-10-23
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MITRANI, Eduardo, N.
发明人： MITRANI, Eduardo, N.
IPC分类号： C12N5/00
CPC分类号： C12N5/0627 , A61K35/12 , C12N5/0062 , C12N5/0629 , C12N5/0648 , C12N5/065 , C12N5/0671 , C12N5/0677
摘要： Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation.
摘要翻译：描述了包括具有特定特征的分离的细胞群体的微器官培养物。受试者微器官培养物的显着特征包括在较长时间内维持在培养物中的能力，以及保护器官微结构，其有助于例如类似于细胞 - 细胞和细胞 - 基质的相互作用发生在源器官。本发明的微器官培养物可用于将基因产物递送至受试者，用于鉴定细胞增殖和细胞分化剂以及鉴定和分离祖细胞和干细胞的方法。此外，本发明的微器官培养物可用于鉴定细胞增殖抑制剂，细胞分化和病毒感染性的方法。在其他实施方案中，微器官培养物可用于移植。

3. 发明申请

WO2003006669A3 EFFICIENT METHODS FOR ASSESSING AND VALIDATING CANDIDATE PROTEIN-BASED THERAPEUTIC MOLECULES ENCODED BY NUCLEIC ACID SEQUENCES OF INTEREST 审中-公开
公开(公告)号：WO2003006669A3
公开(公告)日：2003-01-23
申请号：PCT/IL2002/000549
申请日：2002-07-07
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MEDGENICS, INC. , GARFINKEL, Leonard, I. , PEARLMAN, Andrew, L. , MITRANI, Eduardo, N.
发明人： GARFINKEL, Leonard, I. , PEARLMAN, Andrew, L. , MITRANI, Eduardo, N.
IPC分类号： A01N63/00
摘要： A method of determining at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of a recombinant gene product in vivo, the method comprises (a) obtaining at least one micro-organ explant from a donor subject, the micro-organ explant comprising a population of cells, the micro-organ explant maintaining a microarchitecture of an organ from which it is derived and at the same time having dimensions selected so as to allow diffusion of adequate nutrients and gases to cells in the micro-organ explant and diffusion of cellular waste out of the micro-organ explant so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of the waste in the micro-organ explant, at least some cells of the population of cells of the micro-organ explant expressing and secreting at least one recombinant gene product; (b) implanting the at least one micro-organ explant in a recipient subject; and (c) determining the at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of the recombinant gene product in the recipient subject.

4. 发明申请

WO2010086856A3 METHODS OF GENERATING TISSUE USING DEVITALIZED, ACELLULAR SCAFFOLD MATRICES DERIVED FROM MICRO-ORGANS 审中-公开
公开(公告)号：WO2010086856A3
公开(公告)日：2010-08-05
申请号：PCT/IL2010/000076
申请日：2010-01-31
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , MITRANI, Eduardo, N.
发明人： MITRANI, Eduardo, N.
IPC分类号： A61L27/36 , A61L27/38 , C12N5/00
摘要： A composition of matter is provided comprising a devitalized, acellular tissue-derived scaffold seeded with differentiated cells, particularly pancreatic islet cells, wherein the cells can maintain cell-specific function or structure in culture on the scaffold. Methods of generating same and uses thereof are also provided.

5. 发明申请

WO2004078916A3 IN VITRO MICRO-ORGANS, AND USES RELATED THERETO 审中-公开
标题翻译：在体外微型器官，以及相关的使用
公开(公告)号：WO2004078916A3
公开(公告)日：2005-02-10
申请号：PCT/IL2004000202
申请日：2004-03-02
申请人： YISSUM RES DEV CO , MITRANI EDUARDO N
发明人： MITRANI EDUARDO N
IPC分类号： A01K67/027 , A01N1/02 , C12N20060101 , C12N5/00 , C12N5/08 , C12N15/85
CPC分类号： C12N5/0062 , A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2227/108 , C12N2510/02
摘要： Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation.
摘要翻译：描述了包括具有特定特征的分离的细胞群体的微器官培养物。受试者微器官培养物的显着特征包括在相对长的时间段内维持培养的能力，以及保护器官微结构，其有助于例如类似于细胞 - 细胞和细胞 - 基质的相互作用发生在源器官。本发明的微器官培养物可用于将基因产物递送至受试者，用于鉴定细胞增殖和细胞分化剂以及鉴定和分离祖细胞和干细胞的方法。此外，本发明的微器官培养物可用于鉴定细胞增殖，细胞分化和病毒感染性的抑制剂的方法。在其他实施方案中，微器官培养物可用于移植。

6. 发明申请

WO2010086856A2 METHODS OF GENERATING TISSUE USING DEVITALIZED, ACELLULAR SCAFFOLD MATRICES DERIVED FROM MICRO-ORGANS 审中-公开
标题翻译：利用微生物来源的装置化的，细胞支架基质产生组织的方法
公开(公告)号：WO2010086856A2
公开(公告)日：2010-08-05
申请号：PCT/IL2010000076
申请日：2010-01-31
申请人： YISSUM RES DEV CO , MITRANI EDUARDO N
发明人： MITRANI EDUARDO N
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , A61K35/12 , A61L27/3604 , A61L27/3804 , C12N5/0606 , C12N5/067 , C12N5/0676 , C12N5/0677 , C12N5/0689 , C12N2506/02 , C12N2533/90
摘要： A composition of matter is provided comprising a devitalized, acellular tissue-derived scaffold seeded with differentiated cells, particularly pancreatic islet cells, wherein the cells can maintain cell-specific function or structure in culture on the scaffold. Methods of generating same and uses thereof are also provided.
摘要翻译：提供了包含用分化细胞特别是胰岛细胞接种的失活的无细胞组织衍生支架的物质组合物，其中细胞可以在支架上培养时保持细胞特异性功能或结构。还提供了生成它们的方法及其用途。

7. 发明申请

WO03006669A2 EFFICIENT METHODS FOR ASSESSING AND VALIDATING CANDIDATE PROTEIN-BASED THERAPEUTIC MOLECULES ENCODED BY NUCLEIC ACID SEQUENCES OF INTEREST 审中-公开
标题翻译：用于评估和验证核苷酸基因治疗分子的有效方法由核酸酸序列编码
公开(公告)号：WO03006669A2
公开(公告)日：2003-01-23
申请号：PCT/IL0200549
申请日：2002-07-07
申请人： YISSUM RES DEV CO , MEDGENICS INC , GARFINKEL LEONARD I , PEARLMAN ANDREW L , MITRANI EDUARDO N
发明人： GARFINKEL LEONARD I , PEARLMAN ANDREW L , MITRANI EDUARDO N
IPC分类号： C12N15/10 , C12Q
CPC分类号： C12N15/1079 , C12N15/1034 , C12N15/1055
摘要： A method of determining at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of a recombinant gene product in vivo, the method comprises (a) obtaining at least one micro-organ explant from a donor subject, the micro-organ explant comprising a population of cells, the micro-organ explant maintaining a microarchitecture of an organ from which it is derived and at the same time having dimensions selected so as to allow diffusion of adequate nutrients and gases to cells in the micro-organ explant and diffusion of cellular waste out of the micro-organ explant so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of the waste in the micro-organ explant, at least some cells of the population of cells of the micro-organ explant expressing and secreting at least one recombinant gene product; (b) implanting the at least one micro-organ explant in a recipient subject; and (c) determining the at least one quantitative or qualitative pharmacological, physiological and/or therapeutic, parameter or effect of the recombinant gene product in the recipient subject.
摘要翻译：一种确定体内重组基因产物的至少一种定量或定性药理，生理和/或治疗，参数或作用的方法，所述方法包括（a）从供体受试者获得至少一种微器官外植体，所述微观 - 包含细胞群的组织外植体，所述微器官外植体保持其来源的器官的微结构，并且同时具有选择的尺寸，以允许足够的营养物和气体扩散到微器官中的细胞细胞废弃物从微器官外植体中的外植和扩散，以便最小化细胞毒性和伴随死亡，这是由于营养不良和微器官外植体中的废物积累不足，微生物细胞群体的至少一些细胞表达和分泌至少一种重组基因产物的外植体; （b）将至少一个微器官外植体植入受体受试者; 和（c）确定重组基因产物在受体受试者中的至少一种定量或定性的药理学，生理学和/或治疗学参数或作用。

8. 发明申请

WO2004006831A3 METHOD AND DEVICE FOR INDUCING BIOLOGICAL PROCESSES BY MICRO-ORGANS 审中-公开
标题翻译：微生物诱导生物过程的方法和装置
公开(公告)号：WO2004006831A3
公开(公告)日：2004-08-26
申请号：PCT/IL0300578
申请日：2003-07-13
申请人： YISSUM RES DEV CO , MITRANI EDUARDO N , MITRANI DOV ELIEZER
发明人： MITRANI EDUARDO N , MITRANI DOV ELIEZER
IPC分类号： A61K48/00 , A61B17/20 , A61B17/28 , A61F2/82 , A61K20060101 , A61K35/23 , A61K35/34 , A61K35/36 , A61K35/407 , A61K35/42 , A61M29/00 , A61N1/30 , A61P43/00
CPC分类号： A61B17/3468 , A61B17/32093 , A61B17/322 , A61B2017/00247 , A61B2017/00969 , A61B2018/00392 , A61K35/22 , A61K35/28 , A61K35/34 , A61K35/36 , A61K35/407 , A61K35/42
摘要： A method, extract, and pharmaceutical composition for inducing angiogenesis in a tissue of a mammal, and of a device for the preparation and delivery of micro-organs into a mammal, are provided.
摘要翻译：提供了用于在哺乳动物的组织中诱导血管生成的方法，提取物和药物组合物，以及用于将哺乳动物的微器官制备和递送的装置。

9. 发明申请

WO2004006831A2 METHOD AND DEVICE FOR INDUCING BIOLOGICAL PROCESSES BY MICRO-ORGANS 审中-公开
标题翻译：微生物诱导生物过程的方法和装置
公开(公告)号：WO2004006831A2
公开(公告)日：2004-01-22
申请号：PCT/IL2003/000578
申请日：2003-07-13
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MITRANI, Eduardo, N. , MITRANI, Dov, Eliezer
发明人： MITRANI, Eduardo, N. , MITRANI, Dov, Eliezer
IPC分类号： A61K
CPC分类号： A61B17/3468 , A61B17/32093 , A61B17/322 , A61B2017/00247 , A61B2017/00969 , A61B2018/00392 , A61K35/22 , A61K35/28 , A61K35/34 , A61K35/36 , A61K35/407 , A61K35/42
摘要： A method, extract, and pharmaceutical composition for inducing angiogenesis in a tissue of a mammal, and of a device for the preparation and delivery of micro-organs into a mammal, are provided.
摘要翻译：提供了用于在哺乳动物的组织中诱导血管生成的方法，提取物和药物组合物，以及用于制备和递送微器官到哺乳动物中的装置。

10. 发明申请

WO1996040872A1 BILE DUCT PROGENITOR CELLS AND METHODS OF USE 审中-公开
标题翻译：双歧杆菌PROGENITOR细胞和使用方法
公开(公告)号：WO1996040872A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009656
申请日：1996-06-07
申请人： ONTOGENY, INC. , MITRANI, Eduardo, N. , PANG, Kevin, K. , HOMA, Monica, W.
发明人： ONTOGENY, INC.
IPC分类号： C12N05/06
CPC分类号： A61K35/39 , A61K35/407 , A61K35/413 , C12N5/0672 , C12N5/0678 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/148
摘要： The present invention relates to a substantially pure population of viable bile duct progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
摘要翻译：本发明涉及基本上纯的可行胆管祖细胞群，以及分离这些细胞的方法。本发明还涉及这些祖细胞及其后代的某些治疗用途。

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