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1. 发明申请

WO2013066619A1 METHODS AND DEVICES FOR CONNECTING NERVES 审中-公开
标题翻译：用于连接神经的方法和装置
公开(公告)号：WO2013066619A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/060439
申请日：2012-10-16
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , AGARWAL, Jayant, P. , GALE, Bruce, Kent , SANT, Himanshu, Jayant , LIN, Keng-Min
发明人： AGARWAL, Jayant, P. , GALE, Bruce, Kent , SANT, Himanshu, Jayant , LIN, Keng-Min
IPC分类号： A61F2/00
CPC分类号： A61B17/1128 , A61B2017/1132 , A61F2/00 , A61F2/0063 , A61F2250/0067 , A61L27/18 , A61L27/3675 , A61L27/383 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2430/32 , C08L67/04
摘要： A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).
摘要翻译：构造成固定在所选神经的第一和第二部分上的神经修复导管。神经修复导管包括具有近端，远端，外表面和限定内腔的内表面的聚合体。此外，神经导管包括至少一个药物储存器以保持例如可促进神经再生的药剂。这些药物通过邻近选定神经的第一和第二部分的出口（例如半透膜）从药物储存器扩散到神经修复导管中。神经修复导管可以被配置为以选定的时间段（例如，至少1周）以基本上零级动力学和/或以恒定速率递送药剂。

2. 发明申请

WO2009111461A3 MICROFLUIDIC FLOW CELL 审中-公开
标题翻译：微流感细胞
公开(公告)号：WO2009111461A3
公开(公告)日：2010-01-07
申请号：PCT/US2009035859
申请日：2009-03-03
申请人： UNIV UTAH RES FOUND , SUNDBERG SCOTT O , WITTNER CARL T , GALE BRUCE K
发明人： SUNDBERG SCOTT O , WITTNER CARL T , GALE BRUCE K
IPC分类号： G01N35/02 , C12Q1/68 , G01N33/48
CPC分类号： C12Q1/6844 , B01L3/50273 , B01L3/50851 , B01L7/52 , B01L2200/0642 , B01L2300/0806 , B01L2300/0887 , B01L2400/0409
摘要： A microfluidic flow cell having a body with a fluid transport channel disposed therein, the fluid transport channel having a proximal end and a distal end defining a fluid flow path, a fluid inlet port disposed at the proximal end of the fluid transport channel at a central portion of the body and an outlet port disposed at the distal end of the fluid transport channel at an outer portion of the body, and a plurality sample wells disposed in the fluid transport channel substantially perpendicular to the fluid flow path in the fluid transport channel. The microfluidic flow cell may have hundreds or thousands of individual, sub-microliter sample wells. The microfluidic flow cell can be filled by applying a flowable liquid to the inlet port and spinning the flow cell to cause fluid to flow into fluid transport channel. The microfluidic flow cells described herein can be used in a variety of applications where small sample size and/or a large number of replicates are desirable.
摘要翻译：一种微流体流动池，其具有设置在其中的流体输送通道的主体，所述流体输送通道具有限定流体流动路径的近端和远端;流体入口，其设置在所述流体输送通道的近端处的中心主体的一部分和设置在主体的外部部分处的流体输送通道的远端处的出口端口以及设置在流体输送通道中的基本上垂直于流体输送通道中的流体流动路径的多个样本阱。微流体流动池可以具有数百或数千个单独的亚微升样品孔。可以通过将可流动的液体施加到入口端口并旋转流动池以使流体流入流体输送通道来填充微流体流动池。本文所述的微流体流动池可以用于需要小样品量和/或大量重复的各种应用中。

3. 发明申请

WO2007117335A3 HIGH FIELD STRENGTH MAGNETIC FIELD GENERATION SYSTEM AND ASSOCIATED METHODS 审中-公开
标题翻译：高强度磁场发生系统及相关方法
公开(公告)号：WO2007117335A3
公开(公告)日：2008-04-10
申请号：PCT/US2007000217
申请日：2007-01-04
申请人： UNIV UTAH RES FOUND , STEPHENSON JAMES C , GALE BRUCE K , FURSE CYNTHIA
发明人： STEPHENSON JAMES C , GALE BRUCE K , FURSE CYNTHIA
IPC分类号： H01F1/00
CPC分类号： H01F7/0284 , G01R33/3806 , G01R33/383
摘要： A magnetic field generation system can comprise first (28a) and second (28b) magnetic flux concentrators each spaced apart to form a sample volume (30). The first (28a) and second (28b) magnetic flux concentrators can be formed of a material having a magnetic field saturation. A first set of auxiliary permanent magnets (10a, 10b) can be symmetrically oriented about a portion of the first magnetic flux concentrator (28a) and can be in substantial contact with the first magnetic flux concentrator. Similarly, a second set of auxiliary permanent magnets (1 Oc, 1 Od) can be symmetrically oriented about a portion of the second magnetic flux concentrator (28b) and can be in substantial contact with the second magnetic flux concentrator. Generally, the first set (10a,10b) and second set (10c,10d) of auxiliary permanent magnets can be remote from the sample volume (30). Each of the first set and second set of auxiliary permanent magnets can be oriented in a magnetically repulsive orientation with respect to at least one other member of their respective sets. The first (10a,10b) and second (10c,10d) sets of auxiliary magnets can be magnetically associated via the first (28a) and second (28b) magnetic flux concentrators. The present invention can further be configured to allow variation of the magnetic field strength across the sample volume by disrupting the field flux across the magnetic flux concentrators. This can be accomplished by orienting one or more magnetically soft shunts (38) in a sufficient proximity to at least one of the magnetic flux concentrators (28a,28b).
摘要翻译：磁场产生系统可以包括第一（28a）和第二（28b）磁通量聚集器，每个间隔开以形成样品体积（30）。第一（28a）和第二（28b）磁通量聚集器可以由具有磁场饱和的材料形成。第一组辅助永久磁铁（10a，10b）可围绕第一磁通量聚集器（28a）的一部分对称地取向，并且可以与第一磁通集中器实质接触。类似地，第二组辅助永磁体（1 Oc，1 Od）可以围绕第二磁通量聚集器（28b）的一部分对称地定向，并且可以与第二磁通量集中器实质接触。通常，辅助永磁体的第一组（10a，10b）和第二组（10c，10d）可以远离样品体积（30）。第一组和第二组辅助永磁体中的每一个可以相对于它们各自的组的至少一个其它构件以磁性排斥取向定向。第一（10a，10b）和第二（10c，10d）组辅助磁体可以经由第一（28a）和第二（28b）磁通量集中器磁性地相关联。本发明还可以被配置为允许通过扰乱磁通集中器上的磁场通量来改变跨样品体积的磁场强度。这可以通过将一个或多个磁软分流器（38）定向到至少一个磁通量聚集器（28a，28b）的足够接近来实现。

4. 发明申请

WO2006014460A2 SPOTTING DEVICE AND METHOD FOR HIGH CONCENTRATION SPOT DEPOSITION ON MICROARRAYS AND OTHER MICROSCALE DEVICES 审中-公开
标题翻译：微型装置和其他微型装置的高浓度点沉积物的分选装置和方法
公开(公告)号：WO2006014460A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/023895
申请日：2005-07-06
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , GALE, Bruce , CHANG-YEN, David , MYSZKA, David
发明人： GALE, Bruce , CHANG-YEN, David , MYSZKA, David
CPC分类号： B01J19/0046 , B01J2219/00353 , B01J2219/00367 , B01J2219/00369 , B01J2219/00371 , B01J2219/00497 , B01J2219/00527 , B01J2219/00536 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/00736 , B01J2219/00743 , B01L3/0293 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0822 , B01L2300/0877 , B01L2300/1827 , B01L2400/0415 , B01L2400/0487 , B82Y30/00 , C12M23/16 , C40B50/14 , C40B60/14 , G01N35/1002 , G01N35/1065 , G01N35/1074 , G01N2035/00158 , G01N2035/1034 , G01N2035/1039 , Y10T29/49
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other substrate. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow of solution bearing the desired substance over the spot area until surface saturation is accomplished. The spotter uses microfluidic conduits and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate substrate. Each orifice is part of a fluid pathways that includes an inlet conduit and an outlet conduit. When the spotter contacts a substrate a seal is formed between the orifices and the substrate. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a substrate, since the spotter may be placed on a substrate for an extended period of time.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它基底上。它也可以用于在同一点上执行各种化学步骤。点样器通过将含有所需物质的溶液流引导到斑点区域，直到达到表面饱和为止，增加每个斑点处物质的表面密度。点样器使用微流体导管和孔口在单独的基底上的斑点上沉积蛋白质，其他生物分子或化学物质。每个孔是包括入口导管和出口导管的流体路径的一部分。当检测器接触基板时，在孔和基板之间形成密封。相同或不同的物质可能流过每个孔口。任何数量的孔口都可以并入到一个定点器中。斑点剂对于在基质上沉积高浓度的蛋白质是特别有用的，因为可以将斑点剂放置在衬底上较长时间。

5. 发明申请

WO2005024230A3 ROTARY CENTRIFUGAL AND VISCOUS PUMPS 审中-公开
标题翻译：旋转离心泵和粘性泵
公开(公告)号：WO2005024230A3
公开(公告)日：2005-07-28
申请号：PCT/US2004028890
申请日：2004-09-03
申请人： UNIV UTAH RES FOUND , BLANCHARD DANNY , LIGRANI PHIL , GALE BRUCE
发明人： BLANCHARD DANNY , LIGRANI PHIL , GALE BRUCE
IPC分类号： F01D1/36 , F04B20060101
CPC分类号： F04D5/001 , F04D1/02 , F04D29/22 , F04D29/426
摘要： A pump device (10a, 10b, 10c) includes means for both transferring rotational momentum to the fluid by viscous forces, and imparting centrifugal forces to the fluid. The pump (10a, 10b) can include a wiper (44) extending partially across at least one rotatable disc surface (48, 48b, 48c) of at least one rotatable disc (52, 52b, 52c). The pump (10c) can include a rotatable shaft (150) with a hollow cavity (154) extending from one end to at least one slot (158) extending radially from the hollow cavity.
摘要翻译：泵装置（10a，10b，10c）包括用于通过粘滞力将旋转动量传递给流体并将离心力施加给流体的装置。泵（10a，10b）可以包括擦拭器（44），该擦拭器部分地延伸穿过至少一个可旋转盘（52,52b，52c）的至少一个可旋转盘表面（48,48b，48c）。泵（10c）可以包括具有空腔（154）的可旋转轴（150），所述空腔从一端延伸到从空腔径向延伸的至少一个槽（158）。

6. 发明申请

WO2009140246A3 INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：内镜药物递送装置及相关方法
公开(公告)号：WO2009140246A3
公开(公告)日：2010-04-01
申请号：PCT/US2009043566
申请日：2009-05-12
申请人： UNIV UTAH RES FOUND , AMBATI BALAMURALI K , GALE BRUCE K
发明人： AMBATI BALAMURALI K , GALE BRUCE K
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , B33Y80/00
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。在一个方面，例如，眼部活性剂递送装置（10）可以包括设置在环形壳体（12）中的活性剂储存器（14），所述环形壳体（12）被配置成装配在透镜囊内部，至少部分地包围晶状体囊内的眼内透镜的视线。装置（10）还可以包括可操作地耦合到活性剂储存器（14）的半透膜（16），其中半透膜（16）构造成允许活性剂从活性剂储存器（14）扩散。此外，阀（18）可以可操作地联接到活性剂储存器（14），其中阀（18）构造成允许用活性剂填充活性剂储存器（14）。

7. 发明申请

WO2010034010A2 MICROASSAY WITH INTERNAL REFERENCING 审中-公开
标题翻译：微型内镜参考
公开(公告)号：WO2010034010A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057901
申请日：2009-09-22
申请人： WASATCH MICROFLUIDICS , MYSZKA, David , GALE, Bruce, K. , ECKMAN, Joshua, Wayne , NATARAJAN, Sriram
发明人： MYSZKA, David , GALE, Bruce, K. , ECKMAN, Joshua, Wayne , NATARAJAN, Sriram
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： C40B60/12 , B01J2219/0036 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0262 , B01L3/5027 , B01L2200/0689 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , G01N33/54366
摘要： Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.
摘要翻译：专用的微流体网络用于将物质沉积在传感器表面上。特别地，基于流动的微流体打印头用作将多个分析物递送到传感器用于同时分析的界面。此外，内部参考被并入传感器区域以提高灵敏度。

8. 发明申请

WO2009140246A2 INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：内镜药物递送装置及相关方法
公开(公告)号：WO2009140246A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043566
申请日：2009-05-12
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , AMBATI, Balamurali, K. , GALE, Bruce, K.
发明人： AMBATI, Balamurali, K. , GALE, Bruce, K.
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , B33Y80/00
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。在一个方面，例如，眼部活性剂递送装置（10）可以包括设置在环形壳体（12）中的活性剂储存器（14），所述环形壳体（12）被配置成装配在透镜囊内部，至少部分地包围晶状体囊内的眼内透镜的视线。装置（10）还可以包括可操作地耦合到活性剂储存器（14）的半透膜（16），其中半透膜（16）构造成允许活性剂从活性剂储存器（14）扩散。此外，阀（18）可以可操作地联接到活性剂储存器（14），其中阀（18）构造成允许用活性剂填充活性剂储存器（14）。

9. 发明申请

WO2008061129A3 METHODS AND COMPOSITIONS RELATED TO CONTINUOUS FLOW THERMAL GRADIENT PCR 审中-公开
标题翻译：与连续流式梯度PCR相关的方法和组合物
公开(公告)号：WO2008061129A3
公开(公告)日：2008-10-30
申请号：PCT/US2007084652
申请日：2007-11-14
申请人： UNIV UTAH RES FOUND , GALE BRUCE KENT , CREWS NIEL DAVENPORT , WITTWER CARL THOMAS
发明人： GALE BRUCE KENT , CREWS NIEL DAVENPORT , WITTWER CARL THOMAS
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： G01N21/6456 , B01L3/502707 , B01L7/525 , B01L7/54 , B01L2300/0816 , B01L2300/0861 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , G01N21/6428 , Y10T156/1056 , Y10T156/1062
摘要： Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.
摘要翻译：公开了用于基于连续流动热梯度PCR扩增和检测核酸序列的组合物和方法。

10. 发明申请

WO2006110489A2 RAPID PROTOTYPING OF MICROSTRUCTURES USING A CUTTING PLOTTER 审中-公开
标题翻译：使用切割机快速实现微结构
公开(公告)号：WO2006110489A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/012899
申请日：2006-04-07
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , BARTHOLOMEUSZ, Daniel, A. , KANTAK, Ameya , LEE, Sung , SRINIVAS, Merugu , SANT, Himanshu , BOUTTE, Ronald, W. , GALE, Bruce , THOMAS, Charles
发明人： BARTHOLOMEUSZ, Daniel, A. , KANTAK, Ameya , LEE, Sung , SRINIVAS, Merugu , SANT, Himanshu , BOUTTE, Ronald, W. , GALE, Bruce , THOMAS, Charles
IPC分类号： B32B37/04
CPC分类号： B32B38/10 , B26D7/10 , B26D7/2628 , B26F1/24 , B26F1/3806 , B26F2001/3893 , B29C64/141 , B81B2201/058 , B81C99/009 , B81C2201/019 , Y10T83/293 , Y10T83/303
摘要： A method for making a microstructure includes: providing a film (100) on a release liner (110); feeding the film through a cutting plotter (10); cutting the film with a knife blade (34) of the cutting plotter to form a microstructure pattern; peeling the microstructure pattern from the release liner; and transferring the microstructure pattern to a substrate (170). The cutting plotter for making microstructures includes a knife head with a knife blade disposed adjacent a feed mechanism (20), a motor (42) and control system coupled to the knife head for selectively moving the knife head in relation to the film, and the control system and the knife head having an addressable positioning resolution less than approximately 10 μm.
摘要翻译：制造微结构的方法包括：在剥离衬垫（110）上提供膜（100）; 通过切割机（10）将胶片进给; 用切割机的刀片（34）切割薄膜以形成微结构图案; 从分离衬片剥离微结构图案; 并将微结构图案转移到基板（170）。用于制造微结构的切割机包括具有邻近进给机构（20）设置的刀片的刀头，马达（42）和耦合到刀头的控制系统，用于相对于薄膜选择性地移动刀头，控制系统和刀头具有小于约10μm的可寻址定位分辨率。

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