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1. 发明申请

WO2010034010A2 MICROASSAY WITH INTERNAL REFERENCING 审中-公开
标题翻译：微型内镜参考
公开(公告)号：WO2010034010A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057901
申请日：2009-09-22
申请人： WASATCH MICROFLUIDICS , MYSZKA, David , GALE, Bruce, K. , ECKMAN, Joshua, Wayne , NATARAJAN, Sriram
发明人： MYSZKA, David , GALE, Bruce, K. , ECKMAN, Joshua, Wayne , NATARAJAN, Sriram
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： C40B60/12 , B01J2219/0036 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0262 , B01L3/5027 , B01L2200/0689 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , G01N33/54366
摘要： Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.
摘要翻译：专用的微流体网络用于将物质沉积在传感器表面上。特别地，基于流动的微流体打印头用作将多个分析物递送到传感器用于同时分析的界面。此外，内部参考被并入传感器区域以提高灵敏度。

2. 发明申请

WO2007100356A2 A MICROFLUIDIC INTERFACE FOR HIGHLY PARALLEL ADDRESSING OF SENSING ARRAYS 审中-公开
标题翻译：用于感测阵列高度并行寻址的微流体接口
公开(公告)号：WO2007100356A2
公开(公告)日：2007-09-07
申请号：PCT/US2006/038505
申请日：2006-10-02
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , GALE, Bruce, K. , MYSZKA, David , CHANG-YEN, David, A. , NATARAJAN, Sriram , ECKMAN, Josh
发明人： GALE, Bruce, K. , MYSZKA, David , CHANG-YEN, David, A. , NATARAJAN, Sriram , ECKMAN, Josh
CPC分类号： G01N33/553 , B01J19/0046 , B01L3/0293 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C12N15/1093 , G01N35/1074 , G01N2035/00158 , G01N2035/1039 , Y10T436/2575
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein, cells, or other substances on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microconduits, and orifices to deliver the substances. Each orifice may be connected to two wells via microconduits. When the spotter face contacts a surface, a seal is formed between the orifices in the spotter face and the surface. The same or different substances may be flowed to each orifice and over the surface, thereby forming an array of spots on the surface. Any number of wells, microconduits, and orifices may be incorporated into a spotter.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高浓度的蛋白质，细胞或其他物质的斑点沉积在微阵列载玻片，晶片或其他表面上。它也可以用于在同一点上执行各种化学步骤。点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。识别器可以由井板处理设备装载。检测员使用井，微管道和孔口来输送物质。每个孔可以通过微管连接到两个孔。当检查器面接触表面时，在检查器面和表面之间的孔口之间形成密封。相同或不同的物质可以流到每个孔口和表面上，从而在表面上形成点阵列。任何数量的井，微管和孔可以并入到一个点样器中。

3. 发明申请

WO2009140246A2 INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：内镜药物递送装置及相关方法
公开(公告)号：WO2009140246A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043566
申请日：2009-05-12
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , AMBATI, Balamurali, K. , GALE, Bruce, K.
发明人： AMBATI, Balamurali, K. , GALE, Bruce, K.
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , B33Y80/00
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。在一个方面，例如，眼部活性剂递送装置（10）可以包括设置在环形壳体（12）中的活性剂储存器（14），所述环形壳体（12）被配置成装配在透镜囊内部，至少部分地包围晶状体囊内的眼内透镜的视线。装置（10）还可以包括可操作地耦合到活性剂储存器（14）的半透膜（16），其中半透膜（16）构造成允许活性剂从活性剂储存器（14）扩散。此外，阀（18）可以可操作地联接到活性剂储存器（14），其中阀（18）构造成允许用活性剂填充活性剂储存器（14）。

4. 发明申请

WO2009111461A2 MICROFLUIDIC FLOW CELL 审中-公开
标题翻译：微流感细胞
公开(公告)号：WO2009111461A2
公开(公告)日：2009-09-11
申请号：PCT/US2009/035859
申请日：2009-03-03
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , SUNDBERG, Scott, O. , WITTNER, Carl, T. , GALE, Bruce, K.
发明人： SUNDBERG, Scott, O. , WITTNER, Carl, T. , GALE, Bruce, K.
IPC分类号： C12M1/10
CPC分类号： C12Q1/6844 , B01L3/50273 , B01L3/50851 , B01L7/52 , B01L2200/0642 , B01L2300/0806 , B01L2300/0887 , B01L2400/0409
摘要： A microfluidic flow cell having a body with a fluid transport channel disposed therein, the fluid transport channel having a proximal end and a distal end defining a fluid flow path, a fluid inlet port disposed at the proximal end of the fluid transport channel at a central portion of the body and an outlet port disposed at the distal end of the fluid transport channel at an outer portion of the body, and a plurality sample wells disposed in the fluid transport channel substantially perpendicular to the fluid flow path in the fluid transport channel. The microfluidic flow cell may have hundreds or thousands of individual, sub-microliter sample wells. The microfluidic flow cell can be filled by applying a flowable liquid to the inlet port and spinning the flow cell to cause fluid to flow into fluid transport channel. The microfluidic flow cells described herein can be used in a variety of applications where small sample size and/or a large number of replicates are desirable.
摘要翻译：一种微流体流动池，其具有设置在其中的流体输送通道的主体，所述流体输送通道具有限定流体流动路径的近端和远端;流体入口，其设置在所述流体输送通道的近端处的中心主体的一部分和设置在主体的外部部分处的流体输送通道的远端处的出口端口以及设置在流体输送通道中的基本上垂直于流体输送通道中的流体流动路径的多个样本阱。微流体流动池可以具有数百或数千个单独的亚微升样品孔。可以通过将可流动的液体施加到入口端口并旋转流动池以使流体流入流体输送通道来填充微流体流动池。本文所述的微流体流动池可以用于需要小样品量和/或大量重复的各种应用中。

5. 发明申请

WO2011130656A3 METHODS, DEVICES, AND APPARATUS FOR PERFORMING A VASCULAR ANASTOMOSIS 审中-公开
公开(公告)号：WO2011130656A3
公开(公告)日：2011-10-20
申请号：PCT/US2011/032723
申请日：2011-04-15
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , AGARWAL, Jayant, P. , GALE, Bruce, K. , NGUYEN, Lam , SHORR, Cory , STAUFFER, Brian , GEHRKE, Cody, Lee
发明人： AGARWAL, Jayant, P. , GALE, Bruce, K. , NGUYEN, Lam , SHORR, Cory , STAUFFER, Brian , GEHRKE, Cody, Lee
IPC分类号： A61B17/11 , A61B17/122 , A61B17/08 , A61F2/06
摘要： Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to second end tissue by mating the coupling device to a mating anastomosis device.

6. 发明申请

WO2015100251A1 VASCULAR COUPLING DEVICE 审中-公开
标题翻译：血管联接装置
公开(公告)号：WO2015100251A1
公开(公告)日：2015-07-02
申请号：PCT/US2014/071930
申请日：2014-12-22
申请人： AGARWAL, Jayant, P. , GALE, Bruce, K. , LI, Huizhong , SANT, Himanshu, J.
发明人： AGARWAL, Jayant, P. , GALE, Bruce, K. , LI, Huizhong , SANT, Himanshu, J.
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1107 , A61B2017/1132
摘要： Implementations of the present disclosure relate to apparatuses, systems, and methods for anastomosing vascular systems in medical procedures. A pair of similar or identical coupling devices may be disposed at the ends of two vessels, either natural or synthetic. The coupling devices may be capable of hermaphroditically connecting to one another to provide a simple and secure connection which promotes growth of the vessels between the bio-absorbable coupling devices.
摘要翻译：本公开的实施方式涉及用于在医疗过程中吻合血管系统的装置，系统和方法。一对相似或相同的耦合装置可以设置在两个容器的端部，天然的或合成的。联接装置可能能够彼此相互连接以提供促进生物可吸收耦合装置之间的容器生长的简单和可靠的连接。

7. 发明申请

WO2007117335A2 HIGH FIELD STRENGTH MAGNETIC FIELD GENERATION SYSTEM AND ASSOCIATED METHODS 审中-公开
标题翻译：高强度磁场发生系统及相关方法
公开(公告)号：WO2007117335A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/000217
申请日：2007-01-04
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , STEPHENSON, James, C. , GALE, Bruce, K. , FURSE, Cynthia
发明人： STEPHENSON, James, C. , GALE, Bruce, K. , FURSE, Cynthia
IPC分类号： H01F7/08
CPC分类号： H01F7/0284 , G01R33/3806 , G01R33/383
摘要： A magnetic field generation system can comprise first (28a) and second (28b) magnetic flux concentrators each spaced apart to form a sample volume (30). The first (28a) and second (28b) magnetic flux concentrators can be formed of a material having a magnetic field saturation. A first set of auxiliary permanent magnets (10a, 10b) can be symmetrically oriented about a portion of the first magnetic flux concentrator (28a) and can be in substantial contact with the first magnetic flux concentrator. Similarly, a second set of auxiliary permanent magnets (1 Oc, 1 Od) can be symmetrically oriented about a portion of the second magnetic flux concentrator (28b) and can be in substantial contact with the second magnetic flux concentrator. Generally, the first set (10a,10b) and second set (10c,10d) of auxiliary permanent magnets can be remote from the sample volume (30). Each of the first set and second set of auxiliary permanent magnets can be oriented in a magnetically repulsive orientation with respect to at least one other member of their respective sets. The first (10a,10b) and second (10c,10d) sets of auxiliary magnets can be magnetically associated via the first (28a) and second (28b) magnetic flux concentrators. The present invention can further be configured to allow variation of the magnetic field strength across the sample volume by disrupting the field flux across the magnetic flux concentrators. This can be accomplished by orienting one or more magnetically soft shunts (38) in a sufficient proximity to at least one of the magnetic flux concentrators (28a,28b).
摘要翻译：磁场产生系统可以包括第一（28a）和第二（28b）磁通量聚集器，每个间隔开以形成样品体积（30）。第一（28a）和第二（28b）磁通量聚集器可以由具有磁场饱和的材料形成。第一组辅助永久磁铁（10a，10b）可围绕第一磁通量聚集器（28a）的一部分对称地取向，并且可以与第一磁通集中器实质接触。类似地，第二组辅助永磁体（1 Oc，1 Od）可以围绕第二磁通量聚集器（28b）的一部分对称地定向，并且可以与第二磁通量集中器实质接触。通常，辅助永磁体的第一组（10a，10b）和第二组（10c，10d）可以远离样品体积（30）。第一组和第二组辅助永磁体中的每一个可以相对于它们各自的组的至少一个其它构件以磁性排斥取向定向。第一（10a，10b）和第二（10c，10d）组辅助磁体可以经由第一（28a）和第二（28b）磁通量集中器磁性地相关联。本发明还可以被配置为允许通过扰乱磁通集中器上的磁场通量来改变跨样品体积的磁场强度。这可以通过将一个或多个磁软分流器（38）定向到至少一个磁通量聚集器（28a，28b）的足够接近来实现。

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