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1. 发明申请

US20130011878A1 ANTIGEN BINDING PROTEINS THAT BIND PAR-2 有权
标题翻译：抗体结合蛋白质，包括PAR-2
公开(公告)号：US20130011878A1
公开(公告)日：2013-01-10
申请号：US13532242
申请日：2012-06-25
申请人： G. DUKE VIRCA , SHAW-FEN SYLVIA HU
发明人： G. DUKE VIRCA , SHAW-FEN SYLVIA HU
IPC分类号： C12N15/13 , C12P21/02 , C12N5/16 , C12N1/19 , C12N1/15 , C12N5/10 , C12N15/63 , C12N1/21
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/30
摘要： The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
摘要翻译：本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。在具体实施方案中，本发明提供了结合PAR-2，PAR-2结合片段和此类抗体的衍生物的人抗体，以及包含此类片段的PAR-2结合多肽。其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断患有PAR-2相关疾病或病症的受试者。

2. 发明申请

US20110059063A1 Antigen binding proteins that bind PAR-2 有权
标题翻译：结合PAR-2的抗原结合蛋白
公开(公告)号：US20110059063A1
公开(公告)日：2011-03-10
申请号：US12215304
申请日：2008-06-26
申请人： G. Duke Virca , Shaw-Fen Sylvia Hu
发明人： G. Duke Virca , Shaw-Fen Sylvia Hu
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/30
摘要： The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
摘要翻译：本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。在具体实施方案中，本发明提供了结合PAR-2，PAR-2结合片段和此类抗体的衍生物的人抗体，以及包含此类片段的PAR-2结合多肽。其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断患有PAR-2相关疾病或病症的受试者。

3. 发明授权

US06911336B2 GNK interacting amino acid decarboxylase and methods of use thereof 失效
标题翻译： GNK相互作用的氨基酸脱羧酶及其使用方法
公开(公告)号：US06911336B2
公开(公告)日：2005-06-28
申请号：US09978248
申请日：2001-10-16
申请人： Pamela M. Holland , G. Duke Virca , Timothy A. Bird , Kirsten Garka
发明人： Pamela M. Holland , G. Duke Virca , Timothy A. Bird , Kirsten Garka
IPC分类号： C12N9/88 , C12N15/60 , C12N11/00 , G01N33/573 , A23D1/00 , C07N16/00
CPC分类号： C12N9/88 , C07K2319/00
摘要： The present invention discloses a novel polypeptide that contains an amino acid decarboxylase domain, and is a substrate for caspase-3. Nucleic acids that encode the novel polypeptide and antibodies to the polypeptide are also part of the present invention. Methods of using the polypeptide, the nucleic acids and antibodies are also provided.
摘要翻译：本发明公开了一种含有氨基酸脱羧酶结构域的新型多肽，是胱天蛋白酶-3的底物。编码新多肽的核酸和多肽的抗体也是本发明的一部分。还提供了使用多肽，核酸和抗体的方法。

4. 发明授权

US07285643B2 Antibodies to novel murine and human kinases 失效
标题翻译：抗小鼠和人类激酶的抗体
公开(公告)号：US07285643B2
公开(公告)日：2007-10-23
申请号：US11241056
申请日：2005-09-30
申请人： Timothy A. Bird , G. Duke Virca , Unja Martin , Dirk M. Anderson
发明人： Timothy A. Bird , G. Duke Virca , Unja Martin , Dirk M. Anderson
IPC分类号： C07K16/00
CPC分类号： C12N9/1205 , C12Q1/48 , C12Q1/485 , G01N2500/04
摘要： The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
摘要翻译：本发明涉及纯化和分离的新型鼠和人激酶多肽，编码这种多肽的核酸，用于产生这些多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽，以及以上。

5. 发明授权

US07001752B1 Murine and human kinases 失效
标题翻译：鼠和人类激酶
公开(公告)号：US07001752B1
公开(公告)日：2006-02-21
申请号：US09980464
申请日：2000-05-26
申请人： Timothy A. Bird , G. Duke Virca , Unja Martin , Dirk M. Anderson
发明人： Timothy A. Bird , G. Duke Virca , Unja Martin , Dirk M. Anderson
IPC分类号： C12N9/12 , C12N15/00 , C12N1/20 , C07K1/00 , C07H21/04
CPC分类号： C12N9/1205
摘要： The inventions is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acid encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
摘要翻译：本发明涉及纯化和分离的新型鼠和人激酶多肽，编码此类多肽的核酸，用于产生这些多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽，以及以上。

6. 发明授权

US06867013B2 Methods of screening for antagonists and agonists of polypeptides having kinase functions 失效
标题翻译：筛选具有激酶功能的多肽的拮抗剂和激动剂的方法
公开(公告)号：US06867013B2
公开(公告)日：2005-03-15
申请号：US10024828
申请日：2001-12-18
申请人： G. Duke Virca , Timothy A. Bird , Dirk M. Anderson , John S. Marken
发明人： G. Duke Virca , Timothy A. Bird , Dirk M. Anderson , John S. Marken
IPC分类号： G01N33/50 , C07H21/04 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/00 , C12Q1/68 , G01N33/15 , G01N33/566 , G01N33/577 , C12Q1/48
CPC分类号： C12N9/1205
摘要： The invention is directed to purified and isolated human polypeptides having kinase function, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in phosphorylation reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, the use of such polypeptides in screening assays, and kits comprising these reagents.
摘要翻译：本发明涉及具有激酶功能的纯化和分离的人多肽，编码此类多肽的核酸，用于产生这些多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽，使用此类多肽和磷酸化反应中的片段化肽和分子量标记，使用这些多肽和片段化肽作为肽断裂的对照，在筛选测定中使用此类多肽，以及包含这些试剂的试剂盒。

7. 发明授权

US06794173B2 Dendritic cell transmembrane serine protease 失效
标题翻译：树突状细胞跨膜丝氨酸蛋白酶
公开(公告)号：US06794173B2
公开(公告)日：2004-09-21
申请号：US10177661
申请日：2002-06-20
申请人： Dirk M. Anderson , G. Duke Virca
发明人： Dirk M. Anderson , G. Duke Virca
IPC分类号： C12N964
CPC分类号： C12N9/6424 , C12Q1/37 , G01N2500/02
摘要： Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can be used to hydrolyze peptide bonds. The DCTSPs are also useful in screening for inhibitors or agonists thereof.
摘要翻译：公开了分离的树突状细胞跨膜丝氨酸蛋白酶（DCTSP），编码这种DCTSP的DNA，以及由其制备的药物和/或诊断组合物。分离的DCTSP可用于水解肽键。 DCTSP也可用于筛选抑制剂或其激动剂。

8. 发明授权

US06759223B2 Calcium/calmodulin-dependent kinase 失效
标题翻译：钙/钙调蛋白依赖性激酶
公开(公告)号：US06759223B2
公开(公告)日：2004-07-06
申请号：US10355975
申请日：2003-01-30
申请人： Timothy A. Bird , G. Duke Virca , Unja Martin , Dirk M. Anderson
发明人： Timothy A. Bird , G. Duke Virca , Unja Martin , Dirk M. Anderson
IPC分类号： C12N912
CPC分类号： C12N9/1205 , C12Q1/48 , C12Q1/485 , G01N2500/04
摘要： The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
摘要翻译：本发明涉及纯化和分离的新型鼠和人激酶多肽，编码这种多肽的核酸，用于产生这些多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽，以及以上。

9. 发明授权

US08470556B2 Nucleic acids that encode antigen binding proteins that bind PAR-2 有权
标题翻译：编码结合PAR-2的抗原结合蛋白的核酸
公开(公告)号：US08470556B2
公开(公告)日：2013-06-25
申请号：US13532242
申请日：2012-06-25
申请人： G. Duke Virca , Shaw-Fen Sylvia Hu
发明人： G. Duke Virca , Shaw-Fen Sylvia Hu
IPC分类号： C12N15/00 , C12N15/85 , C12N15/63 , C07H21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/30
摘要： The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
摘要翻译：本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。在具体实施方案中，本发明提供了结合PAR-2，PAR-2结合片段和此类抗体的衍生物的人抗体，以及包含此类片段的PAR-2结合多肽。其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断患有PAR-2相关疾病或病症的受试者。

10. 发明授权

US08357367B2 Antibodies that bind PAR-2 有权
标题翻译：结合PAR-2的抗体
公开(公告)号：US08357367B2
公开(公告)日：2013-01-22
申请号：US12215304
申请日：2008-06-26
申请人： G. Duke Virca , Shaw-Fen Sylvia Hu
发明人： G. Duke Virca , Shaw-Fen Sylvia Hu
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/30
摘要： The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
摘要翻译：本发明提供了与抗PAR-2抗体有关或衍生自抗PAR-2抗体的组合物和方法。在具体实施方案中，本发明提供了结合PAR-2，PAR-2结合片段和此类抗体的衍生物的人抗体，以及包含此类片段的PAR-2结合多肽。其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断患有PAR-2相关疾病或病症的受试者。

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