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1. 发明申请

US20120276523A1 LIQUID DROP DIAGNOSTIC ASSAYS 有权
标题翻译：液体滴定诊断
公开(公告)号：US20120276523A1
公开(公告)日：2012-11-01
申请号：US13502966
申请日：2010-10-20
申请人： Frederick R. Haselton , Joshua Robert Trantum , David W. Wright
发明人： Frederick R. Haselton , Joshua Robert Trantum , David W. Wright
IPC分类号： G01N21/78 , C12Q1/70 , C12Q1/68 , G01N33/569 , G01N33/53 , G01N21/76 , G01N33/573 , G01N21/64 , G01N33/574 , B82Y15/00 , B82Y5/00
CPC分类号： G01N33/54313 , G01N33/54393 , G01N33/56905
摘要： The present invention provides simple and inexpensive assays for the detection of virtually any analyte in any sample that is in liquid form or that can be solubilized. The assays utilize the fluid dynamics of drop evaporation whereby soluble materials, including analytes and particles binding thereto, are drawn to the edge of the drop and ultimately form a concentrated residual ring. The presence or absence of certain reagents can then be detected through a number of different approaches.
摘要翻译：本发明提供用于检测液体形式或可溶解的任何样品中几乎任何分析物的简单和便宜的测定。该测定法利用液滴蒸发的流体动力学，从而将可溶性材料（包括分析物和与其结合的颗粒）吸引到液滴的边缘并最终形成浓缩的残余环。然后可以通过多种不同的方法检测某些试剂的存在或不存在。

2. 发明申请

US20120003729A1 CAPILLARY PERFUSED BIOREACTORS WITH MULTIPLE CHAMBERS 审中-公开
标题翻译：毛细管充填生物反应器与多个CHAMBERS
公开(公告)号：US20120003729A1
公开(公告)日：2012-01-05
申请号：US13175659
申请日：2011-07-01
申请人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
IPC分类号： C12M1/34 , C12M1/12 , C12M1/04 , C12M1/00
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译：用于在液体培养基中培养活细胞的生物反应器。在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。控制液体的流动以便向细胞层提供已知的剪切力。可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。

3. 发明授权

US07534601B2 Capillary perfused bioreactors with multiple chambers 有权
标题翻译：毛细管灌注生物反应器与多个室
公开(公告)号：US07534601B2
公开(公告)日：2009-05-19
申请号：US10525559
申请日：2003-08-27
申请人： John P. Wikswo , Franz J. Baudenbacher , Alex Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Alex Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
IPC分类号： C12M1/00
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译：用于在液体培养基中培养活细胞的生物反应器。在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。控制液体的流动以便向细胞层提供已知的剪切力。可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。

4. 发明授权

US3969775A Water closet flushing device 失效
标题翻译：水厕冲洗装置
公开(公告)号：US3969775A
公开(公告)日：1976-07-20
申请号：US538617
申请日：1975-01-06
申请人： Frederick R. Haselton
发明人： Frederick R. Haselton
IPC分类号： E03D1/14 , E03D1/34 , A61B19/00 , E03D5/02
CPC分类号： E03D1/144 , Y10S4/01
摘要： The disclosed device provides a normal minimum flush cycle for water closets with the ability to override the short cycle to cause a larger water volume flush cycle. The conventional tank flapper dump valve is modified so as to retain no buoyancy during the flush cycle and a positively buoyant member is adjustably fixed on the valve operating chain an appropriate distance from the valve. When the operating handle is actuated, the added buoyancy holds the valve open while the water level in the tank falls until the added buoyancy member surfaces at which time the valve closes and the tank refills normally. Short cycle override is accomplished by merely holding the handle in the actuated position allowing a greater portion of the water in the reservoir to pass.
摘要翻译：所公开的设备为水厕提供正常的最小冲洗循环，具有超越短循环以产生更大的水量冲洗循环的能力。改进了常规的挡泥板卸料阀，以便在冲洗循环期间不保持浮力，并且将正向浮力构件可调节地固定在阀操作链上与阀适当的距离。当操作手柄启动时，增加的浮力将保持阀打开，同时水箱中的水位下降直到添加的浮力构件表面，此时阀关闭，并且油箱正常填充。通过仅将手柄保持在致动位置来实现短周期超驰，允许储存器中的较大部分的水通过。

5. 发明授权

US07790443B2 Bioreactors with substance injection capacity 有权
标题翻译：具有物质注入能力的生物反应器
公开(公告)号：US07790443B2
公开(公告)日：2010-09-07
申请号：US10525648
申请日：2003-08-27
申请人： John P. Wikswo , Franz J. Baudenbacher , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Mark A. Stremler , Alissa Weaver
发明人： John P. Wikswo , Franz J. Baudenbacher , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Mark A. Stremler , Alissa Weaver
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： B01L3/502761 , B01L3/502723 , B01L3/502746 , B01L2200/0668 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2300/10 , B01L2400/0633 , B01L2400/086 , C12M23/16 , C12M25/14 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46
摘要： A bioreactor with substance injection capability. In one embodiment, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a chamber for receiving cells and a liquid medium. A port is formed in the second substrate between the bottom surface and the first surface of the second substrate. As formed, the port is in fluid communication with the chamber to allow a stream of substance to be introduced into the chamber. The stream of substance is controlled so as to provide a gradient, or a concentration gradient of the substance, to the chamber. The stream of substance includes a substance affecting the growth of cells such as chemokine.
摘要翻译：具有物质注入能力的生物反应器。在一个实施例中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。第一基板的第一表面被第二基板的第二表面接收以覆盖空腔，以形成用于容纳电池和液体介质的室。在第二基板的第二基板的底表面和第一表面之间形成端口。如此形成的，端口与腔室流体连通，以允许物质流被引入腔室。物质流被控制以便向腔室提供物质的梯度或浓度梯度。物质流包括影响细胞生长的物质，如趋化因子。

6. 发明申请

US20090215654A1 Capillary Perfused Bioreactors with Multiple Chambers 有权
标题翻译：具有多个腔室的毛细管灌注生物反应器
公开(公告)号：US20090215654A1
公开(公告)日：2009-08-27
申请号：US12398825
申请日：2009-03-05
申请人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene J. Leboeuf , Chang Y. Chung , David Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
IPC分类号： C40B60/00 , C12M1/00 , G01N27/26 , G01N33/50
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译：用于在液体培养基中培养活细胞的生物反应器。在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。控制液体的流动以便向细胞层提供已知的剪切力。可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。

7. 发明授权

US3986471A Semi-submersible vessels 失效
标题翻译：半潜式船舶
公开(公告)号：US3986471A
公开(公告)日：1976-10-19
申请号：US599751
申请日：1975-07-28
申请人： Frederick R. Haselton
发明人： Frederick R. Haselton
IPC分类号： B63B35/44 , B63B39/06
CPC分类号： B63B39/06 , B63B1/107 , B63B35/4413 , B63B2039/067
摘要： An apparatus for damping vertical movement of a semi-submersible vessel having a small waterplane area, whose buoyancy is provided substantially completely by submerged pontoon means and which includes at least one submerged damper plate having valves or similar flow controllers therein for providing substantially greater resistance to upward movement of the plate than downward movement. The damper plate is supported deep beneath the semi-submersible vessel by flexible, tensioned support elements such as chains or cables, at a depth beneath the water surface in the semi-submerged condition of the vessel, at which depth the amplitude of subsurface wave motion is less than the maximum heave amplitude which would be experienced by the semi-submersible vessel alone under identical sea conditions. The area of the damper plate is several times larger than the waterplane area of the vessel. An upward only-damping action is achieved due to the entrainment of large apparent masses of relatively still water by the damper plate.
摘要翻译：一种用于阻止具有小水面区域的半潜式容器的垂直运动的装置，其浮力基本上完全由浸没的浮筒装置提供，并且其包括至少一个具有阀或类似流量控制器的浸没式阻尼板，用于提供基本上更大的阻力板向上运动比向下运动。阻尼板在半潜式船舶的下方通过柔性的，张紧的支撑元件（如链条或电缆）支撑在船舶半浸没状态下的水面下方的深度处，在该深度处，地下波浪运动的幅度小于在相同海况下仅由半潜式船只经历的最大起伏振幅。阻尼板的面积是容器的水面面积的几倍。由于通过阻尼板夹带大量相对静止的水的明显质量，实现了向上的仅阻尼作用。

8. 发明授权

US09575061B2 Liquid drop diagnostic assays 有权
标题翻译：液滴诊断测定
公开(公告)号：US09575061B2
公开(公告)日：2017-02-21
申请号：US13502966
申请日：2010-10-20
申请人： Frederick R. Haselton , Joshua Robert Trantum , David W. Wright
发明人： Frederick R. Haselton , Joshua Robert Trantum , David W. Wright
IPC分类号： G01N33/534 , G01N33/543 , G01N33/569
CPC分类号： G01N33/54313 , G01N33/54393 , G01N33/56905
摘要： The present invention provides simple and inexpensive assays for the detection of virtually any analyte in any sample that is in liquid form or that can be solubilized. The assays utilize the fluid dynamics of drop evaporation whereby soluble materials, including analytes and particles binding thereto, are drawn to the edge of the drop and ultimately form a concentrated residual ring. The presence or absence of certain reagents can then be detected through a number of different approaches.
摘要翻译：本发明提供用于检测液体形式或可溶解的任何样品中几乎任何分析物的简单和便宜的测定。该测定法利用液滴蒸发的流体动力学，从而将可溶性材料（包括分析物和与其结合的颗粒）吸引到液滴的边缘并最终形成浓缩的残余环。然后可以通过多种不同的方法检测某些试剂的存在或不存在。

9. 发明授权

US08003378B2 Capillary perfused bioreactors with multiple chambers 有权
标题翻译：毛细管灌注生物反应器与多个室
公开(公告)号：US08003378B2
公开(公告)日：2011-08-23
申请号：US12398825
申请日：2009-03-05
申请人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene LeBoeuf , Chang Y. Chung , David E. Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , Ales Prokop , Eugene LeBoeuf , Chang Y. Chung , David E. Cliffel , Frederick R. Haselton , William H. Hofmeister , Charles P. Lin , Lisa J. McCawley , Randall S. Reiserer , Mark A. Stremler
IPC分类号： C12M1/00
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/10 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12M23/16 , C12M29/10
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.
摘要翻译：用于在液体培养基中培养活细胞的生物反应器。在本发明的一个实施方案中，生物反应器包括具有第一表面，相对的第二表面和边缘的第一基底。生物反应器还包括具有第一表面和相对的第二表面的第二基底，其限定具有底表面的空腔，其中底表面位于第一表面和第二表面之间。第一基板的第一表面由第二基板的第二表面接收以覆盖空腔，以形成用于接收电池和液体介质的通道。在形成生物反应器时，通道的大小适于允许生物相容性涂层上的细胞层的生长和通道中的液体流。控制液体的流动以便向细胞层提供已知的剪切力。可以进一步控制液体的流动，以便提供模拟通道中血管空间的环境。

10. 发明授权

US07977089B2 Bioreactors with multiple chambers 有权
标题翻译：具有多个室的生物反应器
公开(公告)号：US07977089B2
公开(公告)日：2011-07-12
申请号：US10525549
申请日：2003-08-27
申请人： John P. Wikswo , Franz J. Baudenbacher , David Cliffel , Frederick R. Haselton , Eugene J. Leboeuf , Ales Prokop , Randall S. Reiserer , Mark A. Stremler
发明人： John P. Wikswo , Franz J. Baudenbacher , David Cliffel , Frederick R. Haselton , Eugene J. Leboeuf , Ales Prokop , Randall S. Reiserer , Mark A. Stremler
IPC分类号： C12M1/22 , C12M3/00 , C12M1/34
CPC分类号： C12M23/16 , B01L3/5027 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/163 , B01L2400/0472 , C12M23/12 , C12M29/10 , C12M41/00 , Y10S435/808
摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber.
摘要翻译：用于在液体培养基中培养活细胞的生物反应器。在本发明的一个实施方案中，生物反应器具有第一基底，其具有第一表面和相对的第二表面，在其间限定用于接收细胞和液体介质的腔室。所述生物反应器还具有将所述室分成第一子室和第二子室的屏障，其中所述阻挡层具有孔隙率以允许所述第一子室和所述第二子室流体连通，并允许至少一个预定类型的泡孔在所述第一室子房和第二个子房。

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