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1. 发明申请

US20050220871A1 Taste masking granules 审中-公开
标题翻译：味道掩蔽颗粒
公开(公告)号：US20050220871A1
公开(公告)日：2005-10-06
申请号：US11145354
申请日：2005-06-03
申请人： Franz Schwarz
发明人： Franz Schwarz
IPC分类号： A61K20060101 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/50
CPC分类号： A61K31/33 , A61K9/0095 , A61K9/1617 , A61K9/1652 , A61K9/5026 , A61K9/5047
摘要： Pellets of granulated particles comprising at least one pharmaceutically active compound, which pellets are characterised in that a bad taste of a pharmaceutically active compound when taken by patients is reduced or eliminated, said pellets comprise a pharmaceutically active compound and further comprise an organic carboxylic acid and/or a surfactant and/or a hydrocolloid and said pellets are coated with an enteric film-forming composition comprising an enteric film-forming component and pharmaceutical compositions comprising such pellets.
摘要翻译：包含至少一种药物活性化合物的粒状颗粒颗粒，其特征在于，当患者服用时药物活性化合物的味道减弱或消除，所述丸粒包含药物活性化合物，并且还包含有机羧酸和 /或表面活性剂和/或水胶体，并且所述颗粒用包含肠溶膜形成组分的肠溶膜形成组合物和包含这种颗粒的药物组合物包衣。

2. 发明授权

US06266710B1 Serial data transfer device 有权
标题翻译：串行数据传输设备
公开(公告)号：US06266710B1
公开(公告)日：2001-07-24
申请号：US09128871
申请日：1998-08-04
申请人： Bernd Dittmer , Franz Schwarz
发明人： Bernd Dittmer , Franz Schwarz
IPC分类号： G06F300
CPC分类号： G06F13/4045 , B60R16/0315
摘要： A data transfer device for unidirectional serial data transfer from a transmitting device to a receiving device, in particular from a microcontroller to an output stage IC of a motor vehicle control unit. The data transfer device includes a P/S converter provided in the transmitting device for converting a parallel data stream made available in the transmitting device into a serial data stream with transfer frames of a predefined format and for transmitting the serial data stream to the receiving device over a data transfer channel. The data transfer device also includes an S/P converter provided in the receiving device for converting the transmitted serial data stream back into a parallel data stream, and a clock signal generating device for generating a clock signal and for sending the clock signal to the P/S converter and the S/P converter to perform the conversion operations continuously and in-phase. In addition, the data transfer device includes a synchronizing device for generating a synchronizing signal according to the conversion operation of the P/S converter and for supplying the same to the S/P converter for synchronizing the conversion operations.
摘要翻译：一种用于从发送设备到接收设备的单向串行数据传输的数据传输设备，特别是从微控制器到机动车辆控制单元的输出级IC。数据传送装置包括一个P / S转换器，它设置在发送装置中，用于将发送装置中可用的并行数据流转换成具有预定义格式的传输帧的串行数据流，并将串行数据流发送到接收装置通过数据传输通道。数据传送装置还包括设置在接收装置中的用于将发送的串行数据流转换回并行数据流的S / P转换器，以及用于产生时钟信号并将时钟信号发送到P的时钟信号产生装置 / S转换器和S / P转换器进行连续和同相的转换操作。另外，数据传送装置包括：同步装置，用于根据P / S转换器的转换操作产生同步信号，并将其提供给S / P转换器以使转换操作同步。

3. 发明申请

US20150080435A1 PHARMACEUTICAL COMPOSITION CONTAINING CRYSTALLINE SORAFENIB TOSYLATE 有权
标题翻译：含有结晶硫酸苯甲酸酯的药物组合物
公开(公告)号：US20150080435A1
公开(公告)日：2015-03-19
申请号：US14371034
申请日：2013-01-23
申请人： Stefan Scheler , Heiko Degendorfer , Johannes Raneburger , Franz Schwarz
发明人： Stefan Scheler , Heiko Degendorfer , Johannes Raneburger , Franz Schwarz
IPC分类号： C07D213/81 , A61K31/4412 , A61K9/20
CPC分类号： C07D213/81 , A61K9/0095 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K31/4412 , A61K47/20
摘要： The present invention relates to an oral solid dosage form, in particular a tablet, comprising sorafenib tosylate polymorphic form III.
摘要翻译：本发明涉及口服固体剂型，特别是包含索拉非尼甲苯磺酸多晶型III的片剂。

4. 发明授权

US5903355A Method and apparatus for checking a predetermined monitoring area 失效
标题翻译：用于检查预定监视区域的方法和装置
公开(公告)号：US5903355A
公开(公告)日：1999-05-11
申请号：US414659
申请日：1995-03-30
申请人： Franz Schwarz
发明人： Franz Schwarz
IPC分类号： G01S17/02 , G07C9/00 , G01B11/24
CPC分类号： G01S17/026 , G07C9/00
摘要： Method for checking a predetermined monitoring area, wherein at least one distance sensor provided in particular in the edge region of the monitored area, which transmits a scanning beam which sweeps over the monitored area in a predetermined scanning movement and thereby changes its direction, which receives the scanning beam which is reflected at boundaries of the monitored area and/or at objects located in the monitored area, and which determines a distance signal representative of the distance of the point of reflection of the scanning beam from the distance sensor and also a direction signal representing the direction of the scanning beam. The distance signals and the direction signals found during the scanning movement define a distance contour function, and an evaluation unit connected to the distance sensor compares the distance contour function which has been found with at least one stored reference contour function representing an expected object contour. Moreover, the evaluation unit generates an output signal, providing the distance contour function which has been found and the reference contour function correspond, or do not correspond, within preset tolerance limits.
摘要翻译：用于检查预定监视区域的方法，其中特别设置在所述被监视区域的边缘区域中的至少一个距离传感器，所述至少一个距离传感器传送扫描光束，所述扫描光束以预定扫描运动扫过所述监视区域，从而改变其方向，所述扫描光束接收扫描光束在监视区域的边界和/或位于被监测区域的物体处被反射，并且确定表示扫描光束与距离传感器的反射点的距离的距离信号，以及方向表示扫描光束的方向的信号。在扫描运动期间发现的距离信号和方向信号定义了距离轮廓功能，连接到距离传感器的评估单元将已发现的距离轮廓功能与表示预期物体轮廓的至少一个存储的参考轮廓函数进行比较。此外，评估单元产生输出信号，提供已经找到的距离轮廓函数和参考轮廓函数在预设公差范围内对应或不对应的距离轮廓函数。

5. 发明授权

US09227938B2 Pharmaceutical composition containing crystalline sorafenib tosylate 有权
标题翻译：含有结晶索拉非尼甲苯磺酸盐的药物组合物
公开(公告)号：US09227938B2
公开(公告)日：2016-01-05
申请号：US14371034
申请日：2013-01-23
申请人： Stefan Scheler , Heiko Degendorfer , Johannes Raneburger , Franz Schwarz
发明人： Stefan Scheler , Heiko Degendorfer , Johannes Raneburger , Franz Schwarz
IPC分类号： A61K31/4412 , C07D213/81 , A61K9/20 , A61K9/00 , A61K47/20
CPC分类号： C07D213/81 , A61K9/0095 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K31/4412 , A61K47/20
摘要： The present invention relates to an oral solid dosage form, in particular a tablet, comprising sorafenib tosylate polymorphic form III.
摘要翻译：本发明涉及口服固体剂型，特别是包含索拉非尼甲苯磺酸多晶型III的片剂。

6. 发明申请

US20080095855A1 Taste Masking Granules 审中-公开
标题翻译：味道面膜颗粒
公开(公告)号：US20080095855A1
公开(公告)日：2008-04-24
申请号：US11876214
申请日：2007-10-22
申请人： Franz Schwarz
发明人： Franz Schwarz
IPC分类号： A61K9/50 , A61K31/33 , A61P43/00
CPC分类号： A61K31/33 , A61K9/0095 , A61K9/1617 , A61K9/1652 , A61K9/5026 , A61K9/5047
摘要： Pellets of granulated particles comprising at least one pharmaceutically active compound, which pellets are characterised in that a bad taste of a pharmaceutically active compound when taken by patients is reduced or eliminated, said pellets comprise a pharmaceutically active compound and further comprise an organic carboxylic acid and/or a surfactant and/or a hydrocolloid and said pellets are coated with an enteric film-forming composition comprising an enteric film-forming component and pharmaceutical compositions comprising such pellets.
摘要翻译：包含至少一种药物活性化合物的粒状颗粒颗粒，其特征在于，当患者服用时药物活性化合物的味道减弱或消除，所述丸粒包含药物活性化合物，并且还包含有机羧酸和 /或表面活性剂和/或水胶体，并且所述颗粒用包含肠溶膜形成组分的肠溶膜形成组合物和包含这种颗粒的药物组合物包衣。

7. 发明申请

US20060263424A1 Pharmaceutical compositions comprising clavulanic acid 审中-公开
标题翻译：包含克拉维酸的药物组合物
公开(公告)号：US20060263424A1
公开(公告)日：2006-11-23
申请号：US11449041
申请日：2006-06-07
申请人： Otto Damon , Herwig Jennewein , Thomas Lentner , Franz Schwarz , Robert Veigl
发明人： Otto Damon , Herwig Jennewein , Thomas Lentner , Franz Schwarz , Robert Veigl
IPC分类号： A61K31/407 , A61K9/20
CPC分类号： A61K31/42 , A61K9/16 , A61K9/1641 , A61K9/2077 , A61K31/424 , A61K31/43 , A61K2300/00
摘要： A pharmaceutical composition comprising an active ingredient and clavulanate wherein the clavulanate is in the form of granulated and hydrophobised particles; and intermediates in its preparation, e.g. clavulanate in granulated and/or hydrophobised form.
摘要翻译：一种药物组合物，其包含活性成分和克拉维酸盐，其中所述克拉维酸盐为颗粒化和疏水化颗粒的形式; 和其制备中的中间体，例如棒状和/或疏水形式的克拉维酸。

8. 发明授权

US06284792B1 Formulation of valnemulin 有权
标题翻译： valnemulin的配方
公开(公告)号：US06284792B1
公开(公告)日：2001-09-04
申请号：US09733477
申请日：2000-12-08
申请人： Kurt Koller , Franz Schwarz
发明人： Kurt Koller , Franz Schwarz
IPC分类号： A61K3122
CPC分类号： A61K9/0019 , A61K31/221 , A61K47/10 , A61K47/12
摘要： The preparation of an improved galenic delivery form of valnemulin, which is notable for its good tolerance and stability in storage, is described. The new delivery form in question is a non-aqueous or oily injection formulation, which is obtainable by means of in-situ preparation and subsequent stabilisation of the free, relatively unstable base of the active ingredient. A further aspect of the present invention concerns the usage of such an injection formulation in a method of treating infectious diseases in productive livestock or domestic animals.
摘要翻译：描述了一种改进的盖仑剂递送形式的valnemulin的制备，其在其储存中的良好耐受性和稳定性方面是显着的。所述新的递送形式是非水或油性注射制剂，其可通过原位制备和随后稳定活性成分的游离相对不稳定的碱而获得。本发明的另一方面涉及这种注射制剂在用于治疗生产性家畜或家畜中的感染性疾病的方法中的用途。

9. 发明申请

US20080008765A1 Taste-Masking Pharmaceutical Compositions 有权
标题翻译：口味掩蔽药物组合物
公开(公告)号：US20080008765A1
公开(公告)日：2008-01-10
申请号：US11576890
申请日：2005-10-10
申请人： Franz Schwarz , Irina Kosilek
发明人： Franz Schwarz , Irina Kosilek
IPC分类号： A61K9/50 , A61K31/7048 , A61K9/16
CPC分类号： A61K31/7048 , A61K9/0095 , A61K9/5026
摘要： The present invention relates to a pharmaceutical composition for oral administration suitable for the preparation of a ready-to-use suspension comprising coated particles comprising an active substance having an unpleasant and/or bitter taste, such as clarithromycin, and a suspension base comprising an osmotically active substance capable of providing a high osmolality to the admixture of the suspension base with an aqueous suspending medium in the ready-to-use suspension. Said ready-to-use suspension maintains its palatability over a prolonged period of time by those defined osmotic conditions.
摘要翻译：本发明涉及适用于制备即用型悬浮液的口服给药药物组合物，其包含包含具有不愉快和/或苦味的活性物质的包衣颗粒，例如克拉霉素，以及包含渗透性的悬浮液能够在悬浮液与悬浮液的混合物中提供高渗透压的活性物质与即用型悬浮液中的水性悬浮介质。所述即用型悬浮液通过这些定义的渗透条件在长时间内保持其适口性。

10. 发明申请

US20050084541A1 Antibiotic compositions 有权
标题翻译：抗生素组合物
公开(公告)号：US20050084541A1
公开(公告)日：2005-04-21
申请号：US10768562
申请日：2004-01-30
申请人： Indranil Nandi , Mintong Guo , Chad Gassert , Franz Schwarz , Irina Kosilek
发明人： Indranil Nandi , Mintong Guo , Chad Gassert , Franz Schwarz , Irina Kosilek
IPC分类号： A61K9/16 , A61K9/50 , A61K9/24
CPC分类号： A61K9/1652 , A61K9/167 , A61K9/1694 , A61K9/5026 , A61K9/5073
摘要： An oral suspension comprising (a) an antibiotic composition which comprises coated micropellets and optionally one or more excipients, (b) additional excipients, and (c) a solvent, wherein said coated micropellets comprise (i) a core comprising at least one antibiotic; (ii) an inner coating comprising at least one cellulose polymer which is not an enteric coating polymer; and (iii) an outer coating comprising at least one enteric coating polymer, wherein said coated micropellets have a mean particle size of about 100 μm to about 650 μm. The oral suspension of the invention is characterized by a lack of bitter taste.
摘要翻译：一种口服悬浮液，其包含（a）抗生素组合物，其包含包被的微丸和任选的一种或多种赋形剂，（b）另外的赋形剂和（c）溶剂，其中所述包被的微丸包含（i）包含至少一种抗生素的核心; （ii）包含至少一种不是肠溶衣聚合物的纤维素聚合物的内涂层; 和（iii）包含至少一种肠溶衣聚合物的外涂层，其中所述涂覆的微丸具有约100μm至约650μm的平均粒度。本发明的口服悬浮液的特征在于缺乏苦味。

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